So happy to share our paper on the role of the hippocampus as a mismatch detector:
doi.org/10.1073/pnas...

We show that the hippocampus detects mismatches between ongoing experiences and episodic memories but not generalised schematic knowledge.

See 🧵for how we got here:
#neuroskyence #PsychSciSky

Now out in PNAS doi.org/10.1073/pnas...

New fMRI study shows the hippocampus signals mismatches only when our expectations are based on episodic memories — not general knowledge. Challenges theories of the hippocampus as a domain-general comparator. We also explore how brain networks respond to surprise: doi.org/10.1101/2025...

New CamCAN study led by @praykov.bsky.social used 11 different white matter (WM) measures to show that WM health is multidimensional: 4 latent MRI-derived factors explained 89% of WM variance, were predicted by vascular health, and predicted cognition: doi.org/10.1038/s415...

This work was done with Chris Bird @chrismbird.bsky.social & Jessica Daly who last year published a review on APOE effects on spatial memory doi.org/10.1016/j.co...

These results suggest that the APOE4 gene does not directly affect these parts of the brain, and changes may only be seen if adults start to develop Alzheimer’s disease.

Importantly, we showed that there were no differences between adults with/without the APOE4 gene. We focused on univariate and connectivity differences during event boundaries; But also examined full-movie/ whole brain functional connectivity and graph-theoretical measures like system-segregation.

Our lab and others have shown that the brain regions that are active when we watch movies overall with regions that are damaged by Alzheimer’s disease. In this study we used MRI brain imaging data collected from 425 people while they watched a short Alfred Hitchcock movie.

Apolipoprotein E e4 (APOE4) is a significant genetic risk factor for Alzheimer’s disease. However, it is not known whether there are differences in the brains of healthy adults who carrying the APOE4 gene.

We recently published a new paper investigating APOE effects in Cam-CAN @camcan-2010.bsky.social movie dataset. Examining various measures we failed to find any APOE effects in healthy individuals. You can read more about it in the paper doi.org/10.1177/2398... or the thread below

Would you like to learn Python to create experiments and do analyses? BUY OUR BOOK! www.routledge.com/products/978...

This is a new edition for Python 3, with #PsychoPy chapters by @hirstrj.bsky.social and @peircej.bsky.social from @psychopy.org

#cogneuro #psychology #Python #programming

Join us for another two weeks of Cognitive Neuroimaging Skills Training In Cambridge, #COGNESTIC, 16-27 September, 2024. We provide training in state-of-the-art methods for open neuroimaging analysis, focussing on MRI, fMRI and EEG/MEG.
www.mrc-cbu.cam.ac.uk/events/cogne...

Very excited that @akulsatish.bsky.social's MEG paper on spatial representations and theta/alpha is officially published in Hippocampus!

Theta and alpha oscillations in human hippocampus and medial parietal cortex support the formation of location-based representations

#neuroskyence #psychscisky

I'm elated to share my PhD keystone paper published
@PNAS
www.pnas.org/doi/10.1073/... I've poured my heart & soul into this project since 2016 (8 yrs!) & I'm happy to introduce the Effort Foraging Task to the world #CognitivePsychology #Motivation #Effort #Foraging #DecisionMaking 🧵

PhD funding alert! A second round of up to 4 School of UK + International Psychology studentships at Sussex this year - deadline 15th Feb.

Application FAQ: t.ly/ZLoEJ - contact potential supervisor/s first to check fit!

For my lab, episodic memory + ageing

#neuroskyence #cognition #psychscisky

Check out our new paper showing that functional system segregation in fMRI predicts fluid intelligence, but does not meditate the benefits midlife activities have on late life intelligence doi.org/10.1016/j.ne...

Now out in Cognitive Science! We use GPT-2 to show that Bayesian surprise, which tracks changes in the content and confidence of predictions, accounts for human event boundaries in a narrative better than surprisal, which only tracks the predicted probability of individual words tinyurl.com/kd9dpub8