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Rob van Montfort @robvanmontfort.bsky.social · Jun 30

Thank you for a great day with us @icr.ac.uk and wonderful drug discovery talk @hartungingo.bsky.social!

Rossanese Lab @temt-icr.bsky.social · Jun 30

Great day & night discussing how to design impactful drugs 💊 with @hartungingo.bsky.social!
Thanks for a great talk and lively discussion with @agako7.bsky.social, @robvanmontfort.bsky.social, Zoran Rankovich & the ICR Centre for Protein Degradation! Cheers 🍻!

Five people at a restaurant table, looking in to the camera and smiling.

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Agnieszka Konopacka @agako7.bsky.social · May 13

Agnieszka Konopacka @agako7.bsky.social · Mar 8

🌟🌟🌟 Join our cancer drug discovery team in London-Sutton! 🌟🌟🌟
We’re looking for a passionate biologist eager to drive innovation in targeted protein degradation and cancer drug discovery. If you’re seeking to make a real impact, we would love to hear from you! #CancerResearch #DrugDiscovery
#ICR

ICR Centre for Protein Degradation on LinkedIn: Higher Scientific Officer - Drug Discovery Biology, Centre for Protein…

🤝 Are you passionate about Targeted Protein Degradation and want to join us on our mission to make the discoveries that defeat cancer? Dr Agnieszka…

www.linkedin.com

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Rob van Montfort @robvanmontfort.bsky.social · May 2

A nice blog about the acoustic dispensing robotics used in cancer drug discovery @icr.ac.uk. A big thank you to Mark Stubbs and Caroline Ewens for explaining it all! www.icr.ac.uk/research-and...

How advances in technology are speeding up the discovery of new cancer drugs

www.icr.ac.uk

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The Institute of Cancer Research @icr.ac.uk · Apr 11

NEWS: NICE has recommended capivasertib for advanced #BreastCancer.

The decision makes the targeted drug available, in combination with fulvestrant, for some NHS patients with the most common type of breast cancer.

Read more about the history of the drug⬇️
www.icr.ac.uk/about-us/icr...

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Rob van Montfort @robvanmontfort.bsky.social · Mar 29

Fondly remember Jan for his enthusiasm, rigorous science, and the kind person that he was.

Structural Biology @actacrystd.iucr.org · Mar 29

Bauke W. Dijkstra et al.: Jan Drenth (1925–2025) @univgroningen...##IUCrhttps://journals.iucr.org/paper?S205979832500275X

Jan Drenth (1925–2025)

Jan Drenth is remembered.

journals.iucr.org

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Rob van Montfort @robvanmontfort.bsky.social · Mar 20

The Centre for Cancer Drug Discovery @icr.ac.uk looking fantastic in today's evening sun

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Peter Kenny @pwk2024.bsky.social · Mar 20

Sharp et al (2024) Integrating fragment-based screening with targeted protein degradation and genetic rescue to explore eIF4E function. Nat Commun 15 10037 #TPD #FBDD #FBLD #MedChem #DrugDesign #DrugDiscovery #OpenAccess #chemsky 🧪
doi.org/10.1038/s414...

Integrating fragment-based screening with targeted protein degradation and genetic rescue to explore eIF4E function - Nature Communications

A structure-guided fragment screen identified a compound, which interacts with a ligand-binding site of unknown function in eukaryotic initiation factor 4E (eIF4E). X-ray crystallography was used...

doi.org

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The Institute of Cancer Research @icr.ac.uk · Mar 8

Today is #InternationalWomensDay 👏

We are incredibly proud to celebrate the women of the ICR who are dedicated, driven, and determined to make a difference.

You inspire us every day 👩‍🔬👩‍💻👩‍💼

#IWD2025 #AccelerateAction

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Titia Sixma @titiasixma.bsky.social · Feb 20

Today Jan Drenth would have been 100 years, but sadly he passed away last week.
He was the founding father of structural biology in the Netherlands and his modesty, his gentle humor and his generosity set the spirit for the amazing environment in Groningen where i did my PhD.

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The Institute of Cancer Research @icr.ac.uk · Feb 21

It's #InternationalMotherLanguageDay 🌍

We're proud of our diverse community who are dedicated to defeating cancer.

Our staff and students from across the globe come from a variety of backgrounds and cultures, and speak different languages, but are united by one mission ♥️

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Rob van Montfort @robvanmontfort.bsky.social · Feb 21

We are recruiting a Higher Scientific Officer experienced in recombinant protein production and assay development to join an exciting collaboration to develop novel small molecule-controlled molecular switches to modulate CAR-T cell activity.
jobs.icr.ac.uk/vacancies/11...

Higher Scientific Officer - Protein production, purification and assay specialist in Sutton | The Institute of Cancer Research

View details and apply for this Higher Scientific Officer - Protein production, purification and assay specialist vacancy in Sutton. Salary : Commencement on the salary range is subject ...

jobs.icr.ac.uk

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Rob van Montfort @robvanmontfort.bsky.social · Feb 21

Are you interested to work in cancer drug discovery? Come and join us, we are recruiting a protein crystallographer to strengthen our structure-based drug discovery efforts.
jobs.icr.ac.uk/vacancies/11...

Postdoctoral Training Fellow – X-Ray Crystallography in Sutton | The Institute of Cancer Research

View details and apply for this Postdoctoral Training Fellow – X-Ray Crystallography vacancy in Sutton. Salary: Dependent on relevant Postdoctoral experience. Future progression is base...

jobs.icr.ac.uk

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The Institute of Cancer Research @icr.ac.uk · Feb 15

📰 Prof Paul Workman, our former CEO, along with his team in our Centre for Cancer Drug Discovery, have made a breakthrough that could lead to new drugs for #chordoma — a rare #BoneCancer that led to the death of his mother.

Read more in @theguardian.com ⤵️

www.theguardian.com/science/2025...

British professor makes ‘thrilling’ breakthrough for cancer that killed his mother

Paul Workman has researched untreatable chordoma for years. Now new technology points towards to a potential drug to beat it

www.theguardian.com

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Stephen Curry @scurry.bsky.social · Feb 12

Now over 900 signatures. Please keep signing and sharing to send a clear message to the Royal Society that we want them to stand up for values that we all hold dear: docs.google.com/forms/d/e/1F...

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The Institute of Cancer Research @icr.ac.uk · Feb 11

On International Day of Women and Girls in Science, we're celebrating our awe-inspiring women helping to defeat cancer 👩‍🔬👏

Hear from Professor Ros Eeles, Professor Helen McNair
(The Royal Marsden NHS) and ICR PhD students Clara, Nivetha, and Anna about what #IDWGS means to them ⬇️

#WomenInScience

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Reposted by Rob van Montfort

The Institute of Cancer Research @icr.ac.uk · Feb 10

We’re delighted that The Scottish Medicines Consortium (SMC) has today recommended olaparib for use in advanced #BreastCancer.

The treatment offers the chance of longer, healthier lives for people with breast cancer caused by faulty #BRCA1 or #BRCA2 genes.

scottishmedicines.org.uk/about-us/lat...

February 2025 decisions news release

scottishmedicines.org.uk

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Sjors Scheres @sjorsscheres.bsky.social · Feb 7

Will these tools further exacerbate biases in the literature: if the opinion of those who write many papers gets fed into their training more than the opinion of those who write sparingly?

Scientists should use their precious time to do good science, not to write many papers...

Nature @nature.com · Feb 6

Many scientists who have tried OpenAI's 'deep research' tool are impressed with its ability to write literature reviews or full review papers and even identify gaps in knowledge. But others are less enthusiastic.

https://go.nature.com/4gu9uOo

OpenAI’s ‘deep research’ tool: is it useful for scientists?

The model produces cited, pages-long reports that might be helpful for generating literature reviews.

go.nature.com

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Reposted by Rob van Montfort

Derek Lowe @dereklowe.bsky.social · Feb 5

I’ve unfortunately needed to add more material to my post from yesterday. The re-election of Donald Trump is looking like the biggest act of American self-destruction since the Civil War.

Same link, new title and some updates.

Revised and Extended: What's Happening Inside the NIH and NSF

www.science.org

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Luke Taylor MP @luketaylorld.bsky.social · Jan 27

ICYMI

The Institute of Cancer Research have made amazing inroads in treating advanced prostate cancer with the new NXP800 drug.

So proud to represent the Institute - they embody the ambition and pursuit of pragmatic hope that Sutton, and the whole country, really needs.

Drug breakthrough offers hope for advanced prostate cancer patients

Research suggests a new drug slowed the growth of prostate cancer cells, including those with a resistance to the hormone therapy enzalutamide.

buff.ly

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Rob van Montfort @robvanmontfort.bsky.social · Jan 31

Looking forward to speak at the 2nd Biophysics for Drug Discovery Summit (ter.li/39kb11) about the integrated biophysical approaches used in our BCL6 project. Collaborative drug discovery with Swen Hoelder, @chemb.bsky.social and @temt-icr.bsky.social at @icrlondon.bsky.social.

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Rob van Montfort @robvanmontfort.bsky.social · Jan 23

We have a vacancy in assay development, compound profiling, and screening to help progress the cancer drug discovery projects of the Centre for Cancer Drug Discovery @icrlondon.bsky.social. If you are interested please check out the details below.
jobs.icr.ac.uk/vacancies/11...

Higher Scientific Officer - Assay development and compound profiling in Sutton | The Institute of Cancer Research

View details and apply for this Higher Scientific Officer - Assay development and compound profiling vacancy in Sutton. Salary : Commencement on the salary range is subject to comparable skil...

jobs.icr.ac.uk

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Rob van Montfort @robvanmontfort.bsky.social · Jan 22

If you are interested in a PhD studentship in chemical biology linked to brain cancer in children, check out the position Gary Newton and myself have available. @icrlondon.bsky.social. www.icr.ac.uk/study-and-ca...

Targeting SRC in G4-Medulloblastoma

OPEN: Targeting SRC in G4-Medulloblastoma

www.icr.ac.uk

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Rob van Montfort @robvanmontfort.bsky.social · Jan 3

Beautiful and frosty morning @icrlondon.bsky.social today.

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Ben Bellenie @chemb.bsky.social · Dec 20

@cancerresearchuk.org Windsor Fellowship and Black in Cancer funded PhD place at @icrlondon.bsky.social and @imperialcollegeldn.bsky.social

Aimed at students from Black heritage background who want to pursue a career in cancer research : www.findaphd.com/phds/project... (1/2)

Design of advanced therapeutics against metastasis at Institute of Cancer Research on FindAPhD.com

PhD Project - Design of advanced therapeutics against metastasis at Institute of Cancer Research, listed on FindAPhD.com

www.findaphd.com

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The Institute of Cancer Research @icr.ac.uk · Dec 16

🆕 We're getting in on the act with an ICR research #StarterPack. Check it out! ⤵️

Let us know if you're a #cancer researcher at the ICR and The Royal Marsden but not in the pack. 💬
#CancerResearch #CanSky #OncSky

go.bsky.app/EGXU5V1

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