Melanie Bonhivers
@mbonhivers.bsky.social
Reposted by Melanie Bonhivers
🔬 Just out in @NatureComms!
Using cryo-CLEM and cryo-ET, we reveal the unique ultrastructure of dopaminergic varicosities in the striatum.
Amazing collaboration with @davip-bdx.bsky.social and Etienne Herzog @iins-bordeaux.bsky.social
Congratulations to Paul and Robin for this fantastic work! 🎉
Using cryo-CLEM and cryo-ET, we reveal the unique ultrastructure of dopaminergic varicosities in the striatum.
Amazing collaboration with @davip-bdx.bsky.social and Etienne Herzog @iins-bordeaux.bsky.social
Congratulations to Paul and Robin for this fantastic work! 🎉
Cryo-correlative light and electron tomography of dopaminergic axonal varicosities reveals non-synaptic modulation of cortico-striatal synapses - Nature Communications
The basic features of dopamine release sites are still largely unknown. Here, the authors determine the ultrastructure of fluorescent dopaminergic and glutamatergic synaptosomes in mouse striatum usin...
www.nature.com
December 13, 2025 at 8:11 PM
🔬 Just out in @NatureComms!
Using cryo-CLEM and cryo-ET, we reveal the unique ultrastructure of dopaminergic varicosities in the striatum.
Amazing collaboration with @davip-bdx.bsky.social and Etienne Herzog @iins-bordeaux.bsky.social
Congratulations to Paul and Robin for this fantastic work! 🎉
Using cryo-CLEM and cryo-ET, we reveal the unique ultrastructure of dopaminergic varicosities in the striatum.
Amazing collaboration with @davip-bdx.bsky.social and Etienne Herzog @iins-bordeaux.bsky.social
Congratulations to Paul and Robin for this fantastic work! 🎉
Reposted by Melanie Bonhivers
We’re excited to announce the opening of the Geneva Expansion Microscopy Facility (GenExM)!
GenExM is a full-service U-ExM platform (U-ExM, Cryo-ExM, iU-ExM), delivering nanoscale imaging.
Led by Dr. Olivier Mercey, GenExM welcomes academic & industrial collaborations.
👉 www.unige.ch/genexm/
GenExM is a full-service U-ExM platform (U-ExM, Cryo-ExM, iU-ExM), delivering nanoscale imaging.
Led by Dr. Olivier Mercey, GenExM welcomes academic & industrial collaborations.
👉 www.unige.ch/genexm/
December 10, 2025 at 8:43 PM
We’re excited to announce the opening of the Geneva Expansion Microscopy Facility (GenExM)!
GenExM is a full-service U-ExM platform (U-ExM, Cryo-ExM, iU-ExM), delivering nanoscale imaging.
Led by Dr. Olivier Mercey, GenExM welcomes academic & industrial collaborations.
👉 www.unige.ch/genexm/
GenExM is a full-service U-ExM platform (U-ExM, Cryo-ExM, iU-ExM), delivering nanoscale imaging.
Led by Dr. Olivier Mercey, GenExM welcomes academic & industrial collaborations.
👉 www.unige.ch/genexm/
Reposted by Melanie Bonhivers
Thrilled to share that my postdoc paper has just been a published in @plosbiology.org !
Thank you to all co-authors, and a special thanks to Paul and Virginie @centriolelab.bsky.social for their support throughout this work.
Proud of what we achieved together!
journals.plos.org/plosbiology/...
Thank you to all co-authors, and a special thanks to Paul and Virginie @centriolelab.bsky.social for their support throughout this work.
Proud of what we achieved together!
journals.plos.org/plosbiology/...
The luminal ring protein C2CD3 acts as a radial in-to-out organizer of the distal centriole and appendages
The centriolar protein C2CD3 has been suggested to be crucial for distal appendage formation in centrioles, but its precise mechanistic role remains unclear. Using a combination of ultrastructure expa...
journals.plos.org
December 10, 2025 at 8:29 AM
Thrilled to share that my postdoc paper has just been a published in @plosbiology.org !
Thank you to all co-authors, and a special thanks to Paul and Virginie @centriolelab.bsky.social for their support throughout this work.
Proud of what we achieved together!
journals.plos.org/plosbiology/...
Thank you to all co-authors, and a special thanks to Paul and Virginie @centriolelab.bsky.social for their support throughout this work.
Proud of what we achieved together!
journals.plos.org/plosbiology/...
Reposted by Melanie Bonhivers
Huge congratulations to @hakimi.bsky.social for receiving the 2025 INSERM Research Award! 🎉
We’re extremely proud to have him as part of LabEx ParaFrap.
👉 : presse.inserm.fr/prix-inserm-...
We’re extremely proud to have him as part of LabEx ParaFrap.
👉 : presse.inserm.fr/prix-inserm-...
Prix Inserm 2025 : l’innovation au cœur de la santé - Salle de presse de l'Inserm
Jeudi 27 novembre, l’Inserm célèbrera par la remise de ses prix annuels celles et ceux qui font avancer la recherche en santé. Les travaux des cinq scientifiques récompensés lors de cette édition 2025...
presse.inserm.fr
November 28, 2025 at 2:56 PM
Huge congratulations to @hakimi.bsky.social for receiving the 2025 INSERM Research Award! 🎉
We’re extremely proud to have him as part of LabEx ParaFrap.
👉 : presse.inserm.fr/prix-inserm-...
We’re extremely proud to have him as part of LabEx ParaFrap.
👉 : presse.inserm.fr/prix-inserm-...
Reposted by Melanie Bonhivers
Very happy to share our work on lipopolysaccharide assembly by the Lpt complex, published today in @natcomms.nature.com
Fantastic collaboration with @raffaeleieva.bsky.social l and t @pstansfeld.bsky.social
Congrats to all authors, especially Haoxiang, Axel & Violette
🔗 doi.org/10.1038/s414...
Fantastic collaboration with @raffaeleieva.bsky.social l and t @pstansfeld.bsky.social
Congrats to all authors, especially Haoxiang, Axel & Violette
🔗 doi.org/10.1038/s414...
Structural basis of lipopolysaccharide assembly by the outer membrane translocon holo-complex - Nature Communications
The asymmetric distribution of lipopolysaccharide (LPS) on the surface of the bacterial outer membrane is essential and crucial for antibiotic resistance. Here, authors characterize the LPS translocon...
doi.org
November 24, 2025 at 3:22 PM
Very happy to share our work on lipopolysaccharide assembly by the Lpt complex, published today in @natcomms.nature.com
Fantastic collaboration with @raffaeleieva.bsky.social l and t @pstansfeld.bsky.social
Congrats to all authors, especially Haoxiang, Axel & Violette
🔗 doi.org/10.1038/s414...
Fantastic collaboration with @raffaeleieva.bsky.social l and t @pstansfeld.bsky.social
Congrats to all authors, especially Haoxiang, Axel & Violette
🔗 doi.org/10.1038/s414...
Reposted by Melanie Bonhivers
Our latest T7SS study is now out in Science Advances!
We solved the cryoEM structure of the T7SSb core unit (T7bCU) composed of YukB, YukC, and YukD from Bacillus subtilis, revealing how these components assemble within the secretion machinery.
www.science.org/doi/10.1126/...
We solved the cryoEM structure of the T7SSb core unit (T7bCU) composed of YukB, YukC, and YukD from Bacillus subtilis, revealing how these components assemble within the secretion machinery.
www.science.org/doi/10.1126/...
A ubiquitin-like protein controls assembly of a bacterial type VIIb secretion system
Cryo-EM structure reveals how a ubiquitin-like protein orchestrates assembly of a bacterial weapon system.
www.science.org
November 21, 2025 at 7:05 PM
Our latest T7SS study is now out in Science Advances!
We solved the cryoEM structure of the T7SSb core unit (T7bCU) composed of YukB, YukC, and YukD from Bacillus subtilis, revealing how these components assemble within the secretion machinery.
www.science.org/doi/10.1126/...
We solved the cryoEM structure of the T7SSb core unit (T7bCU) composed of YukB, YukC, and YukD from Bacillus subtilis, revealing how these components assemble within the secretion machinery.
www.science.org/doi/10.1126/...
Reposted by Melanie Bonhivers
#Agenda 📆Samedi 22/11, le département Sciences biologiques et médicales (SBM) de l’université de Bordeaux ouvre les portes de ses laboratoires de recherche afin de faire découvrir ses activités scientifiques et techniques :
www.u-bordeaux.fr/ev...
www.u-bordeaux.fr/ev...
November 19, 2025 at 12:00 PM
#Agenda 📆Samedi 22/11, le département Sciences biologiques et médicales (SBM) de l’université de Bordeaux ouvre les portes de ses laboratoires de recherche afin de faire découvrir ses activités scientifiques et techniques :
www.u-bordeaux.fr/ev...
www.u-bordeaux.fr/ev...
Reposted by Melanie Bonhivers
Honored to receive the FEBS Booster Funds 2025.
My sincere thanks to FEBS for this recognition and their support of early-career researchers.
This funding will greatly help advance my work.
Congratulations as well to all fellow 2025 awardees.
My sincere thanks to FEBS for this recognition and their support of early-career researchers.
This funding will greatly help advance my work.
Congratulations as well to all fellow 2025 awardees.
November 18, 2025 at 12:54 PM
Honored to receive the FEBS Booster Funds 2025.
My sincere thanks to FEBS for this recognition and their support of early-career researchers.
This funding will greatly help advance my work.
Congratulations as well to all fellow 2025 awardees.
My sincere thanks to FEBS for this recognition and their support of early-career researchers.
This funding will greatly help advance my work.
Congratulations as well to all fellow 2025 awardees.
Reposted by Melanie Bonhivers
We have a 3+ year post doc available in our lab to study trypanosome transmission and virulence. Combined wet lab and bioinformatics expertise preferred. Please apply via the HR link (elxw.fa.em3.oraclecloud.com/hcmUI/Candid...). Find out more about us in the link below.
The Matthews Lab | Biology
The Matthews Lab
biology.ed.ac.uk
October 17, 2025 at 12:06 PM
We have a 3+ year post doc available in our lab to study trypanosome transmission and virulence. Combined wet lab and bioinformatics expertise preferred. Please apply via the HR link (elxw.fa.em3.oraclecloud.com/hcmUI/Candid...). Find out more about us in the link below.
Reposted by Melanie Bonhivers
#FungiDB/#VEuPathDB & #Ensembl are teaming up to improve #fungal & #oomycete genome resources for #phytopathogens — & we want your input! 🧬🍄
🗓️ Complete the survey by Nov 1, 2025:
🔗 zurl.co/gKjC1
Your feedback will guide genome curation, annotation & data integration #genomics #foodsecurity
🗓️ Complete the survey by Nov 1, 2025:
🔗 zurl.co/gKjC1
Your feedback will guide genome curation, annotation & data integration #genomics #foodsecurity
Qualtrics Survey | Qualtrics Experience Management
The most powerful, simple and trusted way to gather experience data. Start your journey to experience management and try a free account today.
zurl.co
October 17, 2025 at 9:13 AM
#FungiDB/#VEuPathDB & #Ensembl are teaming up to improve #fungal & #oomycete genome resources for #phytopathogens — & we want your input! 🧬🍄
🗓️ Complete the survey by Nov 1, 2025:
🔗 zurl.co/gKjC1
Your feedback will guide genome curation, annotation & data integration #genomics #foodsecurity
🗓️ Complete the survey by Nov 1, 2025:
🔗 zurl.co/gKjC1
Your feedback will guide genome curation, annotation & data integration #genomics #foodsecurity
Reposted by Melanie Bonhivers
The flagellar pocket collar (FPC) is a cytoskeletal structure essential for nutrient uptake & immune evasion in #Trypanosome. @mbonhivers.bsky.social &co use U-ExM to provide novel insights into FPC biogenesis, and reveal 2 unknown cytoskeletal structures @plosbiology.org 🧪 plos.io/4n3bWi6
October 10, 2025 at 4:14 PM
The flagellar pocket collar (FPC) is a cytoskeletal structure essential for nutrient uptake & immune evasion in #Trypanosome. @mbonhivers.bsky.social &co use U-ExM to provide novel insights into FPC biogenesis, and reveal 2 unknown cytoskeletal structures @plosbiology.org 🧪 plos.io/4n3bWi6
Reposted by Melanie Bonhivers
ResultatScientifique🔎| Le VIH profite d’une protéine humaine pour mieux s’installer dans notre ADN : une découverte qui ouvre de nouvelles pistes pour le combattre 🦠
✍️ Vincent Parissi
📕 @natmicrobiol.nature.com | buff.ly/Hqeu6kO
✍️ Vincent Parissi
📕 @natmicrobiol.nature.com | buff.ly/Hqeu6kO
Un mécanisme clé de l’intégration du génome du VIH dans nos gènes élucidé
L’infection par le VIH-1 repose sur l’intégration du génome viral dans certaines régions riches en gènes.
www.insb.cnrs.fr
September 25, 2025 at 10:00 AM
ResultatScientifique🔎| Le VIH profite d’une protéine humaine pour mieux s’installer dans notre ADN : une découverte qui ouvre de nouvelles pistes pour le combattre 🦠
✍️ Vincent Parissi
📕 @natmicrobiol.nature.com | buff.ly/Hqeu6kO
✍️ Vincent Parissi
📕 @natmicrobiol.nature.com | buff.ly/Hqeu6kO
Reposted by Melanie Bonhivers
Congrats to all authors, especially Lim who had an impressive PhD viva last week! TAC is a very interesting structure linking mitochondrial DNA and basal bodies in trypanosomes
September 19, 2025 at 11:22 AM
Congrats to all authors, especially Lim who had an impressive PhD viva last week! TAC is a very interesting structure linking mitochondrial DNA and basal bodies in trypanosomes
Reposted by Melanie Bonhivers
🏅 Muriel Priault, chercheuse CNRS à l'IBGC*, a remporté le Prix Académique lors de la 10ᵉ édition de Cosmetic Victories, concours international organisé par la Cosmetic Valley. Ce prix distingue les projets de recherche les plus innovants dans le domaine cosmétique :
Muriel Priault, lauréate du prix Cosmetic Victories 2025 | CNRS Biologie
Muriel Priault, chercheuse CNRS, a remporté le Prix Académique lors de la 10ᵉ édition de Cosmetic Victories, un concours international organisé par la
www.insb.cnrs.fr
September 16, 2025 at 2:36 PM
🏅 Muriel Priault, chercheuse CNRS à l'IBGC*, a remporté le Prix Académique lors de la 10ᵉ édition de Cosmetic Victories, concours international organisé par la Cosmetic Valley. Ce prix distingue les projets de recherche les plus innovants dans le domaine cosmétique :
Reposted by Melanie Bonhivers
The results of the demo of the MINFLUX on our samples were stunning. It is unlikely that we will get such a system in the short term, but the good news is that we are ready for some proper high-res SMLM fun !
July 6, 2025 at 9:38 PM
The results of the demo of the MINFLUX on our samples were stunning. It is unlikely that we will get such a system in the short term, but the good news is that we are ready for some proper high-res SMLM fun !
Reposted by Melanie Bonhivers
#Trypanosoma, fixed, expanded, and imaged with #STED, stained for tubulin. Scale bar refers to expanded specimen, original structures are 3-3x smaller.
Image courtesy: @mbonhivers.bsky.social, MFP, CNRS, Univ. Bordeaux, France
#fluorescencefriday #ExM #STEDmicroscopy
Image courtesy: @mbonhivers.bsky.social, MFP, CNRS, Univ. Bordeaux, France
#fluorescencefriday #ExM #STEDmicroscopy
June 27, 2025 at 9:31 AM
#Trypanosoma, fixed, expanded, and imaged with #STED, stained for tubulin. Scale bar refers to expanded specimen, original structures are 3-3x smaller.
Image courtesy: @mbonhivers.bsky.social, MFP, CNRS, Univ. Bordeaux, France
#fluorescencefriday #ExM #STEDmicroscopy
Image courtesy: @mbonhivers.bsky.social, MFP, CNRS, Univ. Bordeaux, France
#fluorescencefriday #ExM #STEDmicroscopy
Reposted by Melanie Bonhivers
Chaires de Professeur Junior (CPJ) 2025 www.mfp.cnrs.fr/wp/emploi/ch...
Chaires de Professeur Junior (CPJ) 2025 | Laboratoire de Microbiologie Fondamentale et Pathogénicité
Nom du projet : Virus Émergents et Changement Climatique Sections CNU : 64-65 Thématique scientifique : Biologie et santé Mots-clés : Sciences du système Terre et de l’Univers ; Environnement, … Conti...
www.mfp.cnrs.fr
June 18, 2025 at 11:10 AM
Chaires de Professeur Junior (CPJ) 2025 www.mfp.cnrs.fr/wp/emploi/ch...
Reposted by Melanie Bonhivers
Communication institutionnelle @univbordeaux.bsky.social à propos de la plateforme de #cryoEM @iecb.bsky.social
Deux nouveaux microscopes pour aller au cœur du vivant
La plateforme de cryo-microscopie électronique à l’Institut européen de chimie et biologie (IECB) est renforcée par l’acquisition de deux nouveaux microscopes, Glacios 2 et Talos L120. Ces équipements...
www.u-bordeaux.fr
June 10, 2025 at 3:34 PM
Communication institutionnelle @univbordeaux.bsky.social à propos de la plateforme de #cryoEM @iecb.bsky.social
Reposted by Melanie Bonhivers
🧵 Ever wondered what Toxoplasma is doing in your brain years after that undercooked steak 🥩 or a sip of contaminated water? Turns out, it's been hiding in your brain 🧠and we finally have a way to spot it. New study just dropped in EMBO Molecular Medicine 👇
doi.org/10.1038/s443...
doi.org/10.1038/s443...
Uncovering biomarkers for chronic toxoplasmosis detection highlights alternative pathways shaping parasite dormancy | EMBO Molecular Medicine
imageimageDespite their clinical relevance, bradyzoite-filled cysts - the hallmark of chronic
toxoplasmosis - are largely overlooked in current diagnostics. This study highlights
bradyzoite serologica...
doi.org
May 19, 2025 at 10:31 AM
🧵 Ever wondered what Toxoplasma is doing in your brain years after that undercooked steak 🥩 or a sip of contaminated water? Turns out, it's been hiding in your brain 🧠and we finally have a way to spot it. New study just dropped in EMBO Molecular Medicine 👇
doi.org/10.1038/s443...
doi.org/10.1038/s443...
Reposted by Melanie Bonhivers
We are recruiting 🤩🤩🤩!!! If you are looking to establish your lab in a multidisciplinary institute with state-of-the-art facilities, horizontal structure and diverse faculty, all in a near-paradisiac city in the south-west of France, you have 6 weeks left to submit your application 🤓!!!
April 28, 2025 at 7:14 PM
We are recruiting 🤩🤩🤩!!! If you are looking to establish your lab in a multidisciplinary institute with state-of-the-art facilities, horizontal structure and diverse faculty, all in a near-paradisiac city in the south-west of France, you have 6 weeks left to submit your application 🤓!!!
Reposted by Melanie Bonhivers
Une nouvelle cible thérapeutique contre la maladie du sommeil ? 🧬
Des chercheurs ont identifié une protéine clé chez le trypanosome, le parasite responsable.
🤝 @cnrsaquitaine.bsky.social @univbordeaux.bsky.social
buff.ly/lf9dYGp
Des chercheurs ont identifié une protéine clé chez le trypanosome, le parasite responsable.
🤝 @cnrsaquitaine.bsky.social @univbordeaux.bsky.social
buff.ly/lf9dYGp
Découverte d’une protéine d’intérêt chez le trypanosome vecteur de la maladie du sommeil
Trypanosoma brucei est un parasite responsable de graves maladies chez l’Homme et le bétail en Afrique.
www.insb.cnrs.fr
April 22, 2025 at 2:02 PM
Une nouvelle cible thérapeutique contre la maladie du sommeil ? 🧬
Des chercheurs ont identifié une protéine clé chez le trypanosome, le parasite responsable.
🤝 @cnrsaquitaine.bsky.social @univbordeaux.bsky.social
buff.ly/lf9dYGp
Des chercheurs ont identifié une protéine clé chez le trypanosome, le parasite responsable.
🤝 @cnrsaquitaine.bsky.social @univbordeaux.bsky.social
buff.ly/lf9dYGp
Reposted by Melanie Bonhivers
An ISWI-related chromatin remodeller regulates stage-specific gene expression in #Toxoplasma gondii. By Belen Pachano (ParaFrap PhD student) et al., team @hakimi.bsky.social. In @natmicrobiol.nature.com www.nature.com/articles/s41...
An ISWI-related chromatin remodeller regulates stage-specific gene expression in Toxoplasma gondii - Nature Microbiology
Toxoplasma gondii evolved two ISWI remodellers, TgSNF2h and TgSNF2L. TgSNF2h forms a complex that insulates active genes, regulates MORC-driven sexual commitment and ensures precise gene expression, s...
www.nature.com
April 22, 2025 at 2:39 PM
An ISWI-related chromatin remodeller regulates stage-specific gene expression in #Toxoplasma gondii. By Belen Pachano (ParaFrap PhD student) et al., team @hakimi.bsky.social. In @natmicrobiol.nature.com www.nature.com/articles/s41...
Reposted by Melanie Bonhivers
We are recruiting 🤩🤩🤩!!! If you are looking to establish ylur lab in a multidisciplinary institute with state-of-the-art facilities, horizontal structure and diverse faculty, apply!!!
April 14, 2025 at 8:57 AM
We are recruiting 🤩🤩🤩!!! If you are looking to establish ylur lab in a multidisciplinary institute with state-of-the-art facilities, horizontal structure and diverse faculty, apply!!!
Reposted by Melanie Bonhivers
1/ Last call for the EMBL-UNESCO Residency Programme! ⏳
If you’re a female African scientist working in infection biology, this is your opportunity to develop scientific skills while fostering collaboration across borders.
🙌 Apply until 31 March 2025.
www.embl.org/about/info/s...
If you’re a female African scientist working in infection biology, this is your opportunity to develop scientific skills while fostering collaboration across borders.
🙌 Apply until 31 March 2025.
www.embl.org/about/info/s...
March 25, 2025 at 8:51 AM
1/ Last call for the EMBL-UNESCO Residency Programme! ⏳
If you’re a female African scientist working in infection biology, this is your opportunity to develop scientific skills while fostering collaboration across borders.
🙌 Apply until 31 March 2025.
www.embl.org/about/info/s...
If you’re a female African scientist working in infection biology, this is your opportunity to develop scientific skills while fostering collaboration across borders.
🙌 Apply until 31 March 2025.
www.embl.org/about/info/s...
Reposted by Melanie Bonhivers
💼 Associate Professor / Toxoplasma / Bordeaux-France
🎓 Teaching: animal biology, metazoan diversity & phylogeny (Bachelor 1,2,3)
🔬 Research: Apicomplexa parasites, focusing on Toxoplasma gondii. @ MFP Lab (UMR5234) @univbordeaux.bsky.social .
🗓️ Deadline: April 4
labex-parafrap.fr/en/job-offer...
🎓 Teaching: animal biology, metazoan diversity & phylogeny (Bachelor 1,2,3)
🔬 Research: Apicomplexa parasites, focusing on Toxoplasma gondii. @ MFP Lab (UMR5234) @univbordeaux.bsky.social .
🗓️ Deadline: April 4
labex-parafrap.fr/en/job-offer...
Associate professor l Toxoplama l Bordeaux, France
Associate Professor : Animal Biology and Parasitology – Host-Pathogen Interactions, Bordeaux, France
Teaching Profile
...
labex-parafrap.fr
March 11, 2025 at 9:42 AM
💼 Associate Professor / Toxoplasma / Bordeaux-France
🎓 Teaching: animal biology, metazoan diversity & phylogeny (Bachelor 1,2,3)
🔬 Research: Apicomplexa parasites, focusing on Toxoplasma gondii. @ MFP Lab (UMR5234) @univbordeaux.bsky.social .
🗓️ Deadline: April 4
labex-parafrap.fr/en/job-offer...
🎓 Teaching: animal biology, metazoan diversity & phylogeny (Bachelor 1,2,3)
🔬 Research: Apicomplexa parasites, focusing on Toxoplasma gondii. @ MFP Lab (UMR5234) @univbordeaux.bsky.social .
🗓️ Deadline: April 4
labex-parafrap.fr/en/job-offer...