seanamontgomery.bsky.social
Sean Montgomery
@seanamontgomery.bsky.social
820 followers 490 following 30 posts
Postdoc in the Sebé-Pedrós lab at the CRG studying heterochromatin diversity and function across eukaryotes. Can be found chasing frisbees when not in the lab.
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seanamontgomery.bsky.social
Sean Montgomery @seanamontgomery.bsky.social · Jul 15
We're looking for a potential PhD student to come explore the evolution of chromatin across eukaryotes in the @arnausebe.bsky.social lab! The project is flexible and a wide range of backgrounds will be considered! Please reach out if you have any questions. Link to application: shorturl.at/LlsJw
Pre-Doc/PhD job advertisement. Link here: https://recruitment.crg.eu/content/jobs/position/research-trainee-evolutionary-chromatin-biology
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Reposted by Sean Montgomery
n-martin.bsky.social
Nora Martin @n-martin.bsky.social · 1d
Opportunity for a Master’s/Bachelor’s student:
- Join us for up to 5 months 🗓️
- Build computational/mathematical models 💻
- Learn about genotype-phenotype maps and evolution 🧬
- Work closely with PhD student Manuela Giraud - full info here:
www.crg.eu/en/content/t...
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Reposted by Sean Montgomery
arnausebe.bsky.social
Arnau Sebé-Pedrós @arnausebe.bsky.social · 14d
Happy to share the Biodiversity Cell Atlas white paper, out today in @nature.com. We look at the possibilities, challenges, and potential impacts of molecularly mapping cells across the tree of life.
www.nature.com/articles/s41...
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seanamontgomery.bsky.social
Sean Montgomery @seanamontgomery.bsky.social · 16d
Brown algae up to some interesting strategies regarding gene repression, losing all "traditional" pathways while expanding the DOT1 (H3K79me writer) protein family! I hope to learn more at the EMBO workshop next month in Barcelona!
sodail.bsky.social
Jaruwatana (Sodai) Lotharukpong @sodail.bsky.social · 19d
Super glad to contribute to this study on chromatin evolution in brown algae! Special thanks to Jeromine Vigneau, @borglab.bsky.social and Susana Coelho for making this happen.

www.biorxiv.org/content/10.1...
Rewiring of chromatin regulation underlies the evolution of brown algal multicellularity
Chromatin structure plays a central role in regulating transcription, genome stability, and epigenetic inheritance in eukaryotes. Much of our understanding of chromatin architecture and histone post-t...
www.biorxiv.org
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Reposted by Sean Montgomery
kasitc.bsky.social
kasitc.bsky.social @kasitc.bsky.social · Aug 18
Activity of most genes is controlled by multiple enhancers, but is there activation coordinated? We leveraged Nanopore to identify a specific set of elements that are simultaneously accessible on the same DNA molecules and are coordinated in their activation. www.biorxiv.org/content/10.1...
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Reposted by Sean Montgomery
planaria1.bsky.social
A. Sánchez Alvarado @planaria1.bsky.social · Aug 6
Evolution’s eye game is wild, but mollusks take it to another level

CRISPR in apple snails gives us a new model to dissect how nature rebuilds complex organs like the camera-type eyes we humans possess

It turns out Evolution doesn’t just innovate, it rewinds, remixes, & regenerates

rdcu.be/ezw0t
A genetically tractable non-vertebrate system to study complete camera-type eye regeneration
Nature Communications - Accorsi et al. show that the apple snail Pomacea canaliculata has eyes similar to humans and can fully regenerate them. They then developed genetic tools to establish these...
url.us.m.mimecastprotect.com
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Reposted by Sean Montgomery
patriciasuarez.bsky.social
Patricia Suarez Ara @patriciasuarez.bsky.social · Jul 25
Very happy to share our new paper where we develop CRISPR-Cas9 genome editing in our favorite unicellular relative of animals, Corallochytrium limacisporum! With @sebasn1.bsky.social @multicellgenome.bsky.social Elena and Claudio.

Check it out:
royalsocietypublishing.org/doi/10.1098/...
CRISPR-Cas9 genome editing in Corallochytrium limacisporum,a key species for understanding animal origins | Open Biology
Microbial holozoans are the closest unicellular relatives of animals. They share a substantial gene repertoire with animals and exhibit complex life cycles. Studying these organisms is crucial for und...
royalsocietypublishing.org
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Reposted by Sean Montgomery
kamounlab.bsky.social
Sophien Kamoun @kamounlab.bsky.social · Jul 28
I just published: Academic poaching: when other PIs steal your trainees

There are many toxic behaviors in academia, but one we rarely talk about is #AcademicPoaching. Have you ever been a victim?

#AcademicChatter #AcademicSky #phdchat

medium.com/p/academic-p...
Academic poaching: when other PIs steal your trainees
There are many toxic behaviors in academia, but one we rarely talk about is #AcademicPoaching. Have you ever been a victim?
medium.com
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Reposted by Sean Montgomery
chribue.bsky.social
Christa Buecker @chribue.bsky.social · Jul 23
And another opportunity! Any postdocs looking forward to start your lab on a tenure track? Supportive environment, great core facilities and an outstanding PhD program.
maxperutzlabs.ac.at
Max Perutz Labs Vienna @maxperutzlabs.ac.at · Jul 23
📢 Open Call! The Max Perutz Labs invite applications for a Tenure-Track Professorship in Mechanistic Cell and Developmental Biology. More details ➡️ tinyurl.com/3fbkp89c
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Reposted by Sean Montgomery
fromani.bsky.social
Facundo Romani @fromani.bsky.social · Jul 21
New Pre-print! A long-standing question for transcription factor biology is how their chromatin context dependency works in plants. In this collaboration with Fred Berger lab, we present some new ideas not only in Arabidopsis but also in Marchantia. www.biorxiv.org/content/10.1...
Conservation of chromatin states and their association with transcription factors in land plants
The complexity of varied modifications of chromatin composition is integrated in archetypal combinations called chromatin states that predict the local potential for transcription. The degree of conse...
www.biorxiv.org
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Reposted by Sean Montgomery
jgahan.bsky.social
James Gahan @jgahan.bsky.social · Jul 16
We are looking for new colleagues to come join us in Galway as group leaders (Junior and Senior). The Centre for Chromosome Biology is a great place and it is a good time to join. Please reach out if you want to chat about the opportunity!
www.nature.com/naturecareer...
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Reposted by Sean Montgomery
juliusbrennecke.bsky.social
Julius Brennecke @juliusbrennecke.bsky.social · Jul 16
Pls. share widely

Calling all transposon fans & lovers of genetic innovation

MOBILE GENOME welcomes you in Heidelberg, Nov. 4–7 2025

→ Vibrant & friendly community
→ Cutting-edge talks from mechanisms to physiology
→ Plenty of surprises (TEs never stop innovating)

submit abstract by July 29
events.embl.org
EMBL Events @events.embl.org · Jun 18
⏰ Abstract deadline for 'The mobile genome' is 29 July!

👉 https://s.embl.org/mge25-01-bl

Join us 4–7 Nov 2025 at EMBL Heidelberg (or online) to explore the impact of TEs across biology. 🧬🔍

⭐🧑🏼‍🔬 24 talks + 15 flash talks from posters – don't miss out!

#EMBOMobileGenome
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Reposted by Sean Montgomery
arnausebe.bsky.social
Arnau Sebé-Pedrós @arnausebe.bsky.social · Jul 15
We are looking for a student to continue our work on chromatin evolution:
www.nature.com/articles/s41...
www.biorxiv.org/content/10.1...

The project with @seanamontgomery.bsky.social will focus on chromatin state readers across eukaryotes.

More info: recruitment.crg.eu/content/jobs...
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seanamontgomery.bsky.social
Sean Montgomery @seanamontgomery.bsky.social · Jul 15
Sorry, the ad image didn't look so good in dark mode, here it is again!
seanamontgomery.bsky.social
Sean Montgomery @seanamontgomery.bsky.social · Jul 15
To get a taste of what we do, check out our recent work: www.biorxiv.org/content/10.1... and rdcu.be/eeaLN
Diversity and evolution of chromatin regulatory states across eukaryotes
Histone post-translational modifications (hPTMs) are key regulators of chromatin states[1][1],[2][2], influencing gene expression, epigenetic memory, and transposable element repression across eukaryo...
www.biorxiv.org
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seanamontgomery.bsky.social
Sean Montgomery @seanamontgomery.bsky.social · Jul 15
We're looking for a potential PhD student to come explore the evolution of chromatin across eukaryotes in the @arnausebe.bsky.social lab! The project is flexible and a wide range of backgrounds will be considered! Please reach out if you have any questions. Link to application: shorturl.at/LlsJw
Pre-Doc/PhD job advertisement. Link here: https://recruitment.crg.eu/content/jobs/position/research-trainee-evolutionary-chromatin-biology
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Reposted by Sean Montgomery
xgrau.bsky.social
Xavier Grau-Bové 🌾 @xgrau.bsky.social · Jul 4
A single-cell ATACseq atlas of our favourite sea anemone, Nematostella vectensis! By @aelek.bsky.social @martaig.bsky.social
UMAP 2D projections of single-cell ATAC atlases of a Nematostella gastrula (left) and an adult specimen (right)
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Reposted by Sean Montgomery
jakobschnabl.bsky.social
Jakob Schnabl @jakobschnabl.bsky.social · Jul 3
📖 Happy to share our recent preprint! www.biorxiv.org/content/10.1... We discovered how SINEs are kept silent: the ChAHP protein complex acts as a molecular brake on POL III transcription retrotransposons. A 🧵:
ChAHP Silences SINE Retrotransposons by Inhibiting TFIIIB Recruitment
Short interspersed nuclear elements (SINEs) are abundant non-autonomous transposable elements derived from RNA polymerase III (POL III)-transcribed short non-coding RNAs. SINEs retain sequence feature...
www.biorxiv.org
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Reposted by Sean Montgomery
chenxinli2.bsky.social
Chenxin Li, PhD @chenxinli2.bsky.social · Jul 2
Transcription factors targeting RNA-directed DNA methylation machinery in Arabidopsis reproductive tissues.

From: www.nature.com/articles/s41...

I think I saw another preprint on this by another lab too.
REM transcription factors and GDE1 shape the DNA methylation landscape through the recruitment of RNA polymerase IV transcription complexes - Nature Cell Biology
Wu et al. demonstrate that REM transcription factors and GDE1 guide RNA polymerase IV to specific genomic loci, establishing a DNA sequence-dependent mechanism for siRNA biogenesis and DNA methylation...
www.nature.com
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Reposted by Sean Montgomery
plantophagy.bsky.social
Yasin Dagdas @plantophagy.bsky.social · Jun 25
How 🆒 is this?!? www.cell.com/cell/abstrac...
A host organelle integrates stolen chloroplasts for animal photosynthesis
Sea slugs steal foreign chloroplasts and store them in specialized organelles that facilitate photosynthesis and eventual digestion to mediate starvation resistance.
www.cell.com
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seanamontgomery.bsky.social
Sean Montgomery @seanamontgomery.bsky.social · Jun 13
Updating my intro slides with this fantastic figure now! (And maybe I'll add an extra dashed line for my beloved bryophytes)
strassert.bsky.social
Jürgen Strassert @strassert.bsky.social · Jun 13
Happy to have contributed to this great article: #Protist genomics: key to understanding eukaryotic evolution. Congrats Alexandra Schoenle et al. #ProtistsOnSky
authors.elsevier.com/sd/article/S...
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Reposted by Sean Montgomery
maxstammnitz.bsky.social
Max Stammnitz @maxstammnitz.bsky.social · Jun 2
1 plant hormone receptor ☘️
3,500 mutants, to single-site saturation 🧬
>45,000 binding and abundance measurements 📶

Very happy to present our latest work – where deep mutational scanning meets the world of small molecules.



www.biorxiv.org/content/10.1...



With @benlehner.bsky.social

[1/7]
The genetic architecture of an allosteric hormone receptor
Many proteins function as switches, detecting chemicals and transducing their concentrations into cellular responses. Receptor switches are key to the integration of environmental signals, yet it is n...
www.biorxiv.org
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Reposted by Sean Montgomery
dodonova-sveta.bsky.social
Svetlana Dodonova @dodonova-sveta.bsky.social · May 26
We’ve uncovered Asgard chromatin structures formed by a Hodarchaeal histone : closed hypernucleosome conserved in archaea and an open form resembling the H3-H4 eukaryotic octasome. Fantastic work by @harshranawat.bsky.social!
www.biorxiv.org/content/10.1...
#Chromatin #Asgard #Archaea #cryoEM
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beatfierz.bsky.social
Beat Fierz @beatfierz.bsky.social · May 21
Our new study of chromatin ubiquitylation by variant PRC1 on the single-molecule scale: We visualize directly how vPRC1 ubiquitylates neighboring nucleosomes during a single binding event, showing a potential mechanism how H2Aub domains are established.
www.science.org/doi/10.1126/...
Single-molecule analysis reveals the mechanism of chromatin ubiquitylation by variant PRC1 complexes
Single-molecule experiments show that active conformation formation controls chromatin ubiquitylation kinetics by variant PRC1.
www.science.org
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Reposted by Sean Montgomery
leootsuki.bsky.social
Leo Otsuki @leootsuki.bsky.social · May 21
Delighted that our work on positional memory is now published. We asked how axolotl cells 'know' which part of the limb to regenerate after injury.
www.nature.com/articles/s41...
A joy to work with super team Sarah Plattner, Yuka Sugiura, Francisco Falcon and Elly Tanaka.
🧵1/14
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borglab.bsky.social
Michael Borg @borglab.bsky.social · May 10
Delighted to see our work now published in @currentbiology.bsky.social. A great place for Bostrychia to stake its claim as an emerging red algal model system. Check it out here: www.cell.com/current-biol...
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