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Shira Weingarten-Gabbay @shiraweingarten.bsky.social · 9d

Thank you for having us Akos! It was a great session.

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Shira Weingarten-Gabbay @shiraweingarten.bsky.social · 22d

Congratulation to all the laureate and finalists and to the brilliant Maria Cecilia Canesso 🤩

The Rockefeller University @rockefeller.edu · 22d

Congratulations to all, especially Rockefeller's @veenapadmanaban.bsky.social, a research associate in
@sohailtavazoie.bsky.social's lab, and Maria Cecilia Campos Canesso, formerly a postdoc in @danmucida.bsky.social and @victora.bsky.social’s labs. A very well-deserved recognition!

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Shira Weingarten-Gabbay @shiraweingarten.bsky.social · 25d

Looking forward to a terrific symposium on Synthetic Biology and it's implication in therapeutic development ✨

Akos Nyerges @akosnyerges.bsky.social · 28d

Excited to chair #BostonDOT 's SynBio symposium with talks from
🔸Farren Isaacs
🔸Jessica Stark @jcstark.bsky.social
🔸Shira Weingarten-Gabbay @shiraweingarten.bsky.social
🔸Abhishek Chatterjee @achemsynbio.bsky.social
🔸Wen Tseng
🔸Michael Krogh Jensen
🔸Ryan Clarke
🔸Alex Reis @alexcampreis.com

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Reposted by Shira Weingarten-Gabbay

Sorek Lab @soreklab.bsky.social · Sep 2

Preprint: De-novo design of proteins that inhibit bacterial defenses

Our approach allows silencing defense systems of choice. We show how this approach enables programming of “untransformable” bacteria, and how it can enhance phage therapy applications

Congrats Jeremy Garb!
tinyurl.com/Syttt
🧵

Synthetically designed anti-defense proteins overcome barriers to bacterial transformation and phage infection

Bacterial defense systems present considerable barriers to both phage infection and plasmid transformation. These systems target mobile genetic elements, limiting the efficacy of bacteriophage-based t...

www.biorxiv.org

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Reposted by Shira Weingarten-Gabbay

Waggoner Lab @labwaggoner.bsky.social · Aug 12

SPEAR (bacterial nanosynringe) enables loading of different types of cargo (including folded ribonucleoproteins and single-stranded DNA) and targeting of defined cell types both in vitro and in vivo
www.nature.com/articles/s41...
@natbiotech.nature.com @zhangf.bsky.social

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Reposted by Shira Weingarten-Gabbay

abrahamlabhms.bsky.social @abrahamlabhms.bsky.social · Aug 9

Excited to share our new @natmicrobiol.nature.com paper revealing the most complete arenavirus glycoprotein complex (GPC) structures to date 🤩 www.nature.com/articles/s41...

Molecular organization of the New World arenavirus spike glycoprotein complex - Nature Microbiology

Cryo-EM structures of the full-length Junin virus and Machupo virus spike glycoprotein complexes stabilized in the prefusion conformation. Analyses reveal features that regulate glycoprotein pH-depend...

www.nature.com

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Shira Weingarten-Gabbay @shiraweingarten.bsky.social · Aug 9

Super interesting insights on the evolutionary constrains on synonymous codons 🤩 "Our results suggest that cotranslational localization and translational accuracy, more than cotranslational protein folding, are major drivers of selective pressure on codon choice in eukaryotes."

Liana Lareau @lianafaye.bsky.social · Aug 7

This preprint from Helen Sakharova is one of the coolest things to come out of my lab: “Protein language models reveal evolutionary constraints on synonymous codon choice.” Codon choice is a big puzzle in how information is encoded in genomes, and we have a new angle. www.biorxiv.org/content/10.1...

Protein language models reveal evolutionary constraints on synonymous codon choice

Evolution has shaped the genetic code, with subtle pressures leading to preferences for some synonymous codons over others. Codons are translated at different speeds by the ribosome, imposing constrai...

www.biorxiv.org

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Shira Weingarten-Gabbay @shiraweingarten.bsky.social · Jul 15

The most humble scientist I know and a true legend

Matt Frieman @mattfrieman.bsky.social · Jul 14

Charlie Rice is the only scientist who could get a Nobel Prize for his findings and give a keynote address at #ASV2025 and never mention he won a Nobel Prize! #LoveVirology

Shira Weingarten-Gabbay @shiraweingarten.bsky.social · Jul 13

On my way to #ASV2025. Two flights canceled due to weather ⛈️ but should make it on time! Join us for a terrific symposium tomorrow morning on #NextGenerationVirology with
#BenhurLee #JesseBloom #LisaWagner @wchnicholas.bsky.social and #IleanaCristea. Safe travel everyone! #LoveVirology

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Reposted by Shira Weingarten-Gabbay

American Society for Virology @amersocvirology.bsky.social · Dec 4

Get ready for ASV 2025! The 2025 American Society for Virology meeting will be hosted by McGill University and held at the Palais des Congrès de Montréal, Montréal, Québec, Canada from July 14 - 17, 2025. Abstract submission, travel award apps, and registration are now open! asv.org/asv2025/regi...

Register 2025 | American Society for Virology

The 44th Annual Meeting of the American Society for Virology! Dates: July 14 – 17, 2025 (Monday – Thursday) Palais des congrès de Montréal Host: McGill University *TEACHER TRAVEL GRANTS: Applications…

asv.org

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Reposted by Shira Weingarten-Gabbay

Science in Boston @scienceinboston.com · Jun 30

Dr. Shira Weingarten-Gabbay (@shiraweingarten.bsky.social) from @harvardmed.bsky.social is leading the new Laboratory of Systems #Virology.

Her lab uncovers the inner workings of viruses and their interaction with the immune system to prevent current and future viral diseases: bit.ly/44peaBa

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Reposted by Shira Weingarten-Gabbay

The Rockefeller University @rockefeller.edu · Jun 30

"This work by Shira highlights new dark matter in viral genomes that can influence disease and how we design vaccines," says Charles Rice. "It’s yet another layer of biology that was not appreciated but opens up exciting new opportunities for exploration."

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Reposted by Shira Weingarten-Gabbay

The Rockefeller University @rockefeller.edu · Jun 30

A recent study from @shiraweingarten.bsky.social, a former postdoc in the Rice laboratory, revealed 4,208 previously unknown proteins that are made by viruses such as influenza and H.I.V. using a new technique called massively parallel ribosome profiling.

Shining a Light on the World of Tiny Proteins

www.nytimes.com

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Reposted by Shira Weingarten-Gabbay

Thelonevirologist @thelonevirologist.bsky.social · Jun 13

Pan-viral ORFs discovery using massively parallel ribosome profiling www.science.org/doi/10.1126/...

Pan-viral ORFs discovery using massively parallel ribosome profiling

Defining viral proteomes is crucial to understanding viral life cycles and immune recognition but the landscape of translated regions remains unknown for most viruses. We have developed massively para...

www.science.org

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Reposted by Shira Weingarten-Gabbay

Ophir Shalem @ophirshalem.bsky.social · Jun 17

Congratulation @shiraweingarten.bsky.social! Beautiful work!

Shira Weingarten-Gabbay @shiraweingarten.bsky.social · Jun 12

If you love #viruses, #ribosomes, and genomic #darkmatter, this thread is for you!! 💫
We're excited to share our new publication developing Massively Parallel Ribosome Profiling (MPRP), which uncovered ~4,000 hidden proteins in ~700 viral genomes. www.science.org/doi/10.1126/...

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Shira Weingarten-Gabbay @shiraweingarten.bsky.social · Jun 19

Thank you Ophir!! 🙏

Shira Weingarten-Gabbay @shiraweingarten.bsky.social · Jun 17

Thank you so much Akos! 🙏

Reposted by Shira Weingarten-Gabbay

Akos Nyerges @akosnyerges.bsky.social · Jun 17

Super exciting work! Congrats @shiraweingarten.bsky.social and everyone involved!

Shira Weingarten-Gabbay @shiraweingarten.bsky.social · Jun 12

If you love #viruses, #ribosomes, and genomic #darkmatter, this thread is for you!! 💫
We're excited to share our new publication developing Massively Parallel Ribosome Profiling (MPRP), which uncovered ~4,000 hidden proteins in ~700 viral genomes. www.science.org/doi/10.1126/...

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Reposted by Shira Weingarten-Gabbay

Roland Pease @peaseroland.bsky.social · Jun 12

Also pleased to learn from @shiraweingarten.bsky.social about a new way of interrogating viral genomes to find, much faster than with conventional methods, what parts of the genetics are most important to the viral life cycle. Important for finding vaccines, antivirals etc. Using ribosomes.

Graphic showing how Massively Parallel Ribosome Profiling scans numerous viruses for translated regions of their genomes.

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Reposted by Shira Weingarten-Gabbay

Fede Fuchs W @fedefuchsw.bsky.social · Jun 12

Super super cool!

Shira Weingarten-Gabbay @shiraweingarten.bsky.social · Jun 12

If you love #viruses, #ribosomes, and genomic #darkmatter, this thread is for you!! 💫
We're excited to share our new publication developing Massively Parallel Ribosome Profiling (MPRP), which uncovered ~4,000 hidden proteins in ~700 viral genomes. www.science.org/doi/10.1126/...