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Reposted by Régis Joulia

Caetano Reis e Sousa @reisesousalab.bsky.social · 6d

Applications for the Crick PhD programme now open. One studentship available in our lab, starting Autumn 2026. Apply!

The Francis Crick Institute @crick.ac.uk · 6d

Motivated graduates with backgrounds in biological or biomedical sciences, physics, chemistry, mathematics, engineering and/or computer science are invited to apply to our 4-year fully funded PhD programme.

Apply by 05 November 2025

www.crick.ac.uk/careers-and-...

PhD students

Our PhD programme attracts the brightest scientific minds and is an opportunity for talented people to embark on their career in biomedical research.

www.crick.ac.uk

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Régis Joulia @regisjoulia.bsky.social · 14d

🚨 We are #recruiting! 🚨My lab is looking for a highly motivated Research Technician to join us for the next 3 years.

👉 Apply via the link www.imperial.ac.uk/jobs/search-... or feel free to reach out for more information!

Description

Please note that job descriptions are not exhaustive, and you may be asked to take on additional duties that align with the key responsibilities ment...

www.imperial.ac.uk

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Reposted by Régis Joulia

Helen Stölting @helenisinthelab.bsky.social · 16d

New paper alert - congratulations, Franz & team 🥳

Epithelial cell-derived lumican modulates extracellular matrix dynamics in early-life airways disease - Journal of Allergy and Clinical Immunology www.jacionline.org/article/S009...

Epithelial cell-derived lumican modulates extracellular matrix dynamics in early-life airways disease

www.jacionline.org

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Reposted by Régis Joulia

Adrian Liston @labliston.bsky.social · 19d

For our #flowcytometry peeps, would you like to have a single fix/perm protocol that is optimised for everything? One that preserves fluorophores while allowing simultaneous TF and cytokine staining? How about 100-fold cheaper?

You got it:
currentprotocols.onlinelibrary.wiley.com/doi/10.1002/...

currentprotocols.onlinelibrary.wiley.com

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Reposted by Régis Joulia

Medicine at Cambridge @medcambridge.bsky.social · 23d

📢 Meet #BSICambridge25 speaker: @regisjoulia.bsky.social

Dr Régis Joulia, @wellcometrust.bsky.social -funded Group Leader @imperialnhli.bsky.social, will be speaking on mast cells in the lungs at the 2025 Cambridge Immunology Forum.

🎟️ Register now: buff.ly/jhoEQJ0

@britsocimm.bsky.social

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Reposted by Régis Joulia

NHLI @imperialnhli.bsky.social · Aug 4

NHLI's Joulia Lab made a short animation explaining what goes wrong in the lungs during asthma! 🫁📽️

Check out how immune cells respond to threats & how asthma treatments work. With thanks to
Wellcome Trust & Acteria

Watch it here: youtu.be/Skp_CNWOYSA

What is happening at the lung wall during immune response and what goes wrong in asthma?

YouTube video by Imperial NHLI

youtu.be

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Régis Joulia @regisjoulia.bsky.social · Aug 4

We made a short animation explaining what goes wrong in the lungs during asthma! 🫁🎬 Designed for the public, students & patients—check out how immune cells respond to threats & how asthma treatments work.

Big thanks to @WellcomeTrust & Acteria!

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Régis Joulia @regisjoulia.bsky.social · Jul 22

🎉 Exciting news! I’ve recently been elected to the @britsocimm.bsky.social Congress Committee and to the Board of the @societymucosalimm.bsky.social (SMI) representing the voices of ECRs! Looking forward to working with these fantastic scientific organisations.

www.immunology.org/news/new-bsi...

New BSI committee members 2025 | British Society for Immunology

www.immunology.org

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Reposted by Régis Joulia

Axel Montagne @axelmontagne.bsky.social · Jul 22

🚨 Review Alert

*Walking on the tightrope: the shared roles of the bridging pericytes in the brain*

Congratulations Audrey Chagnot!! 🥳

Bias aside, this feels like a really meaningful piece for the cerebrovascular field! 😊

www.frontiersin.org/journals/cel...

Frontiers | Walking on the tightrope: the shared roles of the bridging pericytes in the brain

The vasculature of the central nervous system (CNS) is a highly specialized structure that delivers oxygen and nutrients to energy-demanding neural cells whi...

www.frontiersin.org

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Reposted by Régis Joulia

Iannacone Lab @iannaconelab.bsky.social · Jun 30

1/ 🚨 Hot off the press in Nature Immunology: CD4⁺ T cells can license Kupffer cells to rescue dysfunctional CD8⁺ T cells in the liver. Hepatitis B virus (HBV) infection is just the proving ground—this is a paradigm shift in tissue immunity. www.nature.com/articles/s41... 🧵(1/11)

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Reposted by Régis Joulia

Madhvi Menon @madhvimenon.bsky.social · Jun 20

🚨 The Menon lab is hiring a postdoc!

Interested in mucosal immunology? Come join our team to study lung-infiltrating B cell dynamics in COPD & other chronic lung diseases
@ukri.org @lydiabeckeriii.bsky.social

Please help spread the word #ImmunoSky

www.jobs.manchester.ac.uk/Job/JobDetai...

Research Associate in Mucosal Immunology :Manchester

www.jobs.manchester.ac.uk

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Reposted by Régis Joulia

Pallett Lab UCL @pallettlab.bsky.social · Jun 17

#Immunologists - have you signed up for BSI's @london-immuno.bsky.social 1d conference yet?
Fri 11th July

Speakers include: Jan Böttcher, Tao Dong, @labliston.bsky.social, @beecell.bsky.social, Claudia Mauri & Claire Malone

REPOST to share as widely as poss

www.immunology.org/events/diver...

Diversity in immunology | British Society for Immunology

www.immunology.org

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Reposted by Régis Joulia

EVBO @evborg.bsky.social · Jun 13

#EVBOSeminarSeries Moderated by Joanna Kalucka. Speakers: Ralf Adams and Mariona Graupera. ⏰When: Wednesday, 18th June 2025, 3PM EU time (2PM UK). Place: online. See you there! For registration evbo.org

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Reposted by Régis Joulia

natimmunol.nature.com @natimmunol.nature.com · Jun 3

Joulia et al use single cell spatial transcriptomics to profile the lung in health and during asthma and identify discrete proinflammatory spatial niches that produce alarmins and chemokines. Read it here: rdcu.be/epjN7
www.nature.com/articles/s41...

A single-cell spatial chart of the airway wall reveals proinflammatory cellular ecosystems and their interactions in health and asthma

Nature Immunology - Here, the authors use single-cell spatial transcriptomics to profile the airway wall landscape in health and during asthma. Discrete proinflammatory ecosystems containing...

rdcu.be

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Reposted by Régis Joulia

Bryan Yipp @bryanyipp.bsky.social · May 30

Our latest work on how nerves safeguard lung fibrosis. Congrats to Dr. Hiroki and collaborators. @cp-immunity.bsky.social @kavithascranton.bsky.social @hotchkissbrain.bsky.social @ucalgary.bsky.social @ucalgarymed.bsky.social @libininstitute.bsky.social

www.cell.com/immunity/abs...

Nociceptor neurons suppress alveolar macrophage-induced Siglec-F+ neutrophil-mediated inflammation to protect against pulmonary fibrosis

Sensory innervation impacts several lung diseases, but whether it influences pulmonary fibrosis (PF) is unclear. Hiroki et al. report that depletion of TRPV1+ nociceptors leads to worsening of inflamm...

www.cell.com

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Régis Joulia @regisjoulia.bsky.social · May 28

Our recent Nature Immunology paper is featured in the latest Nature Research Briefing, offering more context and our perspective on the findings and the power of spatial transcriptomics.

www.nature.com/articles/s41...

Location matters: defining the architecture of the bronchial wall in health and asthma - Nature Immunology

Using spatial single-cell transcriptomics of human lung biopsies, we mapped cellular interactions at the airway wall in health and asthma. We identified specialized cellular communities marked by high...

www.nature.com

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Reposted by Régis Joulia

NHLI @imperialnhli.bsky.social · May 23

Our researchers have created the first high-res map of the lung airway wall, revealing how cell organisation & interactions are disrupted in asthma 🫁

Published in @natimmunol.nature.com, it's a key step towards understanding the mechanisms that drive the disease

www.imperial.ac.uk/news/264294/...

Pioneering spatial map of the airways could transform understanding of asthma | Imperial News | Imperial College London

Researchers have identified distinct differences in the spatial organisation of cells in the airway of healthy people and those with asthma.

www.imperial.ac.uk

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Reposted by Régis Joulia

John Tregoning @prof-tregoning.bsky.social · May 22

We have a funded PhD studentship on RSV antibodies working with RQ bio, deadline June 30

www.imperial.ac.uk/medicine/stu...

MRC MultiSci iCASE Studentships

MRC MultiSci iCASE Studentships enable graduates with excellent honours degrees to undertake a three and a half year training programme, which includ...

www.imperial.ac.uk

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Régis Joulia @regisjoulia.bsky.social · May 21

#SpatialBiology #Asthma #MastCells #Transcriptomics #LungImmunology #ImperialCollegeLondon

@britsocimm.bsky.social @natrevimmunol.nature.com @imperialnhli.bsky.social @10xgenomics.bsky.social @brukerspatial.bsky.social @nature.com @societymucosalimm.bsky.social @asthmaandlung.org.uk

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Régis Joulia @regisjoulia.bsky.social · May 21

👉 What’s next? We’re diving deeper into the makeup and function of these ecosystems, exploring how treatments—and other lung diseases—reshape them.

Huge thanks to our funders @wellcometrust.bsky.social , @BHF CRE, @ACTERIA and @BRCimperial

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Régis Joulia @regisjoulia.bsky.social · May 21

🧪 How’s this regulated? Mast cells play a starring role—expressing proteases, amphiregulin, and more. We also found a unique endothelial cell subpopulation expressing ACKR1, which may help retain chemokines locally and structure these immune hubs.

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Régis Joulia @regisjoulia.bsky.social · May 21

🔬 In asthma lungs, the landscape shifts: chemokine and alarmin expression drops, but cells are packed more tightly together, forming larger, altered ecosystems. Multiple stromal cell profiles are disrupted, creating a very different immune environment.

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Régis Joulia @regisjoulia.bsky.social · May 21

What did we discover? Using single-cell spatial transcriptomics on human lung biopsies, we identified distinct "cellular ecosystems"—specialised microenvironments packed with inflammatory potential. We mapped out which cells produce key chemokines and alarmins, and how tightly they interact.

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Régis Joulia @regisjoulia.bsky.social · May 21

🚨 We did it! Our latest work—led by my lab and the @lloydlab.bsky.social is now published in Nature Immunology! 🎉

Using single-cell spatial transcriptomics, we provide the first map of the airway wall.

🔗 www.nature.com/articles/s41...

#spatialbiology #asthma #mastcells #lungimmunology

A single-cell spatial chart of the airway wall reveals proinflammatory cellular ecosystems and their interactions in health and asthma - Nature Immunology

Here, the authors use single-cell spatial transcriptomics to profile the airway wall landscape in health and during asthma. Discrete proinflammatory ecosystems containing alarmins, chemokines and a un...

www.nature.com

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Reposted by Régis Joulia

Guillaume Jacquemet @guijacquemet.bsky.social · Apr 7

Here we share our opinions on "Practical considerations for data exploration in quantitative cell biology"
journals.biologists.com/jcs/article/...

Joanna, Hanna and I worked quite a bit on this piece and I hope you find it useful
Many thanks to @jcellsci.bsky.social for publishing it

Practical considerations for data exploration in quantitative cell biology

Summary: We present practical guidelines for data exploration in quantitative cell biology that are designed to help yield reliable conclusions and promote a collaborative, transparent approach to dat...

journals.biologists.com

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