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Mary Mirvis

@marymirvis.bsky.social

890 followers 1.3K following 150 posts

mesoscale structural cell bio :: cell anatomy, organelle systems, synthesis, language, interdisciplinarity :: PD @UCSF @wallaceucsf.bsky.social :: toddler mama :: mary.mirv.is Any other cell biologists into meta-research, synthesis, HPS or vice versa? HMU

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Mary Mirvis @marymirvis.bsky.social · Apr 19

New(ish) preprint! 📰What whole-cell patterns emerge from the arrangement, morphologies, and interactions of organelles in the 3D space of the cell? What would we see if we could gather ALL the whole-cell reconstruction data that's out there in one place? www.biorxiv.org/content/10.1...
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A scoping study of the whole-cell imaging literature: a foundational corpus, potential for mesoscale data synthesis, and implications for standardization of an emerging field

The level of cellular organization bridging the mesoscale and whole-cell scale is coming into focus as a new frontier in cell biology. Great progress has been made in unraveling the complex physical a...

www.biorxiv.org

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Reposted by Mary Mirvis

Guillermina Ramirez-SanJuan @guille-rochelle.bsky.social · 20d

In another exciting development our new preprint is online:
www.biorxiv.org/cgi/content/...

This is the work of my brilliant graduate student Katerina Kourkoulou in collaboration with Maggie Liu and Arnold Mathijssen. Here is a video of the subject of our study:

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Center for Open Science @cos.io · Aug 12

Metascience 2025 recordings are now available! #Metascience25 gathered researchers, funders, policymakers & more to explore how the research process can improve. The program included preconference symposia & plenary sessions on topics from policy change to AI in research.

🎥 cassyni.com/s/metasc...

Cassyni | Science starts with a seminar

Seamlessly organise, run and publish academic research seminars. Get started in minutes.

cassyni.com

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Reposted by Mary Mirvis

EMBL Events @events.embl.org · Jul 31

📢 Abstract submission deadline reminder for 'Cell biology of the nucleus'!

Before packing your bags and leaving for your summer vacation, there is one important task left to do: submit your abstract for #EESNucleus ✍️

Deadline is 26 August: https://s.embl.org/ees25-07-bl

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Mary Mirvis @marymirvis.bsky.social · May 6

So excited to be in Heidelberg for www.embl.org/about/info/c... ! This is going to be an awesome meeting, been looking forward to it for months! #EESTCBio

Theory and concepts in biology

www.embl.org

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American Society for Cell Biology @ascbiology.bsky.social · May 2

Unlawful grant terminations are harming young scientists and threatening innovation. ASCB joins leaders calling for immediate funding restoration.

www.ascb.org/society-news...

Leading Life Science Organizations: Unlawful Grant Terminations Pose Grave Threat to America’s Innovation Pipeline - ASCB

Amicus Brief Filed in Support of Suit Calling for Immediate Funding Restoration WASHINGTON, DC – Four leading life science organizations, including the ASCB, filed an amicus brief today asking the cou...

www.ascb.org

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Danielle Grotjahn @nanigrotjahn.bsky.social · May 1

🚨New preprint!🚨 #teamtomo
We expanded Surface Morphometrics to quantify membrane thickness from cryo-ET—revealing local variation across organelles.

Led by the lab’s first grad student, @mmedina300kv.bsky.social (defending Monday! 🍾) w/ @attychang.bsky.social @hamid13r.bsky.social & @tomo.science

bioRxivpreprint @biorxivpreprint.bsky.social · May 1

Surface morphometrics reveals local membrane thickness variation in organellar subcompartments https://www.biorxiv.org/content/10.1101/2025.04.30.651574v1

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Mary Mirvis @marymirvis.bsky.social · Apr 29

I’ll be there! Can’t wait!

SFB1348 @sfb1348.bsky.social · Apr 29

Just one week to go ⏳ until the "Cellular Interfaces Across Scales: From Molecules to Tissue Dynamics" meeting @sfb1348.bsky.social @uni-muenster.de
We can't wait to see you there!
crc1348-conference.ycode.site
#DynamicCellularInterfaces #Münster

Mary Mirvis @marymirvis.bsky.social · Apr 29

Thanks! I think it’s just edge detection & 3D project plus a little B&C adjustment in FIJI 🙂

Mary Mirvis @marymirvis.bsky.social · Apr 28

a bald man says most certainly i deny it while wearing a red shirt

Alt: Captain Picard says most certainly i deny it while wearing a red shirt

media.tenor.com

Mary Mirvis @marymirvis.bsky.social · Apr 28

Losing MOSAIC is such a senseless gut punch to so many deserving people like my lab mate @aralbright.bsky.social and science as a whole.

www.npr.org/sections/sho...

As a diversity grant dies, young scientists fear it will haunt their careers

The Trump administration defunded the National Institute of Health's MOSAIC grant program, which launched the careers of scientists from diverse backgrounds.

www.npr.org

Mary Mirvis @marymirvis.bsky.social · Apr 28

I agree, lately I increasingly prefer to frame gaps in knowledge as questions rather than these types of “little is known/poorly understood” statements, which are inherently vague and subjective. Questions are more engaging to a reader too imo

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Rachael Ott @rachaelott.bsky.social · Apr 25

For #FluorescenceFriday, a GFP reporter shows nuclei (fire) nestled between lots of lipid droplets in this set of adipocytes 🔬 #Microscopy #CellBiology

Nuclei (fire) and lipid droplets (black; seen by negative staining) are shown in adipocytes.

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Reposted by Mary Mirvis

C.H. Romatowski @chromatowski.bsky.social · Apr 21

This is incredibly cool: if you search for a condition that’s affected your family, the site returns stats on how much NIH has done for that disease, *and* a contact form for reaching out to tell your Members of Congress why you want to see them defend NIH.

Pass it on!

Nihil Dev @nihildev.bsky.social · Apr 21

Ever wonder how many lives have been saved by NIH-funded research - including your own? Enter any medical condition and instantly see how your tax dollars transformed science into survival.

www.ourhealthroi.com

Our Health ROI

Explore how your tax dollars fund life‑saving medical research.

www.ourhealthroi.com

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Reposted by Mary Mirvis

Jeremy Berg @jeremymberg.bsky.social · Apr 23

ACTION ITEM-----ACTION ITEM

Implementation of Schedule F

This is what a lot of us have been worried about.

This allows for many civil service positions to replaced with political appointees. This could include NIH institute directors and even POs.

BUT THERE IS A COMMENT PERIOD...

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the word alert is in a purple circle

ALT: the word alert is in a purple circle

media.tenor.com

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Thibaut Brunet @thibautbrunet.bsky.social · Apr 22

A dream come true: the first expansion microscopy images of C. flexa 🤩 Generated by Mylan & Uzuki who learned from the best (@hiralshah.bsky.social @gautamdey.bsky.social @dudinlab.bsky.social). We will learn so much from these!

Expansion microscopy micrograph of the choanoflagellate Choanoeca flexa, vaguely evocative of a cactus. Red = tubulin, green = actin, blue = DNA

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Reposted by Mary Mirvis

Fletcher Lab @fletcherlabucb.bsky.social · Apr 21

Come to the Annual Fletcher Lab Artshow on Friday May 9th, 2025! We host this event yearly as an opportunity for folks to display their artwork, come together with wine and cheese, and admire artwork!

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Mary Mirvis @marymirvis.bsky.social · Apr 20

Thanks Andrew! Yes that’s exactly the type of analysis I’m working on, defining “organization” in a way that can be compared between different cell types (I.e a specific set of morph metrics) is gonna be crucial

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Mary Mirvis @marymirvis.bsky.social · Apr 19

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Reposted by Mary Mirvis

Mary Mirvis @marymirvis.bsky.social · Apr 19

Many thanks to my co-author Brooke Weingard, my advisors Steve Goodman & @wallaceucsf.bsky.social , my Marshall lab mates and many others who have been supportive of this sort of oddball project. Now more than ever, I'm humbled by the absolute privilege of doing science! thanks for reading!
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Mary Mirvis @marymirvis.bsky.social · Apr 19

I'm excited for this chance to highlight the power of rigorous evidence synthesis for fundamental cell biology, something I hope to see more of and help develop in the future! If you're interested in the intersection of evidence/knowledge synthesis & fundamental bio please connect with me!
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Mary Mirvis @marymirvis.bsky.social · Apr 19

Stay tuned for part two of this story which will dive into the linguistic and conceptual basis of "cell anatomy" throughout the corpus. We plan on keeping this corpus up to date & expanding its scope as a collaborative interactive resource (we call it a "living corpus" as a running joke )
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a statue of a zombie is kneeling down with his arm outstretched

Alt: a statue of a zombie is kneeling down with his arm outstretched

media.tenor.com

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Mary Mirvis @marymirvis.bsky.social · Apr 19

We believe that the acceleration of whole-cell imaging tech & data in recent years represents the early stages of an emerging field. Hopefully this work will serve as a useful tool and catalyst for community discourse to standardize technical & conceptual norms.
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Mary Mirvis @marymirvis.bsky.social · Apr 19

But there are biases in the dataset! Namely small sample sizes, small cell types, non-mammalian cell types. This is a reflection of how technically challenging and costly whole-cell data is, even further highlighting the value of pooling datasets for research synthesis work.
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Mary Mirvis @marymirvis.bsky.social · Apr 19

This lights the way for lots of followup work e.g., which organelle-organelle relationships are more robust vs variable across perturbations? what geometric rules govern whole-cell patterns in eukaryotes?
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Mary Mirvis @marymirvis.bsky.social · Apr 19

Our corpus includes 89 studies published bw 2004-2024 screened from >11000 Pubmed results: nearly 1700 individual cells, 118 distinct datasets in 80 cell types using 13 volumetric imaging modalities, 71 comparative conditions, and at least 12 types of quantitative analyses.
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overview of study: 89 studies, 118 datasets, 1689+ cells, 58 organelle combos, 13 imaging modalities, 12+ quantitative metrics, 80 cell types, 71 comparative conditions

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