Milka Kostic
@milkakostic.bsky.social
620 followers
720 following
12 posts
chemical biology enthusiast & strategist; I make impossible things possible - all before breakfast!
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Milka Kostic
@milkakostic.bsky.social
· Sep 3
Milka Kostic
@milkakostic.bsky.social
· Jun 6
Rapid clearance of achiral small-molecule drugs using de novo-designed proteins and their cyclic and mirror-image variants - Nature Biomedical Engineering
Cyclic and mirror-image variants of de novo-designed proteins effectively bind and clear small-molecule drugs in vivo in less than 30 min, highlighting the applicability of computational tools to prod...
www.nature.com
Reposted by Milka Kostic
Reposted by Milka Kostic
Ben Mudrak
@benmudrak.bsky.social
· Jun 5
ChemRxiv Community Survey
ChemRxiv is conducting a survey to better understand your views on preprints. Your input will be invaluable in helping us shape new features, understand your questions or concerns about preprints, and...
americanchemical.co1.qualtrics.com
Reposted by Milka Kostic
Reposted by Milka Kostic
Reposted by Milka Kostic
Milka Kostic
@milkakostic.bsky.social
· May 8
Functional Spectrum of USP7 Pathogenic Variants in Hao-Fountain Syndrome: Insights into the Enzyme’s Activity, Stability, and Allosteric Modulation
Hao-Fountain syndrome is a rare neurodevelopmental disorder caused by mutations in the de-ubiquitinating enzyme USP7 (Ubiquitin Specific Protease 7). Due to the novelty of the disease and its poorly u...
www.biorxiv.org
Milka Kostic
@milkakostic.bsky.social
· May 8
Small-molecule allosteric activator of ubiquitin-specific protease 7 (USP7)
Ubiquitin-specific protease 7 (USP7) is a deubiquitylase essential for cell homeostasis, DNA repair, and regulation of both tumor suppressors and oncogenes. Inactivating USP7 mutations have been assoc...
www.biorxiv.org
Reposted by Milka Kostic
Nick Polizzi
@nickpolizzi.bsky.social
· Apr 28
Zero-shot design of drug-binding proteins via neural selection-expansion
Computational design of molecular recognition remains challenging despite advances in deep learning. The design of proteins that bind to small molecules has been particularly difficult because it requ...
www.biorxiv.org
Reposted by Milka Kostic
Reposted by Milka Kostic
Waggoner Lab
@labwaggoner.bsky.social
· Mar 7
Mechanisms and functions of lysosomal lipid homeostasis
In this review Ebner et al. summarize and discuss the rapidly increasing knowledge
regarding the mechanisms of lysosomal lipid turnover and export as well as the pathways
for the homeostatic control a...
www.cell.com
Reposted by Milka Kostic
Milka Kostic
@milkakostic.bsky.social
· Feb 4
Sexually dimorphic dopaminergic circuits determine sex preference
Sociosexual preference is critical for reproduction and survival. However, neural mechanisms encoding social decisions on sex preference remain unclear. In this study, we show that both male and femal...
www.science.org
Milka Kostic
@milkakostic.bsky.social
· Feb 4
Scratching promotes allergic inflammation and host defense via neurogenic mast cell activation
Itch is a dominant symptom in dermatitis, and scratching promotes cutaneous inflammation, thereby worsening disease. However, the mechanisms through which scratching exacerbates inflammation and wheth...
www.science.org
Reposted by Milka Kostic
Vega Shah
@dr-alphalyrae.bsky.social
· Jan 23
The impact of library size and scale of testing on virtual screening - Nature Chemical Biology
The docking of a 1.7 billion- versus a 99 million-molecule virtual library against β-lactamase revealed that the larger-sized library produced improved hit rates and potency along with an increased nu...
www.nature.com
Milka Kostic
@milkakostic.bsky.social
· Jan 22
Episode 2: Why Open Science with Aled Edwards? by Target 2035 Podcast series
What if the greatest breakthroughs in research were locked away, inaccessible to the world? For Aled Edwards, this wasn’t just a hypothetical but a reality he encountered early in his career. In this ...
creators.spotify.com
Reposted by Milka Kostic
Reposted by Milka Kostic
Reposted by Milka Kostic
