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Leo Scheller

@leoscheller.bsky.social

1.2K followers 680 following 16 posts

Immunotherapy, CAR-T, Protein Design, Synthetic biology, Cell Signaling. Head of Research Group | Structural Biochemistry | LIT Leibniz Institute for Immunotherapy https://lit.eu/our-scientists/dr-leo-scheller/

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Leo Scheller @leoscheller.bsky.social · Feb 26

I’m happy to share that I will join the LIT in Regensburg (lit.eu) as a Group Leader in Structural Biochemistry in May. We will combine synthetic biology and protein design to develop synthetic receptors and protein therapeutics to improve immunotherapy. Job openings will be available soon!

Leibniz Institute for Immunotherapy

The LIT develops innovative therapies for the treatment of cancer, autoimmunity, and chronic inflammation by reprogramming immune cells.

lit.eu

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Reposted by Leo Scheller

Adrian Woolfson @adrianwoolfson.bsky.social · 4d

A computationally-designed ‘random walker’ protein with tiny feet can walk back and forth across a micrometer-long fiber

share.google/3gzWosAVOeAh...

De-novo design of a random protein walker

Molecular machines hold great potential. Design of static monomeric and oligomeric protein structures has advanced tremendously, but few dynamic protein systems have been designed. Here we present the...

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Reposted by Leo Scheller

Nature @nature.com · Sep 1

Nature research paper: One-shot design of functional protein binders with BindCraft

go.nature.com/46bhOAv

One-shot design of functional protein binders with BindCraft - Nature

BindCraft, an open-source, automated pipeline for de novo protein binder design with experimental success rates of 10–100%, leverages AlphaFold2 weights to generate binders with nanomolar affinity without the need for high-throughput screening.

go.nature.com

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Reposted by Leo Scheller

Martin Pacesa @martinpacesa.bsky.social · Aug 27

Exciting to see our protein binder design pipeline BindCraft published in its final form in @Nature ! This has been an amazing collaborative effort with Lennart, Christian, @sokrypton.org, Bruno and many other amazing lab members and collaborators.

www.nature.com/articles/s41...

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Reposted by Leo Scheller

Martin Pacesa @martinpacesa.bsky.social · Jul 25

I am super excited to announce that I will be starting my lab at the Department of Pharmacology of the University of Zurich in Switzerland next year!

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Leo Scheller @leoscheller.bsky.social · Jul 26

Watch out, one of the best in the field! 😀

Martin Pacesa @martinpacesa.bsky.social · Jul 25

I am super excited to announce that I will be starting my lab at the Department of Pharmacology of the University of Zurich in Switzerland next year!

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Martin Pacesa @martinpacesa.bsky.social · Jul 12

We (meaning Aswin and Stan www.biorxiv.org/content/10.1...) found this jumbophage protein homologue of PhiKZ_124 that activates Avast5 and we solved a 2.1A cryoEM structure of but we have no idea what it does. Let me know it you got some idea. www.rcsb.org/structure/9RP3

Molecular basis for anti-jumbo phage immunity by AVAST Type 5

Jumbo phages protect their genomes from DNA-sensing bacterial defense systems by enclosing them within vesicles and nucleus-like compartments. Very little is known about defense systems specialized to...

www.biorxiv.org

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Leo Scheller @leoscheller.bsky.social · Jul 8

My highest recommendation! Working with Martin is the ideal entry point into protein design.

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Reposted by Leo Scheller

bioRxiv Synthetic Biology @biorxiv-synthbio.bsky.social · Jun 14

Humanized Caffeine-Inducible Systems for Controlling Cellular Functions https://www.biorxiv.org/content/10.1101/2025.06.13.659463v1

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Reposted by Leo Scheller

bioRxiv Synthetic Biology @biorxiv-synthbio.bsky.social · Jun 14

Caffeine-regulated molecular switches for functional control of CAR T cells in vivo https://www.biorxiv.org/content/10.1101/2025.06.13.659487v1

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Reposted by Leo Scheller

Gregor Hagelueken @gha14.bsky.social · May 18

Happy to share our first foray into the world of AI-based #ProteinDesign. www.biorxiv.org/content/10.1...

Development of AI-designed protein binders for detection and targeting of cancer cell surface proteins

Artificial intelligence (AI)-based protein design opens new avenues for the rapid generation of new research tools and therapeutics, but experimental validation lags behind the computational design th...

www.biorxiv.org

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Reposted by Leo Scheller

Chise @sailorrooscout.bsky.social · May 16

THIS IS HUGE! TWO Phase I HIV vaccine clinical trials have demonstrated that a stepwise mRNA-based vaccination strategy can SUCCESSFULLY activate AND advance immune responses toward producing broadly neutralizing antibodies (bnAbs), a CRITICAL milestone in HIV prevention. Let’s talk about that! 🧪🧵⬇️

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Reposted by Leo Scheller

Diego del Alamo @delalamo.xyz · May 15

"Adapting ProteinMPNN for antibody design without retraining"

Our several-years-old fix to ProteinMPNN's tendency to make weird antibody CDR sequences is finally preprinted

Adapting ProteinMPNN for antibody design without retraining

The neural network ProteinMPNN designs protein sequences capable of folding into predefined tertiary structures and quaternary assemblies. It has become widely used due to its high success rates when ...

www.biorxiv.org

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Reposted by Leo Scheller

Roger Castells @rcastellsg.bsky.social · May 7

Hi everyone! I’m a #NewPI just starting my lab and would love to hear your advice on lab management and building the lab culture. Any tips, lessons learned, or resources you’ve found helpful are very welcome! Feel free to reply, message me, or email me at rcastellsg(at)cnio.es
thanks a lot!! 🤗

a cat is sitting in front of a laptop computer asking for advice

ALT: a cat is sitting in front of a laptop computer asking for advice

media.tenor.com

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Reposted by Leo Scheller

Erik van Nimwegen @erikvannimwegen.bsky.social · May 9

Here it is! Bonsai. Now there is really no more excuse for using t-SNE/UMAP. Bonsai not only makes cool pictures of your data. It actually rigorously preserves its structure. No tunable parameters. Incredible work by @dhdegroot.bsky.social.
I'm so excited about this!
www.biorxiv.org/content/10.1...

Bonsai: Tree representations for distortion-free visualization and exploratory analysis of single-cell omics data

Single-cell omics methods promise to revolutionize our understanding of gene regulatory processes during cell differentiation, but analysis of such data continues to pose a major challenge. Apart from...

www.biorxiv.org

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Reposted by Leo Scheller

Dominik Niopek @dominikniopek.bsky.social · May 5

www.biorxiv.org/content/10.1...

Modular Engineering of Thermo-Responsive Allosteric Proteins

Thermogenetics enables non-invasive spatiotemporal control over protein activity in living cells and tissues, yet its applications have largely been restricted to transcriptional regulation and membra...

www.biorxiv.org

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Reposted by Leo Scheller

Max Fürst @maxfus.bsky.social · May 3

If u ever had to depict proteins as schematics in papers, u know the dilemma: how to create a pretty “blob”?
If structure ends up big & central, u’ll render it with PyMol et al, but for a truly schematic depiction u want a biorender-style icon, but for YOUR protein.
Think I’ve finally found a way.

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Reposted by Leo Scheller

ross @rosscloney.bsky.social · May 2

Programmable protein stabilization with language model-derived peptide guides

www.nature.com/articles/s41...

Programmable protein stabilization with language model-derived peptide guides - Nature Communications

Dysregulated protein degradation drives diseases like cancer. Here, authors use protein language models to design target-binding peptides, which are subsequently attached to the catalytic domain of th...

www.nature.com

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Reposted by Leo Scheller

Aaron Ring @aaronmring.bsky.social · Apr 29

You’ve heard of vibe coding—meet vibe protein design. Click, launch, and watch the binders roll in. That’s what we're unveiling with @ariaxbio.bsky.social today.

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Reposted by Leo Scheller

Martin Steinegger 🇺🇦 @martinsteinegger.bsky.social · Apr 27

AFESM: a metagenomic guide through the protein structure universe! We clustered 821M structures (AFDB&ESMatlas) into 5.12M groups; revealing biome-specific groups, only 1 new fold even after AlphaFold2 re-prediction & many novel domain combos. 🧵
🌐 afesm.foldseek.com
📄 www.biorxiv.org/content/10.1...

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Reposted by Leo Scheller

James Lingford @jameslingford.bsky.social · Apr 28

Baker lab PyMOL config 👇

spellock.bsky.social @spellock.bsky.social · Apr 27

this is what we use:
set specular, 0
set ray_shadow, off
set antialias, 2
set ray_trace_mode, 1
set ray_trace_disco_factor, 1
set ray_trace_gain, 0.1
set ambient, 0.4
set direct, 0.45
set cartoon_sampling, 10
set ray_trace_color, black
set reflect, 1
set reflect_power, 0

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Reposted by Leo Scheller

Miha Modic @paraspeckle.bsky.social · Apr 18

Thank you, Lennart! I'm very excited to join the newly founded Carl Zeiss Center for Synthetic Genomics and KIT with your lab nextdoor! Exciting times ahead!

Lennart Hilbert @lennarthilbert.bsky.social · Apr 18

While it is hard to predict ahead of time *what* the actual discoveries will be that we will make together, it is relatively safe to assume *that* they will happen.

Welcome new T-Track Prof. Miha Modic @paraspeckle.bsky.social to @kit.edu Karlsruhe

I am so very excited to have you with us now!

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Leo Scheller @leoscheller.bsky.social · Mar 13

I’m looking for a BTA and a Postdoc to help set up the Structural Biochemistry group at the Leibniz Institute for Immunotherapy (LIT) in Regensburg 😀.

We apply synthetic biology and protein design to address key challenges in immunotherapy.
lit.eu/work-with-us/
#SynBio #ProteinDesign #Immunotherapy

Work With Us

The LIT welcomes individuals from all life paths and academic backgrounds. If you are passionate about science we could be the perfect home for you.

lit.eu

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Reposted by Leo Scheller

Academic Europe @academiceurope.bsky.social · Mar 13

Job - Alert 🌱

‼️ POSTDOCTORAL SCIENTIST (M/F/D)

Deadline: 2025-04-06
Location: Germany, Regensburg, Bayern

www.academiceurope.com/job/?id=7176

#hiring #Immunotherapy #Postdoc #LIT #syntheticbiology #proteindesign

Academic Europe - Postdoctoral scientist (m/f/d)

www.academiceurope.com

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Reposted by Leo Scheller

Brian Naughton @btnaughton.bsky.social · Mar 8

new blogpost on protein binder design blog.booleanbiotech.com/protein-bind...

Boolean Biotech

blog.booleanbiotech.com

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Reposted by Leo Scheller

Adrian Stefanov @adrian-stefanov.bsky.social · Mar 8

Hello bluesky

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