Ben 🦠
@individualpttrn.bsky.social
190 followers
420 following
60 posts
Molecular biology, directed evolution, recombinant proteins, genome editing and some ghoulish tinkering. Formerly @INRAE_PACA and @Michiganstateu . Now @LRSV_Toulouse
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Ben 🦠
@individualpttrn.bsky.social
· Sep 8
Exploring the deletion landscape of S. aureus Cas9 with SABER
Profiling tolerated amino acid deletions in proteins can elucidate structure-function relationships, reconstruct intermediate stages in protein evolution, and be used to engineer minimized versions of...
www.biorxiv.org
Reposted by Ben 🦠
Reposted by Ben 🦠
Joe Peters Lab
@joepeterslab.bsky.social
· Aug 28
De novo engineered guide RNA-directed transposition with TnpB-family proteins reveals features of naturally evolved systems
Programmable DNA integration using CRISPR-associated transposons (CASTs) offers powerful capabilities for genome engineering. The single effector Cas12k CAST examples evolved from a fixed guide TnpB n...
www.biorxiv.org
Reposted by Ben 🦠
Gozde Demirer
@prof-gozde.bsky.social
· Aug 26
Reposted by Ben 🦠
Reposted by Ben 🦠
Reposted by Ben 🦠
Reposted by Ben 🦠
The Onion
@theonion.com
· Aug 12
RFK Jr. Mandates All Americans Drink Mysterious Glowing Liquid
WASHINGTON—Claiming the luminous potion would make the nation strong and vigorous, Health and Human Services Secretary Robert F. Kennedy Jr. issued an order Friday directing all Americans to drink a m...
theonion.com
Reposted by Ben 🦠
Reposted by Ben 🦠
Reposted by Ben 🦠
Liana Lareau
@lianafaye.bsky.social
· Aug 7
Protein language models reveal evolutionary constraints on synonymous codon choice
Evolution has shaped the genetic code, with subtle pressures leading to preferences for some synonymous codons over others. Codons are translated at different speeds by the ribosome, imposing constrai...
www.biorxiv.org
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Dave Vetter
@davidrvetter.bsky.social
· Aug 8
Why a NASA satellite that scientists and farmers rely on may be destroyed on purpose
The Trump administration has asked NASA staffers to draw up plans to end at least two satellite missions that measure carbon dioxide in the atmosphere, according to current and former NASA employees.
www.npr.org
Ben 🦠
@individualpttrn.bsky.social
· Aug 7
Unlocking genetic potential: harnessing phage for targeted mutagenesis in phage-assisted evolution
Abstract. A critical challenge in DNA library genesis for evolution systems is avoiding off-target mutations, which can introduce undesirable changes elsew
academic.oup.com
Reposted by Ben 🦠
Reposted by Ben 🦠
Ben 🦠
@individualpttrn.bsky.social
· Aug 1
A visual monitoring DNA‐free multi‐gene editing system excised via LoxP::FRT/FLP in poplar
The CRISPR-Cas9 system has emerged as a potent molecular scalpel for precise genome editing, and profoundly revolutionized plant genetics and breeding, facilitating the development of innovative and ....
onlinelibrary.wiley.com
Reposted by Ben 🦠
