PiescheLab
@pieschelab.bsky.social
Associate Prof @ UCM.
@DanaFarber/@HarvardMed Alumni. Passionate about #cancer immunology, #immunotherapy, #biomarkers & what the gut #microbiome has to do with it
@DanaFarber/@HarvardMed Alumni. Passionate about #cancer immunology, #immunotherapy, #biomarkers & what the gut #microbiome has to do with it
Been through some storms, but hard work has paid off. Thanks @ucatolicamaule @facmedicinaucm
With new energy back what I love...how to manipulate the immune system to fight diseases.
#promotion #fullprofessor #immunotherapy #cancer #scienceworks
With new energy back what I love...how to manipulate the immune system to fight diseases.
#promotion #fullprofessor #immunotherapy #cancer #scienceworks
August 29, 2025 at 12:29 AM
Been through some storms, but hard work has paid off. Thanks @ucatolicamaule @facmedicinaucm
With new energy back what I love...how to manipulate the immune system to fight diseases.
#promotion #fullprofessor #immunotherapy #cancer #scienceworks
With new energy back what I love...how to manipulate the immune system to fight diseases.
#promotion #fullprofessor #immunotherapy #cancer #scienceworks
Expected, considering how Twitter changed since it was taken over.
arstechnica.com/science/2025...
arstechnica.com/science/2025...
August 29, 2025 at 12:09 AM
Expected, considering how Twitter changed since it was taken over.
arstechnica.com/science/2025...
arstechnica.com/science/2025...
Yeah right, they are all corrupt. What is his agenda? Ridiculous!
I could agree that they take too much $ for publications, hiding important papers behind pay walls, etc. but corrupt?
www.statnews.com/2025/05/27/r...
I could agree that they take too much $ for publications, hiding important papers behind pay walls, etc. but corrupt?
www.statnews.com/2025/05/27/r...
‘Corrupt’ medical journals have to change, RFK Jr. says, or the NIH will publish in-house
The criticism of The Lancet, NEJM and JAMA is not new, but the health secretary may use his position to influence research that journals publish.
www.statnews.com
May 28, 2025 at 9:32 PM
Yeah right, they are all corrupt. What is his agenda? Ridiculous!
I could agree that they take too much $ for publications, hiding important papers behind pay walls, etc. but corrupt?
www.statnews.com/2025/05/27/r...
I could agree that they take too much $ for publications, hiding important papers behind pay walls, etc. but corrupt?
www.statnews.com/2025/05/27/r...
Without basic science, translational, applied sciences wouldnt be possible. It is fundamental!!
No immunotherapy, no flying, no smart phones, no smart TV...and so on and so on...
Basic research advances science, and can also have broader impacts on modern society
theconversation.com/basic-resear...
No immunotherapy, no flying, no smart phones, no smart TV...and so on and so on...
Basic research advances science, and can also have broader impacts on modern society
theconversation.com/basic-resear...
Basic research advances science, and can also have broader impacts on modern society
Basic research that doesn’t have a specific industrial or experimental application still adds value outside the lab by engaging people with exciting research.
theconversation.com
May 9, 2025 at 1:48 AM
Without basic science, translational, applied sciences wouldnt be possible. It is fundamental!!
No immunotherapy, no flying, no smart phones, no smart TV...and so on and so on...
Basic research advances science, and can also have broader impacts on modern society
theconversation.com/basic-resear...
No immunotherapy, no flying, no smart phones, no smart TV...and so on and so on...
Basic research advances science, and can also have broader impacts on modern society
theconversation.com/basic-resear...
FDA approves nivolumab with ipilimumab for unresectable or metastatic hepatocellular carcinoma www.fda.gov/drugs/resour...
FDA approves nivolumab with ipilimumab for hepatocellular carcinoma
On April 11, 2025, the FDA approved nivolumab with ipilimumab for the first-line treatment of unresectable or metastatic hepatocellular carcinoma.
www.fda.gov
April 14, 2025 at 3:44 PM
FDA approves nivolumab with ipilimumab for unresectable or metastatic hepatocellular carcinoma www.fda.gov/drugs/resour...
'Bluesky has overtaken its flailing rival X in hosting posts related to new academic research, indicating the platform is fast becoming the go-to place for scholars to share their work.'
X’s dominance ‘over’ as Bluesky becomes new hub for research
Data indicates more scholars turning to alternative social media site to post about their work after Elon Musk’s Twitter takeover
www.timeshighereducation.com
April 9, 2025 at 1:01 PM
Sometimes, science could be so easy.
Vaccines work ... Or was it thoughts and prayers?
Vaccines work ... Or was it thoughts and prayers?
Update on measles in the US, cases and deaths, in context of vaccine introduction
April 6, 2025 at 10:02 PM
Sometimes, science could be so easy.
Vaccines work ... Or was it thoughts and prayers?
Vaccines work ... Or was it thoughts and prayers?
Preclinical - targeting MARCO on macrophages in combination with CTLA4 enhances Melanoma regression in mice - but not with anti PD1
medicalxpress.com/news/2025-03...
medicalxpress.com/news/2025-03...
New immunotherapy strategy targets macrophage receptors to enhance melanoma treatment
Researchers from Moffitt Cancer Center have found a new way to boost cancer immunotherapy by targeting a protein called macrophage receptor with collagenous structure, or MARCO. Their study, published...
medicalxpress.com
March 18, 2025 at 1:14 AM
Preclinical - targeting MARCO on macrophages in combination with CTLA4 enhances Melanoma regression in mice - but not with anti PD1
medicalxpress.com/news/2025-03...
medicalxpress.com/news/2025-03...
Viral mimicry to enhance cancer immunotherapy
medicalxpress.com/news/2025-03...
medicalxpress.com/news/2025-03...
Suppressing key protein may unlock immunotherapy for glioblastoma
Glioblastoma has remained one of the toughest cancers to treat, resisting even the latest advances in immunotherapy. But new research from Sylvester Comprehensive Cancer Center, part of the University...
medicalxpress.com
March 17, 2025 at 9:11 PM
Viral mimicry to enhance cancer immunotherapy
medicalxpress.com/news/2025-03...
medicalxpress.com/news/2025-03...
Someone should tell the current administration.
"Over time, the U.S. military would come to see climate change as both a threat in itself and a threat multiplier for national security."
theconversation.com/the-us-milit...
Science works, b***
"Over time, the U.S. military would come to see climate change as both a threat in itself and a threat multiplier for national security."
theconversation.com/the-us-milit...
Science works, b***
The US military has cared about climate change since the dawn of the Cold War – for good reason
During the Cold War, the US poured support into Arctic military outposts and climate research amid fears of a Russian invasion. Climate change is still on the military’s radar as a threat multiplier.
theconversation.com
March 17, 2025 at 8:57 PM
Someone should tell the current administration.
"Over time, the U.S. military would come to see climate change as both a threat in itself and a threat multiplier for national security."
theconversation.com/the-us-milit...
Science works, b***
"Over time, the U.S. military would come to see climate change as both a threat in itself and a threat multiplier for national security."
theconversation.com/the-us-milit...
Science works, b***
Potential biomarker?
Fibronectin and smooth muscle actin within colorectal cancer tissues are associated with resistance to immunotherapy treatment.
www.onclive.com/view/mayo-cl...
Fibronectin and smooth muscle actin within colorectal cancer tissues are associated with resistance to immunotherapy treatment.
www.onclive.com/view/mayo-cl...
Mayo Clinic Researchers Identify Proteins Linked to Immunotherapy Resistance in Metastatic Colorectal Cancer
A discovery by researchers from Mayo Clinic may help explain why immunotherapy hasn't been helpful for many patients with metastatic colorectal cancer.
www.onclive.com
March 14, 2025 at 11:03 PM
Potential biomarker?
Fibronectin and smooth muscle actin within colorectal cancer tissues are associated with resistance to immunotherapy treatment.
www.onclive.com/view/mayo-cl...
Fibronectin and smooth muscle actin within colorectal cancer tissues are associated with resistance to immunotherapy treatment.
www.onclive.com/view/mayo-cl...
When politics overrule science. Very sad to read this:
NIH to terminate hundreds of active research grants
www.nature.com/articles/d41...
NIH to terminate hundreds of active research grants
www.nature.com/articles/d41...
Exclusive: NIH to terminate hundreds of active research grants
Studies that touch on LGBT+ health, gender identity and DEI in the biomedical workforce could be terminated, according to documents obtained by Nature.
www.nature.com
March 6, 2025 at 10:05 PM
When politics overrule science. Very sad to read this:
NIH to terminate hundreds of active research grants
www.nature.com/articles/d41...
NIH to terminate hundreds of active research grants
www.nature.com/articles/d41...
PubMed is down. I am currently going cold turkey and experiencing severe withdrawal symptoms. #PubMed please come back, I need you urgently.
March 2, 2025 at 4:42 PM
PubMed is down. I am currently going cold turkey and experiencing severe withdrawal symptoms. #PubMed please come back, I need you urgently.
No, artificial sweeteners are not better than sugar (avoid both, but if you have to better use sugar). Another evidence (how many we need to get rid of them?):
Mice fed artificial sweetener exhibit alarming health issues www.earth.com/news/mice-fe...
Mice fed artificial sweetener exhibit alarming health issues www.earth.com/news/mice-fe...
Mice fed artificial sweetener exhibit alarming health issues
Aspartame, a common sweetener in diets, could affect vascular health, according to a new study that warns of a possible higher arterial risk.
www.earth.com
February 27, 2025 at 10:23 AM
No, artificial sweeteners are not better than sugar (avoid both, but if you have to better use sugar). Another evidence (how many we need to get rid of them?):
Mice fed artificial sweetener exhibit alarming health issues www.earth.com/news/mice-fe...
Mice fed artificial sweetener exhibit alarming health issues www.earth.com/news/mice-fe...
After first measle death. Kennedy about measles “So it’s not unusual. You have measles outbreaks every year.” - NO you dont if you get vaccinated. edition.cnn.com/2025/02/26/h...
Child in West Texas is first US measles death in a decade | CNN
The first measles death in the growing outbreak in West Texas was a school-aged child.
edition.cnn.com
February 27, 2025 at 10:09 AM
After first measle death. Kennedy about measles “So it’s not unusual. You have measles outbreaks every year.” - NO you dont if you get vaccinated. edition.cnn.com/2025/02/26/h...
Sad, but well said. NIH funding www.nytimes.com/2025/02/14/o...
Opinion | American Science is Under Attack (Gift Article)
The Trump administration hobbles research and endangers the public health.
www.nytimes.com
February 14, 2025 at 5:52 PM
Sad, but well said. NIH funding www.nytimes.com/2025/02/14/o...
I see a lot of combo trials with ICIs, but most fail. We need to be smarter how to choose combos to select patients who are more likely to benefit.
Nivolumab Plus Relatlimab Fails to Improve RFS in Resected Stage III/IV Melanoma
www.onclive.com/view/nivolum...
www.onclive.com/view/nivolum...
Nivolumab Plus Relatlimab Fails to Improve RFS in Resected Stage III/IV Melanoma
Nivolumab plus relatlimab did not improve recurrence-free survival vs nivolumab in resected stage III/IV melanoma.
www.onclive.com
February 14, 2025 at 4:44 PM
I see a lot of combo trials with ICIs, but most fail. We need to be smarter how to choose combos to select patients who are more likely to benefit.
How can we predict which patients respond to cancer immunotherapy? Here's a potential path: scitechdaily.com/scientists-i...
and here's the paper: www.nature.com/articles/s41...
and here's the paper: www.nature.com/articles/s41...
Five latent factors underlie response to immunotherapy - Nature Genetics
Analysis of human tumor datasets shows that all features that appear significantly associated with immunotherapy response and survival may be collapsed into five latent factors: tumor mutation burden,...
www.nature.com
February 14, 2025 at 4:21 PM
How can we predict which patients respond to cancer immunotherapy? Here's a potential path: scitechdaily.com/scientists-i...
and here's the paper: www.nature.com/articles/s41...
and here's the paper: www.nature.com/articles/s41...
More evidence here:
www.news-medical.net/news/2025021...
And here the paper: www.nature.com/articles/s41...
Microbiome immunotherapy cancer ici
www.news-medical.net/news/2025021...
And here the paper: www.nature.com/articles/s41...
Microbiome immunotherapy cancer ici
February 14, 2025 at 3:20 AM
More evidence here:
www.news-medical.net/news/2025021...
And here the paper: www.nature.com/articles/s41...
Microbiome immunotherapy cancer ici
www.news-medical.net/news/2025021...
And here the paper: www.nature.com/articles/s41...
Microbiome immunotherapy cancer ici
Microbiome and ICI: potential synergy for better cancer treatments www.jci.org/articles/vie...
JCI -
The gut microbiome and cancer response to immune checkpoint inhibitors
www.jci.org
February 14, 2025 at 3:13 AM
Microbiome and ICI: potential synergy for better cancer treatments www.jci.org/articles/vie...
Reposted by PiescheLab
The Race to Explain Why More Young Adults Are Getting Cancer
Researchers are racing to find out.
time.com
February 14, 2025 at 12:31 AM
Bye-bye X, enough is enough. I'm interested in science and, to say it nicely, not the things that are offered now. Looking forward to bluesky and hope to find it similar informative as old twitter was.
February 14, 2025 at 1:16 AM
Bye-bye X, enough is enough. I'm interested in science and, to say it nicely, not the things that are offered now. Looking forward to bluesky and hope to find it similar informative as old twitter was.