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Reposted by Masa A. Shimazoe

Science Magazine @science.org · 16h

This year’s #NobelPrize in Chemistry has gone to the architects of molecular “cages” that could be used for everything from carbon capture to drug delivery. https://scim.ag/4mTE1Z6

Architects of molecular cages win Chemistry Nobel
Susumu Kitagawa, Richard Robson, and Omar Yaghi honored for developing metal-organic frameworks

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Reposted by Masa A. Shimazoe

Science Magazine @science.org · 2d

This year’s #NobelPrize in Physiology or Medicine has been awarded to three scientists for discovering how the immune system distinguishes friend from foe. https://scim.ag/3Wt5rdi

Medicine Nobel goes to three researchers who identified immune system’s security guards

Mary Brunkow, Fred Ramsdell, and Shimon Sakaguchi discovered regulatory T cells that prevent autoimmune disease

scim.ag

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Reposted by Masa A. Shimazoe

janeskok.bsky.social @janeskok.bsky.social · 29d

@kazu_maeshima from the Genome Dynamics Laboratory at the National Institute of Genetics (@NIG_idenken) will present groundbreaking research on chromatin organization and behavior in live cells revealed by super-resolution imaging. nyulangone.zoom.us/webinar/regi... #chromatin2025

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Masa A. Shimazoe @masaashimazoe.bsky.social · Aug 29

Condensed chromatin domain structure and cohesin-constrained mobility assure independent transcription regulation for each domain!
Also consistent with many previous studies.
(4/n)

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Masa A. Shimazoe @masaashimazoe.bsky.social · Aug 29

We got a clue to my unsolved question from high school 🌱
“Chromatin loop organization insulates transcription”—a schematic I once scribbled in my textbook like this.
But ever since, I’ve wondered: How can neighboring loops avoid interacting?
(3/n)

Reposted by Masa A. Shimazoe

Kazuhiro Maeshima @kazu-maeshima.bsky.social · Aug 28

Is euchromatin really “open”? Our new study @bioRxiv suggests otherwise. Using super-resolution imaging @shiori-iida.bsky.social‬ @masaashimazoe.bsky.social reveals: Euchromatin forms condensed domains in live cells. Cohesin constrains them and prevents domain mixing.
www.biorxiv.org/cgi/content/...

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Reposted by Masa A. Shimazoe

Shiori Iida @shiori-iida.bsky.social · Aug 29

One more movie!
Using the RL algorithm (from pnas.org/doi/10.1073/...),
@masaashimazoe.bsky.social analyzed our nucleosome tracking data and classified them by their mobility.
Hotter color = faster motion (Slow🔵→ 🟢 → 🟡 → 🟠 Fast)

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Masa A. Shimazoe @masaashimazoe.bsky.social · Aug 28

All efforts by coauthors made this happen! :
@katsuminami.bsky.social, Tamura-san, Ashwin-san, Higashi-san, Nishiyama-san, Kanemaki-san, Sasai-san, @lschermelleh.bsky.social ‬, Toyoda-san, Kurokawa-san.
And, as always, I deeply appreciate @kazu-maeshima.bsky.social 's supervision!
(2/n)

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Masa A. Shimazoe @masaashimazoe.bsky.social · Aug 28

Euchromatin is mostly condensed⁉️

With @shiori-iida.bsky.social , We revealed the detailed structure of euchromatin using super-resolution imaging.

Cohesin regulates the function of euchromatin via chromatin dynamics!
(1/n)

Kazuhiro Maeshima @kazu-maeshima.bsky.social · Aug 28

Is euchromatin really “open”? Our new study @bioRxiv suggests otherwise. Using super-resolution imaging @shiori-iida.bsky.social‬ @masaashimazoe.bsky.social reveals: Euchromatin forms condensed domains in live cells. Cohesin constrains them and prevents domain mixing.
www.biorxiv.org/cgi/content/...

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Reposted by Masa A. Shimazoe

Christophe Chapard @christophechapard.bsky.social · Aug 9

Pleased to see this study out, combining experimental work from our lab at the @cbitoulouse.bsky.social, in particular by @nathaliebastie.bsky.social and @beckof.bsky.social, and from Laura Chaptal and @alengronne.bsky.social at IGH Montpellier
@cnrs.fr @cnrsbiologie.bsky.social

Congrats to all!

RNA Pol II-based regulations of chromosome folding

How transcription and cohesin complexes interact to regulate 3D genome organization remains unclear. Chapard et al. dissect their respective contributions and their interplay in shaping the genome arc...

www.cell.com

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Masa A. Shimazoe @masaashimazoe.bsky.social · Jul 19

Thank you very much!
Hope you enjoy reading!

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Masa A. Shimazoe @masaashimazoe.bsky.social · Jul 18

Thank you for your kind words.
It was great to meet you, and I enjoyed your talk!

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Masa A. Shimazoe @masaashimazoe.bsky.social · Jul 18

Go to the link to see our preprint about linker histone H1!
www.biorxiv.org/content/10.1...

Linker histone H1 functions as a liquid-like glue to organize chromatin in living human cells

Linker histone H1, the most abundant chromatin protein, condenses chromatin, modulates DNA transactions such as transcription and DNA replication/repair, and participates in differentiation, developme...

www.biorxiv.org

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Masa A. Shimazoe @masaashimazoe.bsky.social · Jul 18

And again, Fantastic meeting! 🔬
Single-molecule studies are advancing biology into new territory—thrilled to be involved. 💡
#EMBLSingleMolecule

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Masa A. Shimazoe @masaashimazoe.bsky.social · Jul 18

I had an amazing time at EMBL Heidelberg!
I was absolutely impressed by the facilities—everything operates on a completely different scale here.
Definitely hope to work in an environment like this someday.

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Masa A. Shimazoe @masaashimazoe.bsky.social · Jul 18

Honored to receive 1st Place Poster Award 🏆 at the EMBL meeting "Gene Regulation: One Molecule at a Time"!
Thank you to all who visited and engaged in exciting discussions.
Grateful to the organizers for an excellent event! #EMBLSingleMolecule

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Reposted by Masa A. Shimazoe

EMBL Events @events.embl.org · Jul 17

🔬 #EMBLSingleMolecule poster session highlights 📜
Big ideas, bold questions, and lots of sticky notes!
From molecular mechanics to late-breaking results – the poster session was buzzing with energy and conversation 💬 Loved seeing early-career researchers shine!

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Reposted by Masa A. Shimazoe

Kazuhiro Maeshima @kazu-maeshima.bsky.social · Jul 10

Our new preprint 🧬🔗 www.biorxiv.org/content/10.1...
BRD4-NUT forms liquid-like condensates that locally constrain nucleosomes via BRD4-mediated crosslinking— physical control of #chromatin by #LLPS transcription condensates. @semeigazin.bsky.social @katsuminami.bsky.social @masaashimazoe.bsky.social

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Reposted by Masa A. Shimazoe

Kazuhiro Maeshima @kazu-maeshima.bsky.social · Mar 29

Our new paper is out@ScienceAdvances👇
www.science.org/doi/10.1126/...
🧬Our Repli-Histo labeling marks nucleosomes in euchromatin and heterochromatin in live human cells.
🔍 @katsuminami.bsky.social et al. have developed a chromatin behavior atlas within the nucleus. 1/2

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Reposted by Masa A. Shimazoe

Masa A. Shimazoe @masaashimazoe.bsky.social · Mar 10

My first, first author paper is now on bioRxiv! 🤩

Linker histone H1 is a liquid-like "glue" condensing chromatin, which revises textbooks! 📖✨
biorxiv.org/content/10.1...

Huge thanks to my PI, @kazu-maeshima.bsky.social, for supervision.
Amazing collab with @rcollepardo.bsky.social’s group!" (1/n)

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Masa A. Shimazoe @masaashimazoe.bsky.social · Mar 10

Huge thanks to Rosana @rcollepardo.bsky.social, Charlie, Jan @janhuemar.bsky.social, and Stephen! 🙌
Their simulations revealed in stunning detail how H1 and nucleosomes interact.
I was amazed—so consistent with our experiments! 🔬💻
(4/n)

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Masa A. Shimazoe @masaashimazoe.bsky.social · Mar 10

Single molecule imaging revealed that H1 behaves like a liquid inside chromatin! 🫧
It's amazing to witness how H1 behaves in living cells 🔬✨
(3/n)

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Masa A. Shimazoe @masaashimazoe.bsky.social · Mar 10

H1 is the most abundant chromatin protein, condensing chromatin—but how? 🤔
The textbook model suggests H1 stabilizes 30-nm fiber, but recent studies dispute this. So, what's the true mechanism?
We think: H1 acts as a liquid-like "glue"! (2/n)

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Masa A. Shimazoe @masaashimazoe.bsky.social · Mar 10

My first, first author paper is now on bioRxiv! 🤩

Linker histone H1 is a liquid-like "glue" condensing chromatin, which revises textbooks! 📖✨
biorxiv.org/content/10.1...

Huge thanks to my PI, @kazu-maeshima.bsky.social, for supervision.
Amazing collab with @rcollepardo.bsky.social’s group!" (1/n)

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Reposted by Masa A. Shimazoe

Jan Huertas @janhuemar.bsky.social · Mar 7

Excited to share our newest collaboration with @kazu-maeshima.bsky.social and @masaashimazoe.bsky.social, where we show that H1 acts as a liquid-like glue in chromatin.
Go check the paper on the biorXiv!

Kazuhiro Maeshima @kazu-maeshima.bsky.social · Mar 7

Our new preprint is out＠bioRxiv: www.biorxiv.org/content/10.1...
@masaashimazoe.bsky.social et al. reveal that linker histone H1 acts as a liquid-like glue to organize chromatin in living cells. 🎉 Fantastic collab with @rcollepardo.bsky.social @janhuemar.bsky.social and others—huge thanks! 🙌 1/

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