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Reposted by Rossanese Lab

Ingo Hartung @hartungingo.bsky.social · Jul 1

Great visit to our longstanding collaboration partners at the ICR discussing how small molecules continue to generate clinical impact. Learned a lot about how Zoran and his team tackle glue degrader discovery to deliver on the promise of expanding the druggable space.

Rossanese Lab @temt-icr.bsky.social · Jun 30

Great day & night discussing how to design impactful drugs 💊 with @hartungingo.bsky.social!
Thanks for a great talk and lively discussion with @agako7.bsky.social, @robvanmontfort.bsky.social, Zoran Rankovich & the ICR Centre for Protein Degradation! Cheers 🍻!

Five people at a restaurant table, looking in to the camera and smiling.

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Reposted by Rossanese Lab

Agnieszka Konopacka @agako7.bsky.social · Jun 30

Unfinished Symphony
@icr.ac.uk @temt-icr.bsky.social

youtu.be/yjelh9iQWMA?...

ICR - The Unfinished Symphony

YouTube video by ukjoncollins

youtu.be

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Reposted by Rossanese Lab

Milka Kostic @milkakostic.bsky.social · Jun 30

We are looking to hire an Assistant/Associate Professor interested in creating an innovative (and exciting) program of research in chemical biology, medicinal chemistry, ML/AI, drug discovery - all in the context of cancer biology!
careers.dana-farber.org/job/11813/as...

Faculty/Health Educator Job: Assistant/Associate Professor, Chemical Biology at Dana-Farber Cancer Institute in 450 Brookline Ave, Boston, MA

Assistant/Associate Professor, Chemical Biology job

careers.dana-farber.org

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Rossanese Lab @temt-icr.bsky.social · Jun 30

Great day & night discussing how to design impactful drugs 💊 with @hartungingo.bsky.social!
Thanks for a great talk and lively discussion with @agako7.bsky.social, @robvanmontfort.bsky.social, Zoran Rankovich & the ICR Centre for Protein Degradation! Cheers 🍻!

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Reposted by Rossanese Lab

Alexis Barr @alexisbarr.bsky.social · Jun 3

11. The Authority Gap by Mary Ann Sieghart.

Non-fiction this time & a book that everyone should read. At times, left me angry & upset with what some women have gone through. Ends on very practical ways to narrow the gap

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Rossanese Lab @temt-icr.bsky.social · Jun 2

The timing on this is perfect 👌 as the #TEMTiversary merch arrived today! We are branded 🧬 💊!!

A black T-shirt, white coffee mug, and some white stickers with our lab TMET logos on them.

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Reposted by Rossanese Lab

Unofficial BBCNews (UK) Bot @bbcnews-uk-rss.bsky.social · Jun 1

Capivasertib given to breast cancer patients in Wales for first time

Gwen Buchan, 62, says capivasertib will allow her to see her son's wedding and offers her "hope".

www.bbc.com

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Rossanese Lab @temt-icr.bsky.social · Jun 2

LOL

Rossanese Lab @temt-icr.bsky.social · Jun 2

Does it have a swear word in it?

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Rossanese Lab @temt-icr.bsky.social · Jun 2

Official one here 👇 (only took us 10 years…)

Rossanese Lab @temt-icr.bsky.social · Jun 2

Decided to celebrate lab anniversary by reenergising our social media & sharing lab highlights every day in June…and forgot on the very 1st day 🫠
Anyway, it’s our 10th anniversary & we’ve got a new official (see bio) and unofficial logo 🎉; the latter has a story, b/c of course it does… #TEMTiversary

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ICR_DDU_IIT @icrdduiit.bsky.social · May 20

Happy #InternationalClinicalTrialsDay! 🎉
At DDU-IIT @icr.ac.uk , we’re proud to help turn cutting-edge science into real-world impact. 🔬🌍
To the patients, families & teams behind every trial—your courage fuels the future of medicine. ❤️‍🔥
#ClinicalTrialsDay #ICR #RoyalMarsden #ResearchMatters#ACRP

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Rossanese Lab @temt-icr.bsky.social · May 21

In June, we are having 5-yr external scientific review & the lab celebrates 10-yr anniversary 🎉! Both good things, but prep has me reflecting…a lot. My time at the ICR is almost perfectly bisected by the pandemic & the two halves feel like different life times. Literally The Before Times™️ & After.

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Reposted by Rossanese Lab

Rob van Montfort @robvanmontfort.bsky.social · May 2

A nice blog about the acoustic dispensing robotics used in cancer drug discovery @icr.ac.uk. A big thank you to Mark Stubbs and Caroline Ewens for explaining it all! www.icr.ac.uk/research-and...

How advances in technology are speeding up the discovery of new cancer drugs

www.icr.ac.uk

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Reposted by Rossanese Lab

Cancer Research UK @cancerresearchuk.org · Apr 26

Get up to speed with the cancer dormancy field.

Clare Isacke chairs the session and opens the discussion with the latest on breast cancer dormancy and regulation by the metastatic microenvironment.

#AACR2025 | @icr.ac.uk

A graphic with a photo of Clare Isacke smiling to camera. The text reads: #AACR25 Educational Session: Clare Isacke. The Institute of Cancer Research.

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Reposted by Rossanese Lab

Peter Kenny @pwk2024.bsky.social · Mar 20

Sharp et al (2024) Integrating fragment-based screening with targeted protein degradation and genetic rescue to explore eIF4E function. Nat Commun 15 10037 #TPD #FBDD #FBLD #MedChem #DrugDesign #DrugDiscovery #OpenAccess #chemsky 🧪
doi.org/10.1038/s414...

Integrating fragment-based screening with targeted protein degradation and genetic rescue to explore eIF4E function - Nature Communications

A structure-guided fragment screen identified a compound, which interacts with a ligand-binding site of unknown function in eukaryotic initiation factor 4E (eIF4E). X-ray crystallography was used...

doi.org

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Reposted by Rossanese Lab

The Downs Lab @thedownslab.bsky.social · Mar 19

Hey, look at this story that our @postdockatie.bsky.social wrote! magazine.eacr.org/nobel-prize-...

Nobel prize-winning technology in cancer care - The Cancer Researcher

Katalin Karikó's work into mRNA vaccines

magazine.eacr.org

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Reposted by Rossanese Lab

Human Technopole @humantechnopole.bsky.social · Mar 19

💡 Thinking about a PhD?

✨ Join us on 15 April for the #PhD Open Day at Human Technopole! Explore cutting-edge research, meet our Group Leaders, and discover training opportunities in an international, dynamic environment.

Register now 👉 humantechnopole.it/en/trainings... #phdlife

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Reposted by Rossanese Lab

Rossanese Lab @temt-icr.bsky.social · Mar 18

🚨We’re recruiting!🚨
Looking directly at my oncology drug discovery biology folks 👀
3️⃣ faculty-level biology posts, including leadership in drug discovery & target validation.
Drug discovery experience a must, industry experience valued, you’ve gotta be in London.
ICR.ac.uk/CCDDjobs for info/contact

Recruitment brochure featuring a picture of our Centre for Cancer Drug Discovery and the same web address from the main post.

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Reposted by Rossanese Lab

Society for Medicines Research @socmedres.bsky.social · Mar 17

📣 Last chance to register! The 2nd SMR Molecular Glues Meeting - 21st March 2025 🚀🚀🚀

🌟 World-class Speakers
🌟 Cutting-edge Insights
🌟 Networking Opportunities

📅 Date: 21st March 2025
📍 Location: GSK Stevenage, UK
🔗 Register here: www.smr.org.uk/Meetings/202...

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Reposted by Rossanese Lab

Rob van Montfort @robvanmontfort.bsky.social · Jan 31

Looking forward to speak at the 2nd Biophysics for Drug Discovery Summit (ter.li/39kb11) about the integrated biophysical approaches used in our BCL6 project. Collaborative drug discovery with Swen Hoelder, @chemb.bsky.social and @temt-icr.bsky.social at @icrlondon.bsky.social.

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Rossanese Lab @temt-icr.bsky.social · Mar 18

🚨We’re recruiting!🚨
Looking directly at my oncology drug discovery biology folks 👀
3️⃣ faculty-level biology posts, including leadership in drug discovery & target validation.
Drug discovery experience a must, industry experience valued, you’ve gotta be in London.
ICR.ac.uk/CCDDjobs for info/contact

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Reposted by Rossanese Lab

The Institute of Cancer Research @icr.ac.uk · Mar 14

We were delighted to host Shadow Secretary of State for Science, Innovation & Technology, Alan Mak MP at our Chester Beatty Labs last week 👋

We introduced Alan to scientists working in our Division of Structural Biology and Division of Cell and Molecular Biology 🧵

#CancerResearch

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Rossanese Lab @temt-icr.bsky.social · Mar 14

Happy Pi Day ! Our lab has a long and frankly sit-com quality relationship with Pi Day due to the inevitable date confusion when I moved to the UK 🇬🇧. Yes, we also celebrate on 22 July as the closest fractional approximation of pi, why do you ask?
View from lab meeting this morning 🥧 ☕️ 📊

A large round (frankly English) apple pie. Two mugs of coffee and a knife sit next to it on a conference room table.

Reposted by Rossanese Lab

The Downs Lab @thedownslab.bsky.social · Mar 5

If you like chromatin remodellers and centromeres, this might be of interest. In it, we generated omics data from isogenic PBRM1 cell lines, which we hope is of use to the community, freely available (when evil forces aren't messing with the publicly funded websites 🙄) www.nature.com/articles/s41...

PBRM1 directs PBAF to pericentromeres and protects centromere integrity - Nature Communications

Centromere fragility can drive tumourigenesis, so protective mechanisms are important. Here, the authors suggest that the PBAF chromatin remodelling complex, which is frequently misregulated in cancer...

www.nature.com

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