Biology and chemistry are both fields where papers are generally 4-16 pages.

We present multi-immersion Oblique Plane microscope (miOPM), a light-sheet platform that can be adapted to a wide range of applications, from sensitive live cell imaging to imaging organs and cleared tissues.
www.biorxiv.org/content/10.1...

As far as I know it’s not well understood. There are some papers discussing it: pmc.ncbi.nlm.nih.gov/articles/PMC... and pubs.acs.org/doi/10.1021/... and www.sciencedirect.com/science/arti...

It’s certainly had a good run - it’s been a workhorse for at least 25 years.

"Moral courage springs from genuine conviction founded on sound principles. You will not find such conviction nor such principles in the latest polling. Morality is not a popularity contest."

www.liberalcurrents.com/democrats-mu...

I made this #cocktail last night: mixology.tools/search.html?...

Highly recommended. I used Brugal 1888 rum. The sweet vermouth - sherry swap is one I want to explore more.

Test the activity of 300+ natural enzymes against 100+ substrates, discover 200+ new enzymatic reactions, and train machine learning models to predict which enzymes can do which reactions.

@aepaton.bsky.social @gabegomes.bsky.social @alisonnarayan.bsky.social

www.nature.com/articles/s41...

In honor of National Poetry Day, the greatest parody rewrite of all time:

this piece has been in the works a while but honestly i could not have asked for a better foil than ezra klein's interview with ta-nehisi coates. klein longs for peacetime--but you don't get to decide when you're in a fight.

www.liberalcurrents.com/democrats-mu...

Also the more pragmatic issue that it’s so hard to find *any* antibiotic development that a peptide is just adding challenges to an already very hard process.

A couple of reasons: typical antibiotic doses are several orders of magnitude higher - 100s of milligrams per dose, because you need to be stoichiometric with the infection. Also getting distribution to the site of infection and side effects as many antimicrobial peptides are membrane disruptors.

All this work on antimicrobial peptides is cool technically but I don’t see a path to the clinic for them, let alone a way to be profitable. It’s hard enough to get an oral small molecule antibacterial to the clinic…

Huh, they forgot “to keep up with what’s happening in other industries and fields.” I hear that’s what all the cool zoomers are doing.

I really like this essay from @owlposting1.bsky.social : www.owlposting.com/p/ask-not-wh...

Clarence Thomas announced that he doesn't care about precedent and is making it up as he goes along. He didn't say it *like that* of course, because then people would have noticed.
But I noticed, through the jargon, and explain it here in @thenation.
www.thenation.com/article/soci...

This is quite funny

This is just incredible. Someone made not just a computer, but an *entire working LLM* out of (438 million) minecraft blocks www.tomshardware.com/tech-industr...

We did a version of this in 9th grade biology. The results were memorable.

Absolutely nobody asked for this but I reformatted my animal yeetability thread into printable poster & zine files.

Introducing, the "Pocket Guide to Responsible & Sustainable Animal YEETING" featuring a revamped rating system. Download links below.

1/ A longtime Wired editor just wrote a mush-brained essay about how he totally missed the political rot of Silicon Valley (& still doesn't get it).

But in the late 1990s, a Wired journalist warned of a toxic ideology bubbling up from tech. Paulina Borsook has largely been erased. Let's change that

ChEMBL 36 is out! if you're using chembl-downloader for all of your ChEMBL needs, then you just have to re-run your reproducible workflows and get arbitrarily new and better results, you beautiful nerd

https://chembl.blogspot.com/2025/09/chembl-36-is-out.html

#chembl #Cheminformatics […]

This is brilliant, and a must read if you need a laugh.

Did it create an inverse McSweeney's article?

@tanner-fadero.bsky.social told me there was a discussion about the unofficial name for #snouty V3. We have had Mr. Snouty and King Snouty, and there were people suggesting Emperor Snouty. I think it is time for a Lady or EMPRESS snouty. I have created Art to support this.

The previously sensible advice to never use ChatGPT for search needs to be rethought - GPT-5 in thinking mode is shockingly good at running searches now https://simonwillison.net/2025/Sep/6/research-goblin/