Guillaume Charriere
@gm-charriere.bsky.social
370 followers 1.1K following 3 posts
Professor at Montpellier University, IHPE Lab, France. http://ihpe.univ-perp.fr/ihpe-charriere-guillaume/ Curious and interested in many aspects of phagocyte biology, vibrios, amoebae, oysters, host-pathogen co-evolution, and comparative immunology.
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Reposted by Guillaume Charriere
hansonmark.bsky.social
But in fact, fly immunity is highly reproducible! 🎊

~80% of claims could be verified. Moreover, some challenged claims just reflect the field advancing its knowledge/tools.

The lesson: if the tools are good and the research largely exempt from direct translation pressures, science works.

3.5/n
A chart depicting the track of claims into verified, unchallenged, challenged, partially verified, or mixed.

Figure 1: Flow of the study.
Claims were first classified in five categories based on literature. 45 unchallenged claims were selected to be experimentally tested and
classified either as challenged or as verified. We further classify some unchallenged as consistent or inconsistent depending on their
consistency with current knowledge.
Reposted by Guillaume Charriere
Reposted by Guillaume Charriere
caitlyncardetti.bsky.social
🚨Call for papers on Non-traditional model organisms for #BMCBiology🚨

Guest Editors:
Eve Gazave @stemdevevo.bsky.social, @ijmonod.bsky.social
Vladimír Hampl, @sciencecharles.bsky.social
Jason Podrabsky, Portland State U
Deanne Whitworth, U of Queensland

www.biomedcentral.com/collections/...
Image Credit: Bob Goldstein, a black and white sketch of various organisms - butterfly, fish, worm, some sort of plant, a rodent, some un-named sea creatures.
Reposted by Guillaume Charriere
nizet.bsky.social
Exciting fundamental discovery!

Early embryos fight bacteria WITHOUT immune cells

Zebrafish, mouse, and human embryos use epithelial cells (trophoectoderm)—not immune cells—to engulf and destroy 𝘌. 𝘤𝘰𝘭𝘪 and 𝘚. 𝘢𝘶𝘳𝘦𝘶𝘴

Hoijman Lab Barcelona 🇪🇸
𝘊𝘦𝘭𝘭 𝘏𝘰𝘴𝘵 𝘔𝘪𝘤𝘳𝘰𝘣𝘦

www.sciencedirect.com/science/arti...
gm-charriere.bsky.social
Thank you @soldatilab.bsky.social it was great to benefit from your inputs and expertise !
Reposted by Guillaume Charriere
nadinelaguette.bsky.social
Check out our most recent preprint where we describe Mecp2 as a régulatrice of cGAS-STING associated signaling. 🧪🔥
biorxiv-immuno.bsky.social
The methyl-CpG-binding protein 2 inhibits cGAS-associated signaling https://www.biorxiv.org/content/10.1101/2025.01.30.635818v1
Reposted by Guillaume Charriere
duckswabber.bsky.social
Between 2019 and 2023, researchers paid $8.968 billion to make papers open access. Imagine what else could be done with this money if it wasnt paid to for profit publishing companies...
👉 arxiv.org/abs/2407.16551
Reposted by Guillaume Charriere
abalkina.bsky.social
I'm delighted to share our opinion on #papermills published in Nature. Science is flooded with papers from paper mills.Certain steps can be taken, but this is a challenge that neither universities nor journals are ready to face.Some use paper mills to their advantage.
www.nature.com/articles/d41...
‘Stamp out paper mills’ — science sleuths on how to fight fake research
A group of scientists who are experts at spotting fraudulent research outline five essential steps to combat industrialized scientific misconduct.
www.nature.com
Reposted by Guillaume Charriere
prlogos.bsky.social
Les couloirs bruissaient depuis plusieurs semaines d'une nouvelle phase de démantèlement du CNRS menée par Antoine Petit: les labo étoilés sur lesquels se concentreraient les moyens, les autres étant laissés à l'abandon. Ils s’appelleront "keylabs".
Reposted by Guillaume Charriere
christlet.bsky.social
Newsletter CNRS:
'Création du label CNRS Keylabs. Pour faire face à la compétition internationale, le CNRS doit construire des masses critiques et faire porter un effort particulier sur un nombre plus restreint d’unités, celles qui peuvent légitimement prétendre à être qualifiée “de rang mondial”'
Reposted by Guillaume Charriere
mfgrp.bsky.social
Today we report that an engineered skin bacterium, swabbed gently on the head of a mouse, can unleash a potent antibody response against a pathogen. Could lead to topical vaccines that are applied in a cream. @djenetbousbaine.bsky.social led the charge... @natureportfolio.bsky.social 1/55
Reposted by Guillaume Charriere
relenski.bsky.social
Frequent Q is how mirror bacterium could persist in nature. Marine Prochlorococcus good example. Little downside in terms of competitiveness + resistant to protists and phages. Net positive growth allows invasion.

See Chapter 8 of technical report here:
purl.stanford.edu/cv716pj4036
Figure 8.2 from technical report on mirror bacteria, showing potential for net population growth and invasion of marine environment by mirror phototrophic bacteria.
Reposted by Guillaume Charriere
bjenquist.bsky.social
Important piece by Gittleman - “It’s impossible to separate human health from health of the natural world. Ecology is the unifying science that integrates knowledge..[the] One Health approach is unlimited, exciting, & necessary for the health of life on our planet” www.pnas.org/doi/10.1073/... 🧪🌎🌐🌾
Photo of the front page of the paper - showing animals and plants and people encircled across the globe - There needs to be more emphasis on the ecological component of One Health as we consider the problems of biodiversity loss, climate extremes, habitat fragmentation, and emerging disease. Image credit: Shutterstock/BeataGFX.
Reposted by Guillaume Charriere
daltmann.bsky.social
I don’t normally stray here into politics, but this is global health and child mortality: somewhat terrified this will negatively impact not just public health in the USA, but could normalise this view further afield
Reposted by Guillaume Charriere
soreklab.bsky.social
Registration is now open for the 2025 Symposium on the Immune System of Bacteria, taking place this year in Paris (April 8-10).

We have a fantastic lineup of speakers!

Register here: www.sisb2025.conferences-pasteur.org/home
audeber.bsky.social
Registration now open for the EMBO Workshop: Immune System of Bacteria !!!!

www.sisb2025.conferences-pasteur.org/home

Joins us in Institut Pasteur, Paris, April 8-10th.
Reposted by Guillaume Charriere
craigmaclean.bsky.social
Plasmid afficionados: Does anybody know of any chromosomal genes that are required for plasmid conjugation? We have found a few by chance in a recent experiment and I would be really interested to know if there are other examples.
#microsky
#plasmid
Reposted by Guillaume Charriere
hansonmark.bsky.social
The #Drosophila Immunity Handbook 🧵

This project started as a review with the aim, in some sense, to update Lemaitre and Hoffmann (2007; Ann Rev Imm). Then it kinda... got out of hand. But the reason that happened is because Hannah is amazing.

Find the free PDF here btw: bit.ly/DrosImmBook
1/n
Reposted by Guillaume Charriere
atp-alker.bsky.social
🚨 The Alker Lab is starting at the University of Rhode Island in early 2025 and we will be hiring! 🚨

If you are interested in marine microbiology, bacterial genetics and/or symbiosis, please consider reaching out! Repost to help spread the word 🪸🧪🧬🌊
The Alker lab at the University of Rhode Island is hiring (students, postdocs and lab staff)! We use cutting edge tools in microbiology to investigate marine animal symbioses. Email or DM for further inquiries