Osvaldo Chara
@osvaldo-chara.bsky.social
160 followers 110 following 51 posts
Biophysicist/Modeller playing with tissues in Development and Regeneration School of Biosciences, University of Nottingham
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osvaldo-chara.bsky.social
Cells in a regenerating axolotl limb somehow know their place—but how?
In our new paper, we trace the dynamics of positional memory, release open-source code to quantify it, and introduce a theoretical framework for proximalisation.
🧵👇
🔗 www.nature.com/articles/s41...
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osvaldo-chara.bsky.social
I'm looking forward to reading it. Qapla'!!
osvaldo-chara.bsky.social
Congratulations, Kuba! Looking forward to reading it!!
osvaldo-chara.bsky.social
Congratulations Anna!! So happy for you!!
osvaldo-chara.bsky.social
Congratulations Can!!! Great news!!! Looking forward to chat with you soon!!
Reposted by Osvaldo Chara
giuliapaci.bsky.social
These are great - and could support your attendance to the 2025 CBIAS napari workshop for example! www.crick.ac.uk/whats-on/cbi...
Reposted by Osvaldo Chara
carolynbertozzi.bskyverified.social
Spread the word - we at @stanford-chemh.bsky.social are searching to fill a new junior faculty at the interface of molecular and computational science. See link below!
stanford-chemh.bsky.social
Open faculty position!
We're seeking applicants for a tenure-track faculty position at the junior level (Assistant or untenured Associate Professor) with research programs that exist at the interface between molecular science and computation. Apply here: stanford.io/45MF3Qa
Open Faculty Position: Assistant or Associate (Untenured) Professor 

Application deadline: 11:55 PM on Wednesday, October 15, 2025

Sarafan ChEM-H is seeking candidates with research programs that exist at the interface between molecular science and computation.  

Click the link above to learn more & apply!
osvaldo-chara.bsky.social
Congratulations!!! I cannot wait to read it!!
osvaldo-chara.bsky.social
Great to see the story out!!! Congratulations!!!
Reposted by Osvaldo Chara
giuliapaci.bsky.social
Thrilled to share the first story from my postdoc! 🎉 A wonderful experiment + simulations collaboration. In the Drosophila wing, we find that 3D cell shapes affect signalling range and fine-tune developmental patterning www.biorxiv.org/content/10.1... Thread below ⬇️
Reposted by Osvaldo Chara
yanlanmao.bsky.social
An exciting new paper from the lab! Check it out:
giuliapaci.bsky.social
Thrilled to share the first story from my postdoc! 🎉 A wonderful experiment + simulations collaboration. In the Drosophila wing, we find that 3D cell shapes affect signalling range and fine-tune developmental patterning www.biorxiv.org/content/10.1... Thread below ⬇️
Reposted by Osvaldo Chara
bensteventon.bsky.social
Check out this work from @gserranonajera.bsky.social and Apolline Delahaye! They show how gastruloids can employ different morphogenetic strategies to set up a body axis. It nicely builds from Guillermo’s PhD work recapitulating gastrulation modes in the chick: www.science.org/doi/10.1126/...
Reposted by Osvaldo Chara
idrm.ox.ac.uk
It is day 3 of our #ResearchAppreciationDay2025 countdown!

Dr Filipa Simões and team reveal how immune cells shape the heart from the earliest stages and guide regeneration in species like zebrafish.

🔬 Read the review: shorturl.at/kIYBf
Reposted by Osvaldo Chara
dev-journal.bsky.social
Pathway to Independence – an interview with Giulia Paci

In this interview, @giuliapaci.bsky.social talks about physics, mechanics, comics, her research journey, and the importance of public engagement:

journals.biologists.com/dev/article/...
Reposted by Osvaldo Chara
ritamateus.bsky.social
Hot off the press!!! Proudly presenting our lab's new review on how do cells communicate to control organ size :) We focus specially on dynamic connections that operate at different timescales to regulate organ growth and morphogenesis. #devbio #SizeandShape www.sciencedirect.com/science/arti...
Start-Shape-Stop: Cell communication mechanisms controlling organ size
Accurate growth control is critical for the achievement of proportional organs during animal development and repair processes. Either extra or deficie…
www.sciencedirect.com
osvaldo-chara.bsky.social
Thanks for sharing, Rita! Looking forward to reading it!!
Reposted by Osvaldo Chara
slcuplants.bsky.social
📢 Final hours to register for the Plant Computational Biology Workshop 2025! 📢
Don’t miss your chance to take part in talks and hands-on sessions with other plant modelling enthusiasts🪴
Deadline tomorrow (31 July) - www.slcu.cam.ac.uk/computationa...
#ComputationalBiology #PlantSci
osvaldo-chara.bsky.social
So nice to see your lab finally open to the world!!! Congratulations!!!
Reposted by Osvaldo Chara
leootsuki.bsky.social
Grateful and excited to launch the Otsuki Regeneration Group at the Hubrecht Institute!
🔗 www.hubrecht.eu/research-gro...

We study how tissues regenerate - and use those principles to build 3D tissues in vitro.

Full announcement: www.linkedin.com/in/leo-otsuk...

@hubrechtinstitute.bsky.social
osvaldo-chara.bsky.social
We’re also grateful to the Editor and Reviewers for their helpful feedback. We hope this study contributes to a deeper understanding of how cells regain their place in a regenerating organ.
Thanks for reading! 🙌
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osvaldo-chara.bsky.social
This work was made possible by a stellar team: Hernan Arce (PhD), Alberto Cecarelli (postdoc), @rodricc.bsky.social (Diploma student) from my lab and our collaborators Catarina Oliveira, and @maxyunlab.bsky.social. Huge thanks to all!
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osvaldo-chara.bsky.social
We propose that this velocity results from a proximalisation force, derived from a proximalisation potential. This gives us a quantitative, testable framework to study a central mechanism of regenerative patterning.
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osvaldo-chara.bsky.social
By fitting our model to the data, we inferred—for the first time—the proximalisation velocity (vp): how fast cells shift identity from distal to proximal!
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osvaldo-chara.bsky.social
To interpret the data, we developed a reaction–diffusion–advection (RDA) model. This allowed us to describe proximalisation as a velocity field resulting from changes in positional cues due to Tig1/Prod1.
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