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Reposted by Pablo Pelegrin

Ivan Zanoni @lozanzi.bsky.social · Sep 8

Fantastic new story @jkagan1.bsky.social & friends showing that human dendritic cells can become hyperactive activating the inflammasome without dying, & that this approach can be used in mice and NHPs to potentiate anti-influenza vaccine responses! 👇👇👇

Jonathan Kagan @jkagan1.bsky.social · Sep 8

An NLRP3 stimulatory universal influenza vaccine.
We report an NLRP3 stimulus that generates hyperactive dendritic cells (hDCs).
journals.asm.org/doi/10.1128/...

An NLRP3-stimulatory adjuvant improves the immunogenicity of influenza virus vaccines in mice and non-human primates | mBio

The generation of vaccines that stimulate T cell activities is an unmet need for the scientific community, as T cells are the primary mediators of immune memory. In this study, we report a new vaccine...

journals.asm.org

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Pablo Pelegrin @ppelegrin.bsky.social · Sep 7

Looking for passionate candidate to apply to PhD fellowship to University of Murcia call:

www.um.es/documents/d/...

Interested students contact me!

www.um.es

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Pablo Pelegrin @ppelegrin.bsky.social · Sep 7

www.linkedin.com/posts/albert...

Intrahepatic donor microbiota-based metataxonomic signature detected in organ preservation solution enables prediction of short-term liver transplant outcomes | Alberto Baroja-Mazo

Thrilled to share that our latest work has just been published in Gut 🚀 We show that donor intrahepatic microbial DNA signatures, detected in organ preservation solution, can predict post-transplant o...

www.linkedin.com

Reposted by Pablo Pelegrin

Journal of Experimental Medicine @jem.org · Sep 5

Cheng, Qiu et al @jhu.edu provide new insights into the molecular mechanism of #phagosome maturation and the dynamics of host defense response following phagosome-mediated bacterial degradation in peritoneal #macrophages. rupress.org/jem/article/...

#InnateImmunity #inflammation #InfectiousDisease

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Reposted by Pablo Pelegrin

Dr Rebecca Coll @colllab.bsky.social · Sep 2

So excited that this study is now online! It's been a pleasure to work with BioAge Labs and our collaborators on this story. We characterise a new class of #NLRP3 inhibitors with translational potential for so many inflammatory diseases.

Journal of Experimental Medicine @jem.org · Sep 2

#NLRP3 is a target for antiinflammatory therapies & can be inhibited by the tool compound MCC950. Wilhelmsen, @colllab.bsky.social et al characterize new small-molecule inhibitors, BAL-0028 & BAL-0598, that have a distinct mechanism of action & binding site. rupress.org/jem/article/...
#Inflammasome

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Reposted by Pablo Pelegrin

Journal of Experimental Medicine @jem.org · Sep 2

#NLRP3 is a target for antiinflammatory therapies & can be inhibited by the tool compound MCC950. Wilhelmsen, @colllab.bsky.social et al characterize new small-molecule inhibitors, BAL-0028 & BAL-0598, that have a distinct mechanism of action & binding site. rupress.org/jem/article/...
#Inflammasome

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Reposted by Pablo Pelegrin

Waggoner Lab @labwaggoner.bsky.social · Aug 18

Review @natimmunol.nature.com
The expanding role of the NLRP3 inflammasome from periodic fevers to therapeutic targets
www.nature.com/articles/s41...

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Reposted by Pablo Pelegrin

Ivan Zanoni @lozanzi.bsky.social · Aug 21

#InterferonPower! Thrilled for our latest work @cp-cell.bsky.social! With @danielboehmer.bsky.social, we dug into tons of papers & created what we hope will be a go-to resource for immunologists & non-immunologist about type I, II, III (& IV😉) #interferons! Free👉 authors.elsevier.com/a/1leKGL7PXu...

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Reposted by Pablo Pelegrin

Malvina Pizzuto @malvinapiz.bsky.social · Jul 23

🚨It’s out @embojournal.org 🚨
Cardiolipin inhibits Caspase-4/11!
Huge thanks to my brilliant supervisors Kate & Pablo, to @s-burgener.bsky.social & Mercedes and all the @inflammasomelab.bsky.social, it was a joy working and laughing with you, and to @brozlab.bsky.social & Si Ming lab.

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Reposted by Pablo Pelegrin

Inflammasome Lab @inflammasomelab.bsky.social · Dec 9

Have you ever wondered whether pyroptotic corpses have functions beyond the grave? We made the surprising discovery that pyroptotic corpses are flagged by #filopodia to alert #DendriticCells they need autopsy. A short Bluetorial (1/13)👇with movies!
Link: rdcu.be/d2mjm

Pyroptotic cell corpses are crowned with F-actin-rich filopodia that engage CLEC9A signaling in incoming dendritic cells

Nature Immunology - Pyroptotic cell death results in inflammation. Here the authors find that F-actin-rich structures formed during macrophage pyroptosis persist after cell death to activate...

rdcu.be

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