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Reposted by Akos Nyerges

Carl Zimmer @carlzimmer.com · 12h

Today my @nytimes.com colleagues and I are launching a new series called Lost Science. We interview US scientists who can no longer discover something new about our world, thanks to this year‘s cuts. Here is my first interview with a scientist who studied bees and fires. Gift link: nyti.ms/3IWXbiE

nyti.ms

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Akos Nyerges @akosnyerges.bsky.social · 16d

Abhishek Chatterjee @achemsynbio.bsky.social and Michael Krogh Jensen's talks are opening the afternoon session of SynBio @ #BostonDOT

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Akos Nyerges @akosnyerges.bsky.social · 16d

SynBio @ #BostonDOT started with a fantastic morning session, with talks from Farren Isaacs, Shira @shiraweingarten.bsky.social, and Ryan Clarke

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Michael Baym @baym.lol · 22d

If there were a collection of E. coli with every combination of a bunch of resistance markers fluorophores on the chromosome, would this be something people would be interested in using?

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Reposted by Akos Nyerges

Heng Li @lh3lh3.bsky.social · 27d

New blog post – A quick look at Roche's SBX
lh3.github.io/2025/09/11/a...

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Enrico Orsi @eorsi.bsky.social · 27d

Please repost!

Postdoc in adaptive laboratory evolution and C1 synthetic metabolism!

Location: DTU Biosustain

🦠🧬🔬

Starting in 01/2026!

Fell free to reach out if you have questions!
efzu.fa.em2.oraclecloud.com/hcmUI/Candid...

efzu.fa.em2.oraclecloud.com

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Shira Weingarten-Gabbay @shiraweingarten.bsky.social · 25d

Looking forward to a terrific symposium on Synthetic Biology and it's implication in therapeutic development ✨

Akos Nyerges @akosnyerges.bsky.social · 28d

Excited to chair #BostonDOT 's SynBio symposium with talks from
🔸Farren Isaacs
🔸Jessica Stark @jcstark.bsky.social
🔸Shira Weingarten-Gabbay @shiraweingarten.bsky.social
🔸Abhishek Chatterjee @achemsynbio.bsky.social
🔸Wen Tseng
🔸Michael Krogh Jensen
🔸Ryan Clarke
🔸Alex Reis @alexcampreis.com

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Reposted by Akos Nyerges

Jim Van Deventer @vandeventerjim.bsky.social · 27d

Today, I’m grateful that I can finally share Briana Lino’s @blino237.bsky.social work on engineering eukaryotic release factor 1 (eRF1) for enhanced noncanonical amino acid incorporation. I highlight some key findings in this thread (1/n).

www.biorxiv.org/content/10.1...

High throughput screening of eukaryotic release factor 1 variants to enhance noncanonical amino acid incorporation

Noncanonical amino acids (ncAAs) enable diversification of protein functions, but the efficiency of genetic code expansion (GCE) in eukaryotes is hindered by competition between suppressor tRNAs and r...

www.biorxiv.org

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Akos Nyerges @akosnyerges.bsky.social · 28d

Join us on September 22, in person or online. Visit 🔗 discoveryontarget.com/synthetic-biol… for the full agenda and to register.

We still have spots available, and please reach out (email or DM me) if you are a trainee, student, or postdoc and need registration support to attend!

https://discoveryontarget.com/synthetic-biol…

Akos Nyerges @akosnyerges.bsky.social · 28d

Excited to chair #BostonDOT 's SynBio symposium with talks from
🔸Farren Isaacs
🔸Jessica Stark @jcstark.bsky.social
🔸Shira Weingarten-Gabbay @shiraweingarten.bsky.social
🔸Abhishek Chatterjee @achemsynbio.bsky.social
🔸Wen Tseng
🔸Michael Krogh Jensen
🔸Ryan Clarke
🔸Alex Reis @alexcampreis.com

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Reposted by Akos Nyerges

Type VI Sophia System @wheezenfeld.bsky.social · Sep 2

This is one of the findings that really motivates my research: yes, antibiotic resistance genes are ancient, but the age of antibiotics has likely contributed to a big change in their mobility and of the landscape of MGEs we see today! Very happy for Arya and to see this published.

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Albert Vilella, PhD. @albertvilella.bsky.social · Aug 30

Dave Baker, not on bluesky, on the issues of the 600 cycle kit on Illumina NextSeq 2000 instrument.

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Reposted by Akos Nyerges

Carl Zimmer @carlzimmer.com · Aug 24

“We feel like the lost generation.” A story on the collapse of US science, which is hitting young scientists hardest www.washingtonpost.com/education/20...

At Harvard, Trump administration cuts hit young scientists hard

More than 700 graduate students and nearly 800 postdoctoral researchers at Harvard get salaries, stipends or tuition support from federally funded research.

www.washingtonpost.com

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Laura White @laurakwhite.bsky.social · Aug 22

Our paper is out in its final form! Back in April 2023, my coauthor Aleks Radakovic, then a PhD student, approached me after a talk in Chicago to ask what I thought an aminoacylated tRNA would look like if we pulled it through a @nanopore.
doi.org/10.1038/s414...

Nanopore sequencing of intact aminoacylated tRNAs - Nature Communications

Accurate protein synthesis depends on aminoacylated tRNAs, but their identities have been hard to measure. Here, authors present aa-tRNA-seq, a nanopore-based method that reveals the amino acid, seque...

doi.org

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Nature Microbiology @natmicrobiol.nature.com · Aug 8

#NatMicroPicks

Synthetic evolution overdrive 🦠🔧🚅

A highly mutagenic DNA replication system speeds up evolution in Escherichia coli, without harming the host, opening a new way to accelerate protein engineering.

#SynBio #MicroSky

www.science.org/doi/10.1126/...

An orthogonal T7 replisome for continuous hypermutation and accelerated evolution in E. coli

Systems that perform continuous hypermutation of designated genes without compromising the integrity of the host genome can substantially accelerate the evolution of new or enhanced protein functions....

www.science.org

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bioRxiv Synthetic Biology @biorxiv-synthbio.bsky.social · Aug 6

Simulating a for-loop in the human genome: Design and evaluation of recombinase genetic programs that count to three. https://www.biorxiv.org/content/10.1101/2025.08.04.668540v1

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Nature Microbiology @natmicrobiol.nature.com · Aug 1

#NatMicroPicks

Engineering Peace in the Gut Microbiome ☮️🔧🦠

BACTRINS, a microbiome engineering platform that precisely edits gut pathogens by inserting therapeutic payloads and neutralizing virulence genes, transforming them into allies.

@natbiomedeng.nature.com
www.nature.com/articles/s41...

Precise virulence inactivation using a CRISPR-associated transposase for combating Enterobacteriaceae gut pathogens - Nature Biomedical Engineering

A self-transmissible CRISPR-associated transposase system encodes a nanobody payload to treat Shiga toxin infections.

www.nature.com

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Reposted by Akos Nyerges

Ardem Patapoutian @ardemp.bskyverified.social · Jul 31

BIG NEWS:

“Senate appropriators on Thursday approved an FY26 Labor-HHS bill that included a slight bump in funding for the NIH, with a strong 26–3 bipartisan vote.”

Thank you to members of the Senate Appropriations Committee on both sides of the aisle!

www.axios.com/pro/health-c...

Senate appropriators approve Labor-HHS bill with NIH bump

The vote and lawmaker comments show that most senators aren't going along with the White House's proposed 40% budget cut to NIH.

www.axios.com

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Vaughn Cooper @vscooper.micropopbio.org · Jul 31

E. coli, but with only 57 codons! Honey, who shrunk the genetic code?

By @carlzimmer.com quoting @akosnyerges.bsky.social about work from Jason Chin's lab at the MRC LMB.

"There’s a lot more in genomes than we thought. We are still not great at designing biology.”
www.nytimes.com/2025/07/31/s...

Scientists Are Learning to Rewrite the Code of Life

www.nytimes.com

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Carl Zimmer @carlzimmer.com · Jul 31

Meet Syn57, a living cell that only needs 57 codons, not the standard 64. Here's my story on how synthetic biology is tackling the mystery of our bloated genetic code. Gift link: nyti.ms/3Hf4f9v

Scientists are Learning to Rewrite the Code of Life

In a giant feat of genetic engineering, scientists have created bacteria that make proteins in a radically different way than all natural species do.

nyti.ms

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Mo Khalil @mokhalil.bsky.social · Jul 21

We traveled to DC to talk to Congressional Staffers about the impact of NIH and NIBIB funding. It enables us to develop synthetic biology tools to advance cell & genetic medicines for patients in need. REPOST to deliver the message that SCIENCE saves lives & makes America GREAT!

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Reposted by Akos Nyerges

Amy Weeks @amyweeks.bsky.social · Jul 18

Excited to share our latest: we engineered the reactivity of a bacterial E1-like enzyme for ATP-driven modification of C termini. Our tool mimics the logic of peptide bond formation in biology for precision modification of proteins in vitro. 🧪https://rdcu.be/ewN7C

Engineered reactivity of a bacterial E1-like enzyme enables ATP-driven modification of protein and peptide C termini

Nature Chemistry - In living systems, ATP provides an energetic driving force for protein synthesis and modification. Now, an engineered enzymatic tool has been developed for high-yield, ATP-driven...

rdcu.be

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Victor de Lorenzo (CNB, Madrid) @vdlorenzo.bsky.social · Jul 9

Deadline for applications extended to July 22 🔔! An unique opportunity to engage with cutting-edge science in a highly interactive format 👇

Victor de Lorenzo (CNB, Madrid) @vdlorenzo.bsky.social · Jun 11

Dear Pseudomonas aficionados: just a few weeks left to apply for this milestone CSH-Asia hands-on Course on Pseudomonas SynBio & Biotech in Suzhou www.csh-asia.org?content/2645. The experiments run there will be the basis of a dedicated CSHL protocol book on our fav microorganism!

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Bram van Dijk 🏳️‍🌈 @bramvandijk.bsky.social · Jul 3

Amazing stuff by one of the most hard working lab rats I’ve ever met. In a good way ;p

www.biorxiv.org/content/10.1...

Jumbo phage-mediated transduction of genomic islands

Bacteria acquire new genes by horizontal gene transfer (HGT), typically mediated by mobile genetic elements (MGEs). While plasmids, bacteriophages and certain integrative and conjugative elements (ICE...

www.biorxiv.org

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Craig Kaplan @triggerloop.bsky.social · Jun 26

Massive prime editing approach to look at synonymous variant effects in human cells. In this assay, synonymous variants do not generally have the same level of effect as non synonymous 1/ www.nature.com/articles/s41...

Prime editor-based high-throughput screening reveals functional synonymous mutations in human cells - Nature Biotechnology

A prime editor screen systematically identifies deleterious synonymous variants in human cells.

www.nature.com

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