Gary Mirams
@mirams.bsky.social
Prof. of Mathematical Physiology, University of Nottingham. Like: rambling, scrambling, climbing, surfing, Irish trad music, VW vans.
Reposted by Gary Mirams
📝 Excited to share our latest work, now out at European Heart Journal! We studied 252 SCN5A variants previously found in patients with Brugada Syndrome, an inherited arrhythmia disorder linked to sudden cardiac death. [1/4]
November 20, 2025 at 7:22 PM
📝 Excited to share our latest work, now out at European Heart Journal! We studied 252 SCN5A variants previously found in patients with Brugada Syndrome, an inherited arrhythmia disorder linked to sudden cardiac death. [1/4]
I hope @teamlabouruk.bsky.social are getting some statistical input. If 84% of your landslide-victory voters have unfavourable view of Farage, adopting policies he likes is not going to be a winning strategy (as you can see from how well Davey and Polanski are polling amongst your core vote).
Zack Polanski and Ed Davey have positive net ratings among 2024 Labour voters, while a majority of those who backed the party at the last election now have unfavourable views of Keir Starmer and Rachel Reeves
Polanski: +24 net favourable
Davey: +17
Starmer: -10
Corbyn: -15
Reeves: -31
Polanski: +24 net favourable
Davey: +17
Starmer: -10
Corbyn: -15
Reeves: -31
November 20, 2025 at 10:17 AM
I hope @teamlabouruk.bsky.social are getting some statistical input. If 84% of your landslide-victory voters have unfavourable view of Farage, adopting policies he likes is not going to be a winning strategy (as you can see from how well Davey and Polanski are polling amongst your core vote).
Reposted by Gary Mirams
“Enjoy the result you have found by exploratory subgroup analysis, for you will not find it again.” Sayings of Confuseus
November 20, 2025 at 10:03 AM
“Enjoy the result you have found by exploratory subgroup analysis, for you will not find it again.” Sayings of Confuseus
Thanks for the email summary #GMail. The only thing is, it is longer than the actual email was.
Can we put in some common sense checks before rolling this AI stuff out?!
Can we put in some common sense checks before rolling this AI stuff out?!
November 19, 2025 at 4:58 PM
Thanks for the email summary #GMail. The only thing is, it is longer than the actual email was.
Can we put in some common sense checks before rolling this AI stuff out?!
Can we put in some common sense checks before rolling this AI stuff out?!
Reposted by Gary Mirams
Postdoc Position (2y) in Physics-informed Model Discovery for Reaction-Diffusion Equations @ Roskilde, Denmark
Deadline: 15 Dec 2025
candidate.hr-manager.net/ApplicationI...
Deadline: 15 Dec 2025
candidate.hr-manager.net/ApplicationI...
Postdoc of Physics-informed Model Discovery for Reaction-Diffusion Equations
Department of Science and Environment, Roskilde University, invites applications for a position as postdoc of Physics-informed Model Discovery for Reaction-Diff
candidate.hr-manager.net
November 11, 2025 at 7:48 PM
Postdoc Position (2y) in Physics-informed Model Discovery for Reaction-Diffusion Equations @ Roskilde, Denmark
Deadline: 15 Dec 2025
candidate.hr-manager.net/ApplicationI...
Deadline: 15 Dec 2025
candidate.hr-manager.net/ApplicationI...
Reposted by Gary Mirams
Research aims and objectives aren’t the same thing but are related It helps to understand the differences and connections patthomson.net/2025/11/01/r...
research aims vs. objectives – what’s the difference?
You’re finally sitting down to write your research proposal and you’ve hit that section where you need to outline your aims and objectives. You stare at the page. Aren’t these bas…
patthomson.net
November 2, 2025 at 6:32 AM
Research aims and objectives aren’t the same thing but are related It helps to understand the differences and connections patthomson.net/2025/11/01/r...
Reposted by Gary Mirams
Ozempic, MRI machines and flat screen televisions all emerged out of fundamental research decades earlier — the very types of study being slashed by the US government
www.nature.com/articles/d41...
www.nature.com/articles/d41...
7 basic science discoveries that changed the world
Ozempic, MRI machines and flat screen televisions all emerged out of fundamental research decades earlier — the very types of study being slashed by the US government.
www.nature.com
October 29, 2025 at 11:10 AM
Ozempic, MRI machines and flat screen televisions all emerged out of fundamental research decades earlier — the very types of study being slashed by the US government
www.nature.com/articles/d41...
www.nature.com/articles/d41...
Reposted by Gary Mirams
Language models are terrible at counting (part 12381...)
It's concerning how many workflows/copilots etc. these tools are now creeping into, despite making small numerical errors all over the place (which a causal eye might not catch).
Below from GPT-5 and Sonnet-4.5:
It's concerning how many workflows/copilots etc. these tools are now creeping into, despite making small numerical errors all over the place (which a causal eye might not catch).
Below from GPT-5 and Sonnet-4.5:
October 29, 2025 at 10:36 AM
Language models are terrible at counting (part 12381...)
It's concerning how many workflows/copilots etc. these tools are now creeping into, despite making small numerical errors all over the place (which a causal eye might not catch).
Below from GPT-5 and Sonnet-4.5:
It's concerning how many workflows/copilots etc. these tools are now creeping into, despite making small numerical errors all over the place (which a causal eye might not catch).
Below from GPT-5 and Sonnet-4.5:
Reposted by Gary Mirams
Calling ALL health data folk: Re UK Health Data Research Service.
The UK gov & Wellcome have pledged up to £600 million to create a HDRS.
Myself & an ace team have been tasked by Wellcome to assess the existing health data ecosystem & identify what is needed to support the HDRS 👇.
Get in touch
The UK gov & Wellcome have pledged up to £600 million to create a HDRS.
Myself & an ace team have been tasked by Wellcome to assess the existing health data ecosystem & identify what is needed to support the HDRS 👇.
Get in touch
October 28, 2025 at 6:02 PM
Calling ALL health data folk: Re UK Health Data Research Service.
The UK gov & Wellcome have pledged up to £600 million to create a HDRS.
Myself & an ace team have been tasked by Wellcome to assess the existing health data ecosystem & identify what is needed to support the HDRS 👇.
Get in touch
The UK gov & Wellcome have pledged up to £600 million to create a HDRS.
Myself & an ace team have been tasked by Wellcome to assess the existing health data ecosystem & identify what is needed to support the HDRS 👇.
Get in touch
Reposted by Gary Mirams
So I've been reading the Post-16 Education and Skills White Paper. There's some good things in there. But when it comes to universities there's very little to cheer. The situation is very tough and will get worse. The last chance to preserve what we've got has passed. Let me explain why. (1/?)
October 24, 2025 at 2:46 PM
So I've been reading the Post-16 Education and Skills White Paper. There's some good things in there. But when it comes to universities there's very little to cheer. The situation is very tough and will get worse. The last chance to preserve what we've got has passed. Let me explain why. (1/?)
About 50% of my time interacting with #MacOS is navigating to a folder in a "Save As" pop up window to download attachments etc., then doing exactly the same thing in Finder to open it 10 seconds later. Am I missing some workflow that avoids this bluesky-o-sphere!?
October 21, 2025 at 2:40 PM
About 50% of my time interacting with #MacOS is navigating to a folder in a "Save As" pop up window to download attachments etc., then doing exactly the same thing in Finder to open it 10 seconds later. Am I missing some workflow that avoids this bluesky-o-sphere!?
October 20, 2025 at 4:02 PM
Reposted by Gary Mirams
New blogpost on my concerns about Wellcome LEAP new $50m program on autism/microbiome links. deevybee.blogspot.com/2025/10/a-le...
#autism #microbiome #biomarkers #diagnostic
#autism #microbiome #biomarkers #diagnostic
A LEAP into the future, or off a cliff: Wellcome LEAP's new $50M program
A few days ago, I saw this post on LinkedIn: How does the gut microbiome shape early brain development? That’s what FORM, a new $50 million...
deevybee.blogspot.com
October 20, 2025 at 1:53 PM
New blogpost on my concerns about Wellcome LEAP new $50m program on autism/microbiome links. deevybee.blogspot.com/2025/10/a-le...
#autism #microbiome #biomarkers #diagnostic
#autism #microbiome #biomarkers #diagnostic
Reposted by Gary Mirams
Our ForSys method to infer the mechanical state of a tissue in space and time is published now in @cp-iscience.bsky.social !
www.cell.com/iscience/ful...
(1/10)
www.cell.com/iscience/ful...
(1/10)
October 20, 2025 at 1:03 PM
Our ForSys method to infer the mechanical state of a tissue in space and time is published now in @cp-iscience.bsky.social !
www.cell.com/iscience/ful...
(1/10)
www.cell.com/iscience/ful...
(1/10)
Reposted by Gary Mirams
Ultra-processed food - the eternal enemy of the people. And, apparently, testicles.
Or...is it? My new piece.
gidmk.substack.com/p/is-ultra-p...
Or...is it? My new piece.
gidmk.substack.com/p/is-ultra-p...
Is Ultra-Processed Food Destroying Men's Health?
The details of a new study on ultra-processed food.
gidmk.substack.com
October 15, 2025 at 1:38 AM
Ultra-processed food - the eternal enemy of the people. And, apparently, testicles.
Or...is it? My new piece.
gidmk.substack.com/p/is-ultra-p...
Or...is it? My new piece.
gidmk.substack.com/p/is-ultra-p...
"Important update about *Diversity Travel*...for those who don’t already know us, our name doesn’t always make clear what we do....That’s why we’re rebranding as *DGI* "
That's a lot clearer, thanks 🤣.
That's a lot clearer, thanks 🤣.
October 10, 2025 at 7:46 AM
"Important update about *Diversity Travel*...for those who don’t already know us, our name doesn’t always make clear what we do....That’s why we’re rebranding as *DGI* "
That's a lot clearer, thanks 🤣.
That's a lot clearer, thanks 🤣.
Reposted by Gary Mirams
We have built a society in which people of different skin tones, religious backgrounds & cultures get along, share power, work alongside each other, procreate with each other, recognise the each other’s humanity and democratic rights. It is a STUNNING ACHIEVEMENT OF WORLD HISTORIC PROPORTIONS.
I know statistics are poorly understood and are misused. But facts matter
Between the 1991, 2001, 2011 and 2021 Census *every* ethnic group in the UK has become *less* geographically segregated and *all* groups, majority and minorities, are more likely to interact with people not like them
Between the 1991, 2001, 2011 and 2021 Census *every* ethnic group in the UK has become *less* geographically segregated and *all* groups, majority and minorities, are more likely to interact with people not like them
October 8, 2025 at 10:08 AM
We have built a society in which people of different skin tones, religious backgrounds & cultures get along, share power, work alongside each other, procreate with each other, recognise the each other’s humanity and democratic rights. It is a STUNNING ACHIEVEMENT OF WORLD HISTORIC PROPORTIONS.
Down at the #AlanTuringInstitute today to give an afternoon workshop on ion channel and action potential modelling at cvd-net.com/events/cardi... . Great questions from a very engaging audience. Thanks to @michaelclerx.com and Frankie Patten-Elliott who helped deliver the session.
CVD-Net: Networks of Cardiovascular Digital Twins
Pioneering personalised cardiovascular care through interconnected digital twins.
cvd-net.com
October 8, 2025 at 4:38 PM
Down at the #AlanTuringInstitute today to give an afternoon workshop on ion channel and action potential modelling at cvd-net.com/events/cardi... . Great questions from a very engaging audience. Thanks to @michaelclerx.com and Frankie Patten-Elliott who helped deliver the session.
Reposted by Gary Mirams
"We're going to create superintelligence" How about making outlook search work first. How about that
October 3, 2025 at 5:18 PM
"We're going to create superintelligence" How about making outlook search work first. How about that
Reposted by Gary Mirams
Heilbronn fellowship call now open for researchers in Algebra, Algebraic Geometry, Combinatorics, Data Science, Number Theory, Probability, and Quantum Information.
heilbronn.ac.uk/fellowships/
heilbronn.ac.uk/fellowships/
Heilbronn Institute for Mathematical Research | Fellowships
heilbronn.ac.uk
October 1, 2025 at 8:03 AM
Heilbronn fellowship call now open for researchers in Algebra, Algebraic Geometry, Combinatorics, Data Science, Number Theory, Probability, and Quantum Information.
heilbronn.ac.uk/fellowships/
heilbronn.ac.uk/fellowships/
Reposted by Gary Mirams
I have just left a lengthy Pubpeer comment on the autism/Tylenol study being cited by the Trump administration. There appear to be a number of fairly straightforward errors in the paper.
pubpeer.com/publications...
pubpeer.com/publications...
PubPeer - Evaluation of the evidence on acetaminophen use and neurodev...
There are comments on PubPeer for publication: Evaluation of the evidence on acetaminophen use and neurodevelopmental disorders using the Navigation Guide methodology (2025)
pubpeer.com
October 1, 2025 at 5:03 AM
I have just left a lengthy Pubpeer comment on the autism/Tylenol study being cited by the Trump administration. There appear to be a number of fairly straightforward errors in the paper.
pubpeer.com/publications...
pubpeer.com/publications...
Since I've abandoned Twitter, thought I would make a 'Starter Pack' of #cardiac #modellers on here: go.bsky.app/Aetbprg
Let me know of anyone to add...
Let me know of anyone to add...
September 28, 2025 at 7:11 AM
Since I've abandoned Twitter, thought I would make a 'Starter Pack' of #cardiac #modellers on here: go.bsky.app/Aetbprg
Let me know of anyone to add...
Let me know of anyone to add...
Reposted by Gary Mirams
How do cells navigate up gradients of adhesive proteins?
🤔
Termed "Haptotaxis", this effect is ubiquitous in cell migration, but it's mechanism was poorly understood
We show that passive friction directs cells & explains complex trajectories on gradients
👉 www.nature.com/articles/s41...
🤔
Termed "Haptotaxis", this effect is ubiquitous in cell migration, but it's mechanism was poorly understood
We show that passive friction directs cells & explains complex trajectories on gradients
👉 www.nature.com/articles/s41...
September 27, 2025 at 8:48 AM
How do cells navigate up gradients of adhesive proteins?
🤔
Termed "Haptotaxis", this effect is ubiquitous in cell migration, but it's mechanism was poorly understood
We show that passive friction directs cells & explains complex trajectories on gradients
👉 www.nature.com/articles/s41...
🤔
Termed "Haptotaxis", this effect is ubiquitous in cell migration, but it's mechanism was poorly understood
We show that passive friction directs cells & explains complex trajectories on gradients
👉 www.nature.com/articles/s41...
🚨 We've written a #primer on #identifiability
Preprint: doi.org/10.48550/arX...
Brief to brilliant co-authors was "everything a PhD student needs to know about identifiability before trying to fit a model"
Fig shows how Fisher Info. becomes excellent with lots of data, even for nonlinear models.
Preprint: doi.org/10.48550/arX...
Brief to brilliant co-authors was "everything a PhD student needs to know about identifiability before trying to fit a model"
Fig shows how Fisher Info. becomes excellent with lots of data, even for nonlinear models.
September 24, 2025 at 12:23 PM
🚨 We've written a #primer on #identifiability
Preprint: doi.org/10.48550/arX...
Brief to brilliant co-authors was "everything a PhD student needs to know about identifiability before trying to fit a model"
Fig shows how Fisher Info. becomes excellent with lots of data, even for nonlinear models.
Preprint: doi.org/10.48550/arX...
Brief to brilliant co-authors was "everything a PhD student needs to know about identifiability before trying to fit a model"
Fig shows how Fisher Info. becomes excellent with lots of data, even for nonlinear models.
🤔
UKRI-funded project recruits AI to fill evidence gaps for policy.
www.researchprofessionalnews.com/rr-news-uk-r...
www.researchprofessionalnews.com/rr-news-uk-r...
UKRI-funded project recruits AI to fill evidence gaps for policy - Research Professional News
New £11.5m scheme will “revolutionise” how scientific evidence is delivered to decision-makers, funder says
www.researchprofessionalnews.com
September 22, 2025 at 1:54 PM
🤔