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Reposted by Can Senkal

The Cancer Letter @cancerletter.com · 6d

Many observers view Anthony Letai’s appointment as part of a series of hopeful events that followed months of reductions in force, proposed reorganizations, and efforts to cut intramural and extramural spending.
https://cancerletter.com/nci/20250925_1/

Anthony G. Letai to be named NCI director The Dana-Farber and Harvard physician-scientist is an inspired choice, colleagues say - The Cancer Letter

Anthony G. Letai, a physician-scientist at Harvard Medical School and Dana-Farber Cancer Institute whose research is focused on apoptosis and functional diagnostics, has been tapped by the Trump administration to become the 18th director of the National Cancer Institute. To access this subscriber-only content please log in or subscribe.If your institution has a site license, […]

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The Society for Functional Precision Medicine @thesfpm.bsky.social · 9d

We want to congratulate our President, Dr. Tony Letai, on his appointment as Director of the NCI. This announcement marks an historic moment for cancer research. Dr. Letai has been a tireless advocate and visionary leader for functional precision medicine 🧵

www.nih.gov/news-events/...

Secretary Kennedy Swears in Dr. Anthony Letai as Director of the National Cancer Institute

Dr. Letai will serve as NCI’s 18th director.

www.nih.gov

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Benoit Bruneau @benoitbruneau.bsky.social · 9d

thank you to all the NIH staff who stand by their duty and put in heroic efforts to get it done. I'll never forget it and will be eternally grateful.

Jeremy Berg @jeremymberg.bsky.social · 9d

The fiscal year ends tomorrow.

Here are results from NIH Reporter downloaded an hour ago.

The total amount of funding committed for FY2025 at this point is 99.0% of that for FY2024. The same difference could be due to a variety of technical factors.

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$A graph showing the fraction of annual grant funding committed for NIH for fiscal years 2015 to 2025. The fiscal year 2025 lagged behind but then caught up over the last two months.$

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Can Senkal @senkalce.bsky.social · 12d

Congratulations!

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The Cancer Letter @cancerletter.com · 13d

SPECIAL REPORT: Anthony G. Letai to be named NCI director
The Dana-Farber (@danafarber.bsky.social) and Harvard physician-scientist is an inspired choice, colleagues say
https://cancerletter.com/nci/20250925_1/

Anthony G. Letai to be named NCI director The Dana-Farber and Harvard physician-scientist is an inspired choice, colleagues say - The Cancer Letter

Anthony G. Letai, a physician-scientist at Harvard Medical School and Dana-Farber Cancer Institute whose research is focused on apoptosis and functional diagnostics, has been tapped by the Trump administration to become the 18th director of the National Cancer Institute. To access this subscriber-only content please log in or subscribe.If your institution has a site license, […]

cancerletter.com

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Piali Sengupta @senguptalab.bsky.social · 23d

A huge shoutout to all the dedicated grants management specialists at the NIH who are working around the clock to push grants out before the Sep 30 deadline. And also to the POs responding to frantic emails.
Not an easy job under the best of circumstances and right now it's the pits.
Thank you!

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Itay Budin @ibudin.bsky.social · 23d

Very excited to share new work out today in @natchembio.nature.com on a new approach - FACES - for selectively imaging of phospholipids and other biomolecules at spatial resolutions down to individual membrane leaflets (1/n) www.nature.com/articles/s41...

Leaflet-specific phospholipid imaging using genetically encoded proximity sensors - Nature Chemical Biology

An approach combining bioorthogonal chemistry with genetically encoded fluorogen-activating proteins enables subcellular imaging of phospholipids and glycans, as well as the visualization of lipid tra...

www.nature.com

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Can Senkal @senkalce.bsky.social · 27d

Some happy news to share: We received the NOA of our R01 today.

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Can Senkal @senkalce.bsky.social · Sep 6

Congrarulations!

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Juan S. Bonifacino @juanbonifacino.bsky.social · Aug 26

Excited to share our new review with @depaceraffa.bsky.social‬, @saikat2025.bsky.social‬, and Chad Williamson on the BLOC-1 and BORC complexes—key regulators of endolysosomal processes and linked to several genetic diseases. #NIH #Lysosomes #RareDiseases authors.elsevier.com/a/1lg4i8jWWJ...

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Jeremy Baskin @jeremybaskin.bsky.social · Aug 20

Quite a week for #lipidtime: phenomenal study using bifunctional lipid probes to quantify intracellular lipid transport from @nadlerlab.bsky.social and colleagues is now out @nature.com! www.nature.com/articles/s41...

Quantitative imaging of lipid transport in mammalian cells - Nature

Directional, non-vesicular lipid transport is responsible for fast, species-selective lipid sorting into organelle membranes.

www.nature.com

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TanentzapfLab @tanentzapflab.bsky.social · Aug 13

The goal of a PhD is not to learn some facts or read a few papers or learn a bunch of techniques. The goal of a PhD is to learn independence, problem solving, how to finish things you start, resilience, & gain the ability to adapt & think creatively. Learning these things is hard.

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American Society for Biochemistry and Molecular Biology @asbmb.bsky.social · Aug 12

Ray Blind (@blindlab.bsky.social), an associate professor at Vanderbilt University Medical Center & @vumedicine.bsky.social, investigates how ligands bind & change the activity of two nuclear receptor 5A, or NR5A, family members called steroidogenic factor-1 & liver receptor homomlog-1, or LRH-1.

American Society for Biochemistry and Molecular Biology @asbmb.bsky.social · Aug 12

Find out how lipids and sugars in the cell nucleus are involved in signaling and gene expression and how these pathways could be targeted to identify therapeutics for diseases like #cancer ⏯️: youtu.be/KO_Z9rJmN2M?....
➡️More info: ow.ly/fHs050WELyB
#ASBMBBreakthroughs #asbmbJLR #cancersky #sciencesky

Nuclear second messenger signaling

YouTube video by American Society for Biochemistry and Molecular Biology (ASBMB)

youtu.be

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Lydia Lynch @lydialynch.bsky.social · Jul 28

This was a labor of love requiring lots of teamwork over years, repeating in 3 locations! Thanks to all the lab over the years, giving their time generously to this team project, & our wonderful collaborators. The source of fat matters for anti-tumor immunity 🐄🐖🧈🌴🫒🥥
www.nature.com/articles/s42...

The source of dietary fat influences anti-tumour immunity in obese mice - Nature Metabolism

This study shows that animal-based high-fat diets accelerate tumour growth and impair anti-tumour response to melanoma in obese mice, whereas plant-based high-fat diets do not.

www.nature.com

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Can Senkal @senkalce.bsky.social · Jul 10

Congratulations!

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Can Senkal @senkalce.bsky.social · Jul 6

Congratulations!

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Christian Frezza @frezzalab.bsky.social · Jul 3

Microbial riboflavin inhibits ceramide synthase 3 to lower ceramide (d18:1/26:0) and delay colorectal cancer progression: Cell Metabolism www.cell.com/cell-metabol...

Microbial riboflavin inhibits ceramide synthase 3 to lower ceramide (d18:1/26:0) and delay colorectal cancer progression

This study identifies C26 ceramide and CERS3 as critical factors in colorectal cancer progression, which is modulated by microbial metabolite riboflavin. C26 ceramide directly activates EGFR, and the ...

www.cell.com

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The Cancer Letter @cancerletter.com · Jul 1

‪@cityofhope.bsky.social‬ launches AI tool to reduce burden of cancer care
https://cancerletter.com/clinical-roundup/20250627_8b/

City of Hope launches AI tool to reduce burden of cancer care - The Cancer Letter

City of Hope is using generative artificial intelligence to create operational efficiency, enable AI-driven patient personalization, improve access to clinical trials, and empower breakthrough research. To access this subscriber-only content please log in or subscribe.If your institution has a site license, log in with IP-login or register for a sponsored account.**Not all site licenses are […]

cancerletter.com

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Nature Portfolio @natureportfolio.nature.com · Jun 28

Age-related macular degeneration (AMD) is a leading cause of blindness. A study in Nature Communications identifies a role for the protein apolipoprotein M in AMD that may present a therapeutic target. go.nature.com/40jhrAA #medsky 🧪

This is figure 7, which shows ApoM-S1P as a potential therapeutic for early dry AMD.

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Can Senkal @senkalce.bsky.social · Jun 20

Yes, we need this.

Kevin R. McClure @drkevinrmcclure.com · Jun 20

Not feeding into the Bluesky debate but I would love to see more academics sharing papers on here. Revive the ‘ol “here’s a thread about this paper” thing. I think it’s good for the information ecosystem.

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Nature Cell Biology @natcellbio.nature.com · Jun 13

💫NEW: Xu et al. show that S1P in HDL induces a calcium signaling cascade involving E-Syt1 that ultimately promotes the formation of contact sites between the endoplasmic reticulum and the plasma membrane, as well as HDL-derived #cholesterol transport.
👉https://rdcu.be/eqT5v
bit.ly/3FWGgv8

Sphingosine-1-phosphate signalling activates E-Syt1 to facilitate HDL-derived cholesterol transport - Nature Cell Biology

Xu, Meng, St-Germain et al. report that S1P in HDL induces a calcium signalling cascade involving E-Syt1 that ultimately promotes the formation of contact sites between the endoplasmic reticulum and t...

bit.ly

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Christian Baumann @cjbaumann.bsky.social · Jun 10

For everyone interested in how membrane thickness differs between and within organelles, by @deglushk.bsky.social, S. Böhm & M. Beck: www.biorxiv.org/content/10.1...

www.biorxiv.org

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The Cancer Letter @cancerletter.com · Jun 5

Boris Pasche (@karmanoscancer.bsky.social‬): "Considering the growing number of survivors who may require only sporadic oncology office visits, there is a need for better collaboration between PCPs and treating oncologists."
https://cancerletter.com/trials-and-tribulations/20250530_4/

Surviving cancer is often not a patient’s most challenging battle - The Cancer Letter

With advances in treatment and screening for earlier detection, oncologists have improved cancer survival rates dramatically. That is excellent news, but the surging number of survivors means it is increasingly important for providers to focus more diligently on what patients need to thrive after treatment. To access this subscriber-only content please log in or subscribe.If […]

cancerletter.com

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Drug Monkey @drugmonkey.bsky.social · May 21

You are not alone in this NIH grant game drugmonkey.wordpress.com/2025/05/21/y...

You are not alone in this NIH grant game

Many years ago I started blogging about the NIH system of extramural grant award because of my own frustrations with the system, as it appeared to be to me. Over time, I realized that there were a …

drugmonkey.wordpress.com

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Drug Monkey @drugmonkey.bsky.social · May 21

I think this was a little slow to emerge this year, compared with prior years (?) but the NIH R01equiv funding patterns by percentile for FY2024 are available now. Have fun with your favorite IC.

report.nih.gov/nihdatabook/...

NIH Data Book

report.nih.gov

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