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Reposted by Nico Franzmeier

Pavan Chaggar @pavanchaggar.bsky.social · Aug 11

I'm thrilled that our paper "Personalised regional modelling predicts tau progression in the human brain" is finally published in PLoS Biology!

Here's a short thread about the main findings of the paper...

PLOS Biology @plosbiology.org · Jul 22

Accumulation of aggregated tau shows a complex spatio-temporal pattern during #AlzheimersDisease, but why? @pavanchaggar.bsky.social @alaingoriely.bsky.social &co describes #TauProtein dynamics in AD, showing stage-specific shifts in production & transport @plosbiology.org 🧪 plos.io/4kNA6vX

Simulated transport and production dynamics in the local FKPP model. Left: Simulation from the local FKPP model using carrying capacities derived from Gaussian mixture models (shown top right). Each line in the middle panel represents the SUVR trajectory of one DK atlas brain region. Values at time points years are projected onto a cortical rendering in the top panel. Each line in the bottom panel represents concentration averaged over Braak regions. Top right: Two component Gaussian mixture model fit to a multi-cohort tau PET dataset [24] and data from ADNI for right inferior temporal lobe. Bottom right: Right hemisphere cortical rendering of the SUVR carrying capacities as determined through Gaussian mixture modelling.

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Reposted by Nico Franzmeier

Gemma Salvadó @gsalvado.bsky.social · 20d

🚨Postdoc position open at @BarcelonaBeta🚨
We're looking someone to work on a project at the intersection of cardiovascular and neurodegenerative research 🫀🧠
Fully funded position!!!
More details: www.imim.cat/media/upload...
Please share!
#Alzheimer's #ENDALZ

www.imim.cat

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Reposted by Nico Franzmeier

Russ Poldrack @russpoldrack.org · 20d

I have just dropped a new version of my academicdb project, which helps prolific researchers generate a CV automatically. Now with a web interface! If you are interested, please try it out and let me know what you think - it takes a bit of setup work but then runs easily using Docker.

GitHub - poldrack/academicdb: Project to maintain a database for CV/website rendering

Project to maintain a database for CV/website rendering - poldrack/academicdb

github.com

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Nico Franzmeier @nfranzme.bsky.social · 24d

Out now in Brain: Our new study shows that tau deposits in Alzheimer’s disease not affect gray matter but also drive degeneration of connected white matter tracts, offering mechanistic insight into how tau disrupts brain networks
academic.oup.com/brain/articl...

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Reposted by Nico Franzmeier

Julie Ottoy @ottoyjulie.bsky.social · 29d

🔥Recent advances in #neuroimaging of #Alzheimers disease 🧠✨

dx.doi.org/10.1002/alz....

➡️ Valuable resource for both researchers & clinicians!
➡️ ATNIV biomarkers, staging, connectomics & more
➡️ Plus: how are sex & country represented in first/last authorship?

@istaart.bsky.social Neuroimaging PIA

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Nico Franzmeier @nfranzme.bsky.social · Jun 10

Working Link:
movementdisorders.onlinelibrary.wiley.com/doi/10.1002/...

Brain Networks Route Neurodegeneration Patterns in Patients with Progressive Supranuclear Palsy

Background Progressive supranuclear palsy (PSP) is a neurodegenerative disease driven by 4-repeat τ pathology, which is thought to propagate across interconnected neurons. Objectives We hypothesiz...

movementdisorders.onlinelibrary.wiley.com

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Nico Franzmeier @nfranzme.bsky.social · Jun 10

Many thanks to co-senior author @matthiasbrendel.bsky.social as well as Günter Höglinger, Johannes Gnörich @sebroemer.bsky.social, Carla Palleis, Anna Dewenter, Anna Steward, Davina Biel, @johanneslevin.bsky.social and many others

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Nico Franzmeier @nfranzme.bsky.social · Jun 10

The study was motivated by cerebellar 4R tau in PSP potentially confounding conventional cerebellar tau-PET reference regions. Using a data driven approach, we identified temporo-orbital white matter as a suitable reference that may support the biomarker workup in 4R tauopathies

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Nico Franzmeier @nfranzme.bsky.social · Jun 10

Very happy to share our 2nd paper today, led by Lukas Frontzkowski: We developed a novel data driven reference region for PI-2620 PET tailored to assess 4R tauopathies, improving i) PSP vs. control separation and ii) PET associations with clinical scores
doi.org/10.1007/s002...

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Nico Franzmeier @nfranzme.bsky.social · Jun 10

Many thanks to co-senior author Günter Höglinger, @matthiasbrendel.bsky.social, @johanneslevin.bsky.social, @sebroemer.bsky.social, Johannes Gnörich, @mauramalpetti.bsky.social and many others!

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Nico Franzmeier @nfranzme.bsky.social · Jun 10

Happy to share our new work by Carla Palleis in Movement Disorders showing that brain networks shape neurodegeneration patterns in PSP
=> This suggests that grey matter atrophy expands across connected brain regions, potentially following tau accumulation in PSP

doi.org/10.1002/mds....

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Reposted by Nico Franzmeier

Suzanne E. Schindler @suzanneeschindler.bsky.social · Jun 4

Alzheimer's disease drug development pipeline: 2025 - Cummings - 2025 - Alzheimer's & Dementia: Translational Research & Clinical Interventions - Wiley Online Library alz-journals.onlinelibrary.wiley.com/doi/10.1002/...

Alzheimer's disease drug development pipeline: 2025

Clinical trials for Alzheimer's disease (AD) must be registered on clinicaltrials.gov. The registry presents a variety of types of information related to the planned clinical trial. We assess clinic...

alz-journals.onlinelibrary.wiley.com

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Reposted by Nico Franzmeier

Carl Zimmer @carlzimmer.com · Jun 4

“I would like to cure brain cancer. I think that's not particularly controversial.” Be that as it may, the NIH terminated that scientist's grant. Here's a huge survey of the 2,500 grants that NIH has killed or delayed...so far. Gift link: nyti.ms/43Jz1yJ

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Reposted by Nico Franzmeier

oZgun Gokce @gokcegroup.bsky.social · Jun 5

This is a well done study! congrats www.cell.com/cell-reports...

Astrocyte induction of disease-associated microglia is suppressed by acute exposure to fAD neurons in human iPSC triple cultures

Lish et al. present a co-culture system of iPSC-derived human microglia, astrocytes, and neurons to investigate intercellular communication across different environmental and genetic contexts. Transcr...

www.cell.com

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Reposted by Nico Franzmeier

Marc Aurel Busche @marcaurelbusche.bsky.social · May 16

Hiring! We're looking for a postdoc to join my lab at the @ukdri.ac.uk @ucl.ac.uk We’re investigating neuronal and circuit dysfunction in Alzheimer's, and developing innovative new treatments.

Apply here👇
shorturl.at/LpCAq

UCL – University College London

UCL is consistently ranked as one of the top ten universities in the world (QS World University Rankings 2010-2022) and is No.2 in the UK for research power (Research Excellence Framework 2021).

shorturl.at

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Reposted by Nico Franzmeier

Marc Aurel Busche @marcaurelbusche.bsky.social · Apr 28

Our latest work, published in @cellpress.bsky.social, identifies a rare soluble #tau species in human #Alzheimer’s brain that suppresses CA1 complex-spike bursting, a hippocampal neuronal firing pattern that is critical for learning and memory.
www.cell.com/cell/fulltex...

Alzheimer’s disease patient-derived high-molecular-weight tau impairs bursting in hippocampal neurons

In mouse models, tau impairs neuronal complex spike bursting and associated network processes in hippocampus CA1 alongside CaV2.3 downregulation. Soluble high-molecular-weight tau species drive these ...

www.cell.com

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Reposted by Nico Franzmeier

Laura Wisse @lemwisse.bsky.social · Apr 23

Super excited to announce a PhD position on polypathology in the medial temporal lobe at the Paris Brain Institute together with @nvillain-alz.bsky.social and @robindeflores.bsky.social!

offres.institutducerveau-icm.org/fr/jobs/1935...

Please repost!

Nos super offres || PhD - polypathology in the medial temporal lobe

offres.institutducerveau-icm.org

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Reposted by Nico Franzmeier

Jean-Charles Lambert @jclambert.bsky.social · Apr 22

When I was a student, I dreamed of one day publishing in Trends In Neurosciences. So I'm proud that we had the opportunity to write an invited review on BIN1, a major genetic determinant of Alzheimer's disease that we've been working on for over 10 years.

www.sciencedirect.com/science/arti...

BIN1 and Alzheimer’s disease: the tau connection

Bridging integrator 1 (BIN1) is a ubiquitously expressed protein that plays a critical role in endocytosis, trafficking and cytoskeletal dynamics. In …

www.sciencedirect.com

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Reposted by Nico Franzmeier

Nicolas Villain @nvillain-alz.bsky.social · Apr 5

Just out in JAMA Neurol blood biomarkers are powerful—but without cognitive phenotyping, we risk more noise than signal.
Plasma p-tau217 needs clinical context or we’ll end up in a false-positive factory!
Clinico-biological AD is a reality!
👉🏻 jamanetwork.com/journals/jam...

bsky.app/profile/vinc...

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Reposted by Nico Franzmeier

Carolyn Fredericks @carolynfredericks.bsky.social · Mar 28

We are HIRING!! Postdoc for multimodal imaging lab at Yale. If you get excited about preclinical and prodromal states, atypical Alzheimer’s, graph theory, predictive modeling, and/or baked goods at lab meetings, come join us: postdocs.yale.edu/postdoctoral...

Please share with your circles!

The Fredericks Lab! - with deliberately poor photoshopping of lab members who couldn't be there that day.

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Nico Franzmeier @nfranzme.bsky.social · Mar 18

Also out today in EJNMMI, led by @matthiasbrendel.bsky.social and Johannes Gnörich:

Ever wondered about the strong PI-2620 tau-PET signal in the vermis and superior cerebellum? We found that this signal is driven by leptomeningeal melanozytes rather than tau deposits.

doi.org/10.1007/s002...

Exploring the origins of frequent tau-PET signal in vermal and adjacent regions - European Journal of Nuclear Medicine and Molecular Imaging

Purpose Off-target binding remains a significant challenge in tau-PET neuroimaging. While off-targets including monoamine oxidase enzymes and neuromelanin-containing cells have been identified, recent...

doi.org

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Nico Franzmeier @nfranzme.bsky.social · Mar 18

Many thanks to @sebroemer.bsky.social, @matthiasbrendel.bsky.social, @johanneslevin.bsky.social, Günter Höglinger and many more

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Nico Franzmeier @nfranzme.bsky.social · Mar 18

Excited to share our new work in Molecular Neurodegeneration, showing that α-synuclein co-pathology is common in Alzheimer’s and accelerates amyloid-related tau accumulation, supporting its role as a tau co-aggregation factor.

doi.org/10.1186/s130...

Alpha synuclein co-pathology is associated with accelerated amyloid-driven tau accumulation in Alzheimer’s disease - Molecular Neurodegeneration

Background Aggregated alpha-Synuclein (αSyn) is a hallmark pathology in Parkinson’s disease but also one of the most common co-pathologies in Alzheimer’s disease (AD). Preclinical studies suggest that...

doi.org

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Reposted by Nico Franzmeier

Melissa E. Murray @drneurochic.bsky.social · Mar 17

Great working with Sujala Ghatamaneni, Val Lowe, and colleagues on this high resolution autoradiography study of MK-6240 and flortaucipir🧠🖥️
link.springer.com/article/10.1...

@drchristinamoloney.bsky.social @davidjonesbrain.bsky.social

High resolution autoradiography of [18F]MK-6240 and [18F]Flortaucipir shows similar neurofibrillary tangle binding patterns preferentially recognizing middling neurofibrillary tangle maturity - Acta N...

Recent developments in tau positron emission tomography (PET) radiotracers have enhanced the visualization of tau aggregates in Alzheimer’s disease (AD). The maturity level of neurofibrillary tangles ...

link.springer.com

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Reposted by Nico Franzmeier

PaquetLab @paquetlab.bsky.social · Mar 12

Open #Postdoc position @isd-research.bsky.social @lmumuenchen.bsky.social to develop an #iPSC-derived #BBB model. Fully funded and embedded in our international Foundation Leducq Network of Excellence www.brenda-leducq.de Experience in vascular biology or related field required. Please RP and apply

The research group of Prof. Dr. Dominik Paquet (https://www.isd-research.de/paquetlab) is looking for a Postdoc. Our research involves the development of human brain tissue models to study the molecular mechanisms of Alzheimer's disease, Frontotemporal dementia, stroke and other related brain diseases and to develop therapeutic approaches. We use state-of-the-art molecular and cell biological methods, such as induced pluripotent stem cells (iPSCs), advanced molecular biology techniques, CRISPR/Cas9 genome editing, brain tissue engineering, scRNAseq, proteomics etc. We offer a highly international, versatile, extremely well equipped and productive work environment.

We have received funding by an international research organization for a very interdisciplinary and collaborative project to develop a human iPSC model of the blood brain barrier and apply it to study neurovascular diseases, with a focus on Small vessel disease (SVD). The project will focus on CRISPR genome engineering of SVD-relevant mutations, differentiation of iPSCs into neurovascular cells, microfluidic 3D vascular tissue engineering, and identifying disease-relevant alterations by microscopy and omics techniques. It will be embedded in the highly collaborative and stimulating environment of the PaquetLab, ISD, SyNergy Cluster of Excellence, and our international collaboration network.

We are looking for a highly motivated individual with the following skills:

-extensive international scientific working experience in vascular
biology or a closely related research field (required)
-experience in molecular biology, biochemistry and/or omics
techniques; cell culture experience is a plus
-excellent English skills in speaking, writing about and
presenting scientific data
-interest in working in collaborative network of
friendly scientists around the world

A start date soon in 2025 is desired.

Join us!
dominik.paquet@med.uni-muenchen.de
www.isd-research.de/paquetlab
www.brenda-leducq.de

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