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Reposted by Kamila Naxerova

Nuria Lopez-Bigas @nlbigas.bsky.social · 10h

🚨 New paper alert!

Sex and smoking bias in the selection of somatic mutations in human bladder

www.nature.com/articles/s41...

by @raquelbmi.bsky.social, @ferriol.bsky.social et al (in collaboration with Rosana Risques lab in @uwmedicine.bsky.social)

Sex and smoking bias in the selection of somatic mutations in human bladder - Nature

Sex bias and association with smoking history identified in the landscape of driver mutations and clonal expansions in normal human bladder tissue may explain the higher bladder cancer risk in men and smokers.

www.nature.com

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Reposted by Kamila Naxerova

Inigo Martincorena @imartincorena.bsky.social · 10h

Our latest work is out in Nature today. In this paper, we introduce an improved version of NanoSeq, a duplex sequencing protocol with <5 errors per billion bp in single DNA molecules, and use it to study the somatic mutation landscape of oral epithelium in >1000 people www.nature.com/articles/s41...

Somatic mutation and selection at population scale - Nature

A new version of nanorate DNA sequencing, with an error rate lower than five errors per billion base pairs and compatible with whole-exome and targeted capture, enables epidemiological-scale studies of somatic mutation and selection and the generation of high-resolution selection maps across coding and non-coding sites for many genes.

www.nature.com

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Reposted by Kamila Naxerova

Dmitri Petrov @petrovadmitri.bsky.social · 23d

Very excited to see this work in press! I think there is a reason to believe that this is a common means of stabilizing large-effect polymorphisms in general and might be an important reason for why diploidy is so common. news.stanford.edu/stories/2025...

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Reposted by Kamila Naxerova

EMBL-EBI @ebi.embl.org · Aug 12

Welcome @timcoorens.bsky.social ‪ ‬🇳🇱, our new Research Group Leader.

Find out how Tim’s group is exploring using large-scale single-cell and spatial data to trace cell lineages, understand cancer origins, and uncover how mutations drive disease.

www.ebi.ac.uk/about/news/p...
🖥️🧬

Welcome: Tim Coorens

EMBL-EBI’s newest Research Group Leader is investigating how somatic mutations reveal the hidden histories of human cells.

www.ebi.ac.uk

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Reposted by Kamila Naxerova

Thomas R. Cox @trcox.matrixandmetastasis.com · Aug 8

@naxerova.bsky.social

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Kamila Naxerova @naxerova.bsky.social · Jul 18

Thank you for thinking of us. It’s been a rough ride. My lab lost two R01s, and as painful as that is for us, we are just one drop in a big bucket of terminations. HMS is doing everything they can to help us in the short term, but we need long term solutions - please keep up the conversation.

Ardem Patapoutian @ardemp.bskyverified.social · Jul 18

I still can’t believe that all NIH grants to my colleagues at Harvard and Harvard Medical School have been nullified. And that, as a nation, we’re somehow okay with this illegal, arbitrary, and petty act. Just think of the consequences: scientists, students, and patients will all suffer.

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Reposted by Kamila Naxerova

Craig Anderson @craigandersn.bsky.social · Jul 18

Today is my last day at the @uoe-igc.bsky.social in Edinburgh, as I'm starting my own lab in Munich as part of the German Cancer Consortium (DKTK), DKFZ and the LMU. I'll continue to focus on DNA damage and mutagenesis to determine their role in somatic evolution and disease.

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Kamila Naxerova @naxerova.bsky.social · Jul 12

Very cool!

Hao Zhu Lab at UT Southwestern @haozhulab.bsky.social · Jul 12

Consistently, Tbx3 KO protected against, and overexpression worsened fatty liver. This is because Tbx3 KO resulted in more VLDL-triglyceride secretion, which moves lipids from the liver to the rest of the body. Consequently, mice suffered from high blood triglyceride levels. 7/8

Reposted by Kamila Naxerova

Hao Zhu Lab at UT Southwestern @haozhulab.bsky.social · Jul 12

Introducing 2 new papers from my lab on somatic mutations in liver disease. The 1st is about a mutated gene that leads to improved clone fitness and organismal health (CIDEB). The 2nd is about a mutated gene that leads to improved clone fitness but worse overall health (TBX3). 1/8

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Reposted by Kamila Naxerova

Tim Coorens @timcoorens.bsky.social · Jul 3

The cells in our bodies constantly acquire mutations. But what are the patterns of mutations across tissues? How do mutations in normal cells lead to cancer and disease? These are questions we will tackle within the Somatic Mosaicism across Human Tissues (SMaHT) Network, now described in @nature.com

The Somatic Mosaicism across Human Tissues Network - Nature

The Somatic Mosaicism across Human Tissues Network aims to create a reference catalogue of somatic mosaicism across different tissues and cells within individuals.

www.nature.com

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Reposted by Kamila Naxerova

Jamie Blundell @jamie-blundell.bsky.social · Jul 3

Delighted to share our latest on longitudinal methylation dynamics preceding cancer. Epigenetic signs of AML appear in blood DECADES before Dx.
👉 Early cancer detection
👉 Methylation drivers
👉 Epimutation rates
👉 CpG lineage tracing

www.biorxiv.org/content/10.1...

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Reposted by Kamila Naxerova

Dmitri Petrov @petrovadmitri.bsky.social · Jun 27

We are recruiting students who are thinking of applying to Biology PhD programs this fall to apply for the Stanford Biology Preview Program. Please spread the word!

The Stanford Biology Preview Program @stanfordbpp.bsky.social · Jun 24

Applying to Biology PhD programs this year? Let us help!

At BPP, we aim to support students from all backgrounds through the grad school application process. Learn more about grad student life and receive 1-on-1 feedback on your application materials!

Apply here: forms.gle/EvTyUWXFMRSL...

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Reposted by Kamila Naxerova

Martin Taylor @mstaylor.bsky.social · Jan 15

To what extent is cancer development deterministic and predictable..?

Does the germline genome affect that predictability...?

Preprint: www.biorxiv.org/content/10.1...

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Kamila Naxerova @naxerova.bsky.social · Jun 20

www.votervoice.net/mobile/AACR/...

Urge Congress to Support NIH and Protect Medical Research

Protect the Future of Cancer Research: Tell Congress to Reject NIH CutsThe American Association for Cancer Research (AACR) urges you to take immediate action to defend the National Institutes of Healt...

www.votervoice.net

Reposted by Kamila Naxerova

Vladimir (Vova) Seplyarskiy @vseplyarskiy.bsky.social · Jun 4

🚨 Looking for postdocs!
I'm starting my lab at UT Southwestern this September.

If you're interested in:
🧬 Somatic & germline mutagenesis
🐭 Evolution of mutation processes
🧠 Adjacent areas like Mendelian genomics & population genetics—please consider joining.

Formal ad coming soon. DM me!

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Kamila Naxerova @naxerova.bsky.social · May 21

Social media grump Kamila has finally made it onto Bluesky!

Please check out my new perspective on metastasis evolution in @natrevcancer.nature.com if you need a reprieve from the news.

I tried my best to develop some new conceptual thoughts here, you be the judge whether I succeeded.

Nature Reviews Cancer @natrevcancer.nature.com · Apr 30

🚨 PERSEPCTIVE

Naxerova explains how genetic analysis of primary tumors & metastases can distinguish competing metastasis models, arguing that quantifying whether metastasis occurs through nonrandom lineage selection could offer insights into metastasis biology.

📖 👇

Evolutionary paths towards metastasis - Nature Reviews Cancer

In this Perspective, Kamila Naxerova discusses how genetic analyses of primary tumours and matched metastases can distinguish between competing metastasis evolution models, arguing that further insights into human metastasis biology could be enabled by a framework that rigorously quantifies whether metastases descend from a nonrandom selection of primary tumour lineages.

bit.ly

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Reposted by Kamila Naxerova

Vijay G. Sankaran @bloodgenes.bsky.social · May 20

www.forbes.com/sites/johndr...

Trump’s NIH And NSF Cuts Estimated To Cost The U.S. Economy $10 Billion Annually

Economists find public R&D drives U.S. productivity growth — and pays for itself

www.forbes.com

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