Nature - Genetic manipulation of blastoids reveals the role of recently emerged transposable elements and genes in human development.

AussiERV: Australia’s first symposium dedicated to endogenous retroviruses. Join us for this one-day virtual event on November 7th!

Eukaryotic genomes generate a plethora of polyadenylated (pA+) RNAs[1][1],[2][2], that are packaged into ribonucleoprotein particles (RNPs). To ensure faithful gene expression, functional pA+ RNPs, in...

DNA replication is molecularly asymmetric, due to distinct mechanisms for lagging and leading strand DNA synthesis. Whether chromatin assembly on newly replicated strands is also asymmetric remains un...

IMB Mainz

Portell-Montserrat et al. reveal that target RNA recognition by PIWI-piRNA complexes triggers the assembly of conserved PIWI∗ complexes, molecular platforms that recruit silencing effectors in both the nucleus and cytoplasm. This mechanism, conserved across animals, explains how piRNA pathways couple target recognition to transposon silencing.

A microRNA that arose at the origin of eumetazoans regulates cell adhesion and signaling in C. elegans through conserved targets.

This study introduces SDR-seq, a droplet-based single-cell DNA–RNA sequencing platform, enabling the study of gene expression profiles linked to both noncoding and coding variants.

Generative biology holds the promise to transform our ability to design and understand living systems by creating novel proteins, pathways, and organisms with tailored functions that address challenge...