Dr. P
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painterlab.bsky.social
Dr. P
@painterlab.bsky.social
69 followers 120 following 1 posts
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Reposted by Dr. P
sigalalab.bsky.social
Happy to share a new preprint exploring the unusual biochemistry of a "weirdly" diverged cytochrome c in malaria parasites that exemplifies a lineage common to many apicomplexan parasites. @uofubiochem.bsky.social @uuhsresearch.bsky.social @uofutahcihd.bsky.social
www.biorxiv.org/content/10.6...
A Divergent Cytochrome c in Malaria Parasites with an Anomalously Low Redox Potential
Eukaryotic cytochrome (cyt) c is a highly conserved mitochondrial protein central to cellular respiration, featuring a covalently attached hexacoordinate heme whose redox potential is tuned by axial H...
www.biorxiv.org
December 26, 2025 at 4:37 PM
Reposted by Dr. P
rosswaller.bsky.social
Excited to release the Herculean efforts of @scottchisholm.bsky.social &Co. defining the subcellular #hyperLOPIT spatial proteome of #Plasmodium schizonts. Proteomes defining 24 subcellular niches, including exported compartments in the blood cell, are identified.
www.biorxiv.org/content/10.1...
November 28, 2025 at 8:30 AM
Reposted by Dr. P
carlzimmer.com
Today my @nytimes.com colleagues and I are launching a new series called Lost Science. We interview US scientists who can no longer discover something new about our world, thanks to this year‘s cuts. Here is my first interview with a scientist who studied bees and fires. Gift link: nyti.ms/3IWXbiE
nyti.ms
October 8, 2025 at 11:29 PM
Reposted by Dr. P
mcbridetd.bsky.social
CDC, its advisers quietly expand access to Covid-19 shot for pregnant women www.politico.com/news/2025/10...
CDC, its advisers quietly expand access to Covid-19 shot for pregnant women
The panel voted to undo an action by Health Secretary Robert F. Kennedy Jr. which removed the vaccine from the immunization schedule for pregnant women.
www.politico.com
October 9, 2025 at 7:06 AM
Reposted by Dr. P
npr.org
Today marks the first day in public media’s history without federal funding. And we’re not going anywhere.

Listeners like you keep our mission alive. Protect one of the last places where America comes together to hear itself.

Stand with us today. Donate at this link: n.pr/46wamAj
October 1, 2025 at 2:19 PM
Reposted by Dr. P
philmandelbaum.bsky.social
4 new quick-guides to help you help your friends and fam STAND UP FOR SCIENCE and protect democracy

www.standupforscience.net/activate-eng...

www.standupforscience.net/inform-activ...

www.standupforscience.net/team-science

www.standupforscience.net/calling-values

@standupforscience.bsky.social
A cutout of protesters in grayscale over a dark blue background, with the following text in white, all caps: (line 1; larger) ACTIVATE AND ENGAGE; and (line 2) THE TIME IS NOW. A closeup of a polluted river filled with trash, in grayscale, with the following text in white, all caps: (line 1; larger) INFORM AND ACTIVATE; and (line 2) THE TIME IS NOW. A cutout of three lab scientists looking at an iPad over a red background, with the following text in white, all caps: (line 1; larger) TEAM SCIENCE; and (line 2) THE TIME IS NOW. A cutout of a side view of a bronze justice statue over a maroon background, with the following text in white, all caps: (line 1; larger) CALLING ON VALUES; and (line 2) THE TIME IS NOW.
August 11, 2025 at 12:53 AM
Reposted by Dr. P
jessmbryant.bsky.social
We @singh-parul.bsky.social teamed up with the amazing @fariatrypslab.bsky.social @trypsleon.bsky.social to highlight how recent technological advances have revealed exciting new features of parasite genome architecture and its impact on survival and pathogenicity:

www.cell.com/trends/paras...
Parasite genome organization: come together, right now!
Links between genome organization and transcription have been extensively studied in model eukaryotes; however, recent application of state-of-the-art chromosome conformation capture techniques to kin...
www.cell.com
August 10, 2025 at 8:28 AM
Reposted by Dr. P
aguillensamander.bsky.social
One for the Apicomplexa peeps:
ever wonder how does the IMC grow so fast during progeny formation? Where do all the lipids come from? In our latest work on malaria RBC stages we implicate this monster protein (~6000 residues!) and ER contact sites.
Happy+proud to share and keen to hear thoughts!
July 26, 2025 at 5:16 PM
Reposted by Dr. P
luckytran.com
DO NOT GIVE UP!

Our advocacy is working.

A key Senate committee has indicated that it will reject Trump’s proposed cuts to science agencies including NASA and the NSF.

Keep speaking up and calling your electeds 🗣️🗣️🗣️
Nature: US senators poised to reject Trump’s proposed massive science cuts Committee gives first hint that policymakers might preserve, rather than slash, funding for US National Science Foundation and other agencies.
July 11, 2025 at 7:03 PM
Reposted by Dr. P
elizabethjacobs.bsky.social
Dr. Gonsalves has written a piece that is equal parts brilliant and tragic. Read it and use it as motivation to keep fighting the destruction of US science infrastructure. @gregggonsalves.bsky.social
America Is Sliding Into the Abyss
Our science and health infrastructure lies in tatters. Once-dead viruses are roaring back to life. Many people will die. In other words, we’ve reached the point of no return.
www.thenation.com
July 11, 2025 at 7:45 PM
Reposted by Dr. P
cp-trendsparasitol.bsky.social
Drs @mlwilde.bsky.social Sarah Farrell, Christopher Goodman & @fad1.bsky.social review novel techniques for disrupting #malaria #transmission. #Plasmodium #Mosquito #GeneDrive #Paratransgenesis

authors.elsevier.com/a/1lPdi_XTJP...
July 11, 2025 at 7:29 AM
Reposted by Dr. P
standupforscience.bsky.social
🔥 Congress just issued a letter to EPA Admin Zeldin demanding an end to what they call “illegal retaliation” against the #EPA139 for signing the #DeclarationofDissent.

These civil servants warned that EPA leadership was endangering public health, abuse of authority, & gross mismanagement.

(1/2)
First page of a July 8, 2025 letter from the U.S. House Committee on Energy and Commerce to EPA Administrator Lee Zeldin. Signed by hundreds of EPA staff, the letter accuses Zeldin of undermining the EPA’s mission and abusing his office. It states that Zeldin’s actions have harmed communities, set back science, and damaged the agency’s culture. The letter condemns the retaliatory administrative leave placed on at least 139 signatories of a previous dissent letter and warns that these retaliatory acts may violate the Whistleblower Protection Act.
July 8, 2025 at 9:38 PM
Reposted by Dr. P
marketanovotna.bsky.social
I used inducible CRISPR/Cas9 to make Trypanosoma brucei cell line that allowed me to edit originally muti-copy histone gene. We uncovered a novel role of H4 histone tail in gene regulation. I enjoyed working on this exciting project with @joanarcf.bsky.social, a great mentor.
doi.org/10.1038/s414...
Precision-edited histone tails disrupt polycistronic gene expression controls in trypanosomes - Nature Communications
Transcription in trypanosomatids, such as Trypanosoma brucei, is predominantly polycistronic and involves unconventional RNA polymerase II promoters. This study uses precision gene editing, site-satur...
www.nature.com
July 6, 2025 at 3:36 PM
Reposted by Dr. P
physiciandemocracy.medsky.social
@drericding.bsky.social
Devastating for future medical and law students—$50k loan cap per year. This won’t even cover tuition for medical school or law schools. So only the rich will be able to afford to become doctors or lawyers, got it.
July 5, 2025 at 11:45 AM
Reposted by Dr. P
jeremymberg.bsky.social
NIH BREAKING NEWS NIH BREAKING NEWS

Hearing from multiple sources that an email went out late yesterday afternoon

Effective immediately: Please do not terminate any additional grant projects. Please pull back all grant projects that are in the cue to be terminated.
two men in suits and ties are waving their hands in a room
ALT: two men in suits and ties are waving their hands in a room
media.tenor.com
June 25, 2025 at 3:32 PM
Reposted by Dr. P
sifill.bsky.social
On the Crisis of Character in American Leadership.
open.substack.com/pub/sherrily...
When Small Men and Women Rule*
*People of Character Stand Up
open.substack.com
June 21, 2025 at 3:44 PM
Reposted by Dr. P
jvr-lab.bsky.social
Postdoc opportunity ALERT!

Interested in exploring interactions between #wolbachia , #anopheles mosquitoes and #microbiome? check this postdoc position in Dr. Grant Hughes lab at Liverpool School of Tropical Medicine @mosquitomicrobe.bsky.social

app.vacancy-filler.co.uk/salescrm/Car...
Post Doctoral Research Associate in Wolbachia Biology | Liverpool School of Tropical Medicine
Ready to make a difference in vector biology research? We are looking for a dedicated and enthusiastic researcher to join an exciting BBSRC-funded project exploring the fascinating interactions betwee...
app.vacancy-filler.co.uk
June 19, 2025 at 10:20 PM
Reposted by Dr. P
francoismayer.bsky.social
Awesome malaria study out now in Nature Microbiology:

An atypical Arp2/3 complex is required for Plasmodium DNA segregation and malaria transmission

By Franziska Hentzschel, Matthias Marti, Freddy Frischknecht & colleagues!

@freddyfrischknecht.bsky.social

www.nature.com/articles/s41...
An atypical Arp2/3 complex is required for Plasmodium DNA segregation and malaria transmission - Nature Microbiology
A unique Arp2/3 complex in malaria parasites enables DNA segregation during the rapid formation of male gametes by safeguarding the attachment of chromosomes to the mitotic spindle.
www.nature.com
June 13, 2025 at 10:31 AM
Reposted by Dr. P
parasitesrule.org
Registration and Abstract submission for MPMXXXVI are now open! Abstract submission deadline is June 27th, get yours in quickly. @rmc9z.bsky.social @mjgubbels.bsky.social @omarharb.org
🔗https://www.parasitesrule.com/mpm-xxxvi
June 5, 2025 at 1:51 PM
Reposted by Dr. P
macleanlab.bsky.social
Happy to share our latest paper. Result of a great collaboration between @sheinerlab.bsky.social @oninopantsu.bsky.social and Alexander Mühleip’s new group.

www.nature.com/articles/s41...
Structure, assembly and inhibition of the Toxoplasma gondii respiratory chain supercomplex - Nature Structural & Molecular Biology
Here the authors demonstrate that the assembly of mitochondrial respiratory supercomplex (III2–IV) from Toxoplasma gondii is critical for parasite fitness. They reveal the basis for cytochrome b inhib...
www.nature.com
May 19, 2025 at 10:22 AM
Reposted by Dr. P
drsl.bsky.social
The Spencer Foundation is offering rapid response bridge funding for those who lost NSF research grants.

www.spencer.org/grant_types/...
Rapid Response Bridge Funding Program
In the face of recent abrupt shifts in federal funding for education research, including large-scale terminations of National Science Foundation (NSF) research grant awards, we have developed a rap...
www.spencer.org
May 2, 2025 at 9:07 PM
Reposted by Dr. P
jhmrimalaria.bsky.social
What if the key to ending malaria isn't killing mosquitoes, but outsmarting them? 🧬

We’re excited to explore the science behind the molecular approaches to vector control at our in-person #WorldMalariaDay Symposium.

📅 April 25
April 22, 2025 at 12:09 PM
Reposted by Dr. P
petersagal.bsky.social
This letter appeared in the Bloomsburg PA Press Enterprise this morning. I am assured the writer is who he purports to be, an Air Force veteran.
benion Grieving a wasted life At a point in life when there are far too many days behind than ahead, one tends to re-elected in contrast to standing up for the reflect on a life lived. In my lifetime decades greater good? were devoted to protecting America. Sacri A compromised Supreme Court recently fices were made both by myself and my fam- trotted out a shallow token standards of Ily in military service. The tip of the spear: conduct for themselves. Apparently it's Countless weeks over the years were spent not a bribe to accept favors after a deci-sion; only before. Corporations are people? living at the end of a runway on alert with an Really? Whatever happened to Superman's armed B-52 as generations of aviators have motto of "truth, justice, and the American done before and since. way?" The purpose: if required, be airborne Pay-to-play is the theme of the day. Un- in minutes on a one-way trip bringing a challenged and uncontested blatant conflicts nuclear Armageddon to an adversary. Fly: of interest abound. The rule of law is situ- ing the unfriendly skies over North Viet- ational if adhered to at all. America can no nam provided a brief interlude, but overall, longer be trusted. The unbridled pursuit of this long line of silent sentinels stood firm power and wealth driven by unquenchable to protect America by deterring external greed has left service above self and Con- threats to our freedoms and way of life stitutional norms in the dustbin of a quaint across the decades. I was privileged to serve past. with men and women of integrity imbued Recently the VA said exposure to Agent with a sense of service. Orange is the probable cause of the can- I'm truly grateful that the B-52s we flew, which were built tough, were engineered cers I live with. Actually I suspect it's more from yet unspecified sources, which cause on scientific principles and fabricated by experienced, skilled workers rather than military pilots to have significantly higher founded on mere beli…
March 11, 2025 at 10:04 PM
Reposted by Dr. P
jvr-lab.bsky.social
New Pre-print from our lab

High-Resolution Proteomics Unveils Salivary Gland Disruption and Saliva-Hemolymph Protein Exchange in Plasmodium-Infected Mosquitoes

Led by @thiagoluizsilva.bsky.social
🦟 🦟🦟🦟🦟🦟🦟🦟🦟🦟🦟
#mosquito #malaria #proteomics #infectiousdiseases

www.biorxiv.org/content/10.1...
High-Resolution Proteomics Unveils Salivary Gland Disruption and Saliva-Hemolymph Protein Exchange in Plasmodium-Infected Mosquitoes
Plasmodium sporozoites, the stage that initiates a malaria infection, must invade the mosquito salivary glands (SGs) before transmitting to a vertebrate host. However, the effects of sporozoite invasi...
www.biorxiv.org
March 3, 2025 at 3:13 PM