In joints with osteoarthritis, angiogenesis and neuronal growth occur at the osteochondral junction, a process that can contribute to structural joint damage and pain. Targeting this neurovascularizat...

Join us as we unravel the mysteries of pain through talks, hands-on demos, workshops, interviews and art installations.

Some cuts have been starkly visible, but the country’s medical grant-making machinery has also radically transformed outside the public eye.

Osteoarthritis and knee joint pain are driven by systemic leptin and complement factor D secreted by adipose tissue.

NIH Funding Opportunities and Notices in the NIH Guide for Grants and Contracts: Updated NIH Policy on Foreign Subawards NOT-OD-25-104. NIH

Nature Reviews Rheumatology, Published online: 17 April 2025; doi:10.1038/s41584-025-01256-3Calcium pyrophosphate deposition (CPPD) disease is secondary to the pathological accumulation of calcium pyrophosphate (CPP) crystals inside joints and involves acute or chronic inflammatory arthritis. Epidemiological research on CPPD has been slow despite the suspected high prevalence of this condition. Here we highlight key challenges in CPPD imaging, diagnosis and nomenclature that need to be addressed for epidemiological research to progress at a faster pace.

A genome-wide association study meta-analysis combined with multiomics data of osteoarthritis identifies 700 effector genes as well as biological processes with a convergent involvement of multiple ef...

Whether a gut-joint axis exists to regulate osteoarthritis is unknown. In two independent cohorts, we identified altered microbial bile acid metabolism with reduced glycoursodeoxycholic acid (GUDCA) i...

Nature Reviews Rheumatology, Published online: 31 March 2025; doi:10.1038/s41584-025-01234-9This Review discusses how pain in osteoarthritis might involve adaptations of brain circuits, and suggests that osteoarthritis pain management should consider targeting central mechanisms of pain in addition to nociceptive neuron activity.

Altered subchondral bone mineral density (BMD) may be a possible contributor to osteoarthritis (OA) pain. We evaluated the relation of compartment-spe…

Objective Patients with knee osteoarthritis (KOA) rely on symptomatic treatments where up to 75% of the pain reduction can be attributed to the placebo effect. This effect may vary based on treatmen.....