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Linda Sinclair

@lindavsinclair.bsky.social

2.4K followers 580 following 39 posts

Immunologist, working with Cantrell Lab. Interested in LOTS - focused on nutrient and metabolic control of the immune system. (opinions are my own)

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Linda Sinclair @lindavsinclair.bsky.social · Mar 1

I am overjoyed to present our latest paper on Autophagy in CD8 Tcells!
www.nature.com/articles/s41...
It was, as all ‘sciencing’ is, a huge team effort.

I will try to do it some justice in the following thread 😊 1/n
@cantrell-lab.bsky.social @immpres.bsky.social @ajmhowden.bsky.social

Autophagy repression by antigen and cytokines shapes mitochondrial, migration and effector machinery in CD8 T cells - Nature Immunology

Sinclair et al. combine quantitative proteomics and an autophagy flux reporter to map autophagy substrates and triggers during CD8 T cell differentiation. Proteins degraded and fueled by autophagy in ...

www.nature.com

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Reposted by Linda Sinclair

drakesmith-lab.bsky.social @drakesmith-lab.bsky.social · Jun 23

2 new efforts: from Megan Teh on metabolism of CD8 Tcells in iron deficiency and why they love aspartate (+ @sarahdimeloe.bsky.social @lindavsinclair.bsky.social); & reviewing the strong influence of iron on immunity @joefrost.bsky.social
www.nature.com/articles/s41...
www.nature.com/articles/s41...

Iron and the immune system - Nature Reviews Immunology

Iron is crucial for cellular metabolism, but its availability varies greatly within and between individuals and populations. This Review highlights how iron regulates innate and adaptive cellular and ...

www.nature.com

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Reposted by Linda Sinclair

Nature Metabolism @natmetabolism.nature.com · May 13

Metabolic reprogramming of interleukin-17-producing γδ T cells promotes ACC1-mediated de novo lipogenesis under psoriatic conditions

Nature Metabolism, Published online: 13 May 2025; doi:10.1038/s42255-025-01276-zKao et al. provide insight into the metabolic requirements of IL-17A-producing γδ T cells, offering an actionable target to treat psoriasis by inhibiting fatty acid synthesis.

bit.ly

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Reposted by Linda Sinclair

Sparwasser Lab @timsparwasser.bsky.social · May 26

Special issue Immunometabolism and Beyond: from Liver to Brain!
European Journal of Immunology
Article types: reviews and research articles
Submission deadline 1 November 2025
Thanks to Nadja, Matteo and Bin for this wonderful opportunity!
#immunometabolism #EJI #CRC1292 #CRC355 #CRC156 #FZI

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Reposted by Linda Sinclair

RyanLab_TCD @ryanlab.bsky.social · Jun 15

🚨Last week's #immunometabolism findings
@biomednews.bsky.social 🔽🔽🔽

biomed.news/bims-imicid/...

Interesting paper:

Glucose-1-phosphate promotes compartmentalization of glycogen with the pentose phosphate pathway in CD8+ memory T cells

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Reposted by Linda Sinclair

RyanLab_TCD @ryanlab.bsky.social · Jun 20

Iron deficiency causes aspartate-sensitive dysfunction in CD8+ T cells #immunometabolism
www.nature.com/articles/s41...

Iron deficiency causes aspartate-sensitive dysfunction in CD8+ T cells - Nature Communications

Iron has been shown to be necessary for the activation and differentiation of CD8+ T cells. Here the authors investigate changes in CD8+ T cell metabolism in iron limiting conditions and find that asp...

www.nature.com

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Reposted by Linda Sinclair

Marina García Macia @juanaloca2002.bsky.social · Jun 4

So cool to start the afternoon session with @plantophagy.bsky.social !! Here in the @autophagyuk and @UK_proteostasis meeting

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Reposted by Linda Sinclair

Masahiro Ono @ Tocky Lab @monotockylab.bsky.social · Apr 26

What if Tregs are not a separate lineage, but part of spontaneously activated T cells?
In this work, we integrate this idea with our recent findings: Adult T cell leukemia (ATL) is not 'Treg cancer', challenging the current concept of Treg as a distinct entity.🧵(1/4)
academic.oup.com/discovimmuno...

Spectrum of Treg and self-reactive T cells: single cell perspectives from old friend HTLV-1

Summary. Despite extensive regulatory T cell (Treg) research, fundamental questions on in vivo dynamics remain to be answered. The current study aims to di

academic.oup.com

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Linda Sinclair @lindavsinclair.bsky.social · Apr 26

Aaaw, thanks Bob 😄. It was fun pulling it together!

Reposted by Linda Sinclair

Waggoner Lab @labwaggoner.bsky.social · Apr 26

Review @annualreviews.bsky.social @lindavsinclair.bsky.social @cantrell-lab.bsky.social
Protein Synthesis and Metabolism in T Cells
www.annualreviews.org/content/jour...

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Linda Sinclair @lindavsinclair.bsky.social · Apr 26

Our review on Protein Synthesis and Metabolism in T cells is out @annualreviews.bsky.social @cantrell-lab.bsky.social
Protein Synthesis and Metabolism in T Cells #proteomics #immunometabolism #Tcells
www.annualreviews.org/content/jour...

Protein Synthesis and Metabolism in T Cells | Annual Reviews

T lymphocytes are essential for immune responses to pathogens and tumors. Their ability to rapidly clonally expand and differentiate to effector cells following infection, and then to curb effector fu...

www.annualreviews.org

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Reposted by Linda Sinclair

Derek Mann @damann1.bsky.social · Mar 27

Very excited to be just a weekend away from this UK conference on neutrophil biology that we are hosting at Newcastle. It includes international keynotes but most important the majority of speakers are early career researchers. #immunology #inflammation #neutrophils #humandisease

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Reposted by Linda Sinclair

Sarah Ross @sarahhross.bsky.social · Mar 14

ICYMI by First release - now in print @science.org

Identification of APCs in the gut that promote Treg differentiation and how tolerance to food antigens is influenced by helminth infection.

buff.ly/3DjNQ1e

By @cicacanesso.bsky.social @danmucida.bsky.social @victora.bsky.social et al

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Linda Sinclair @lindavsinclair.bsky.social · Mar 27

#Immunosky #Immunometabolism

Linda Sinclair @lindavsinclair.bsky.social · Mar 27

www.nature.com/articles/s42...
Here’s the paper 😊

A functional single-cell metabolic survey identifies Elovl1 as a target to enhance CD8+ T cell fitness in solid tumours - Nature Metabolism

Through a functional CRISPR/Cas9 screening, Pretto et al. identify Elovl1 as a target to improve antitumour immunity by remodelling T cell lipid metabolism.

www.nature.com

Linda Sinclair @lindavsinclair.bsky.social · Mar 27

A lovely News and Views on Samantha Pretto/Max Mazzone’s “ #Elov1 and #CD8s and #tumour paper “ - check it out! www.nature.com/articles/s42...

Disrupting cholesterol homeostasis in T cells boosts antitumour responses - Nature Metabolism

A new study identifies a mechanism by which Elovl1 deletion disrupts the canonical feedback inhibition of cholesterol synthesis in T cells. By fundamentally rewiring cholesterol metabolism, Elovl1-dep...

www.nature.com

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Reposted by Linda Sinclair

Immunology Podcast @immunologypodcast.com · Feb 25

📢 A new episode of the podcast is out!

We chat with Dr. Luke O’Neill (@lukeanthonyoneill.bsky.social) at Trinity College Dublin (@tcddublin.bsky.social) about the metabolic regulation of immune cell function and the innate #ImmuneSystem.

🎧 Listen now: bit.ly/3QybMBq

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Reposted by Linda Sinclair

Emma Slack @mucosalimmunology.bsky.social · Feb 10

Two weeks left to apply for a postdoc position with the Slack group! Please spread the word!

Emma Slack @mucosalimmunology.bsky.social · Jan 26

Interested in microbial #metabolism, #mucosalbiology and #UTI? Then check out the open postdoctoral position in the Mucosal Immunology Group at ETH Zurich! NB: All applications must go via the ETH job portal:

www.jobs.ethz.ch/job/view/JOP...

Closing date: 24th Feburary
🧪🧫🔬

Postdoctoral researcher –Understanding bacterial metabolism in the urinary tract

www.jobs.ethz.ch

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Reposted by Linda Sinclair

Perona Lab, Edinburgh, UK @peronalab.bsky.social · Mar 3

I'm very pleased to have two lab positions open this week, to join our team looking at immune regulation in infection and co-infection. We're especially interested in tissue-based immunity, cytokine regulation and immune metabolism. Join us! Postdoc (3y) and research technician (12mo) posts open.

We're based in the Ashworth Laboratories, King's Buildings, University of Edinburgh. Photo shows the main staircase in the entrance to the Ashworth, stone steps from the 1920s, decorated with a series of bright, colurful banners depicting the science that's tackled in the building.

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Reposted by Linda Sinclair

Andrew S. MacDonald @profandrewmac.bsky.social · Mar 3

Very happy to share our new preprint on hallmarks of human #lung #macrophage activation by type 2 cytokines, and metabolic control of this process 🙂. #immunometabolism #ImmunoSky 🧪 @lydiabeckeriii.bsky.social @edinburgh-uni.bsky.social www.biorxiv.org/content/10.1...

Hallmarks and metabolic regulation of type 2 activated human lung macrophages

Although human lung macrophages are heterogenous and play key roles during health and disease, the mechanisms that govern their activation and function are unclear, particularly in type 2 settings. Ou...

www.biorxiv.org

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Linda Sinclair @lindavsinclair.bsky.social · Mar 3

Thanks Karen 🤗

Linda Sinclair @lindavsinclair.bsky.social · Mar 1

Thanks Hal 😊😊

Linda Sinclair @lindavsinclair.bsky.social · Mar 1

Thanks Bob, glad you enjoyed it 🤩

Linda Sinclair @lindavsinclair.bsky.social · Mar 1

Thread is out now too Mary ;-)

Reposted by Linda Sinclair

Payam Gammage @mito-oncogene.bsky.social · Jan 7

Okey dokey here goes! First real post - please reshare if appropriate 🙏

🔔We’ve got two postdoc level positions opening in our lab! One wet lab, one computational🔔

We’re a scientifically diverse, friendly bunch working at the interface of mitochondrial biology, metabolism & cancer in Glasgow, UK.

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Linda Sinclair @lindavsinclair.bsky.social · Mar 1

*** www.immpres.co.uk *** correct link.

ImmPRes