Rachel 👩🏻🔬
@rachelbiology.bsky.social
UW Genome Sciences PhD candidate | point centromere evo & techdev | Dunham lab | she/her | opinions mine
Pinned
Rachel 👩🏻🔬
@rachelbiology.bsky.social
· Jun 13
Multiplex and multimodal mapping of variant effects in secreted proteins via MultiSTEP - Nature Structural & Molecular Biology
Multiplexed assays of variant effect can resolve clinical variants but are incompatible with secreted proteins. Here Popp et al. develop MultiSTEP, a generalizable surface-tethering method to assess v...
www.nature.com
I’m thrilled to share my first big paper is live on @nature.com SMB! I poured my heart into this project while I was a tech, and I’m so happy it’s out in the world now.
Plus, how often does someone get to say they published with their two best friends? 🎉
www.nature.com/articles/s41...
Plus, how often does someone get to say they published with their two best friends? 🎉
www.nature.com/articles/s41...
Reposted by Rachel 👩🏻🔬
The lab is looking to hire 2 new undergraduate researchers! You'll get to work on yeast experimental evolution & genomics. UW students only (and this link won't work for others, sorry). Work study students very welcome to apply! Pays the prevailing minimum wage. app.joinhandshake.com/emp/jobs/106...
Sign In | Handshake
app.joinhandshake.com
January 14, 2026 at 7:33 PM
The lab is looking to hire 2 new undergraduate researchers! You'll get to work on yeast experimental evolution & genomics. UW students only (and this link won't work for others, sorry). Work study students very welcome to apply! Pays the prevailing minimum wage. app.joinhandshake.com/emp/jobs/106...
Reposted by Rachel 👩🏻🔬
Mapping single-cell diploid chromatin fiber architectures using DAF-seq
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Mapping single-cell diploid chromatin fiber architectures using DAF-seq - Nature Biotechnology
Single-molecule chromatin fiber sequencing exposes single-cell-level heterogeneity in the chromatin architecture of individual regulatory elements.
www.nature.com
December 4, 2025 at 1:14 AM
Mapping single-cell diploid chromatin fiber architectures using DAF-seq
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Rachel 👩🏻🔬
Fun new preprint from the lab, headed up by two incredible undergraduate researchers: Using Experimental Evolution to Correct Mother-Daughter Separation Defects in Brewing Yeast. www.biorxiv.org/content/10.1...
Using Experimental Evolution to Correct Mother-Daughter Separation Defects in Brewing Yeast
The budding yeast, Saccharomyces cerevisiae, is the workhorse of the brewing industry. Brewers have domesticated a vast array of different strains with traits that complement the beers they wish to br...
www.biorxiv.org
November 26, 2025 at 8:18 PM
Fun new preprint from the lab, headed up by two incredible undergraduate researchers: Using Experimental Evolution to Correct Mother-Daughter Separation Defects in Brewing Yeast. www.biorxiv.org/content/10.1...
Reposted by Rachel 👩🏻🔬
Lab freezer defrost day
December 16, 2025 at 3:19 AM
Lab freezer defrost day
Reposted by Rachel 👩🏻🔬
Today, scientists know that genetics plays a role in many conditions and diseases. But back in the ’90s, geneticist Mary-Claire King was the first to link a gene to an inherited form of a common cancer.
A Trailblazing Geneticist Reflects On Her Life And Work
Dr. Mary-Claire King was the first to link a gene to hereditary cancer risk with the identification of BRCA1. She was just getting started.
buff.ly
September 19, 2025 at 6:12 PM
Today, scientists know that genetics plays a role in many conditions and diseases. But back in the ’90s, geneticist Mary-Claire King was the first to link a gene to an inherited form of a common cancer.
Reposted by Rachel 👩🏻🔬
It's been a long time coming but, my postdoc work characterizing thousands of variants in G6PD is now available! Many thanks to @maitreya.bsky.social @dougfowler.bsky.social @afrubin.bsky.social and their labs! www.biorxiv.org/content/10.1...
Functional evidence for G6PD variant classification from mutational scanning
G6PD deficiency is the most common enzyme deficiency worldwide, and increases the likelihood of adverse reactions to certain drugs and foods. Identifying people at risk is challenging, since most are ...
www.biorxiv.org
August 15, 2025 at 2:39 PM
It's been a long time coming but, my postdoc work characterizing thousands of variants in G6PD is now available! Many thanks to @maitreya.bsky.social @dougfowler.bsky.social @afrubin.bsky.social and their labs! www.biorxiv.org/content/10.1...
Reposted by Rachel 👩🏻🔬
Announcing the yEvo Mutation Browser, a Shiny app for visualizing and exploring sequencing data from experimental evolution and genetic screens. This is the latest from our @yevolab.bsky.social high school teaching & research project and led by my grad student Leah. www.biorxiv.org/content/10.1...
The yEvo Mutation Browser: Enhancing student understanding of experimental evolution and genomics through interactive data visualization
Experimental evolution is a powerful method for studying the relationship between genotype and phenotype by observing how populations genetically adapt to controlled selective pressures. In educationa...
www.biorxiv.org
July 22, 2025 at 12:53 PM
Announcing the yEvo Mutation Browser, a Shiny app for visualizing and exploring sequencing data from experimental evolution and genetic screens. This is the latest from our @yevolab.bsky.social high school teaching & research project and led by my grad student Leah. www.biorxiv.org/content/10.1...
Reposted by Rachel 👩🏻🔬
Welcome to our new lab members, postdoc Sarah (co with @kelleyharris.bsky.social) and grad students Zanny and Megan! Very exciting!
June 23, 2025 at 8:01 PM
Welcome to our new lab members, postdoc Sarah (co with @kelleyharris.bsky.social) and grad students Zanny and Megan! Very exciting!
I’m thrilled to share my first big paper is live on @nature.com SMB! I poured my heart into this project while I was a tech, and I’m so happy it’s out in the world now.
Plus, how often does someone get to say they published with their two best friends? 🎉
www.nature.com/articles/s41...
Plus, how often does someone get to say they published with their two best friends? 🎉
www.nature.com/articles/s41...
Multiplex and multimodal mapping of variant effects in secreted proteins via MultiSTEP - Nature Structural & Molecular Biology
Multiplexed assays of variant effect can resolve clinical variants but are incompatible with secreted proteins. Here Popp et al. develop MultiSTEP, a generalizable surface-tethering method to assess v...
www.nature.com
June 13, 2025 at 3:42 PM
I’m thrilled to share my first big paper is live on @nature.com SMB! I poured my heart into this project while I was a tech, and I’m so happy it’s out in the world now.
Plus, how often does someone get to say they published with their two best friends? 🎉
www.nature.com/articles/s41...
Plus, how often does someone get to say they published with their two best friends? 🎉
www.nature.com/articles/s41...
I passed my PhD program qualifying exam today! I am now a PhD candidate 🎉🧬
April 21, 2025 at 6:16 PM
I passed my PhD program qualifying exam today! I am now a PhD candidate 🎉🧬
Reposted by Rachel 👩🏻🔬
The Pacific Northwest Yeast Club is holding their annual meeting on June 20th, 2025 in beautiful Vancouver, Canada! There are only 100 spots and registration is open now: www.pnwyc.net
March 20, 2025 at 5:35 PM
The Pacific Northwest Yeast Club is holding their annual meeting on June 20th, 2025 in beautiful Vancouver, Canada! There are only 100 spots and registration is open now: www.pnwyc.net
Reposted by Rachel 👩🏻🔬
Congratulations to Abby McGee and Val Browning on being awarded NSF Fellowships, and to Matt Chaw, Marazzano Colon, Bria Metzger, Rachel Powell, and Catherine Sniezek on receiving honorable mention!
April 8, 2025 at 11:11 PM
Congratulations to Abby McGee and Val Browning on being awarded NSF Fellowships, and to Matt Chaw, Marazzano Colon, Bria Metzger, Rachel Powell, and Catherine Sniezek on receiving honorable mention!
I am feeling very proud and grateful to have been awarded an Honorable Mention for the 2025 NSF Graduate Research Fellowship Program!
While I didn’t receive the award itself, it is so validating to be recognized at a national level as a junior trainee. I am definitely celebrating this win 🌟
While I didn’t receive the award itself, it is so validating to be recognized at a national level as a junior trainee. I am definitely celebrating this win 🌟
April 8, 2025 at 1:41 PM
I am feeling very proud and grateful to have been awarded an Honorable Mention for the 2025 NSF Graduate Research Fellowship Program!
While I didn’t receive the award itself, it is so validating to be recognized at a national level as a junior trainee. I am definitely celebrating this win 🌟
While I didn’t receive the award itself, it is so validating to be recognized at a national level as a junior trainee. I am definitely celebrating this win 🌟
Check out our updated preprint for MultiSTEP and coagulation Factor IX! This work highlights my most substantial contributions from my tech days in @dougfowler.bsky.social's lab 🧬 www.biorxiv.org/content/10.1...
Multiplex, multimodal mapping of variant effects in secreted proteins
Despite widespread advances in DNA sequencing, the functional consequences of most genetic variants remain poorly understood. Multiplexed Assays of Variant Effect (MAVEs) can measure the function of v...
www.biorxiv.org
January 31, 2025 at 5:37 PM
Check out our updated preprint for MultiSTEP and coagulation Factor IX! This work highlights my most substantial contributions from my tech days in @dougfowler.bsky.social's lab 🧬 www.biorxiv.org/content/10.1...
Reposted by Rachel 👩🏻🔬
After 60 years, scientists finally know why ginger, calico, and tortoiseshell #cats look the way they do. scim.ag/3BpxRxY
Gene behind orange fur in cats found at last
After 60 years, scientists know why gingers, calicos, and tortoiseshells look the way they do
scim.ag
December 4, 2024 at 2:25 PM
After 60 years, scientists finally know why ginger, calico, and tortoiseshell #cats look the way they do. scim.ag/3BpxRxY
Reposted by Rachel 👩🏻🔬
I made a starter pack of folks affiliated with UW Genome Sciences (past and present)
go.bsky.app/L8RAbiJ
It's fairly sparse for now, so please let me know if you'd like to be added!
go.bsky.app/L8RAbiJ
It's fairly sparse for now, so please let me know if you'd like to be added!
UW Genome Sciences
Join the conversation
go.bsky.app
November 8, 2024 at 10:24 PM
I made a starter pack of folks affiliated with UW Genome Sciences (past and present)
go.bsky.app/L8RAbiJ
It's fairly sparse for now, so please let me know if you'd like to be added!
go.bsky.app/L8RAbiJ
It's fairly sparse for now, so please let me know if you'd like to be added!
Channeled my inner Ms. Frizzle today - spent the day doing 1:1 scientific writing & editing with high school students ✍🏻
October 15, 2024 at 8:52 PM
Channeled my inner Ms. Frizzle today - spent the day doing 1:1 scientific writing & editing with high school students ✍🏻
Thanks so much Zymo Research for the graduate student starter kit!! This isn’t sponsored - just super stoked about it 🙌🏻
September 25, 2024 at 11:45 PM
Thanks so much Zymo Research for the graduate student starter kit!! This isn’t sponsored - just super stoked about it 🙌🏻
Attending my conference ever today! 🧬 #pnwyc #pnwyc2024
July 26, 2024 at 7:04 PM
Attending my conference ever today! 🧬 #pnwyc #pnwyc2024
Take a look at the website I created for our lab! 🌐
Nice new lab website, thanks to grad student
@geneticswithrae.bsky.social! depts.washington.edu/dunhamlab/
@geneticswithrae.bsky.social! depts.washington.edu/dunhamlab/
The Dunham Lab
depts.washington.edu
July 19, 2024 at 9:08 PM
Take a look at the website I created for our lab! 🌐
Reposted by Rachel 👩🏻🔬
It's not every day that you get voted on by the UW Board of Regents and get a letter signed by the president and provost. Looks like I'm officially Chair! (effective July 1, which is why this article is from earlier this month) huddle.uwmedicine.org/maitreya-dun...
Maitreya Dunham Named Chair of the Department of Genome Sciences
Starting July 1, 2024.
huddle.uwmedicine.org
July 18, 2024 at 8:53 PM
It's not every day that you get voted on by the UW Board of Regents and get a letter signed by the president and provost. Looks like I'm officially Chair! (effective July 1, which is why this article is from earlier this month) huddle.uwmedicine.org/maitreya-dun...
Reposted by Rachel 👩🏻🔬
Two new students starting in the lab today! Welcome grad student Rachel and undergrad Elinor!
June 17, 2024 at 11:20 PM
Two new students starting in the lab today! Welcome grad student Rachel and undergrad Elinor!
Reposted by Rachel 👩🏻🔬
New @yevolab.bsky.social paper in G3 led by @reneegeck.bsky.social and featuring work from the classrooms of Tim Renz and Rebecca Brewer! Experimental evolution of S. cerevisiae for caffeine tolerance alters multidrug resistance and TOR signaling pathways academic.oup.com/g3journal/ar...
Experimental evolution of S. cerevisiae for caffeine tolerance alters multidrug resistance and TOR signaling pathways
Abstract. Caffeine is a natural compound that inhibits the major cellular signaling regulator TOR, leading to widespread effects including growth inhibitio
academic.oup.com
July 11, 2024 at 10:32 PM
New @yevolab.bsky.social paper in G3 led by @reneegeck.bsky.social and featuring work from the classrooms of Tim Renz and Rebecca Brewer! Experimental evolution of S. cerevisiae for caffeine tolerance alters multidrug resistance and TOR signaling pathways academic.oup.com/g3journal/ar...
I am thrilled to share that I will be joining @maitreya.bsky.social’s lab for my thesis work, starting in June! 🔬🧬
May 18, 2024 at 2:52 AM
I am thrilled to share that I will be joining @maitreya.bsky.social’s lab for my thesis work, starting in June! 🔬🧬