The Trump administration’s crackdown is turning a difficult profession into an impossible one for some doctors.

Estimands can be used in studies of healthcare interventions to clarify the interpretation of treatment effects. The addendum to the ICH E9 harmonised guideline on statistical principles for clinical ...

It’s September which means RFK Jr will soon be releasing his promised report on the ‘causes’ of autism. We can prepare by learning some key types of research bias.

The review is based on studies from Denmark, Finland, Norway and Sweden during 1950-1982. In general sarcoidosis was slightly more frequent in females than in males, especially after 40 years of age. The majority of cases were diagnosed bef...

This Special Communication introduces the Transparent Reporting of Observational Studies Emulating a Target Trial (TARGET) 2025 guideline, a consensus-based guidance for reporting observational studie...

Aims To conduct the first cross-sectional epidemiological investigation of pathologic myopia (PM) in UK adults with high myopia.Methods Fundus photographs of 3024 highly myopic eyes (spherical equivalent refraction (SER) ≤–5.00D) from 2000 randomly sampled adults (aged 40–70 years) in the UK Biobank were double graded by an ophthalmic reading centre using the Meta-analysis for Pathologic Myopia framework. Adjudication was performed by one of two retinal specialists. Multivariable mixed-effects logistic regression was used to explore potential risk factors and fundus biomarkers—initially adjusting for SER, age and sex, before including these and other variables with p

A rare copy number variant appears to significantly reduce the risk of schizophrenia.

The share of U.S. workers who belonged to a union in 2024 stood at 9.9%, down from 1983 when 20.1% of American workers were union members.

The NIH introduced a revised approach to the peer review of grant applications in the most recent summer review rounds. The Simplified Peer Review Framework has a number of new features, some of wh…