Imagine we could travel back in time ⏪⌛️to explore the world of bacterial pathogens before humans discovered and industrialised antibiotics

We just did that to study the history of #AMR spread @science.org
doi.org/10.1126/scie...

If you like time travel & biology, this 🧵is for you👇

I do despair at the decisions Wes Streeting is making and the one-sided advice he (and the govt generally) seems so keen to take.

Not just on this topic, but on others too tbf

After a meeting of the excellent MOVE consortium today, and the Wellcome/Novo Nordisk Mucosal Immunity conference last week, think i'm on a 1-man mission to convince everyone that complement should be in all immune assays.

Hope people aren't sick of hearing it.. because i'm not stopping 😅

Where is all this background push for pathogen stocks for CHIM studies to be GMP?

It'll kill the field because it's unaffordable. GMP doesn't guarantee a robust bacterial stock, many requirements are surprisingly lax. Is it just CROs sensing an opportunity to corner a market?

Health and science reporters should lead the coverage of all these health-related conspiracy theories & newsroom leaders should keep their both-sides political reporters out of their way.

Carol Baker is the GOAT.

Those of us working on helping get these much needed maternal vaccines through the pipeline are proud to walk in her footsteps

www.science.org/content/arti...

To all those worried about the Mounjaro shortage and price hikes.

Screw Eli Lilly, Weygovy is absolutely fine.

I lost 62lb/28kg on Weygovy so am happy to swap back. I only moved over due to a short term shortage of Weygovy from my provider late last year

Can't help but feel the UK Govt is really missing a trick with the current state of the US DH/FDA etc.

Invest like hell to encourage the pharma companies to move their vaccine research over to the UK, we have everything they need for clinical trial infrastructure & vaccine testing

Phenomenal amount of data in this paper.

Really important findings for those of us in public health working on CoP
👏

I can seriously see a Labour government, headed by a human rights lawyer, being the one that actually takes us out of the ECHR. Mostly just driven by fear of the RW press.

Introducing a new Section 28 and going further than any RW govt we've had. Didn't see this coming at all

✨We’ve just launched our new guide to #vaccinations during #pregnancy!

Understand how immunity changes, which vaccines the NHS recommends, and how they protect both parent and baby during pregnancy and beyond.

Download a copy for trusted information: bit.ly/4fuRqVw

Research has an economic return multiplier >1. So taxes don't even really pay for research. Research more than pays for itself, the taxes are just used to kick-start the positive economic cycle. The more money invested in research, the better the economy.

Personally I think we're miles away from being able to replace complex systems with in vitro alternatives. Not that in vivo is all that reliable either, but at least we have an idea of the weaknesses

Is there a more depressing travel experience than the Brussels Eurostar facility since Brexit?

Gone is the cafe, now just by a massive, pointless duty free shop, no ability to buy a cup of tea, and people just crammed into a depressing holding area to wait for the train.

Vaccines have literally saved more than 150 million lives over the last 50 years and prevented much more morbidity but hold up guys somebody with a brain worm knows better

🄰🅆🄴🅂🄾🄼🄴
Stubbusch et al 𝘚𝘊𝘐𝘌𝘕𝘊𝘌

Bacteria 🦠 repurpose Type VI Secretion Systems based on environmental cues:

Nutrient-rich environments ➜ kill competitors

Under starvation ➜ lyse neighbors to scavenge their nutrients

Even “non-pathogens” shift from competition to predation as a survival strategy

What a disgrace. And as an old graduate, with many happy memories, I'm appalled. Thinking of cancelling my charity donation now

@uniofreading.bsky.social

The head of the UKs Equality and Human Rights Commission just said that the European Convention on Human Rights Article 8 right to privacy doesn't apply to trans people.

Article 8 is why the UK was forced to create the gender recognition act by the European Court of human Rights in the first place.

Hi! I specialize in medication toxicity. All available, real-world data has proven mifepristone is actually even safer than many over the counter medicines.

Mortality rates:

Mifepristone: 0.65/100,000
Penicillin 2/100K
Viagra 4/100K

Pregnancy in the US: 22/100,000 (some states see rates >60/100K)

Since we joined the civil service a while back it's been really eye opening to see the waste in spending. Endless efficiency drives and tracking/monitoring just creates more costs than it saves. The worry about PS fraud drives up costs massively

When will the government finally give up on this ridiculous boondoggle of moving UKHSA Porton to Harlow? The amount of public money already wasted shouldn't be chased with more even money for something absolutely no-one wants.

Just let the idea die

www.bbc.co.uk/news/article...

I stand by every word. JK Rowling's war on trans people has terrifying consequences for trans people, profoundly negative ones for all women cis or trans who don't conform to gender norms, and ignores the real problems all women face.

Still, it delights the Far Right: there is that.

Just out! Our peer-reviewed critique of the Cass Review has been published by BMC Medical Research Methodology. Please read and share. We show that the Cass Review is fatally flawed and should not be the basis for policy or practice in transgender healthcare.

link.springer.com/article/10.1...

Which FDA-approved vaccines had randomized, placebo-controlled trials?

ALL OF THEM.

Polio?
Measles, mumps, rubella?
Haemophilus influenzae B?
Diphtheria, tetanus, pertussis?
Meningococcus?
Varicella?
Pneumococcus?
Rotavirus?
RSV?
Hepatitis B?
Influenza?
HPV?
COVID-19?
Shingles?

YEP.

A thread🧵
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