Reposted by Fan Hag
Discovery of an LSD1 PROTAC degrader
Discovery of an LSD1 PROTAC degrader | PNAS
Aberrant expression of lysine-specific demethylase 1 (LSD1) has been implicated in
various cancers, including acute myeloid leukemia (AML). Recent ...
www.pnas.org
June 6, 2025 at 11:00 AM
Discovery of an LSD1 PROTAC degrader
Reposted by Fan Hag
A 2-year-old boy presented with a 1-week history of itchy, red spots. Tense vesicles, erosions, and inflammatory plaques were seen. Direct immunofluorescence revealed a linear band of IgA at the dermoepidermal junction. Read the full case details: nej.md/3R6CIIA
#MedSky #DermSky #PedSky
#MedSky #DermSky #PedSky
March 16, 2025 at 1:36 PM
A 2-year-old boy presented with a 1-week history of itchy, red spots. Tense vesicles, erosions, and inflammatory plaques were seen. Direct immunofluorescence revealed a linear band of IgA at the dermoepidermal junction. Read the full case details: nej.md/3R6CIIA
#MedSky #DermSky #PedSky
#MedSky #DermSky #PedSky
Reposted by Fan Hag
Single-base CRISPR gene editing from Beam seems to have passed its first test in human trials. This is very good news indeed, and as the year goes on we’ll see even more readouts.
Single-Base Editing Seems to Work
www.science.org
March 10, 2025 at 4:52 PM
Single-base CRISPR gene editing from Beam seems to have passed its first test in human trials. This is very good news indeed, and as the year goes on we’ll see even more readouts.
Reposted by Fan Hag
$MLYS announced topline results from its pivotal Phase 3 Launch-HTN and Phase 2 Advance-HTN trials for lorundrostat for hypertension, with both trials meeting primary efficacy endpoints
See More Pre-market Movers 👇
www.biopharmcatalyst.com/news/2025/mi...
$CKPT $QTTB $TRVI $BEAM $PSTV $PRLD $ARWR
See More Pre-market Movers 👇
www.biopharmcatalyst.com/news/2025/mi...
$CKPT $QTTB $TRVI $BEAM $PSTV $PRLD $ARWR
March 10, 2025 at 12:29 PM
$MLYS announced topline results from its pivotal Phase 3 Launch-HTN and Phase 2 Advance-HTN trials for lorundrostat for hypertension, with both trials meeting primary efficacy endpoints
See More Pre-market Movers 👇
www.biopharmcatalyst.com/news/2025/mi...
$CKPT $QTTB $TRVI $BEAM $PSTV $PRLD $ARWR
See More Pre-market Movers 👇
www.biopharmcatalyst.com/news/2025/mi...
$CKPT $QTTB $TRVI $BEAM $PSTV $PRLD $ARWR
Reposted by Fan Hag
Spectacular news this morning for CRISPR gene editing to treat genetic disease from Beam Therapeutics.
This method was developed by David Liu's lab at the Broad.
= "academic" science produces innovations that enables the biotech sector to build medicines
investors.beamtx.com/news-release...
This method was developed by David Liu's lab at the Broad.
= "academic" science produces innovations that enables the biotech sector to build medicines
investors.beamtx.com/news-release...
investors.beamtx.com
March 10, 2025 at 11:48 AM
Spectacular news this morning for CRISPR gene editing to treat genetic disease from Beam Therapeutics.
This method was developed by David Liu's lab at the Broad.
= "academic" science produces innovations that enables the biotech sector to build medicines
investors.beamtx.com/news-release...
This method was developed by David Liu's lab at the Broad.
= "academic" science produces innovations that enables the biotech sector to build medicines
investors.beamtx.com/news-release...
Reposted by Fan Hag
Cancer-free for 18 years: CAR-T therapy sets new milestone in neuroblastoma treatment 🎗️🔬🧬 www.news-medical.net/news/2025021... #Cancer #CARTTherapy #Neuroblastoma #MedicalBreakthrough #ChildhoodCancer #Immunotherapy #Oncology #Biotech
Cancer-free for 18 years: CAR-T therapy sets new milestone in neuroblastoma treatment
A groundbreaking study in Nature Medicine reveals that GD2 CAR-T cell therapy can lead to long-term remission in children with neuroblastoma, with one patient remaining cancer-free for over 18 years.
www.news-medical.net
February 18, 2025 at 4:18 AM
Cancer-free for 18 years: CAR-T therapy sets new milestone in neuroblastoma treatment 🎗️🔬🧬 www.news-medical.net/news/2025021... #Cancer #CARTTherapy #Neuroblastoma #MedicalBreakthrough #ChildhoodCancer #Immunotherapy #Oncology #Biotech
Reposted by Fan Hag
Cool paper using LLM to discover a protein sequence code for subcellular localization 👏
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Protein codes promote selective subcellular compartmentalization
Cells have evolved mechanisms to distribute ~10 billion protein molecules to subcellular compartments where diverse proteins involved in shared functions must assemble. Here, we demonstrate that prote...
www.science.org
February 9, 2025 at 12:46 AM
Cool paper using LLM to discover a protein sequence code for subcellular localization 👏
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Reposted by Fan Hag
It’s been a tough few weeks. My 10yo daughter was diagnosed with a very rare, aggressive cancer called interdigitating dendritic cell sarcoma (IDCS). I’m reaching out to identify clinicians/patients who have encountered pediatric IDCS or other (non-LCH) dendritic or histiocytic sarcomas cases.
February 8, 2025 at 9:21 PM
It’s been a tough few weeks. My 10yo daughter was diagnosed with a very rare, aggressive cancer called interdigitating dendritic cell sarcoma (IDCS). I’m reaching out to identify clinicians/patients who have encountered pediatric IDCS or other (non-LCH) dendritic or histiocytic sarcomas cases.
Reposted by Fan Hag
In 1887, African American composer Edmond Dédé was living in exile in France and completed the greatest work of his life:
an opera 545 pages long telling a story of epic proportions. He knew that what he had accomplished was important.
Shows 2/5 NYC, 2/7 DC
#BlackSky
Free link: archive.ph/g3AYv
an opera 545 pages long telling a story of epic proportions. He knew that what he had accomplished was important.
Shows 2/5 NYC, 2/7 DC
#BlackSky
Free link: archive.ph/g3AYv
Found: A Manuscript That Unlocks a Forgotten Black Composer’s World
Almost 125 years after Edmond Dédé’s death, his magnum opus “Morgiane,” perhaps the oldest existing opera by a Black American, is to be staged for the first time.
www.nytimes.com
January 31, 2025 at 7:06 PM
In 1887, African American composer Edmond Dédé was living in exile in France and completed the greatest work of his life:
an opera 545 pages long telling a story of epic proportions. He knew that what he had accomplished was important.
Shows 2/5 NYC, 2/7 DC
#BlackSky
Free link: archive.ph/g3AYv
an opera 545 pages long telling a story of epic proportions. He knew that what he had accomplished was important.
Shows 2/5 NYC, 2/7 DC
#BlackSky
Free link: archive.ph/g3AYv
Reposted by Fan Hag
Party Like It's 2015: Celebrate the 10th Anniversary of Timmerman Report in March. Register for these free, fun events in Boston and Seattle. -- timmermanreport.com/2025/01/part...
Party Like It’s 2015: Celebrate the 10th Anniversary of Timmerman Report - TimmermanReport.com
The Timmerman Report is gearing up for the 10th Anniversary. Time to Party! Join a stellar cast of biotech leaders at the TR10 East Coast Party. This free and fun event will celebrate the 10th anniver...
timmermanreport.com
January 23, 2025 at 1:48 PM
Party Like It's 2015: Celebrate the 10th Anniversary of Timmerman Report in March. Register for these free, fun events in Boston and Seattle. -- timmermanreport.com/2025/01/part...
Reposted by Fan Hag
The value of g, the acceleration of an object under gravity at the Earth’s surface (9.81 m/s^2) is very close to pi^2 = 9.87. It’s a better approximation than g = 10 m/s^2, and this is no accident…
January 21, 2025 at 10:26 AM
The value of g, the acceleration of an object under gravity at the Earth’s surface (9.81 m/s^2) is very close to pi^2 = 9.87. It’s a better approximation than g = 10 m/s^2, and this is no accident…
Reposted by Fan Hag
How do cancer cells adapt to the stress of being cancer cells, with the constant stream of mutant and misfolded proteins? There’s more than one strategy, and therapeutically you’d like to know which is being used:
Dealing With Being a Tumor Cell
www.science.org
January 14, 2025 at 8:55 PM
How do cancer cells adapt to the stress of being cancer cells, with the constant stream of mutant and misfolded proteins? There’s more than one strategy, and therapeutically you’d like to know which is being used:
Reposted by Fan Hag
Duke neuroscientist Kafui Dzirasa wants nothing less than to reengineer the brain’s electrical patterns to treat anxiety, depression, bipolar disorder, and schizophrenia.
‘My life’s purpose’: A neuroscientist wants to rewire mental illness treatment and remake the field he loves
Duke neuroscientist Kafui Dzirasa wants nothing less than to reengineer the brain’s electrical patterns to treat anxiety, depression, bipolar disorder, and schizophrenia.
buff.ly
January 13, 2025 at 2:34 PM
Duke neuroscientist Kafui Dzirasa wants nothing less than to reengineer the brain’s electrical patterns to treat anxiety, depression, bipolar disorder, and schizophrenia.
Reposted by Fan Hag
𝐍𝐨𝐭𝐚𝐛𝐥𝐞 𝐀𝐫𝐭𝐢𝐜𝐥𝐞𝐬 𝐨𝐟 𝟐𝟎𝟐𝟒: Omalizumab for Multiple Food Allergies
In a trial involving 180 persons with food allergies, omalizumab was effective in increasing the reaction threshold for peanut & other common food allergens. Read more: nej.md/4bLW7aS
#MedSky
In a trial involving 180 persons with food allergies, omalizumab was effective in increasing the reaction threshold for peanut & other common food allergens. Read more: nej.md/4bLW7aS
#MedSky
January 12, 2025 at 2:42 PM
𝐍𝐨𝐭𝐚𝐛𝐥𝐞 𝐀𝐫𝐭𝐢𝐜𝐥𝐞𝐬 𝐨𝐟 𝟐𝟎𝟐𝟒: Omalizumab for Multiple Food Allergies
In a trial involving 180 persons with food allergies, omalizumab was effective in increasing the reaction threshold for peanut & other common food allergens. Read more: nej.md/4bLW7aS
#MedSky
In a trial involving 180 persons with food allergies, omalizumab was effective in increasing the reaction threshold for peanut & other common food allergens. Read more: nej.md/4bLW7aS
#MedSky
Reposted by Fan Hag
Childhood cancer death rates in the United States have declined six-fold over the last seventy years. 🧵
January 9, 2025 at 1:24 PM
Childhood cancer death rates in the United States have declined six-fold over the last seventy years. 🧵
Reposted by Fan Hag
SLC45A2 is a melanosome-specific transporter important for maintaining proper pH and osmotic balance. It's a wonderful example of "top down" causal gene inference. From its very function we expect it to be a gwas hit for pigmentation, regardless of where it sits in the genome.
January 9, 2025 at 12:53 AM
SLC45A2 is a melanosome-specific transporter important for maintaining proper pH and osmotic balance. It's a wonderful example of "top down" causal gene inference. From its very function we expect it to be a gwas hit for pigmentation, regardless of where it sits in the genome.
Reposted by Fan Hag
AI is hyped as the future of drug development. But has it really changed the game? Let’s break down where AI stands and what’s missing. 🧵
January 7, 2025 at 2:15 PM
AI is hyped as the future of drug development. But has it really changed the game? Let’s break down where AI stands and what’s missing. 🧵
Reposted by Fan Hag
Two federal death row inmates don't want Biden to commute their sentences because they say it would disadvantage them in their efforts to mount innocence claims (via my colleague Erik Ortiz):
www.nbcnews.com/news/us-news...
www.nbcnews.com/news/us-news...
Two death row inmates reject Biden's commutation of their life sentences
Shannon Agofsky and Len Davis were among 37 of the 40 federal prisoners whose death sentences were changed to life in prison without the possibility of parole.
www.nbcnews.com
January 7, 2025 at 3:41 PM
Two federal death row inmates don't want Biden to commute their sentences because they say it would disadvantage them in their efforts to mount innocence claims (via my colleague Erik Ortiz):
www.nbcnews.com/news/us-news...
www.nbcnews.com/news/us-news...
Reposted by Fan Hag
The Vera C. Rubin Observatory—one of this year’s 10 Breakthrough Technologies—will help astronomers study dark matter, explore the Milky Way, and untangle other cosmic unknowns.
Vera C. Rubin Observatory: 10 Breakthrough Technologies 2025
The telescope’s massive digital camera was built to take a lot of photos of the sky, in quick succession, for a very long time.
www.technologyreview.com
January 7, 2025 at 3:46 PM
The Vera C. Rubin Observatory—one of this year’s 10 Breakthrough Technologies—will help astronomers study dark matter, explore the Milky Way, and untangle other cosmic unknowns.
Pluto may have captured its moon Charon following a fleeting ‘kiss-and-capture’ collision, in which both bodies survived largely intact...
www.nature.com/articles/s41...
Capture of an ancient Charon around Pluto - Nature Geoscience
Numerical simulations suggest that Pluto’s moon Charon was captured intact, in a scenario in which the two bodies temporarily merged in a collision but did not coalesce due to solid strength effects.
www.nature.com
January 7, 2025 at 3:42 PM
Pluto may have captured its moon Charon following a fleeting ‘kiss-and-capture’ collision, in which both bodies survived largely intact...
www.nature.com/articles/s41...
Reposted by Fan Hag
I think you're describing science, IMO. Everything is atop a foundation of basic research. An example: at a previous company, I worked on a series of small-molecule inhibitors of Hormone-Sensitive Lipase, a possible target for Type II diabetes and related conditions. (1/10)
January 5, 2025 at 10:04 PM
I think you're describing science, IMO. Everything is atop a foundation of basic research. An example: at a previous company, I worked on a series of small-molecule inhibitors of Hormone-Sensitive Lipase, a possible target for Type II diabetes and related conditions. (1/10)
Reposted by Fan Hag
Very interesting to see the 50 new drugs that made it to FDA approval in 2024 in one place. A lot of really exciting small molecule chemistry with interesting functional groups, deuterations and covalent warheads. #chemsky #chembio
www.linkedin.com/posts/chrisd...
www.linkedin.com/posts/chrisd...
Chris De Savi on LinkedIn: #medicine #pharmaceuticals #healthcare | 90 comments
FDA Novel Drug Approvals 2024 #medicine
That is a wrap for 2024! And another year of relentless drug discovery!
There you have it, drug-hunting aficionados,… | 90 comments on LinkedIn
www.linkedin.com
January 3, 2025 at 9:00 AM
Very interesting to see the 50 new drugs that made it to FDA approval in 2024 in one place. A lot of really exciting small molecule chemistry with interesting functional groups, deuterations and covalent warheads. #chemsky #chembio
www.linkedin.com/posts/chrisd...
www.linkedin.com/posts/chrisd...
Reposted by Fan Hag
Five years ago today, Wuhan public health officials first let the world know about a "viral pneumonia" sweeping the city. www.who.int/news/item/30...
Milestone: COVID-19 five years ago
Five years ago on 31 December 2019, WHO’s Country Office in China picked up a media statement by the Wuhan Municipal Health Commission from their website on cases of ‘viral pneumonia’ in Wuhan, China....
www.who.int
December 31, 2024 at 4:28 PM
Five years ago today, Wuhan public health officials first let the world know about a "viral pneumonia" sweeping the city. www.who.int/news/item/30...