Lightnews — Scholar-powered news

Reposted by Inna Slutsky

Mike Fainzilber @mfainzilber.bsky.social · 4d

Intriguing new insights on axonal TDP-43 in ALS from @labperlson.bsky.social and colleagues

www.nature.com/articles/s41...

Muscle-derived miR-126 regulates TDP-43 axonal local synthesis and NMJ integrity in ALS models - Nature Neuroscience

Ionescu, Ankol et al. show that, in ALS mouse and iPSC models, TDP-43 aggregation at NMJs stems from aberrant axonal translation, normally repressed by muscle EV-derived miR126. Loss of miR126 in ALS increases TDP-43 buildup, impairs local synthesis and triggers degeneration.

www.nature.com

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Inna Slutsky @innaslutsky.bsky.social · 17d

Warmest congratulations, Anita!

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Inna Slutsky @innaslutsky.bsky.social · 22d

Beautiful work, warmest congratulations!

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Reposted by Inna Slutsky

The Venkatesh Lab @venkatesh-lab.bsky.social · 22d

We are excited to share the Venkatesh Lab’s first publication in collaboration with @michellemonje.bsky.social team uncovering how neuronal activity influences the progression of small cell lung cancer #SCLC in the lung and brain. www.nature.com/articles/s41...

Neuronal activity-dependent mechanisms of small cell lung cancer pathogenesis - Nature

Glutamatergic and GABAergic (γ-aminobutyric acid-producing) cortical neuronal activity drives proliferation of small lung cell cancer via paracrine interactions and through synapses formed with tumour...

www.nature.com

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Reposted by Inna Slutsky

Yuval Nir @labnir.bsky.social · 28d

🚨 New paper alert! 🚨(1/6)

Excited to share our work, out now in Science Advances

We show that a rapid norepinephrine surge along a brainstem pathway (LC→PRN) is a key driver of sound-evoked awakenings
www.science.org/doi/10.1126/...

An early surge of norepinephrine along brainstem pathways drives sensory-evoked awakening

The locus coeruleus has a specialized pathway to the brainstem that controls sound-evoked awakening from sleep.

www.science.org

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Reposted by Inna Slutsky

Tobias Rose @trose-neuro.bsky.social · Sep 9

BonnBrain 2026 is a go!
March 23–25, Bonn (DZNE, Bonn, Germany).
Apply now: www.bonnbrain.de
Limited slots. Presentations (posters/talks) selected from submitted abstracts.

Keynotes & invited speakers 👇

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Reposted by Inna Slutsky

Tim Verstynen @tdverstynen.bsky.social · Aug 15

This had me laughing to tears. The person sitting next to me on the flight must have thought I was nuts.

A must read for the FEP curious.

www.researchgate.net/publication/...

(PDF) The Exit Manual: How to Leave the Free Energy Cult and Still Get Tenure

PDF | This manual is not a plea. It is a jailbreak from a cult—the Free Energy Principle, a theoretical metastasis that began in computational... | Find, read and cite all the research you need on Res...

www.researchgate.net

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Reposted by Inna Slutsky

Gan Lab @liganlab.bsky.social · Aug 8

Exciting finding: Endogenous lithium is essential for brain health and its deficiency contributes to the onset and progression of Alzheimer’s disease, by activating GSK3β—leading to impaired Aβ clearance and synapse loss
🧠 Led by Dr. Bruce Yankner @harvardmed.bsky.social
🔗 doi.org/10.1038/s415...

Lithium deficiency and the onset of Alzheimer’s disease - Nature

Lithium has an essential role in the brain and is deficient early in Alzheimer’s disease, which can be recapitulated in mice and treated with a novel lithium salt that restores the physiological level...

doi.org

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Reposted by Inna Slutsky

Harvard_MCB @harvardmcb.bsky.social · Jul 29

Early Exposure to Anesthesia May Shift Brain Development 🧠 🧪🧬 #AcademicSky #higherEd
www.mcb.harvard.edu/department/n... @rachellegaudet.bsky.social @dulaclab.bsky.social @neurovenki.bsky.social @naoshigeuchida.bsky.social @harvardbrainsci.bsky.social @northeasternu.bsky.social

Early Exposure to Anesthesia May Shift Brain Development - Harvard University - Department of Molecular & Cellular Biology

MCB researchers show GABA-based sedation in newborns speeds up brain development, confirming decades of animal research in a human cohort. A new longitudinal study led by MCB’s Takao […]

www.mcb.harvard.edu

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Reposted by Inna Slutsky

Ching-Lung Hsu @hiallen72.bsky.social · Jun 7

www.pnas.org/doi/10.1073/...

Increased excitatory synapse size in hippocampal place cells compared to silent cells | PNAS

Neuronal activity in the hippocampus creates a cognitive map of space that is essential for navigation. In any given environment, a fraction of hip...

www.pnas.org

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Inna Slutsky @innaslutsky.bsky.social · May 31

Congratulations, Joris and the team! Very interesting and important work!

Reposted by Inna Slutsky

Joris de Wit @synapse-lab.bsky.social · Apr 8

Postdoc opportunity in the heart of Europe! Check out the flyer below.
Join our team on an international project with Anthony Holtmaat exploring synaptic plasticity and specificity in cortical and thalamocortical circuits.

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Reposted by Inna Slutsky

Mike Fainzilber @mfainzilber.bsky.social · May 16

Online now at @cp-cell.bsky.social , the culmination of a 12-year effort. 🧵 to follow later this evening

www.cell.com/cell/fulltex...

Repeat-element RNAs integrate a neuronal growth circuit

SINEs of recovery: A subset of small RNAs encoded by repetitive genomic elements are induced by nerve lesion to regulate protein synthesis and enhance axonal growth.

www.cell.com

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Reposted by Inna Slutsky

Society for Neuroscience @sfn.org · May 8

Claim your spot now for the next webinar in partnership with @kavlifoundation.bsky.social!

Join the conversation as experts discuss mechanisms of neural adaptation in changing environments and recent advances in the field.

Register now: bit.ly/4k7h3MX

#NeuroSky

Promotional graphic for a Society for Neuroscience and The Kavli Foundation event titled 'Neuromodulatory Adaptation and Plasticity in Changing Environments’ on Wednesday, May 14, 11:30 a.m.–12:30 p.m. EDT. Features images of speakers Laura Duvall, PhD from Columbia University, Eve Marder, PhD from Brandeis University, and Jan-Erik Siemens, PhD from Heidelberg University.

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Reposted by Inna Slutsky

Mario Carta @mariocarta.bsky.social · May 9

🧠 Registration is open for the Bordeaux Neurocampus Conference on Brain–Body Interactions!
📍 Bordeaux, Oct 1–3, 2025
🗓️ Submit abstracts by July 1
🔗 brainconf.u-bordeaux.fr/en/

@mariocarta.bsky.social, @francoisgeorges.bsky.social, @cglangetas.bsky.social, E. Montalban @agnesnadjar.bsky.social.

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Reposted by Inna Slutsky

Thinking about Thinking @thoughtchannel.bsky.social · Apr 1

We're bringing together leading researchers from top institutions worldwide to Split, Croatia this summer. If you're passionate about brain-inspired AI, computational neuroscience, or fundamental mathematical principles driving intelligence, this conference is the place to be!

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Reposted by Inna Slutsky

Carmen Sandi @carmensandi10.bsky.social · Apr 1

Hiring! Postdoc position in Human Metabolism!
Join us to explore the metabolic underpinnings of human brain & behavior; focusing on anxiety & motivation
Outstanding interdisciplinary environment @epfl-brainmind.bsky.social at EPFL in Lausanne Switzerland
Info here: www.fens.org/careers/job-...

Postdoctoral Position in Human Metabolism, Mitochondria & Behavior at EPFL - Federation of European Neuroscience Societies

www.fens.org

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Reposted by Inna Slutsky

Maya Voichek @mayavoichek.bsky.social · Mar 17

1/ Transposable elements are often called "jumping genes" because they mobilize within genomes. 🧬
But did you know they can also jump 𝘣𝘦𝘵𝘸𝘦𝘦𝘯 cells? 🤯
Our new study reveals how retrotransposons invade the germline directly from somatic cells.
www.biorxiv.org/content/10.1...
A short thread 🧵👇

Drosophila follicle showing retrotransposons (pink & yellow) expressed in somatic cells infecting the oocyte

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Inna Slutsky @innaslutsky.bsky.social · Mar 16

If intracellular hippocampal electrophysiology counts as well😉, would be happy to join

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Inna Slutsky @innaslutsky.bsky.social · Mar 5

Warmest congratulations, Michelle! @michellemonje.bsky.social

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Reposted by Inna Slutsky

Karl Deisseroth @deisseroth.bsky.social · Mar 5

Congratulations to these two outstanding physician-neuroscientists! Many people now are familiar with the fascinating fundamental research of @michellemonje.bsky.social but most people probably don't know she is a truly great physician. I'm fortunate to be inspired by her every day, in every way.

The Brain Prize @brainprize.org · Mar 5

Congratulations to winners of The Brain Prize 2025!
Professors @michellemonje.bsky.social, @stanfordmedicine.bsky.social and @hhmi.org Investigator, and Frank Winkler, Heidelberg University Hospital, have pioneered the field of Cancer Neuroscience.

Learn more: brainprize.org/winners/canc...

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Inna Slutsky @innaslutsky.bsky.social · Feb 4

The one and only Shimon Marom: A physiological pragmatic view of the philosophical debate on freedom to choose. "This essay ... examines whether and how physiological facts can constrain or shape philosophical discussions on the matter..."
physoc.onlinelibrary.wiley.com/doi/10.1113/...

A physiological pragmatic view of the philosophical debate on freedom to choose1

Click on the article title to read more.

physoc.onlinelibrary.wiley.com

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Reposted by Inna Slutsky

Karl Herrup @asparatics.bsky.social · Jan 30

My first science post here on BlueSky is a long one. Setting the contrarian tone from the very beginning, I take strong issue with the recent op-ed by Charles Piller published in the January 24th NY Times on #Alzheimer's disease (nam12.safelinks.protection.outlook.com?url=https%3A...)

Opinion | The Devastating Legacy of Lies in Alzheimer’s Science

Fraud in research needs to end.

nam12.safelinks.protection.outlook.com

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Reposted by Inna Slutsky

Paul Frankland @franklandlab.bsky.social · Jan 23

Just giving this a boost for those who may not have seen it yet... we have a PI position (molecular and cellular basis of cognition) at The Hospital for Sick Children (Toronto). The position comes with an appointment at Assist/Assoc Prof level at U of T. Share widely!
can-acn.org/scientist-se...

Scientist/Senior Scientist – Research Institute, Hospital for Sick Children, University of Toronto – Canadian Association for Neuroscience

can-acn.org

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Inna Slutsky @innaslutsky.bsky.social · Jan 23

link to the paper: www.cell.com/neuron/fullt...

NMDA receptors regulate the firing rate set point of hippocampal circuits without altering single-cell dynamics

NMDARs are central regulators of Hebbian synaptic plasticity, although their role in neuronal homeostasis is debated. Ruggiero et al. reveal a novel role for NMDARs in regulating network, but not sing...

www.cell.com

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