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Reposted

Dr Tanya Soliman @drtanyasoliman.bsky.social · 6d

Are you a future black leader in cancer? Come join @mirazrahman.bsky.social and my labs @qmbci.bsky.social @kingscollegelondon.bsky.social to work on turning defective cell cycle checkpoints into innovative cancer therapies! Get in touch for more details www.colcc.ac.uk/2026-blic-ph...

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nadeemshaikh.bsky.social @nadeemshaikh.bsky.social · 6d

Apply to join our lab for a very cool PhD project studying radiation therapy, chromosomal instability, DNA repair and cancer evolution!

Mcclelland lab @mcclellandlab.bsky.social · 6d

We are looking for our next PhD student to join us 🤩 www.mcclellandlab.com to understand cancer radiation therapy's impact on DNA damage repair and chromosomal instability. Prestigious funding from CRUK RadNet. Please contact me informally - deadline 5th Nov! crukradnet.colcc.ac.uk/phd-students...

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nadeemshaikh.bsky.social @nadeemshaikh.bsky.social · 14d

Ultimate dream - scientific work leading to major impact on people’s lives, the researchers and Drs involved must be over the moon to treat such a difficult and horrendous disease

www.bbc.co.uk/news/article...

Huntington's disease successfully treated for first time

One of the most devastating diseases finally has a treatment that can slow its progression and transform lives, tearful doctors tell BBC.

www.bbc.co.uk

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Reposted

Eric Joyce @ericjoyce.bsky.social · 22d

We’re excited to share that, after receiving many requests each year from the research community for Oligopaint DNA & RNA FISH probes, we’re piloting a service to design & prepare probes for labs.
Please share with colleagues who may benefit!
ericjoycelab.com/oligopaint-f...

Oligopaint Probe Requests

In an effort to make Oligopaint FISH probes more broadly available to the research community, we offer DNA and RNA FISH probe design, synthesis, and generation. By dedicating a full-time staff memb…

ericjoycelab.com

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nadeemshaikh.bsky.social @nadeemshaikh.bsky.social · 22d

Very exciting to see my first co-corresponding author paper in press

pathsocjournals.onlinelibrary.wiley.com/doi/10.1002/...

Chromosomal instability and genomic alterations in cholangiocarcinoma from Northeastern Thailand

Cholangiocarcinoma (CCA) is a lethal cancer of the bile duct and is a major health concern in several parts of the world, including northeastern Thailand, where CCA incidence is the highest due to th...

pathsocjournals.onlinelibrary.wiley.com

nadeemshaikh.bsky.social @nadeemshaikh.bsky.social · 22d

We studied a panel of CCA cell lines in comparison to normal bile duct cells and found evidence of replication stress, ongoing segregation errors and uncovered extensive heterogeneity through mFISH and single cell WGS, whilst Tumour sample sequencing identified patterns of copy number alterations.

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nadeemshaikh.bsky.social @nadeemshaikh.bsky.social · 22d

@mcclellandlab.bsky.social hosted Prof Raksawan Deenonpoe from Thailand so she could collaborate with @mollyguscott.bsky.social & I to look for evidence of chromosomal instability in cholangiocarcinoma. Our work is now published in Journal of Pathology.

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nadeemshaikh.bsky.social @nadeemshaikh.bsky.social · Sep 2

About time academics showed some moral fibre

www.uu.nl/en/news/utre...

Utrecht University will not enter into any new collaborations with Israeli organizations until further notice

Utrecht University has decided to suspend all new collaborations with Israeli organizations until a committee can provide guidance on potential partners.

www.uu.nl

nadeemshaikh.bsky.social @nadeemshaikh.bsky.social · Jul 26

Ever more depraved , like real world Squid Games, they should be relegated to pariah status

www.bbc.co.uk/news/article...

Gaza aid site offered a 'women only' day. It didn't stop the killing

Families say mothers Mary Sheikh al-Eid and Khadija Abu Anza were shot while seeking aid from GHF station in southern Gaza.

www.bbc.co.uk

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Iain Cheeseman @iaincheeseman.bsky.social · Jul 23

New preprint! We solve a mystery you didn't know existed. Mitotic cells lack new transcription but require ongoing translation. Interphase mRNA half life is only 2-4 hrs. So how do cells arrest in mitosis for hours without depleting their transcriptomes?

www.biorxiv.org/content/10.1...

Global inhibition of deadenylation stabilizes the transcriptome in mitotic cells

In the presence of cell division errors, mammalian cells can pause in mitosis for tens of hours with little to no transcription, while still requiring continued translation for viability. These unique...

www.biorxiv.org

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Reposted

Eva Petermann @petermannlab.bsky.social · Jul 23

We're very proud that our recent PhD graduate (and now postdoc) Rosie Wilkins' study on RNase H2 overexpression in human cells has been published in Oncogene.
www.nature.com/articles/s41...

Human RNase H2 upregulation counteracts oncogene- and chemotherapy-induced replication stress - Oncogene

Oncogene - Human RNase H2 upregulation counteracts oncogene- and chemotherapy-induced replication stress

www.nature.com

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nadeemshaikh.bsky.social @nadeemshaikh.bsky.social · Jul 22

It’s starting 😞 12 children, 21 adults starved to death by Israel.

www.bbc.co.uk/news/article...

Gaza health ministry says 33 people died from malnutrition in 48 hours

Fifteen deaths have been reported over the past day, the Hamas-run ministry says, as the UN warns of

www.bbc.co.uk

nadeemshaikh.bsky.social @nadeemshaikh.bsky.social · Jul 16

Sorry I couldn’t get you that standing ovation

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nadeemshaikh.bsky.social @nadeemshaikh.bsky.social · Jul 15

Great talk by @susanagodinho.bsky.social at London Cell Club today

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nadeemshaikh.bsky.social @nadeemshaikh.bsky.social · Jul 13

Two years ago, being accused of bombing a hospital was met with horror and denials. Now, bombing children is met with a shrug

www.bbc.co.uk/news/article...

Gaza officials say children killed in strike as Israeli military admits 'error'

Six children waiting for water are among those killed in an Israeli air strike, emergency service officials say.

www.bbc.co.uk

Reposted

Alexander Stein @alexsteinresearch.bsky.social · May 29

Interested in population genetics of cancer?

If so, have a look at our manuscript accepted by @genetics-gsa.bsky.social, in which we provide a theoretical assessment of the genetic makeup of cancers before and after treatment!

Benjamin Werner @benjaminwerner.bsky.social · May 29

Very happy that @alexsteinresearch.bsky.social manuscript on the patterns of genetic heterogeneity before and after treatment is out now:

academic.oup.com/genetics/adv...

We build on and expand the population genetics theory of gITH.

Very worth a read if you are interested in somatic evolution.

On the patterns of genetic intra-tumour heterogeneity before and after treatment

Abstract. Genetic intra-tumour heterogeneity (gITH) is a universal property of all cancers. It emerges from the interplay of cell division, mutation accumu

academic.oup.com

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Reposted

JStark lab @jstarklab.bsky.social · May 22

We have a new study out - Distinct functions of PAXX and MRI during chromosomal end joining: iScience www.cell.com/iscience/ful...

Distinct functions of PAXX and MRI during chromosomal end joining

A key step of Canonical-Nonhomologous End Joining is synapsis of DNA double strand break (DSB) ends, which appears to be mediated by both the DNA-PKcs dimer and XLF homodimer. We have examined this pr...

www.cell.com

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Reposted

Andreas Panagopoulos @apanagopoulos.bsky.social · May 21

Delighted to share that the results of my main postdoc project are now published in @nature.com

🔗 doi.org/10.1038/s415...

Multigenerational cell tracking of DNA replication and heritable DNA damage - Nature

A multigenerational single-cell tracking approach provides a framework to dissect phenotypic plasticity at the single-cell level, offering insights into cellular processes that may resemble early even...

doi.org

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Reposted

dfachinetti.bsky.social @dfachinetti.bsky.social · May 21

Hi all, my team institut-curie.org/team/fachine... @institutcurie.bsky.social is looking for a Bioinformatician.
You can find more details about the position here: euraxess.ec.europa.eu/jobs/344508 Is anyone looking for a job in the lovely Paris?

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nadeemshaikh.bsky.social @nadeemshaikh.bsky.social · May 20

www.theguardian.com/commentisfre...

A moment of judgment has come at last: not just for Netanyahu but for his enablers | Owen Jones

Israel’s renewed assault on Gaza has prompted international condemnation, but many of those critics will face their own reckoning, says Guardian columnist Owen Jones

www.theguardian.com

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Barts Cancer Institute (Queen Mary University of London) @qmbci.bsky.social · May 20

📰 New research shows women of African and South Asian ancestry tend to develop and die of breast cancer at a younger age.

🎥 Prof Claude Chelala at BCI @qmul.ac.uk discusses why we must rethink screening and research to ensure no one is left behind as cancer care advances.

🧪 #medsky #oncosky

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Reposted

Cold War Steve @coldwarsteve.bsky.social · May 19

Gary Lineker leaving BBC. Director General Tim Davie sweeps a killed Palestinian child (a model of one) under a rug.

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The Guardian @theguardian.com · May 10

If you were shocked by my film on Israeli settlers in the West Bank, you haven’t been paying attention | Louis Theroux

The response to The Settlers has been humbling. But the ongoing displacement and intimidation of Palestinians is more severe than we could capture, says documentary presenter Louis Theroux

www.theguardian.com

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Financial Times @financialtimes.com · May 7

Opinion from the FT's Editorial Board: 'The US and European countries that tout Israel as an ally that shares their values have issued barely a word of condemnation. They should be ashamed of their silence, and stop enabling Netanyahu to act with impunity.' www.ft.com/content/f5fd...

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Reposted

Michelle Lockley @mlockley.bsky.social · Apr 30

Can we use the power of evolution to improve ovarian cancer treatment? Our latest paper says yes! Online now at Cancer Research. Thanks to
@trevorgraham.bsky.social coauthors and @cancerresearchuk.org for funding.

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