Lightnews — Scholar-powered news

Reposted by MS Bioworks

Andrew Gregory @andrewgregory.com · 23h

Scientists say they have developed the world’s first blood test to diagnose myalgic encephalomyelitis, also known as chronic fatigue syndrome (ME/CFS).

Scientists develop first ‘accurate blood test’ to detect chronic fatigue syndrome

Research could offer hope for ME patients – but some experts urge caution and say more studies needed

www.theguardian.com

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MS Bioworks @msbioworks.bsky.social · 7h

Yo yo yo! Mark your calendars for early next year. This one will be a banger #Proteomics #TeamMassSpec

www.grc.org/mhc-restrict...

2026 MHC-Restricted Antigen Processing and Presentation Conference GRC

The 2026 Gordon Research Conference on MHC-Restricted Antigen Processing and Presentation will be held in Galveston, Texas. Apply today to reserve your spot.

www.grc.org

MS Bioworks @msbioworks.bsky.social · 13h

This is fantastic. Great job and good luck!

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Julia MV @julialmv.bsky.social · 1d

We are excited to open enrollment for the Long COVID Treatment Trial (LoCITT) soon!

We designed the first trial to be accessible & inclusive as possible. People across the US can participate from bed!

To sign up for the waitlist and/or watch our webinar recording, visit: longcovid.scripps.edu

Overcoming trial design challenges

Table with parallel challenges & solutions:
Challenge: Heterogeneous presentation
Solution: Match eligibility criteria to intervention & Power trial to detect subgroup effects

Challenge: Don’t understand cause & effect
Solution: Conduct mechanistic trials that can help disentangle

Challenge: Lack of biomarker
Solution: Utilize sensitive survey outcomes & wearable data

Challenge: Many are housebound/bedbound
Solution: Bring trials to participants

First trial size and metrics
Randomized, double-blind placebo controlled trial in 1,000 participants

Table of outcome types and metrics:
Primary: Fatigue Severity Scale (FSS)
Secondary: FUNCAP27, DSQ-PEM, EQ-5D-5L
Exploratory: Wearable data (step count, heart rate, variability, resting heart rate, max heart rate), demographics, medication compliance
Biosample (50 participants): 3 clinical labs, proteomics

Ways LoCITT centers on participants

You can complete study activities from wherever you are
We work to minimize participant burden
Secondary outcomes were selected for validation for future trials
Our first user testers were 2 people with very severe symptoms
Thank you to Catherine Romatowski and a second anonymous tester!
Participants choose how they communicate with the study team
24/7 phone line for time-sensitive matters, video calls, emails, etc.
We share a letter to help coordinate with your health care provider(s)
We welcome caregivers to support you in completing study tasks

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Elisa Fadda @elisafadda.bsky.social · 1d

Tomorrow is #ChemNobel day!! 🥳🥳 While we are all waiting eagerly for the announcement, my cat Salem suggest to you #chemsky friends some important reading to quench the nerves,

1) ACS important content: www.acs.org/pressroom/re...

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The Chemistry of Cats | Reactions Science Videos - American Chemical Society

A look at some of the key "meow-locules" that make up the chemistry of cats.

www.acs.org

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Reposted by MS Bioworks

Lindsay K Pino @lindsaykpino.com · 2d

Still got our latest preprint bookmarked in an unread tab of your browser? We got you. @afederation.bsky.social presenting @talusbio.bsky.social's work-in-progress on Wednesday! 🧬 🖥️ 🧪 #MassSpectrometry #Proteomics

FragileNucleosome @fnucleosome.bsky.social · 2d

🎃 🥁This Wednesday in our 1st session of spookiest month👻 at #FragileNucleosome seminar, we are excited to host @sanimr.bsky.social & Alex Federation!
Register here for upcoming session and the entire series:
us06web.zoom.us/webinar/regi...

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MS Bioworks @msbioworks.bsky.social · 1d

What a difference a database makes. Curious the number of database entries are in ( ) Curious to see how these numbers change with the UniProt update.

MS Bioworks @msbioworks.bsky.social · 1d

UniProt 2025_04 releases tomorrow 10/8 #Proteomics

www.uniprot.org/release-note...

UniProt

UniProt is the world's leading high-quality, comprehensive and freely accessible resource of protein sequence and functional information.

www.uniprot.org

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MS Bioworks @msbioworks.bsky.social · 1d

Credit to @michaelstipe.bsky.social for spotting this one: insideuniprot.blogspot.com/2025/06/capt...

Capturing the Diversity of Life - Reorganizing the Protein Space in UniProtKB

Advances in genome sequencing technology means that large-scale efforts such as the Earth Biogenome project and the Darwin Tree of Life ...

insideuniprot.blogspot.com

MS Bioworks @msbioworks.bsky.social · 1d

The changes in UniProt, between release 2025_04 and 2026_02, will result in a change in the content and size of the database. The number of Reference Proteomes will increase by 36% (reflecting a 34% increase on species covered), while the number of proteins in UniProtKB can be decreased by 43%

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MS Bioworks @msbioworks.bsky.social · 2d

Welcome back!

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Max-Planck-Gesellschaft @maxplanck.de · 2d

Huge congratulations to this year's winners of the #NobelPrize in Physiology or Medicine: Mary Brunkow, Fred Ramsdell & Shimon Sakaguchi! 🏆The trio's groundbreaking work on peripheral immune tolerance is paving the way for crucial new treatments for cancer & autoimmunity. 🧬

Nobel prize in medicine awarded to scientists for immune system research

Mary E Brunkow, Fred Ramsdell and Shimon Sakaguchi worked on how the immune system can be prevented from harming the body

www.theguardian.com

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MS Bioworks @msbioworks.bsky.social · 6d

What's the state-of-the-art in DIA XL-MS? #Proteomics #TeamMassSpec

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The Royal Society @royalsociety.org · 7d

“Jane Goodall was an amazing scientist who inspired people to see the natural world in a new way. She helped us to look at the animal kingdom with fresh eyes and with greater respect.

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Seth Edmunds @phealthy.bsky.social · 8d

This is pretty crazy, study models millions of indirect hurricane deaths potentially driving/contributing to the life expectancy disparity in the US:

www.nature.com/articles/s41...

a, Total incidence of TCs on CONUS by month. Bar height is sum of average maximum wind speeds for all state-by-storm events. Colours correspond to decades. b, Stacked overlapping excess mortality responses to each storm for all of CONUS. Each storm response aggregates state-level responses nationally, accounting for state-level population and adaptation. Outline colours correspond to the decade when the TC occurred. The upper envelope is the total estimated mortality burden for CONUS resulting from all TCs occurring during the prior 172 months (see Supplementary Fig. 3). c, Official deaths directly resulting from TCs for each month according to NOAA National Hurricane Center and NOAA National Weather Service6,7. The y-axis scale is the same for b and c.

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The Tennessee Holler @thetnholler.bsky.social · 8d

And after 40 minutes of cringe-Thunderous applause from the generals!

Just kidding. Total silence. 👀 🦗 🦗

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Michael Steidel @michaelsteidel.bsky.social · 8d

Hey #TeamMassSpec,

Many non-human proteomics studies still search against taxon-filtered FASTAs.

❌ Redundant sequences
❌ Inflated search space
✅ Reference proteomes cut redundancy, improve annotation, and make results comparable.

👉 Time to move beyond taxon filters. #proteomics #massspec #uniprot

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MS Bioworks @msbioworks.bsky.social · 8d

Woah! Good catch, thanks for sharing. It did feel like the protein entries had been ballooning.

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MS Bioworks @msbioworks.bsky.social · 10d

A pretty cool examination of the OLink Reveal 1000+ protein plasma assay

pubs.acs.org/doi/full/10....

Brief Evaluation of Olink Reveal Proximity Extension Assay for High-Throughput Proteomics: A Case Study Using NIST SRM 1950 and Two Spike-In Protein Standards

Plasma proteomics has regained attention in recent years through advancements in mass spectrometry instrumentation and sample preparation as well as new high-throughput affinity-based technologies. He...

pubs.acs.org

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MS Bioworks @msbioworks.bsky.social · 10d

Anyone kicking the tires on the new 96 tip head from Opentrons?

opentrons.com/products/ope...

#Proteomics #TeamMassSpec

Opentrons Flex 96-Channel Pipette - Opentrons

The Opentrons Flex 96-Channel pipette enables accurate high throughput pipetting, optimized for working in 96-well plates. Flex Pipettes use air displacement

opentrons.com

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American Society for Biochemistry and Molecular Biology @asbmb.bsky.social · 11d

Full circle moment!

While visiting ASBMB for a Maximizing Access Committee meeting, @garcialabms.bsky.social spotted one of his early JBC papers.
www.jbc.org/article/S002...

Do you remember the thrill of your early publications? Share below!
@asbmbjournals.bsky.social #asbmbJBC #TeamMassSpec

Ben Garcia stands in front of a bookcase lined with past printed issues of the Journal of Biological Chemistry, which have green covers and gold lettering. He is holding one of the journals open to his 2007 article "Organismal Differences in Post-translational Modifications in Histones H3 and H4."

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MS Bioworks @msbioworks.bsky.social · 11d

For the longest time SwissProt Human was the go to, maybe five years ago UniProt Human became popular. Now, especially for plasma proteomics, I see folks searching any old crap to boost numbers. It's really quite sad.

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Syncell Inc @syncellinc.bsky.social · 12d

🌟 Meet Tina Chong, our Senior Applications Manager! She bridges customer goals with Microscoop workflows—helping uncover proteins that matter in cancer research.

#Proteomics #TeamSyncell

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James Comey @jamescomey.bsky.social · 13d

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MS Bioworks @msbioworks.bsky.social · 19d

Link to open access publication here:

www.nature.com/articles/s41...