Titia Sixma
@titiasixma.bsky.social
1.9K followers
250 following
10 posts
Structural biologist and biochemist, interested in ubiquitin enzymes and DNA repair & regulation
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Titia Sixma
@titiasixma.bsky.social
· Jul 31
Niels Keijzer
@nkeijzer.bsky.social
· Jul 31
USP1/UAF1 targets polyubiquitinated PCNA with an exo-cleavage mechanism that can temporarily enrich for monoubiquitinated PCNA - Nature Communications
DNA damage tolerance is regulated by ubiquitination of PCNA. Here, the authors present kinetic and structural studies showing that USP1/UAF1 prefers trimming K63- and K48-ubiquitin chains down over cl...
doi.org
Reposted by Titia Sixma
Reposted by Titia Sixma
Reposted by Titia Sixma
Reposted by Titia Sixma
Reposted by Titia Sixma
Barack Obama
@barackobama.bsky.social
· Apr 15
Reposted by Titia Sixma
Reposted by Titia Sixma
Yasin Dagdas
@plantophagy.bsky.social
· Apr 3
Doctor Behind Award-Winning Parkinson’s Research Among Scientists Purged From NIH
Leading scientists at the National Institutes of Health, the US’s leading medical research agency, were swept up Tuesday in the Trump administration’s latest firing blitz.
www.wired.com
Reposted by Titia Sixma
Reposted by Titia Sixma
Titia Sixma
@titiasixma.bsky.social
· Mar 21
Titia Sixma
@titiasixma.bsky.social
· Mar 17
Titia Sixma
@titiasixma.bsky.social
· Feb 20
Reposted by Titia Sixma
Dominique Baker
@bakerdphd.bsky.social
· Jan 30
Reposted by Titia Sixma
Reposted by Titia Sixma
Titia Sixma
@titiasixma.bsky.social
· Jan 8
Titia Sixma
@titiasixma.bsky.social
· Dec 16
Titia Sixma
@titiasixma.bsky.social
· Dec 17
Niels Keijzer
@nkeijzer.bsky.social
· Dec 17
USP1/UAF1 targets polyubiquitinated PCNA with an exo-cleavage mechanism that enriches for monoubiquitinated PCNA
DNA damage tolerance (DDT) is an important pathway that allows our cells to bypass DNA lesions during replication. DDT is orchestrated by ubiquitination of PCNA: Monoubiquitination (PCNA-Ub) initiates...
www.biorxiv.org
Titia Sixma
@titiasixma.bsky.social
· Dec 16