John
@johnmrizk.bsky.social
'I'm offen asked 'what made you become a scientist?' Sir Peter Medawar. I tweet science, politics, football and F1. Nerd-ish.
views= my own, ofc.
views= my own, ofc.
Reposted by John
Split-site ubiquitination gives ZNFX1 new power in RNA defense @cellcellpress.bsky.social
www.cell.com/molecular-ce...
www.sciencedirect.com/science/arti...
www.cell.com/molecular-ce...
www.sciencedirect.com/science/arti...
Split-site ubiquitination gives ZNFX1 new power in RNA defense
Recent work by Grabarczyk et al. uncovers the molecular mechanism by which ZNFX1,
an interferon-stimulated gene, employs a novel split-site E3 ligase domain structure
to ubiquitinate both protein lysi...
www.cell.com
October 17, 2025 at 4:37 PM
Split-site ubiquitination gives ZNFX1 new power in RNA defense @cellcellpress.bsky.social
www.cell.com/molecular-ce...
www.sciencedirect.com/science/arti...
www.cell.com/molecular-ce...
www.sciencedirect.com/science/arti...
Reposted by John
Dysregulated T cells and progenitors with lymphoma driver mutations are enriched in duodenal biopsies from patients with refractory celiac disease
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
May 14, 2025 at 7:44 PM
Dysregulated T cells and progenitors with lymphoma driver mutations are enriched in duodenal biopsies from patients with refractory celiac disease
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Reposted by John
Mucosal unadjuvanted booster vaccines elicit local IgA responses by conversion of pre-existing immunity in mice
Nasal vaccines as booster, after i.m vaccination, to improve local IgA production. No additional adjuvant needed (mice and hamsters). Nice paper!
www.nature.com/artic...
1/6
Nasal vaccines as booster, after i.m vaccination, to improve local IgA production. No additional adjuvant needed (mice and hamsters). Nice paper!
www.nature.com/artic...
1/6
Mucosal unadjuvanted booster vaccines elicit local IgA responses by conversion of pre-existing immunity in mice
Nature Immunology - Iwasaki and colleagues show that an intranasal booster with an unadjuvanted recombinant SARS-CoV-2 spike protein, after intramuscular immunization with an mRNA vaccine encoding...
www.nature.com
May 14, 2025 at 10:11 AM
Mucosal unadjuvanted booster vaccines elicit local IgA responses by conversion of pre-existing immunity in mice
Nasal vaccines as booster, after i.m vaccination, to improve local IgA production. No additional adjuvant needed (mice and hamsters). Nice paper!
www.nature.com/artic...
1/6
Nasal vaccines as booster, after i.m vaccination, to improve local IgA production. No additional adjuvant needed (mice and hamsters). Nice paper!
www.nature.com/artic...
1/6
Reposted by John
Impaired Aire-dependent IFN signaling in the thymus precedes the protective autoantibodies to IFNα, say Artur Stoljar, Maksym Zarodniuk, Pärt Peterson and colleagues @unitartu: rupress.org/jem/article/...
#Autoimmunity #Tolerance
#Autoimmunity #Tolerance
May 7, 2025 at 1:42 PM
Impaired Aire-dependent IFN signaling in the thymus precedes the protective autoantibodies to IFNα, say Artur Stoljar, Maksym Zarodniuk, Pärt Peterson and colleagues @unitartu: rupress.org/jem/article/...
#Autoimmunity #Tolerance
#Autoimmunity #Tolerance
It's incredibly disturbing when journal editors act infallible.
A modicum of engagement, or any sort of scientific discourse, would certainly go along way.
These are simply the moments that make me hate, absolutely hate, doing science - and i have been in it long eough to know better !
A modicum of engagement, or any sort of scientific discourse, would certainly go along way.
These are simply the moments that make me hate, absolutely hate, doing science - and i have been in it long eough to know better !
April 16, 2025 at 6:44 AM
It's incredibly disturbing when journal editors act infallible.
A modicum of engagement, or any sort of scientific discourse, would certainly go along way.
These are simply the moments that make me hate, absolutely hate, doing science - and i have been in it long eough to know better !
A modicum of engagement, or any sort of scientific discourse, would certainly go along way.
These are simply the moments that make me hate, absolutely hate, doing science - and i have been in it long eough to know better !
Reposted by John
'We found that citrullinated MBP160–175 (MBP160–175(cit)), when co-immunized with MOG35–55, indeed no longer suppressed EAE, implying a specific immunomodulatory function for naked MBP160–175 peptides in regulating neuroinflammation'
#Immunology #Immunosky
www.nature.com/articles/s41...
#Immunology #Immunosky
www.nature.com/articles/s41...
January 8, 2025 at 3:56 AM
'We found that citrullinated MBP160–175 (MBP160–175(cit)), when co-immunized with MOG35–55, indeed no longer suppressed EAE, implying a specific immunomodulatory function for naked MBP160–175 peptides in regulating neuroinflammation'
#Immunology #Immunosky
www.nature.com/articles/s41...
#Immunology #Immunosky
www.nature.com/articles/s41...