Hauke Drechsler
@hd-sci.bsky.social
Biochemist/Molecular Biologist studying the Biophysics of the human cytoskeleton in a plant institute @unituebingen using Cell Biology and in vitro reconstitution approaches - is interdisciplinarity still a thing?
Mastodon: @[email protected]
Mastodon: @[email protected]
Pinned
Hauke Drechsler
@hd-sci.bsky.social
· Aug 31
#ServiceNotification for the few that work with #KIF15 : please note that the polyclonal KIF15 AB #55407-1-AP by #proteintech creates lots of specific-looking background in IF (especially in interphase cells) that IS NOT KIF15! As tested in a KIF15 KO cell line rescued with a FLAG-tagged WT KIF15.
Behold the beauty of a human metaphase spindle 🫠
[RPE1 cell, confocal expansion microscopy, microtubules in green, chromosomes in blue, kinesin-12 in magenta)
micrograph by Malte Lemmin, Nanoscience Master Student @zmbp-tuebingen.bsky.social @unituebingen.bsky.social
[RPE1 cell, confocal expansion microscopy, microtubules in green, chromosomes in blue, kinesin-12 in magenta)
micrograph by Malte Lemmin, Nanoscience Master Student @zmbp-tuebingen.bsky.social @unituebingen.bsky.social
December 17, 2025 at 5:40 PM
Behold the beauty of a human metaphase spindle 🫠
[RPE1 cell, confocal expansion microscopy, microtubules in green, chromosomes in blue, kinesin-12 in magenta)
micrograph by Malte Lemmin, Nanoscience Master Student @zmbp-tuebingen.bsky.social @unituebingen.bsky.social
[RPE1 cell, confocal expansion microscopy, microtubules in green, chromosomes in blue, kinesin-12 in magenta)
micrograph by Malte Lemmin, Nanoscience Master Student @zmbp-tuebingen.bsky.social @unituebingen.bsky.social
Reposted by Hauke Drechsler
New release of #BigVolumeBrowser. Many things were added: UI improvement (thanks to @kwolbachia.bsky.social feedback), pyramidization for BioFormats dataset, bug fixes.
Now there is an isosurface rendering mode (1/4)
Now there is an isosurface rendering mode (1/4)
December 12, 2025 at 10:10 AM
New release of #BigVolumeBrowser. Many things were added: UI improvement (thanks to @kwolbachia.bsky.social feedback), pyramidization for BioFormats dataset, bug fixes.
Now there is an isosurface rendering mode (1/4)
Now there is an isosurface rendering mode (1/4)
Reposted by Hauke Drechsler
Take a tour of the PDB--The vast range of molecular shapes and sizes in the archive are illustrated by these 96 biomolecular machines.
PDB101: Learn: Flyers, Posters, & Calendars: Posters: Molecular Machinery: A Tour of the Protein Data Bank
The enormous range of molecular shapes and sizes in the PDB archive is illustrated using 96 structures, depicted relative to the cellular membrane.
pdb101.rcsb.org
December 11, 2025 at 6:55 PM
Take a tour of the PDB--The vast range of molecular shapes and sizes in the archive are illustrated by these 96 biomolecular machines.
Reposted by Hauke Drechsler
Just look at those microtubules go! Happy to see our paper out in JCS ✨
Malina Iwanski @mkiwanski.bsky.social, Lukas Kapitein and colleagues discover that stable microtubules reverse their polarity during neuronal development.
journals.biologists.com/jcs/article/...
#OpenAccess #ReadandPublish
journals.biologists.com/jcs/article/...
#OpenAccess #ReadandPublish
December 9, 2025 at 12:22 PM
Just look at those microtubules go! Happy to see our paper out in JCS ✨
Working above the clouds today ...
December 9, 2025 at 9:19 AM
Working above the clouds today ...
Reposted by Hauke Drechsler
December 8, 2025 at 9:01 AM
Reposted by Hauke Drechsler
New to RNA design? Please try pyFuRNAce! Looking forward to your feedback 🧬
PyFuRNAce is an intuitive browser-based RNA design tool.
@monari-luca.bsky.social @kgoepfrich.bsky.social @uniheidelberg.bsky.social realized the largest cotranscriptionally folded RNA nanostructures to date. #BiotechNatureComms
www.nature.com/articles/s41...
@monari-luca.bsky.social @kgoepfrich.bsky.social @uniheidelberg.bsky.social realized the largest cotranscriptionally folded RNA nanostructures to date. #BiotechNatureComms
www.nature.com/articles/s41...
PyFuRNAce: an integrated design engine for RNA origami - Nature Communications
RNA nanotechnology creates structural and functional RNA architectures for biomedicine, synthetic biology and beyond. Here, the authors introduce pyFuRNAce, an intuitive browser-based RNA design tool....
www.nature.com
December 7, 2025 at 4:39 PM
New to RNA design? Please try pyFuRNAce! Looking forward to your feedback 🧬
Reposted by Hauke Drechsler
Have to feel for the grey eduWOSM. It's just so .. grey ..
December 4, 2025 at 4:33 PM
Have to feel for the grey eduWOSM. It's just so .. grey ..
Reposted by Hauke Drechsler
Calling all #MotorsInQuarantine fans: Please join us for 1.5 days of science on motors and the cytoskeleton as we celebrate the career of Rob Cross. More info and sign-up here: tinyurl.com/mechanochemi... #kinesin #dynein #myosin #microtubules #actin #cytoskeleton
December 2, 2025 at 5:53 PM
Calling all #MotorsInQuarantine fans: Please join us for 1.5 days of science on motors and the cytoskeleton as we celebrate the career of Rob Cross. More info and sign-up here: tinyurl.com/mechanochemi... #kinesin #dynein #myosin #microtubules #actin #cytoskeleton
Reposted by Hauke Drechsler
Registration is OPEN for our Spring meeting: Dynamic Cell VI
🗓️ 21st-26th April 2026
📍Reading, UK
Co-organised with @biochemsoc.bsky.social @royalmicrosoc.bsky.social and the Chinese Society for Cell Biology
Register here:
www.eventsforce.net/biochemsoc/f...
🗓️ 21st-26th April 2026
📍Reading, UK
Co-organised with @biochemsoc.bsky.social @royalmicrosoc.bsky.social and the Chinese Society for Cell Biology
Register here:
www.eventsforce.net/biochemsoc/f...
October 31, 2025 at 10:06 AM
Registration is OPEN for our Spring meeting: Dynamic Cell VI
🗓️ 21st-26th April 2026
📍Reading, UK
Co-organised with @biochemsoc.bsky.social @royalmicrosoc.bsky.social and the Chinese Society for Cell Biology
Register here:
www.eventsforce.net/biochemsoc/f...
🗓️ 21st-26th April 2026
📍Reading, UK
Co-organised with @biochemsoc.bsky.social @royalmicrosoc.bsky.social and the Chinese Society for Cell Biology
Register here:
www.eventsforce.net/biochemsoc/f...
Reposted by Hauke Drechsler
And now… part two of our twin papers on how chromosomes find their place before division! Led by @krunovuk.bsky.social at @institutrb.bsky.social, out in @natcomms.nature.com!
doi.org/10.1038/s414...
doi.org/10.1038/s414...
Missed the thread on the first paper? Catch up:
bsky.app/profile/ivat...
doi.org/10.1038/s414...
doi.org/10.1038/s414...
Missed the thread on the first paper? Catch up:
bsky.app/profile/ivat...
October 29, 2025 at 5:09 PM
And now… part two of our twin papers on how chromosomes find their place before division! Led by @krunovuk.bsky.social at @institutrb.bsky.social, out in @natcomms.nature.com!
doi.org/10.1038/s414...
doi.org/10.1038/s414...
Missed the thread on the first paper? Catch up:
bsky.app/profile/ivat...
doi.org/10.1038/s414...
doi.org/10.1038/s414...
Missed the thread on the first paper? Catch up:
bsky.app/profile/ivat...
Reposted by Hauke Drechsler
⚡Ready to grow and be inspired as a scientist?
We’re looking for a *PhD student* to join our lab at @crg.eu
in Barcelona and explore how cells self-organize, uncovering life’s inner design💡
We offer strong mentoring, cutting-edge science, and a vibrant international team🌍
Check the link below!
We’re looking for a *PhD student* to join our lab at @crg.eu
in Barcelona and explore how cells self-organize, uncovering life’s inner design💡
We offer strong mentoring, cutting-edge science, and a vibrant international team🌍
Check the link below!
October 23, 2025 at 9:56 AM
⚡Ready to grow and be inspired as a scientist?
We’re looking for a *PhD student* to join our lab at @crg.eu
in Barcelona and explore how cells self-organize, uncovering life’s inner design💡
We offer strong mentoring, cutting-edge science, and a vibrant international team🌍
Check the link below!
We’re looking for a *PhD student* to join our lab at @crg.eu
in Barcelona and explore how cells self-organize, uncovering life’s inner design💡
We offer strong mentoring, cutting-edge science, and a vibrant international team🌍
Check the link below!
Reposted by Hauke Drechsler
We hiring! Please share this post with your talented ECRs
We're looking for a postdoc interested in the formation and function of tertiary lymphoid structures - project funded by Wellcome
Based at @lmcb-ucl.bsky.social at University College London
Apply here:
www.jobs.ac.uk/job/DPD418/r...
We're looking for a postdoc interested in the formation and function of tertiary lymphoid structures - project funded by Wellcome
Based at @lmcb-ucl.bsky.social at University College London
Apply here:
www.jobs.ac.uk/job/DPD418/r...
October 21, 2025 at 3:57 PM
We hiring! Please share this post with your talented ECRs
We're looking for a postdoc interested in the formation and function of tertiary lymphoid structures - project funded by Wellcome
Based at @lmcb-ucl.bsky.social at University College London
Apply here:
www.jobs.ac.uk/job/DPD418/r...
We're looking for a postdoc interested in the formation and function of tertiary lymphoid structures - project funded by Wellcome
Based at @lmcb-ucl.bsky.social at University College London
Apply here:
www.jobs.ac.uk/job/DPD418/r...
Reposted by Hauke Drechsler
1925: On this date, 100 years ago, The Company of Biologists is founded by George Parker Bidder III. Throughout today, we will be posting some of our key milestones. Read more about the past 100 years at bit.ly/3WnTVA1.
October 15, 2025 at 8:04 AM
1925: On this date, 100 years ago, The Company of Biologists is founded by George Parker Bidder III. Throughout today, we will be posting some of our key milestones. Read more about the past 100 years at bit.ly/3WnTVA1.
Now online @jcellsci.bsky.social: in vitro reconstitution work showing that the tail of plant kinesin-12 POK2 interacts with microtubules, MAP65 and anionic lipids that together could mediate it's targeting to and long-time retention at the cell cortex. journals.biologists.com/jcs/article/...
The tail domain of the plant kinesin-12 POK2 is a versatile interaction hub
Summary: In vitro reconstitution experiments reveal that the tail domain of the kinesin-12 POK2 interacts with microtubules, MAP65-3 and lipids as a possible mechanism for division site deposition and...
journals.biologists.com
October 10, 2025 at 4:11 PM
Now online @jcellsci.bsky.social: in vitro reconstitution work showing that the tail of plant kinesin-12 POK2 interacts with microtubules, MAP65 and anionic lipids that together could mediate it's targeting to and long-time retention at the cell cortex. journals.biologists.com/jcs/article/...
Reposted by Hauke Drechsler
A fantastic #openaccess Techniques and Procedures paper from Kristen Verhey's lab is available in #CYTOSKELETON! Purification, Fluorescent Labeling, and Detyrosination of Mammalian #Cell #Tubulin for #Biochemical Assays. Check it out: onlinelibrary.wiley.com/doi/full/10.... @kjverhey1.bsky.social
September 8, 2025 at 3:13 PM
A fantastic #openaccess Techniques and Procedures paper from Kristen Verhey's lab is available in #CYTOSKELETON! Purification, Fluorescent Labeling, and Detyrosination of Mammalian #Cell #Tubulin for #Biochemical Assays. Check it out: onlinelibrary.wiley.com/doi/full/10.... @kjverhey1.bsky.social
New paper out now @cp-cellreports.bsky.social! If you would like to know, what it takes to turn a classical transport #kinesin motor into a decent #microtubule polymerase read on here www.cell.com/cell-reports.... (Pssst it's the N-terminal motor domain extension of budding yeast kinesin #Kip2)😉
The kinesin Kip2 promotes microtubule growth using a bipartite polymerase module to deliver tubulin to microtubule plus ends
Microtubules act as highways in cells, with kinesins transporting cargo and maintaining
their length for cell survival. Nadalis et al. show that the yeast kinesin Kip2 promotes
microtubule growth by d...
www.cell.com
September 29, 2025 at 6:00 PM
New paper out now @cp-cellreports.bsky.social! If you would like to know, what it takes to turn a classical transport #kinesin motor into a decent #microtubule polymerase read on here www.cell.com/cell-reports.... (Pssst it's the N-terminal motor domain extension of budding yeast kinesin #Kip2)😉
Reposted by Hauke Drechsler
Oftmals knobeln Forschende kleine, aber ausgefuchste Methoden-Tricks aus, die den experimentellen Laboralltag erleichtern und manchmal sogar Geld einsparen helfen. 29 solche #Labor -Tricks haben wir in unserem neuen #Dossier zusammengestellt: www.laborjournal.de/editorials/3...
September 26, 2025 at 9:01 AM
Oftmals knobeln Forschende kleine, aber ausgefuchste Methoden-Tricks aus, die den experimentellen Laboralltag erleichtern und manchmal sogar Geld einsparen helfen. 29 solche #Labor -Tricks haben wir in unserem neuen #Dossier zusammengestellt: www.laborjournal.de/editorials/3...
Reposted by Hauke Drechsler
Time for a thread!🧵 How different is the molecular organization of thylakoids in “higher” plants🌱? To find out, we teamed up with @profmattjohnson.bsky.social to dive into spinach chloroplasts with #CryoET ❄️🔬. Curious? ..Read on!
#TeamTomo #PlantScience 🧪 🧶🧬 🌾
elifesciences.org/articles/105...
1/🧵
#TeamTomo #PlantScience 🧪 🧶🧬 🌾
elifesciences.org/articles/105...
1/🧵
September 25, 2025 at 6:00 PM
Time for a thread!🧵 How different is the molecular organization of thylakoids in “higher” plants🌱? To find out, we teamed up with @profmattjohnson.bsky.social to dive into spinach chloroplasts with #CryoET ❄️🔬. Curious? ..Read on!
#TeamTomo #PlantScience 🧪 🧶🧬 🌾
elifesciences.org/articles/105...
1/🧵
#TeamTomo #PlantScience 🧪 🧶🧬 🌾
elifesciences.org/articles/105...
1/🧵
Reposted by Hauke Drechsler
I get that the news cycle is packed right now, but I just heard from a colleague at the Smithsonian that this is fully a GIANT SQUID BEING EATEN BY A SPERM WHALE and it’s possibly the first ever confirmed video according to a friend at NOAA
10 YEAR OLD ME IS LOSING HER MIND (a thread 🧵)
10 YEAR OLD ME IS LOSING HER MIND (a thread 🧵)
September 24, 2025 at 8:30 PM
I get that the news cycle is packed right now, but I just heard from a colleague at the Smithsonian that this is fully a GIANT SQUID BEING EATEN BY A SPERM WHALE and it’s possibly the first ever confirmed video according to a friend at NOAA
10 YEAR OLD ME IS LOSING HER MIND (a thread 🧵)
10 YEAR OLD ME IS LOSING HER MIND (a thread 🧵)
Reposted by Hauke Drechsler
A milestone for plant genomics just out @natgenet.nature.com
130 bryophyte genomes!
www.nature.com/articles/s41...
130 bryophyte genomes!
www.nature.com/articles/s41...
Bryophytes hold a larger gene family space than vascular plants - Nature Genetics
A super-pangenome analysis incorporating 123 newly sequenced bryophyte genomes reveals that bryophytes exhibit a larger number of unique and lineage-specific gene families than vascular plants.
www.nature.com
September 22, 2025 at 8:42 PM
A milestone for plant genomics just out @natgenet.nature.com
130 bryophyte genomes!
www.nature.com/articles/s41...
130 bryophyte genomes!
www.nature.com/articles/s41...
Reposted by Hauke Drechsler
A new #CryoET study shows that the protein ZapD helps organise FtsZ filaments into stable ring-like structures in building bacterial division machinery.
buff.ly/saLPqJM
buff.ly/saLPqJM
September 21, 2025 at 8:21 AM
A new #CryoET study shows that the protein ZapD helps organise FtsZ filaments into stable ring-like structures in building bacterial division machinery.
buff.ly/saLPqJM
buff.ly/saLPqJM
Reposted by Hauke Drechsler
Exciting news! 🚀
Our latest work has been selected as the cover article in Nano Letters! 🎉
“Attonewton Force Resolution Measurements with Silicon Nanospheres at the Thermal Noise Limit in Ambient-Temperature Liquids”
#NanoLetters #CoverArticle #OpticalTweezers #ForceMeasurement #ZMBP
Our latest work has been selected as the cover article in Nano Letters! 🎉
“Attonewton Force Resolution Measurements with Silicon Nanospheres at the Thermal Noise Limit in Ambient-Temperature Liquids”
#NanoLetters #CoverArticle #OpticalTweezers #ForceMeasurement #ZMBP
September 16, 2025 at 10:47 AM
Exciting news! 🚀
Our latest work has been selected as the cover article in Nano Letters! 🎉
“Attonewton Force Resolution Measurements with Silicon Nanospheres at the Thermal Noise Limit in Ambient-Temperature Liquids”
#NanoLetters #CoverArticle #OpticalTweezers #ForceMeasurement #ZMBP
Our latest work has been selected as the cover article in Nano Letters! 🎉
“Attonewton Force Resolution Measurements with Silicon Nanospheres at the Thermal Noise Limit in Ambient-Temperature Liquids”
#NanoLetters #CoverArticle #OpticalTweezers #ForceMeasurement #ZMBP
Reposted by Hauke Drechsler
PILS-Nir1 is a sensitive phosphatidic acid #biosensor that reveals mechanisms of #lipid production. New study from Claire Weckerly (@cwecks.bsky.social), Taylor Rahn, Gerald Hammond (@gerryhammond.bsky.social) and colleagues (University of Pittsburgh School of Medicine): rupress.org/jcb/article/...
September 16, 2025 at 3:03 PM
PILS-Nir1 is a sensitive phosphatidic acid #biosensor that reveals mechanisms of #lipid production. New study from Claire Weckerly (@cwecks.bsky.social), Taylor Rahn, Gerald Hammond (@gerryhammond.bsky.social) and colleagues (University of Pittsburgh School of Medicine): rupress.org/jcb/article/...
Reposted by Hauke Drechsler
Kinesin-8/Kip3 requires β-tubulin tail for depolymerase activity, say Kaitlin Alemany, Samantha Johnson, and Jeffrey Moore @cuanschutz.bsky.social: rupress.org/jcb/article/...
#Cytoskeleton #Biochemistry #Kinesins #Microtubules
#Cytoskeleton #Biochemistry #Kinesins #Microtubules
September 15, 2025 at 7:31 PM
Kinesin-8/Kip3 requires β-tubulin tail for depolymerase activity, say Kaitlin Alemany, Samantha Johnson, and Jeffrey Moore @cuanschutz.bsky.social: rupress.org/jcb/article/...
#Cytoskeleton #Biochemistry #Kinesins #Microtubules
#Cytoskeleton #Biochemistry #Kinesins #Microtubules