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Marco Hein

@marco.heinlab.org

1.4K followers 2.4K following 26 posts

Systems biologist • Prof at Max Perutz Labs & MedUni Vienna • dad×2 • he/him #LoveVirology #TeamMassSpec #dataviz 📍 Vienna 🇪🇺

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Marco Hein @marco.heinlab.org · Jan 14

Time to share our organelle proteome paper
out in @cellcellpress.bsky.social: doi.org/nzwz
We created a spatial map of human cells using organelle immunoprecipitation at scale.
Locate your fav protein among the 7,600 we mapped across 19 subcellular compartments: organelles.sf.czbiohub.org/

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Graphical abstract of the Organelle Profiling paper, showing the workflow:
Endogenously tagged organelle library;
Native IP proteomics;
Data-driven graph clustering;
resulting in a subcellular proteome map with
more than 7,600 proteins localized across 19 subcellular compartments.

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Reposted by Marco Hein

Institute of Molecular Biotechnology @imbavienna.bsky.social · 13d

🎉 Congratulations to Max Kellner, former PhD student in the Penninger Lab, who was presented with the ÖGBMT Life Sciences PhD Award Austria. The award recognizes Kellner’s PhD research on how dangerous viruses emerge from natural reservoirs like bats. More: https://imba.science/3KiRYSN

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Vienna BioCenter Scientific Training @vbcscitraining.bsky.social · 21d

Our Autumn call is now open with over 20+ fully funded positions in various disciplines in the life sciences. Interested? Check out our vacancies in computational biology, genomes & evolution and the exciting projects being offered here: ow.ly/aBgQ50WY1S2

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Marco Hein @marco.heinlab.org · Jul 15

I couldn’t be prouder of my team! Kavya and Sebastian both won DOC fellowships from the Austrian Academy of Sciences!
Congratulations to all awardees!

Max Perutz Labs Vienna @maxperutzlabs.ac.at · Jul 15

The DOC-torate dream team! 🎓 Seven Perutz PhD students just secured @oeaw.bsky.social DOC Fellowships - the most we've ever had in one year! Huge Congrats! 🎉➡️ tinyurl.com/29nvtf7j

@univie.ac.at
@meduniwien.ac.at

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Reposted by Marco Hein

Anton Goloborodko @golobor.bsky.social · Jul 15

We found a new asymmetry in the large-scale chromosome structure: sister chromatids are systematically shifted by hundreds of kb in the 5′→3′ direction of their inherited strands! The work was led by Flavia Corsi, in close collaboration with the Daniel Gerlich lab.
www.biorxiv.org/content/10.1...
1/

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Marco Hein @marco.heinlab.org · Jul 8

Join us at the Perutz, part of the Vienna Biocenter!
Opening for a full professorship in Molecular Mechanisms of Disease 👇🏻
@maxperutzlabs.bsky.social @viennabiocenter.bsky.social
@univie.ac.at

Max Perutz Labs Vienna @maxperutzlabs.ac.at · Jul 7

📢 Open Call! The Max Perutz Labs invite applications for a Full Professorship in Molecular Mechanisms of Disease. More information ➡️ tinyurl.com/3yn883b8

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Reposted by Marco Hein

Christa Buecker @chribue.bsky.social · Jul 2

Exciting and rare opportunity to join the @maxperutzlabs.bsky.social and the @viennabiocenter.bsky.social as a Full Professor!
www.nature.com/naturecareer...

Full Professorship in Molecular Mechanisms of Disease - Vienna BioCenter, Austria job with Max Perutz Labs, University of Vienna | 12841053

Join theMax Perutz Labs as Full Professor to unravel disease mechanisms—from metabolism and stress to RNA regulation, epigenetics, and immunity.

www.nature.com

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Reposted by Marco Hein

Jason Nomburg @jnoms.bsky.social · Jun 12

Hello everyone! I am pleased to share information on the first ever Computational Structural Virology Symposium, conducted August 4th on zoom and highlighting work in this emerging field. You can register for this event here: forms.gle/CNiqskMwQEuV.... Please re-post!

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Marco Hein @marco.heinlab.org · Jun 13

Congratulations Shira & team!

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Reposted by Marco Hein

Shira Weingarten-Gabbay @shiraweingarten.bsky.social · Jun 12

If you love #viruses, #ribosomes, and genomic #darkmatter, this thread is for you!! 💫
We're excited to share our new publication developing Massively Parallel Ribosome Profiling (MPRP), which uncovered ~4,000 hidden proteins in ~700 viral genomes. www.science.org/doi/10.1126/...

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Reposted by Marco Hein

Randall Munroe @xkcd.com · May 29

Mass Spec

xkcd.com/3094/

[Person with ponytail wearing lab coat hands balloon to another person in front of a springboard, a magnet hanging from above, and then a target] PERSON WITH PONYTAIL to Person 2: Rub this balloon against your head, then go jump past that magnet toward the target on the wall. [caption] Before the bathroom scale was invented, the only way to weigh people was mass spectrometry.

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Reposted by Marco Hein

Max J. Kellner @mjkellner.bsky.social · May 21

Hi 🦋 I’m thrilled to share that our #bat #organoid work has found a publishing home in Nature Immunology!

These models provided unprecedented insight into antiviral immunity at epithelial surfaces of the Egyptian fruit bat 🦇 — a natural reservoir of Marburg virus 🦠

www.nature.com/articles/s41...

Bat organoids reveal antiviral responses at epithelial surfaces - Nature Immunology

Kellner et al. develop respiratory and intestinal organoids from Rousettus aegyptiacus to show elevated basal expression of interferon-ε (IFNε) and IFN-stimulated genes, along with robust, self-amplifying type III IFN responses that drive antiviral defense against zoonotic RNA viruses.

www.nature.com

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Reposted by Marco Hein

MedUni Wien @meduniwien.ac.at · May 6

Innovative Forschung zur Entstehung & Kontrolle von #Metastasen ⤵️

Wir gratulieren @jwinkler.bsky.social von der #MedUniWien zur Auszeichnung der @oeaw.bsky.social mit dem Johann Wilhelm Ritter von Mannagetta-Preis!

Juliane Winkler mit dem Johann Wilhelm Ritter von Mannagetta-Preis ausgezeichnet

Mehr über die Studie zur Entstehung von Metastasen!

www.meduniwien.ac.at

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Reposted by Marco Hein

Juliane Winkler @jwinkler.bsky.social · Apr 7

🌟 Exciting #PhD Opportunity! Join my lab in beautiful #Vienna. We are studying tumor-immune interactions in #metastasis using #singlecell and #spatial omics! ⏰ Apply by 04/25 bit.ly/3l7WMhs more infos 👉 winklerlab.org

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Michael Bronstein @mmbronstein.bsky.social · Mar 17

Aithyra is hiring! We are looking for multiple starting PIs in life sciences and AI/ML. We offer highly competitive packages and salaries among the highest in Europe.

www.oeaw.ac.at/aithyra/news...

Search for LIFE SCIENCE and AI/ML Starting Principal Investigators (m/f/d) at AITHYRA, Vienna

If you are an ambitious early-career scientist ready to propel your research to new heights, we invite you to be part of AITHYRA’s founding generation of Principal Investigators. Together, we will sha...

www.oeaw.ac.at

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Reposted by Marco Hein

Institute of Molecular Biotechnology @imbavienna.bsky.social · Mar 28

IMBA is recruiting a Junior Group Leader! Are you interested in starting your own lab, pursuing curiosity-driven basic research in the life sciences? Apply now to our group leader position. The deadline is May 28. Link is below.

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Marco Hein @marco.heinlab.org · Apr 1

Dear @nature.com publishing group:
We swallowed your $12k article processing charge, but the name of your new journal is too much…

Screenshot of the “aims and scope” page of the fictitious journal “Nature Cell Science” [April fools]

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Reposted by Marco Hein

Maya Voichek @mayavoichek.bsky.social · Mar 17

1/ Transposable elements are often called "jumping genes" because they mobilize within genomes. 🧬
But did you know they can also jump 𝘣𝘦𝘵𝘸𝘦𝘦𝘯 cells? 🤯
Our new study reveals how retrotransposons invade the germline directly from somatic cells.
www.biorxiv.org/content/10.1...
A short thread 🧵👇

Drosophila follicle showing retrotransposons (pink & yellow) expressed in somatic cells infecting the oocyte

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Marco Hein @marco.heinlab.org · Mar 12

Agarose/sepharose doesn't work as affinity resin base for large organelle cargo, only smooth magnetic particles do, limiting the selection of commercial reagents. Nanobodies would have been nice because they generate less background during on-bead digest. Ultimately we went back to square 1: HA.

Marco Hein @marco.heinlab.org · Mar 12

Earlier papers that IPed organelles had already used HA, so this was our starting point. We tried a panel of other tags, hoping to find a better one for which commercial nanobody-conjugated magnetic affinity beads were available. TL;DR: we didn't find a better one.

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Vienna BioCenter Scientific Training @vbcscitraining.bsky.social · Mar 6

Our Spring call is now open with over 25+ fully funded positions in various disciplines in the life sciences. Interested? Check out our vacancies and the exciting projects being offered here: www.vbcphd.at
Application Deadline: 15 April 2025

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Michael Friendly @datavisfriendly.bsky.social · Mar 5

📊Looking to re-decorate your #dataviz office?
You need Boxplot Shelves! |----[ ]--|

A set of three wall shelf sets, in the form of boxplots

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Reposted by Marco Hein

Abby Buchwalter @abbybuch.bsky.social · Mar 6

Heading to my SF local #standupforscience rally tomorrow along with many UCSF colleagues and friends. Making signs this afternoon at departmental happy hour hosted by @elphegenoralab.bsky.social - we need inspiration!

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Reposted by Marco Hein

Biomedical Picture of the Day BPoD @bpodaily.bsky.social · Feb 24

A high-res approach to localise thousands of proteins within a cell

📷: Marco Hein, Duo Peng, Verina Todorova, Frank McCarthy, Kibeom Kim, Chad Liu et al @czbiohub.bsky.social in @cellpress.bsky.social
➡️: bpod.org.uk/archive/2025/2/22 with
@rooph.bsky.social

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Marco Hein @marco.heinlab.org · Feb 6

Welcome to the VBC!

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Marco Hein @marco.heinlab.org · Feb 3

Join me tomorrow 4 Feb at 14:00 CET for an educational seminar about single-cell transcriptomics in virology:
Register here: us06web.zoom.us/meeting/regi...

This is seminar 1 of the new season of @gesvirologie.bsky.social's ACHIEVE Academy's 'How-To' seminars, targeted at PhD and Master's students.

Announcement poster for Marco Hein's seminar 'How to perform and analyze single-cell sequencing"

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