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Reposted

eLife @elife.bsky.social · 2d

High-resolution #CryoET provides ‘compelling’ evidence for the true 3D architecture of glutamatergic synapses: a complex ‘synaptoplasm’ rather than the textbook postsynaptic density.
buff.ly/hOYKjHH

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Reposted

Columbia University's Zuckerman Institute @zuckermanbrain.bsky.social · 28d

How does hunger spur us to consume? @columbiauniversity.bsky.social scientists have found a brain area that drives mice to consume sweets, fats, salt & food. This finding may inform novel treatments for both overeating and undereating:
zuckermaninstitute.columbia.edu/brain-dial-c...

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Reposted

cryoEM papers @cryoempapers.bsky.social · Sep 3

Progress in the development of an ultrafast pulsed ponderomotive phase plate for cryo-electron tomography pubmed.ncbi.nlm.nih.gov/40896196/ #cryoem

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fitzpatricklab.bsky.social @fitzpatricklab.bsky.social · Aug 31

Brooklyn at sunset

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fitzpatricklab.bsky.social @fitzpatricklab.bsky.social · Aug 28

Our latest paper on the development of an #ultrafast #laser #PhasePlate for #cryoET @fitzpatricklab.bsky.social @zuckermanbrain.bsky.social

doi.org/10.1063/4.0000770

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Reposted

Martin Pacesa @martinpacesa.bsky.social · Aug 27

Exciting to see our protein binder design pipeline BindCraft published in its final form in @Nature ! This has been an amazing collaborative effort with Lennart, Christian, @sokrypton.org, Bruno and many other amazing lab members and collaborators.

www.nature.com/articles/s41...

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Reposted

cryoEM papers @cryoempapers.bsky.social · Aug 27

Contrast by electron microscopy in thick biological specimens pubmed.ncbi.nlm.nih.gov/40857101/ #cryoem

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cryoEM papers @cryoempapers.bsky.social · Aug 24

Optimal tilt-increment for cryo-ET www.biorxiv.org/content/10.1101/2025.08.20.671201v1 #cryoem

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Reposted

cryoEM papers @cryoempapers.bsky.social · Aug 22

Fourier-based multiple-slice reconstruction in cryo-electron tomography pubmed.ncbi.nlm.nih.gov/40834650/ #cryoem

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Reposted

Dr. Dominic Ng @dominicng.bsky.social · Aug 22

A massive genetic study in @Nature just identified why chronic pain hits some people harder than others.

They discovered the first neuronal “pain transporter” - and it could unlock entirely new ways to treat pain. 🧵

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Reposted

Nature Structural & Molecular Biology @natsmb.nature.com · Aug 19

ICYMI: New online: Integrated structural biology of the native malarial translation machinery and its inhibition by an antimalarial drug

Integrated structural biology of the native malarial translation machinery and its inhibition by an antimalarial drug

Nature Structural & Molecular Biology, Published online: 18 August 2025; doi:10.1038/s41594-025-01632-3Integrated structural biology approach leveraging in situ cryo-electron tomography reveals molecular details of the native malarial translation elongation cycle and its perturbation by cabamiquine, a potent antimalarial drug candidate.

go.nature.com

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fitzpatricklab.bsky.social @fitzpatricklab.bsky.social · Aug 20

New "Mindscapes" exhibit @zuckermanbrain.bsky.social‬ featuring #cryoEM structures of #TMEM106B fibrils (doi.org/10.1016/j.cell.2022.02.026) and the ligand-bound human sweet receptor (doi.org/10.1016/j.cell.2025.04.021) from the Fitzpatrick (www.fitzpatrick-lab.org) and Zuker (www.zukerlab.com) labs

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Reposted

Chi-Min Ho @cmholab.bsky.social · Aug 18

Our #CryoET story on how a top antimalarial drug candidate perturbs the native malarial translation machinery is out @natsmb.nature.com🥳 rdcu.be/eBbrH

A massive team effort led by @leonieanton.bsky.social Meseret Haile & Wenjing Cheng in collaboration with Jerzy Dziekan & the Alan Cowman! #TeamTomo

Integrated structural biology of the native malarial translation machinery and its inhibition by an antimalarial drug

Nature Structural & Molecular Biology - Integrated structural biology approach leveraging in situ cryo-electron tomography reveals molecular details of the native malarial translation...

rdcu.be

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Reposted

Structura Biotechnology @structurabio.bsky.social · Aug 5

Flexibility can be frustrating when processing a #cryoEM dataset. If your target has a wobbly domain, check out our new case study on FaNaC1 for continuous heterogeneity tips in #CryoSPARC!

guide.cryosparc.com/processing-d...

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Reposted

Saloni @scientificdiscovery.dev · Jul 9

New post! Our summer edition of What's new in biology:

The first gonorrhea vaccination program, contact lenses that see infrared light, the protein behind sweet tastes, baby cured with gene therapy, gene-editing breakthroughs & new cholesterol drugs.

Written by me and @nikomccarty.bsky.social

What's new in biology: summer 2025

The first gonorrhea vaccination program, contact lenses that see infrared light, the protein behind sweet tastes, a baby cured with gene therapy, and more

www.worksinprogress.news

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Reposted

Will Wan @williamnwan.bsky.social · Jul 8

Happy to say that my Current Opinion in Structural Biology article came out today. I hope it helps to guide to you in using cryo-ET to make new biological discoveries!

www.sciencedirect.com/science/arti...

A practical look at cryo-electron tomography image processing: Key considerations for new biological discoveries

Cryo-electron tomography (cryo-ET) enables 3D visualization of complex biological environments without the need for purification, thereby preserving t…

www.sciencedirect.com

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fitzpatricklab.bsky.social @fitzpatricklab.bsky.social · Jul 3

Forward-looking preview by Bin Wu to our latest paper in Structure by @andrewnchang.bsky.social highlighting the power of #AI in #cryoEM of patient-derived samples:

tinyurl.com/tu2fyvme

Paper:

tinyurl.com/3cycffzm

Many thanks to @thorstenwagner.bsky.social @raunser-lab.bsky.social for #crYOLO

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Reposted

Marcus Brubaker @marcusabrubaker.bsky.social · Jun 24

Ever wonder why SGD, which works so well for ab initio cryo-EM, never seems to get to high resolution on its own? Well, we have the answer: conditioning!

Bogdan Toader @btoader.com · Jun 24

Work on SGD for high-resolution cryo-EM refinement from my previous postdoc finally published in @actacrystd.iucr.org

with Roy Lederman and @marcusabrubaker.bsky.social

📜 Paper: journals.iucr.org/paper?S20597...
💻 Code: github.com/bogdantoader...
💾 Data: doi.org/10.5281/zeno...

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Reposted

Michael Grange @michaelgrange.bsky.social · Jun 17

Proud to share our latest paper. doi.org/10.1016/j.cr...

Through the dedication of @glynnca.bsky.social and @cryingem.bsky.social we report a thorough method to image molecular organisation within hippocampus tissue.

Structural biology in tissue is well and truly here!

@rosfrankinst.bsky.social

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fitzpatricklab.bsky.social @fitzpatricklab.bsky.social · Jun 17

New preprint from Daniel Du @fitzpatricklab.bsky.social shows #femtosecond light pulses can lens electron beams, promising higher contrast in #cryoET and better aberration correction in #cryoEM

tinyurl.com/257sw7j9

Experiments made possible by support from @cziscience.bsky.social #ImagingTheFuture

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Reposted

febsopenbio.bsky.social @febsopenbio.bsky.social · May 23

An approach for coherent periodogram averaging of tilt-series data for improved contrast transfer function estimation

👉 buff.ly/hDgWZMA

#cryoEM #StructuralBiology #CryoET

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Reposted

cryoEM papers @cryoempapers.bsky.social · May 10

Structural basis of human uromodulin filament networks in uropathogen capture pubmed.ncbi.nlm.nih.gov/40345203/ #cryoem

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fitzpatricklab.bsky.social @fitzpatricklab.bsky.social · May 7

>20 years ago, Zuker et al. discovered the mammalian sweet taste receptors

Now, an exciting collaboration between our labs reveals the #cryoEM structure of the human sweet receptor-key to sweet taste perception-online @cp-cell.bsky.social!
www.sciencedirect.com/science/article/pii/S0092867425004568

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Reposted

Philippe Van der Stappen @phaips.vd.st · May 6

Hey #TeamTomo,
Ever been in need of a tutorial about the fundamentals of cryo-electron tomography? From preprocessing raw frames to high-res subtomogram averaging?
That's why @florentwaltz.bsky.social and I made this website!

tomoguide.github.io

Follow the thread 1 /🧵
#CryoET #CryoEM 🔬🧪

Welcome to TomoGuide

A step-by-step Cryo-ET guide

tomoguide.github.io

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Reposted

Nature @nature.com · Apr 24

Nature research paper: Structural basis of lipid transfer by a bridge-like lipid-transfer protein

https://go.nature.com/3Gn657r

Structural basis of lipid transfer by a bridge-like lipid-transfer protein - Nature

The LPD-3 complex structure reveals protein–lipid interactions that suggest a model for how the native LPD-3 complex mediates bulk lipid transport and provides a foundation for mechanistic studies of bridge-like lipid-transport proteins.

go.nature.com

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