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Reposted by Fede Fuchs W

LA NACION @lanacioncom.bsky.social · 23h

Investigadores del Laboratorio de Anatomía Comparada y Evolución de los Vertebrados del Conicet (Lacev-Conicet) descubrieron un huevo de dinosaurio carnívoro en perfecto estado de conservación y lo anunciaron en un nuevo streaming de paleontología www.lanacion.com.ar/sociedad/inv...

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Fede Fuchs W @fedefuchsw.bsky.social · 29d

A must read from Luisa, Emi, and team.

Luisa Cochella @lcochella.bsky.social · Sep 3

Our work on the function of miR-51/miR-100 is out! miR-100 is widely conserved across eumetazoans but its function has been mysterious. Emilio Santillán found in worms it regulates signaling and extracellular matrix genes, some of which seem to be conserved targets! www.science.org/doi/10.1126/...

An ancient and essential miRNA family controls cellular interaction pathways in C. elegans

A microRNA that arose at the origin of eumetazoans regulates cell adhesion and signaling in C. elegans through conserved targets.

www.science.org

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Reposted by Fede Fuchs W

David Bartel's Lab @bartellab.bsky.social · Aug 2

Check out the latest study from our lab, led by Coffee Xiang (@coffeebond007.bsky.social) www.nature.com/articles/s41... (1/2)

PAL-AI reveals genetic determinants that control poly(A)-tail length during oocyte maturation, with relevance to human fertility - Nature Communications

Gene regulation in oocytes relies heavily on poly(A) tail-length changes. Here, the authors develop PAL-AI, a neural network model that predicts tail-length changes, identifies regulatory motifs, and ...

www.nature.com

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Fede Fuchs W @fedefuchsw.bsky.social · Jul 31

This work is the result of a collaboration between many wonderful people: @grantyang.bsky.social, Yve, Casper, Matty, Scott, myself, and Silvi from @harvardmed.bsky.social; Dan H from @stanfordpress.bsky.social; and, for the first time as a PI, the great Lauren Hagler from @tamu.bsky.social !!

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Fede Fuchs W @fedefuchsw.bsky.social · Jul 31

Aside from the app itself, we found that DMS-MaPseq + SEISMICgraph can be used to in vitro validate multiple riboswitches at once using a library, and that many of those riboswitches stop functioning if pseudoU is used instead of regular U (an important finding for those working in RNA tx).

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Fede Fuchs W @fedefuchsw.bsky.social · Jul 31

The platform offers a plethora of graphs (see pic), and supports data coming from ShapeMapper, RNA framework, and SEISMIC; it should make the life of anybody analyzing DMS/SHAPE-MaP a lot easier :)

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Fede Fuchs W @fedefuchsw.bsky.social · Jul 31

Our latest publication (doi.org/10.1093/nar/...) from the Rouskin (www.rouskinlab.com) & Hagler Labs (www.haglerlab.org) is out on @narjournal.bsky.social ! We developed a web interface for easy visualization of RNA structure chemical probing data (from DMS/SHAPE-MaP).

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SEISMICgraph: a web-based tool for RNA structure data visualization

Abstract. In recent years, RNA has been increasingly recognized for its essential roles in biology, functioning not only as a carrier of genetic informatio

doi.org

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Fede Fuchs W @fedefuchsw.bsky.social · Jul 31

A wonderful collab between CONICET (Argentina) and the Schmidt Ocean Institute led to the exploration of the Submarine Canyon in Argentina’s deep shores. It is hypnotic to see:

www.youtube.com/live/xg9NLXK...

Lance 22.1 Mar Del Plata Canyon | SOI Divestream 817

YouTube video by Schmidt Ocean

www.youtube.com

Fede Fuchs W @fedefuchsw.bsky.social · Jul 28

A cool one

Danny IncaRNAto @incarnatolab.bsky.social · Jul 27

I am so incredibly excited to share our latest work, on the exploration of #RNA secondary structure ensembles and discovery of RNA regulatory structural switches in bacteria and human cells, just out in
@natbiotech.nature.com: nature.com/articles/s41.... A short tread! (1/n)

Identification of conserved RNA regulatory switches in living cells using RNA secondary structure ensemble mapping and covariation analysis - Nature Biotechnology

Transcriptome-scale maps of RNA secondary structure ensembles in living cells detect candidate RNA structural switches.

nature.com

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Reposted by Fede Fuchs W

Josh Mendell @mendell-lab.bsky.social · Jul 2

I am pleased to present our latest pre-print describing our identification of the long-sought triggers for target-directed microRNA degradation (TDMD) of miR-322 and miR-503, work led by Collette LaVigne and Jaeil Han. For more info, read on! 👇
www.biorxiv.org/content/10.1...

Plagl1 and Lrrc58 control mammalian body size by triggering target-directed microRNA degradation of miR-322 and miR-503

Precise control of microRNA (miRNA) expression is critical during development. An important mechanism of miRNA regulation is target-directed microRNA degradation (TDMD), a pathway in which the binding...

www.biorxiv.org

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Reposted by Fede Fuchs W

New Scientist @newscientist.com · Jun 21

There are hundreds of TV apocalypses to choose from, but The Eternaut, a fresh and compelling adaptation of a classic Argentinian comic book series, is the one to pick, says Bethan Ackerley

This stunning post-apocalyptic drama is the one you should be watching

There are hundreds of TV apocalypses to choose from, but The Eternaut, a fresh and compelling adaptation of a classic Argentinian comic book series, is the one to pick, says Bethan Ackerley

www.newscientist.com

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Fede Fuchs W @fedefuchsw.bsky.social · Jun 12

Super super cool!

Shira Weingarten-Gabbay @shiraweingarten.bsky.social · Jun 12

If you love #viruses, #ribosomes, and genomic #darkmatter, this thread is for you!! 💫
We're excited to share our new publication developing Massively Parallel Ribosome Profiling (MPRP), which uncovered ~4,000 hidden proteins in ~700 viral genomes. www.science.org/doi/10.1126/...

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Fede Fuchs W @fedefuchsw.bsky.social · Jun 3

That looks cool, how did you do it ?!?!

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Ana Fiszbein @anafiszbein.bsky.social · May 16

Very excited to share our new paper out now in
@MolecularCell. We show how U1 snRNP -a well-known splicing factor- regulates the activity of alternative promoters in human cells www.cell.com/molecular-ce...

U1 snRNP regulates alternative promoter activity by inhibiting premature polyadenylation

Kim et al. uncover a role for U1 snRNP in regulating internal promoter activity. Beyond its canonical role in splicing, U1 snRNP suppresses premature polyadenylation, enabling upstream transcription t...

www.cell.com

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Reposted by Fede Fuchs W

Ines Patop @inespatop.bsky.social · Apr 11

And on other news. My first contribution to science as a postdoc with @stirlingchurchman.bsky.social is out! We discuss the knowns and unknowns of post-transcriptional splicing. It was really fun to write with the great @karinechoquet

Nature Reviews Genetics @natrevgenet.nature.com · Apr 11

New online! The regulation and function of post-transcriptional RNA splicing

The regulation and function of post-transcriptional RNA splicing

Nature Reviews Genetics, Published online: 11 April 2025; doi:10.1038/s41576-025-00836-zPost-transcriptional splicing has emerged as a key layer of gene expression regulation but is challenging to differentiate from co-transcriptional splicing. The authors review methodologies to detect post-transcriptional splicing, the mechanisms controlling splicing timing and how the temporal regulation of splicing affects gene expression.

www.nature.com

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Fede Fuchs W @fedefuchsw.bsky.social · Apr 10

Everybody should

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Shira Weingarten-Gabbay @shiraweingarten.bsky.social · Apr 10

Tomorrow at the Systems Virology Journal Club, #AyanoKohlgruber will present her work with #SteveElledge on high-throughput discovery of MHC class I- and II-restricted T cell epitopes using synthetic cellular circuits. pubmed.ncbi.nlm.nih.gov/38956325/

Shira Weingarten-Gabbay @shiraweingarten.bsky.social · Dec 10

@wmschneider.bsky.social and I are thrilled to invite you to the 7th series of the International *Systems Virology Journal Club*! 🎉 🥂🌟
We are hosting a stellar line-up of speakers working at the intersection of virology and systems biology.
Registration (free): forms.gle/edTyLwR8jWkh...

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Fede Fuchs W @fedefuchsw.bsky.social · Mar 26

In vivo folding of nascent RNA! Awesome work from Leo (‪@leoschaerfen.bsky.social‬) and team, check it out:

Leo Schärfen @leoschaerfen.bsky.social · Mar 26

Here is our paper showing in vivo folding of nascent RNA right after synthesis, published now in @cp-molcell.bsky.social!

With @karlaneugebauer.bsky.social, @isaac-vock.bsky.social, @mattdsimon.bsky.social

www.cell.com/molecular-ce...

Rapid folding of nascent RNA regulates eukaryotic RNA biogenesis

Schärfen et al. develop a method to measure the structure of nascent RNAs during their synthesis by RNA polymerases. Base pairing occurs rapidly in cells, revealing the strong regulatory potential of ...

www.cell.com

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Reposted by Fede Fuchs W

Matthew Harry Hall @mhall98.bsky.social · Mar 12

Pleased to share my recent work from the Bartel Lab! Some miRNAs recognize novel target sites called 3'-only sites, which pair to the miRNA 3' region but not to the seed. These sites direct mRNA repression in cells and are engaged by different mechanisms to seed sites
www.biorxiv.org/content/10.1...

Functional microRNA targeting without seed pairing

MicroRNAs (miRNAs) associate with Argonaute (AGO) proteins to serve as guides, directing binding to partially complementary sites in mRNAs, ultimately causing post-transcriptional repression. Compleme...

www.biorxiv.org

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Fede Fuchs W @fedefuchsw.bsky.social · Mar 2

I would have to say circRNAs, never ending possibilities (since they have no ends)

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Fede Fuchs W @fedefuchsw.bsky.social · Mar 1

MicroRNAs are just so much fun

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Reposted by Fede Fuchs W

Randall Munroe @xkcd.com · Feb 26

RNA xkcd.com/3056

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Ryan Flynn @raflynn5.bsky.social · Feb 27

Excited to share the work of Jonathan Perr where he uncovered a surprisingly common feature of cell surfaces - the presentation and clustering of RNA binding proteins with #glycoRNA.

Critically support by #NIH @cp-cell.bsky.social www.cell.com/cell/abstrac...

RNA-binding proteins and glycoRNAs form domains on the cell surface for cell-penetrating peptide entry

Mammalian cells present RNA-binding proteins on the cell surface that form clustered domains containing glycoRNAs.

www.cell.com

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Fede Fuchs W @fedefuchsw.bsky.social · Feb 8

Our very own Scott Grote got into Harvard’s PHD program in Virology! #ProudLab #RouskinLab

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Jeremy Wilusz @jeremywilusz.bsky.social · Jan 18

EMBO practical workshop dedicated to circular RNAs to be held from May 31 to June 6, 2025 at the University of Trento, Italy.

INFO & REGISTRATION: meetings.embo.org/event/25-cir...
DEADLINE: February 1, 2025

gROUNDbreaking approaches for advancing circRNA research: detection, function, therapeutics

Circular RNAs (CircRNAs) are a rediscovered class of RNA species that originate from back-splicing events, which have been reported across all domains of life. Many circRNAs are stable, abundant and …

meetings.embo.org

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