justhikin
@justhikin.bsky.social
Reposted by justhikin
A schematic of the mechanism of the CHIP-protective variant. MSI2 is a drug target for prevention of cancer in preclinical testing science.org/doi/10.1126/...
January 1, 2026 at 7:05 PM
A schematic of the mechanism of the CHIP-protective variant. MSI2 is a drug target for prevention of cancer in preclinical testing science.org/doi/10.1126/...
Reposted by justhikin
New @science.org today
Discovery of a genomic variant that protects against blood cancer by reducing risk of CHIP (blood stem cell mutation clones, common with aging)
@bloodgenes.bsky.social
@kharaslab.bsky.social
science.org/doi/10.1126/...
Discovery of a genomic variant that protects against blood cancer by reducing risk of CHIP (blood stem cell mutation clones, common with aging)
@bloodgenes.bsky.social
@kharaslab.bsky.social
science.org/doi/10.1126/...
Inherited resilience to clonal hematopoiesis by modifying stem cell RNA regulation
Somatic mutations that increase the fitness of hematopoietic stem cells (HSCs) drive their expansion in clonal hematopoiesis (CH) and predispose individuals to blood cancers. Population variation in t...
science.org
January 1, 2026 at 7:03 PM
New @science.org today
Discovery of a genomic variant that protects against blood cancer by reducing risk of CHIP (blood stem cell mutation clones, common with aging)
@bloodgenes.bsky.social
@kharaslab.bsky.social
science.org/doi/10.1126/...
Discovery of a genomic variant that protects against blood cancer by reducing risk of CHIP (blood stem cell mutation clones, common with aging)
@bloodgenes.bsky.social
@kharaslab.bsky.social
science.org/doi/10.1126/...
Reposted by justhikin
The one validated intervention to slow aging and extend healthspan is not for sale.
It's exercise.
sciencedirect.com/science/arti...
It's exercise.
sciencedirect.com/science/arti...
December 20, 2025 at 6:22 PM
The one validated intervention to slow aging and extend healthspan is not for sale.
It's exercise.
sciencedirect.com/science/arti...
It's exercise.
sciencedirect.com/science/arti...
Reposted by justhikin
Please read this piece by the National Review’s Jim Geraghty, if you never read anything else.
www.nationalreview.com/the-morning-...
www.nationalreview.com/the-morning-...
Trump’s Appalling Reiner Reaction Is a Sign of Something Deeply Wrong | National Review
Yes, we must talk about what President Trump posted on Truth Social about the brutal murders of the Reiners.
www.nationalreview.com
December 16, 2025 at 11:57 PM
Please read this piece by the National Review’s Jim Geraghty, if you never read anything else.
www.nationalreview.com/the-morning-...
www.nationalreview.com/the-morning-...
Reposted by justhikin
29% weight loss, 71 pounds!
That what the triple receptor GLP-1 drug retatrutide achieved in a placebo-controlled trial
Plus 3-fold complete relief of knee osteoarthritis pain
www.nytimes.com/2025/12/11/h...
That what the triple receptor GLP-1 drug retatrutide achieved in a placebo-controlled trial
Plus 3-fold complete relief of knee osteoarthritis pain
www.nytimes.com/2025/12/11/h...
Major Weight Loss and Knee-Pain Relief Seen With New Eli Lilly Drug
www.nytimes.com
December 11, 2025 at 7:16 PM
29% weight loss, 71 pounds!
That what the triple receptor GLP-1 drug retatrutide achieved in a placebo-controlled trial
Plus 3-fold complete relief of knee osteoarthritis pain
www.nytimes.com/2025/12/11/h...
That what the triple receptor GLP-1 drug retatrutide achieved in a placebo-controlled trial
Plus 3-fold complete relief of knee osteoarthritis pain
www.nytimes.com/2025/12/11/h...
Reposted by justhikin
The environment flows through our bodies, altering our trajectories in ways medicine is just starting to see. "Your 'environment' could be the refinery a town over, the lead in the paint of your mother’s home, the plastic sheath of a Hot Pocket you microwaved in 1996." www.wired.com/story/scient...
Scientists Thought Parkinson’s Was in Our Genes. It Might Be in the Water
New ideas about chronic illness could revolutionize treatment, if we take the research seriously.
www.wired.com
December 11, 2025 at 7:35 PM
The environment flows through our bodies, altering our trajectories in ways medicine is just starting to see. "Your 'environment' could be the refinery a town over, the lead in the paint of your mother’s home, the plastic sheath of a Hot Pocket you microwaved in 1996." www.wired.com/story/scient...
Reposted by justhikin
A big advance, folks, for off-the-shelf, universal, engineered (base-edited) T cells achieving complete response vs incurable leukemia in several patients
www.nejm.org/doi/full/10....
www.nejm.org/doi/full/10....
December 8, 2025 at 10:10 PM
A big advance, folks, for off-the-shelf, universal, engineered (base-edited) T cells achieving complete response vs incurable leukemia in several patients
www.nejm.org/doi/full/10....
www.nejm.org/doi/full/10....
Reposted by justhikin
Wisconsin finalizes water quality rule over objections of Republicans, business groups via @henry-redman.bsky.social wisconsinexaminer.com/2025/12/01/w...
Water quality rule finalized as Republicans, business groups complain about process • Wisconsin Examiner
A new rule published over Republican objections is meant to protect the health of Wisconsin's highest quality water bodies.
wisconsinexaminer.com
December 1, 2025 at 6:30 PM
Wisconsin finalizes water quality rule over objections of Republicans, business groups via @henry-redman.bsky.social wisconsinexaminer.com/2025/12/01/w...
Reposted by justhikin
Robert Francis Kennedy’s 100th birthday
November 20, 2025 at 3:38 AM
Robert Francis Kennedy’s 100th birthday
Reposted by justhikin
We've seen some remarkable outcomes in people with advanced, refractory cancers, including pancreatic, melanoma, and renal, with personalized neoantigen mRNA vaccines.
But this work is now endangered.
www.scientificamerican.com/article/pers...
But this work is now endangered.
www.scientificamerican.com/article/pers...
November 18, 2025 at 7:16 PM
We've seen some remarkable outcomes in people with advanced, refractory cancers, including pancreatic, melanoma, and renal, with personalized neoantigen mRNA vaccines.
But this work is now endangered.
www.scientificamerican.com/article/pers...
But this work is now endangered.
www.scientificamerican.com/article/pers...
Reposted by justhikin
We need YOU, our readers, to power our work digging up the truth in the Badger State. Please help us meet our $15,000 fundraising goal between today and Dec. 31. If you rely on the Examiner, please consider supporting us today! wisconsinexaminer.com/donate/
Donate • Wisconsin Examiner
wisconsinexaminer.com
November 17, 2025 at 9:11 PM
We need YOU, our readers, to power our work digging up the truth in the Badger State. Please help us meet our $15,000 fundraising goal between today and Dec. 31. If you rely on the Examiner, please consider supporting us today! wisconsinexaminer.com/donate/
Reposted by justhikin
There's a big shift in cardiology to the high-risk, non-obstructed, inflamed artery and reducing heart attacks
erictopol.substack.com/p/the-big-sh...
erictopol.substack.com/p/the-big-sh...
The Big Shift in Cardiology to Atheroma and Inflammation
One A.I. company's tag line: "Creating A World Without Heart Attacks"
erictopol.substack.com
November 16, 2025 at 8:07 PM
There's a big shift in cardiology to the high-risk, non-obstructed, inflamed artery and reducing heart attacks
erictopol.substack.com/p/the-big-sh...
erictopol.substack.com/p/the-big-sh...
Reposted by justhikin
Echocardiography is one of the most complex medical image sets to analyze, with multiple views + cardiac motion. A new
@nature.com
paper shows how A.I. can do that and provide accurate reports
@davidouyang.bsky.social
nature.com/articles/s41...
@nature.com
paper shows how A.I. can do that and provide accurate reports
@davidouyang.bsky.social
nature.com/articles/s41...
November 12, 2025 at 3:29 PM
Echocardiography is one of the most complex medical image sets to analyze, with multiple views + cardiac motion. A new
@nature.com
paper shows how A.I. can do that and provide accurate reports
@davidouyang.bsky.social
nature.com/articles/s41...
@nature.com
paper shows how A.I. can do that and provide accurate reports
@davidouyang.bsky.social
nature.com/articles/s41...
Reposted by justhikin
Here's the Table summarizing the key flaws and why there's lack of confidence in any report
November 10, 2025 at 12:20 AM
Here's the Table summarizing the key flaws and why there's lack of confidence in any report
Reposted by justhikin
Oh look English teachers have their lesson plan for the day on how word choice exposes POV.
anointed not elected: reveals contempt with a whiff of religiosity
strode not walked: implies arrogance
cavernous not packed: evokes emptiness, darkness
It’s you, NYT. You are talking about yourself
anointed not elected: reveals contempt with a whiff of religiosity
strode not walked: implies arrogance
cavernous not packed: evokes emptiness, darkness
It’s you, NYT. You are talking about yourself
Shortly after Zohran Mamdani was anointed the mayor-elect of New York City on Tuesday, he strode onto the stage of a cavernous theater in Brooklyn and delivered a victory speech that celebrated New York’s immigrants, working class and young people. Follow live: nyti.ms/3X9h35I
November 5, 2025 at 12:26 PM
Oh look English teachers have their lesson plan for the day on how word choice exposes POV.
anointed not elected: reveals contempt with a whiff of religiosity
strode not walked: implies arrogance
cavernous not packed: evokes emptiness, darkness
It’s you, NYT. You are talking about yourself
anointed not elected: reveals contempt with a whiff of religiosity
strode not walked: implies arrogance
cavernous not packed: evokes emptiness, darkness
It’s you, NYT. You are talking about yourself
Reposted by justhikin
In advance of Trump shutting down SNAP, this is a way you can help your neighbors.
October 26, 2025 at 6:35 PM
In advance of Trump shutting down SNAP, this is a way you can help your neighbors.
Reposted by justhikin
Current read out for a mammogram leaves a lot on the table.
A new study shows how risk of cardiovascular disease can be predicted as well as traditional cardiovascular risk scores (aka opportunistic A.I.)
heart.bmj.com/content/earl...
A new study shows how risk of cardiovascular disease can be predicted as well as traditional cardiovascular risk scores (aka opportunistic A.I.)
heart.bmj.com/content/earl...
September 16, 2025 at 11:13 PM
Current read out for a mammogram leaves a lot on the table.
A new study shows how risk of cardiovascular disease can be predicted as well as traditional cardiovascular risk scores (aka opportunistic A.I.)
heart.bmj.com/content/earl...
A new study shows how risk of cardiovascular disease can be predicted as well as traditional cardiovascular risk scores (aka opportunistic A.I.)
heart.bmj.com/content/earl...
Reposted by justhikin
Sunday is officially Sun Day in Wisconsin! Thanks Governor Evers!
@sundayofaction.bsky.social
@sundayofaction.bsky.social
September 16, 2025 at 5:59 PM
Sunday is officially Sun Day in Wisconsin! Thanks Governor Evers!
@sundayofaction.bsky.social
@sundayofaction.bsky.social
Reposted by justhikin
p-tau 217 as a stand-alone blood marker establishes risk of Alzheimer's disease in cognitively unimpaired individuals (again)
jamanetwork.com/journals/jam...
jamanetwork.com/journals/jam...
Plasma P-Tau217 to Identify Preclinical AD
This cohort study evaluates the use of plasma phosphorylated tau 217 in identifying preclinical Alzheimer disease in individuals with amyloid β pathology.
jamanetwork.com
September 15, 2025 at 4:28 PM
p-tau 217 as a stand-alone blood marker establishes risk of Alzheimer's disease in cognitively unimpaired individuals (again)
jamanetwork.com/journals/jam...
jamanetwork.com/journals/jam...
Reposted by justhikin
Summary Table of the massive defunding of biomedical research in the United States
www.nytimes.com/interactive/...
www.nytimes.com/interactive/...
July 6, 2025 at 3:13 PM
Summary Table of the massive defunding of biomedical research in the United States
www.nytimes.com/interactive/...
www.nytimes.com/interactive/...
Reposted by justhikin
As a Canadian mining company begins exploration, northern Wisconsin residents raise alarms via @henry-redman.bsky.social wisconsinexaminer.com/2025/06/30/s...
Start of Taylor County drilling operation brings environmental concerns • Wisconsin Examiner
A Canadian mining company started exploratory drilling in Taylor County this month, raising alarms from environmental groups.
wisconsinexaminer.com
June 30, 2025 at 1:36 PM
As a Canadian mining company begins exploration, northern Wisconsin residents raise alarms via @henry-redman.bsky.social wisconsinexaminer.com/2025/06/30/s...
Reposted by justhikin
A message from Carl Sagan from 1995—some of his last prophetic words.
June 10, 2025 at 5:04 PM
A message from Carl Sagan from 1995—some of his last prophetic words.
Reposted by justhikin
Rant: There's no sin in "networking," but if you're going to do it, do it well. Check on colleagues you care about when you don't want something. It's an art, not a transaction, and if done well, you both get something and have a nice time.
But don't call out of the blue because you need a favor.
But don't call out of the blue because you need a favor.
June 3, 2025 at 8:36 PM
Rant: There's no sin in "networking," but if you're going to do it, do it well. Check on colleagues you care about when you don't want something. It's an art, not a transaction, and if done well, you both get something and have a nice time.
But don't call out of the blue because you need a favor.
But don't call out of the blue because you need a favor.
Reposted by justhikin
Meditate today, even for just five minutes.
All we can ever ask of ourselves is to show up as fully as we can.
That’s it. Regardless of what technique you use, all it’s really about is showing up.
All we can ever ask of ourselves is to show up as fully as we can.
That’s it. Regardless of what technique you use, all it’s really about is showing up.
June 3, 2025 at 10:17 AM
Meditate today, even for just five minutes.
All we can ever ask of ourselves is to show up as fully as we can.
That’s it. Regardless of what technique you use, all it’s really about is showing up.
All we can ever ask of ourselves is to show up as fully as we can.
That’s it. Regardless of what technique you use, all it’s really about is showing up.
Reposted by justhikin
In @science.org today my essay on predicting and preventing Alzheimer's disease (open-access)
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Predicting and preventing Alzheimer’s disease
With all the advances in both the science of aging and artificial intelligence (AI), we are in a propitious position to accurately and precisely determine who is at high risk of developing Alzheimer’s...
www.science.org
May 29, 2025 at 6:00 PM
In @science.org today my essay on predicting and preventing Alzheimer's disease (open-access)
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...