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Genetics Society of America @genetics-gsa.bsky.social · 9h

Science is intertwined with eugenics, and eugenic ideologies continue to negatively impact #Indigenous communities and science today.

Read a timely and important perspective piece in #GENETICS from @jazlynmooney.bsky.social and colleagues: buff.ly/T7rbV3k

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April Wei @aprilwei.bsky.social · 15h

Excited to preprint our latest work (w/ Drew DeHaas, Zhibai Jia, Leo Speidel) on using ARGs for demographic inference. w/ applications using data from 1000 Genomes Project. www.biorxiv.org/content/10.1...

Inference of complex demographic history using composite likelihood based on whole-genome genealogies

Accurate parametric inference on complex demographic models is a continuing challenge in population genetics. Ancestral recombination graphs (ARGs) provide richer information than simple population ge...

www.biorxiv.org

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bioRxiv Evolutionary Biology @biorxiv-evobio.bsky.social · 1d

Recovering the pre-colonial population structure of Khoe-San descendant populations https://www.biorxiv.org/content/10.1101/2025.10.05.680541v1

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Dmitri Petrov @petrovadmitri.bsky.social · Jan 14

Happy that this paper - www.biorxiv.org/content/10.1... - was accepted at Mol Ecol Res and excited about the promise of this technology to measure pop sizes for such elusive species as snow leopards + learn about at least 1st-degree relationships + beyond? Congrats to Katie Solari and other authors!

Next-generation snow leopard population assessment tool: multiplex-PCR SNP panel for individual identification from feces

Snow leopards, Panthera uncia , are under threat from numerous pressures and are the focus of a great deal of conservation efforts. However, their elusive nature makes it difficult to estimate populat...

www.biorxiv.org

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Katie Solari @kasolari.bsky.social · 1d

Very excited to share that our work assessing the genomic diversity of snow leopards has come out today in PNAS! Spoiler alert - they have the lowest genetic diversity of all big cats!
www.pnas.org/doi/10.1073/...
news.stanford.edu/stories/2025...
@petrovadmitri.bsky.social @elliecat.bsky.social

Exceedingly low genetic diversity in snow leopards due to persistently small population size | PNAS

Snow leopards (Panthera uncia) serve as an umbrella species whose conservation benefits their high-elevation Asian habitat. Their numbers are belie...

www.pnas.org

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Jazlyn Mooney @jazlynmooney.bsky.social · 1d

🫠feel better

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Megan Dennis @mydennis.bsky.social · 2d

Happy to share work spearheaded by former grad student Colin Shew testing shared duplicated cis regulatory elements (CREs) using an MPRA. While we find some high effect CREs, collectively paralog differences represent modest effects accounting for observed gene expression divergence.

bioRxiv Genomics @biorxiv-genomic.bsky.social · 3d

Influence of cis-regulatory elements on regulatory divergence in human segmental duplications https://www.biorxiv.org/content/10.1101/2025.10.03.680410v1

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David Castellano @castellanoed.bsky.social · 1d

Working link: academic.oup.com/mbe/advance-...

Interpreting supervised machine learning inferences in population genomics using haplotype matrix permutations

Abstract. Supervised machine learning methods, such as convolutional neural networks (CNNs), that use haplotype matrices as input data have become powerful

academic.oup.com

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David Castellano @castellanoed.bsky.social · 1d

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We developed a systematic permutation approach that progressively scrambles features (LD, haplotype structure, allele frequencies) in haplotype matrices to see how each affects model performance.

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David Castellano @castellanoed.bsky.social · 1d

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Excited to share our new paper in Molecular Biology & Evolution!
👉 [https://doi.org/10.1093/molbev/msaf250]
It started as a lab-meeting sanity check for another project — and ended up turning into a new way to interpret machine-learning models in population genomics.

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Stanford University Press @stanfordpress.bsky.social · 8d

Population Biology Modeling & Theory (PBMT) is a peer-reviewed journal reporting advances in modeling and theory within population biology. Its scope spans demography, ecology, epidemiology, evolutionary biology, population genetics, and phylogenetics. PBMT will be online soon.

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Jason Moore @moorejh.bsky.social · 14d

Reference genome choice compromises population genetic analyses - Cell www.cell.com/cell/abstrac... #genetics #genomics #popgen

Reference genome choice compromises population genetic analyses

Using a species-specific reference genome significantly improves the accuracy of population genetic analyses, as exemplified by mapping gray fox sequence data to genomes of several canid species. Mapp...

www.cell.com

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Maria Akopyan, PhD @akopyan.bsky.social · 16d

Now published in Cell! We found that ~15% of SNPs from divergent refs did not liftover as SNPs in the gray fox ref—half mapped to monomorphic sites, half failed to map. Co-authored with Matthew Genchev, @elliecat.bsky.social, and @jazlynmooney.bsky.social

www.sciencedirect.com/science/arti...

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Jazlyn Mooney @jazlynmooney.bsky.social · 16d

TLDR: If you can, generate a conspecific reference genome. If you can't, know that the reference will impact your population genetic analyses/inferences to varying degrees. Reading deeply into your results may mislead you, especially when it comes to selection.

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Jazlyn Mooney @jazlynmooney.bsky.social · 16d

Super excited to see our reference bias work out in Cell! Reviewers gave us some excellent ideas, and Maria added on some new analyses that broke down how SNPs from heterospecific references mapped or did not map in a conspecific reference.

Maria Akopyan, PhD @akopyan.bsky.social · 16d

Now published in Cell! We found that ~15% of SNPs from divergent refs did not liftover as SNPs in the gray fox ref—half mapped to monomorphic sites, half failed to map. Co-authored with Matthew Genchev, @elliecat.bsky.social, and @jazlynmooney.bsky.social

www.sciencedirect.com/science/arti...

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Yun S. Song @yun-s-song.bsky.social · 17d

We are excited to share GPN-Star, a cost-effective, biologically grounded genomic language modeling framework that achieves state-of-the-art performance across a wide range of variant effect prediction tasks relevant to human genetics.
www.biorxiv.org/content/10.1...
(1/n)

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onion person @junlper.beer · 22d

coates is genuinely a generational writer

What are we to make of a man who called for the execution of the American president, and then was executed himself? What are we to make of an NFL that, on one hand, encourages us to "End Racism," and, on the other, urges us to commemorate an unreconstructed white supremacist? And what of the writers, the thinkers, and the pundits who cannot separate the great crime of Kirk's death from the malignancy of his public life? Can they truly be so ignorant to the words of a man they have so rushed to memorialize? I don't know. But the most
telling detail in Klein's column was that, for all his praise, there was not a single word in the piece from Kirk himself.

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Torsten Günther @trstngnthr.bsky.social · 21d

I have funding for a 2-year dry-lab postdoc to join our team @humanevouu.bsky.social 🧪 (Deadline Oct 21st)

The project will utilize modern and #aDNA data from humans and sheep to study environmental adaptation (including method development and simulations).

Please share!
www.uu.se/en/about-uu/...

Postdoctoral position in Population Genomics - Uppsala University

Postdoctoral position in Population Genomics, Department of Organismal Biology, Uppsala University

www.uu.se

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Alison Feder @alisonfeder.bsky.social · 28d

Elena Romero led a new preprint detailing joint work with Lillian Cohn's lab at Fred Hutch describing really crazy parallelism in in vivo HIV escape from broadly neutralizing antibodies! #VirEvol #evoSky

www.biorxiv.org/content/10.1...

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Mick Westbury @mick2474.bsky.social · Sep 5

Excited to share that I’ve started as Associate Professor at the Technical University of Denmark! 🧑‍🎓

I also received an a NNF Emerging Investigator grant to use genomics + machine learning to study extinction.

👉 PhD & Postdoc positions coming soon — follow for updates!
Reposts appreciated 🙏

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Acyn @acyn.bsky.social · Sep 4

Ossoff: Absolutely RFK JR should resign. He should have never been confirmed to begin with. He is utterly unqualified. This is someone who has embraced every piece of quackery and pseudoscience that he’s come across.

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Jeffrey Ross-Ibarra @jrossibarra.bsky.social · Sep 3

Save the date! #PEQG26 June 9-12 2026 in Asilomar, CA. Happens only every 2yrs, but is my favorite conference. Full website coming soon, and registration and abstract submission opens November 14, but I'm allowed to tease that keynotes will be @jnovembre.bsky.social @jennytung.bsky.social and me!

Homepage - Population, Evolutionary, and Quantitative Genetics Conference

Visit our website to learn more.

genetics-gsa.org

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Pleuni Pennings @pleunipennings.bsky.social · Aug 29

I made a video about my new paper. I hope you enjoy it!

vimeo.com/1113132836?s...

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Jazlyn Mooney @jazlynmooney.bsky.social · Aug 23

Lol the giant Yaniv tho

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Matthew Aguirre @aguirre404.bsky.social · Aug 22

Thrilled to share the second half of my PhD work here!

We show how data on expression quantitative trait loci (eQTL) relates to the structure of gene regulatory networks (GRN). Much of the GRN / eQTL picture is unmapped, but what we do have says a lot… (1/)

doi.org/10.1101/2025...

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