Shane McInally
@sgmcinally.bsky.social
Reposted by Shane McInally
My former bench mate @joellemiere.bsky.social from the @fredchanglab.bsky.social giving a killer talk about nuclear size regulation in fission yeast at #ASCB #CellBio2025
Stay tuned for the paper to come soon !
Beautiful experimental data falling on the mathematical model, no fit needed 🤩
Stay tuned for the paper to come soon !
Beautiful experimental data falling on the mathematical model, no fit needed 🤩
December 6, 2025 at 4:07 PM
My former bench mate @joellemiere.bsky.social from the @fredchanglab.bsky.social giving a killer talk about nuclear size regulation in fission yeast at #ASCB #CellBio2025
Stay tuned for the paper to come soon !
Beautiful experimental data falling on the mathematical model, no fit needed 🤩
Stay tuned for the paper to come soon !
Beautiful experimental data falling on the mathematical model, no fit needed 🤩
Reposted by Shane McInally
Too fluid, too rigid, no patterning. Garner et al. identify tissue fluidity—how freely cells move within a tissue—as a critical regulator of adhesion-based cell sorting. Read their study to learn how tissues can tune their fluidity to enable patterning.
Tissue fluidity mediates a trade-off between the speed and accuracy of multicellular patterning by cell sorting
The organization of cells into spatial patterns is a fundamental aspect of multicellularity. One major mechanism underlying tissue patterning is adhesion-based cell sorting, in which a heterogeneous…
www.cell.com
December 4, 2025 at 3:02 PM
Too fluid, too rigid, no patterning. Garner et al. identify tissue fluidity—how freely cells move within a tissue—as a critical regulator of adhesion-based cell sorting. Read their study to learn how tissues can tune their fluidity to enable patterning.
Reposted by Shane McInally
Today, our animation synthesizing decades of research on actin-mediated endocytosis in budding yeast was published:
journals.biologists.com/jcs/article/...
The result of a fantastic Iwasa-Drubin lab collaboration.
@margotriggi.bsky.social @jiwasa.bsky.social
movie.biologists.com/video/10.124...
journals.biologists.com/jcs/article/...
The result of a fantastic Iwasa-Drubin lab collaboration.
@margotriggi.bsky.social @jiwasa.bsky.social
movie.biologists.com/video/10.124...
December 2, 2025 at 9:02 PM
Today, our animation synthesizing decades of research on actin-mediated endocytosis in budding yeast was published:
journals.biologists.com/jcs/article/...
The result of a fantastic Iwasa-Drubin lab collaboration.
@margotriggi.bsky.social @jiwasa.bsky.social
movie.biologists.com/video/10.124...
journals.biologists.com/jcs/article/...
The result of a fantastic Iwasa-Drubin lab collaboration.
@margotriggi.bsky.social @jiwasa.bsky.social
movie.biologists.com/video/10.124...
Reposted by Shane McInally
The lab’s first pre-print! We investigated how growth-inducing Erk activity waves are regulated in regenerating zebrafish scales. We discovered that Erk waves are followed by waves of expression of their own inhibitors, as predicted by excitable waves theory. tinyurl.com/26r2cmpj
November 20, 2025 at 6:11 PM
The lab’s first pre-print! We investigated how growth-inducing Erk activity waves are regulated in regenerating zebrafish scales. We discovered that Erk waves are followed by waves of expression of their own inhibitors, as predicted by excitable waves theory. tinyurl.com/26r2cmpj
Reposted by Shane McInally
Our work on Naegleria Myosin 2 is out!
Naegleria encodes 3 Myo2s which contract its actin network—the first evidence of contractile Myo2 outside of Amorphea.
Myo2 is actually widespread in Naegleria's relatives and correlates with fast cell crawling.
Read more: www.cell.com/current-biol...
Naegleria encodes 3 Myo2s which contract its actin network—the first evidence of contractile Myo2 outside of Amorphea.
Myo2 is actually widespread in Naegleria's relatives and correlates with fast cell crawling.
Read more: www.cell.com/current-biol...
Myosin 2 drives actin contractility in fast-crawling species outside of the amorphean lineage
Myosin 2-dependent actin contractility—the force that powers cell division and migration
in animals, fungi, and other Amorphea—had been previously unknown outside this single
eukaryotic group. Guest e...
www.cell.com
November 17, 2025 at 5:19 PM
Our work on Naegleria Myosin 2 is out!
Naegleria encodes 3 Myo2s which contract its actin network—the first evidence of contractile Myo2 outside of Amorphea.
Myo2 is actually widespread in Naegleria's relatives and correlates with fast cell crawling.
Read more: www.cell.com/current-biol...
Naegleria encodes 3 Myo2s which contract its actin network—the first evidence of contractile Myo2 outside of Amorphea.
Myo2 is actually widespread in Naegleria's relatives and correlates with fast cell crawling.
Read more: www.cell.com/current-biol...
Reposted by Shane McInally
Very excited that my final postdoctoral work is now online in Cell @cellpress.bsky.social.
www.sciencedirect.com/science/arti...
Using 16 (!) cryo-EM structures, we uncovered how the three proteins coronin, cofilin and AIP1 work together to rapidly disassemble actin filaments.
www.sciencedirect.com/science/arti...
Using 16 (!) cryo-EM structures, we uncovered how the three proteins coronin, cofilin and AIP1 work together to rapidly disassemble actin filaments.
October 13, 2025 at 9:04 AM
Very excited that my final postdoctoral work is now online in Cell @cellpress.bsky.social.
www.sciencedirect.com/science/arti...
Using 16 (!) cryo-EM structures, we uncovered how the three proteins coronin, cofilin and AIP1 work together to rapidly disassemble actin filaments.
www.sciencedirect.com/science/arti...
Using 16 (!) cryo-EM structures, we uncovered how the three proteins coronin, cofilin and AIP1 work together to rapidly disassemble actin filaments.
Reposted by Shane McInally
Magliozzi, Goode and colleagues @brandeisuniversity.bsky.social report that fungal proteins form a 'composite' #actin nucleator and pointed end capper. rupress.org/jcb/article/...
#Cytoskeleton #Biochemistry
#Cytoskeleton #Biochemistry
October 9, 2025 at 4:00 PM
Magliozzi, Goode and colleagues @brandeisuniversity.bsky.social report that fungal proteins form a 'composite' #actin nucleator and pointed end capper. rupress.org/jcb/article/...
#Cytoskeleton #Biochemistry
#Cytoskeleton #Biochemistry
Reposted by Shane McInally
PhD or Master's position available for Fall 2026!
Interested in how actin drives cell crawling, eating, dividing, or osmoregulation? What about pathogenesis of a brain-eating amoeba? Or eukaryotic evolution? If so, apply through my website: katrinavelle.wixsite.com/science/cont...
Please share!
Interested in how actin drives cell crawling, eating, dividing, or osmoregulation? What about pathogenesis of a brain-eating amoeba? Or eukaryotic evolution? If so, apply through my website: katrinavelle.wixsite.com/science/cont...
Please share!
October 5, 2025 at 5:29 PM
PhD or Master's position available for Fall 2026!
Interested in how actin drives cell crawling, eating, dividing, or osmoregulation? What about pathogenesis of a brain-eating amoeba? Or eukaryotic evolution? If so, apply through my website: katrinavelle.wixsite.com/science/cont...
Please share!
Interested in how actin drives cell crawling, eating, dividing, or osmoregulation? What about pathogenesis of a brain-eating amoeba? Or eukaryotic evolution? If so, apply through my website: katrinavelle.wixsite.com/science/cont...
Please share!
Reposted by Shane McInally
Allocation of resources among multiple daughter cells. New study from Alison Wirshing, Daniel Lew and colleagues @mit.edu: rupress.org/jcb/article/...
#Cytoskeleton #Development
#Cytoskeleton #Development
September 9, 2025 at 2:16 PM
Allocation of resources among multiple daughter cells. New study from Alison Wirshing, Daniel Lew and colleagues @mit.edu: rupress.org/jcb/article/...
#Cytoskeleton #Development
#Cytoskeleton #Development
Reposted by Shane McInally
📢📢Hiring 2 Research Assistants & 2 Postdocs at Emory University in Atlanta to study cytoskeletal biophysics/biochemistry. Please RT.
RAs: great for recent bachelor's/master's in Physics/Bio/Chem/Biochem. Email CV and interests to [email protected].
More info: www.shekharlab.org
RAs: great for recent bachelor's/master's in Physics/Bio/Chem/Biochem. Email CV and interests to [email protected].
More info: www.shekharlab.org
August 29, 2025 at 3:50 AM
📢📢Hiring 2 Research Assistants & 2 Postdocs at Emory University in Atlanta to study cytoskeletal biophysics/biochemistry. Please RT.
RAs: great for recent bachelor's/master's in Physics/Bio/Chem/Biochem. Email CV and interests to [email protected].
More info: www.shekharlab.org
RAs: great for recent bachelor's/master's in Physics/Bio/Chem/Biochem. Email CV and interests to [email protected].
More info: www.shekharlab.org
Reposted by Shane McInally
The multinucleate, multibudding yeast, A. pullulans delivers nuclei into each daughter bud during #mitosis. Petrucco, @gladfelterlab.bsky.social, Lew et al image #microtubules during mitosis, revealing mechanisms ensuring that most daughters inherit one & only one nucleus rupress.org/jcb/article/...
August 29, 2025 at 4:00 PM
The multinucleate, multibudding yeast, A. pullulans delivers nuclei into each daughter bud during #mitosis. Petrucco, @gladfelterlab.bsky.social, Lew et al image #microtubules during mitosis, revealing mechanisms ensuring that most daughters inherit one & only one nucleus rupress.org/jcb/article/...
Reposted by Shane McInally
What could be more exciting than watching Euplotes scurry around under the microscope? How about adding some raptorial predation by supergiant cannibal cells?
www.biorxiv.org/content/10.1...
Video by Vittorio Boscaro.
1/n
www.biorxiv.org/content/10.1...
Video by Vittorio Boscaro.
1/n
August 26, 2025 at 8:56 PM
What could be more exciting than watching Euplotes scurry around under the microscope? How about adding some raptorial predation by supergiant cannibal cells?
www.biorxiv.org/content/10.1...
Video by Vittorio Boscaro.
1/n
www.biorxiv.org/content/10.1...
Video by Vittorio Boscaro.
1/n
Reposted by Shane McInally
Lawmakers to NIH: Use it or lose it.
14 Republican Senators—including key appropriators—are urging the White House to release NIH FY25 funds without delay, warning that stalled spending could harm future research budgets.
Read more: www.ascb.org/science-poli...
14 Republican Senators—including key appropriators—are urging the White House to release NIH FY25 funds without delay, warning that stalled spending could harm future research budgets.
Read more: www.ascb.org/science-poli...
“Use It or Lose It!” - ASCB
Fourteen Republican Senators have written to Russell Vought, Director of the White House Office of Management and Budget (OMB)—the agency responsible for developing the President’s annual budget propo...
www.ascb.org
July 30, 2025 at 5:15 PM
Lawmakers to NIH: Use it or lose it.
14 Republican Senators—including key appropriators—are urging the White House to release NIH FY25 funds without delay, warning that stalled spending could harm future research budgets.
Read more: www.ascb.org/science-poli...
14 Republican Senators—including key appropriators—are urging the White House to release NIH FY25 funds without delay, warning that stalled spending could harm future research budgets.
Read more: www.ascb.org/science-poli...
Reposted by Shane McInally
My fabulous colleague (and ex-postdoc) @inechipurenko.bsky.social and I (mostly Inna!) wrote a review extolling the many virtues of C. elegans for the study of cilia biology. A really interactive and collaborative community of people working in this field too.
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
C. elegans: An elegant experimental system for the study of cilia biology
Caenorhabditis elegans is a genetically tractable organism that has become one of the leading in vivo models for cilia research. Cilia are not require…
www.sciencedirect.com
July 26, 2025 at 4:15 PM
My fabulous colleague (and ex-postdoc) @inechipurenko.bsky.social and I (mostly Inna!) wrote a review extolling the many virtues of C. elegans for the study of cilia biology. A really interactive and collaborative community of people working in this field too.
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Reposted by Shane McInally
1/27 We have a new paper out! Turns out that snowflake yeast have been hiding a secret from us - they've evolved a (very!) crude circulatory system. Not with blood vessels or a heart, but through spontaneous fluid flows powered by their metabolism. 🧪🔬
www.science.org/doi/full/10....
www.science.org/doi/full/10....
June 24, 2025 at 4:52 PM
1/27 We have a new paper out! Turns out that snowflake yeast have been hiding a secret from us - they've evolved a (very!) crude circulatory system. Not with blood vessels or a heart, but through spontaneous fluid flows powered by their metabolism. 🧪🔬
www.science.org/doi/full/10....
www.science.org/doi/full/10....
Reposted by Shane McInally
Myosin 2 drives actin contractility in fast-crawling species outside of the amorphean lineage https://www.biorxiv.org/content/10.1101/2025.05.16.654244v1
May 19, 2025 at 10:30 AM
Myosin 2 drives actin contractility in fast-crawling species outside of the amorphean lineage https://www.biorxiv.org/content/10.1101/2025.05.16.654244v1
Reposted by Shane McInally
Preprint: IntAct-U-ExM enables robust, isoform-specific expansion microscopy of actin networks in yeast and mammalian cells. A cool study led by @anubhavdhar.bsky.social in collaboration with Sudarshan and Deepak Nair. www.biorxiv.org/content/10.1...
May 16, 2025 at 8:00 AM
Preprint: IntAct-U-ExM enables robust, isoform-specific expansion microscopy of actin networks in yeast and mammalian cells. A cool study led by @anubhavdhar.bsky.social in collaboration with Sudarshan and Deepak Nair. www.biorxiv.org/content/10.1...
Reposted by Shane McInally
In developing embryos, cells move a lot! Plenty of that movement is random. Is random cell mixing a feature or bug for tissue patterning? Turns out, it’s both! Excited to share the 1st preprint from my postdoc w/ Sean Megason @seanemcgeary.bsky.social and Allon Klein. 1/20 doi.org/10.1101/2025...
April 24, 2025 at 1:19 PM
In developing embryos, cells move a lot! Plenty of that movement is random. Is random cell mixing a feature or bug for tissue patterning? Turns out, it’s both! Excited to share the 1st preprint from my postdoc w/ Sean Megason @seanemcgeary.bsky.social and Allon Klein. 1/20 doi.org/10.1101/2025...
Reposted by Shane McInally
Our PhD student Louis Romette is optimizing long-term live-cell imaging. He just casually dropped this 65-hour movie of a growing neuron (div 3 to 6) with knocked-in actin 🔥🕶️ #realtimemicroscopy
April 17, 2025 at 1:30 PM
Our PhD student Louis Romette is optimizing long-term live-cell imaging. He just casually dropped this 65-hour movie of a growing neuron (div 3 to 6) with knocked-in actin 🔥🕶️ #realtimemicroscopy
Reposted by Shane McInally
I’m excited and honored to be giving a talk at The New England Society for Microscopy Spring Symposium! Thanks for the invitation, @andystoneimaging.bsky.social
We also confirmed our final keynote speaker @katrinavelle.bsky.social and we are really excited to see and learn all about the "brain eating amoeba"! Our careers in microscopy panel is also taking shape @bioimagingna.bsky.social #microscopy
April 10, 2025 at 11:10 PM
I’m excited and honored to be giving a talk at The New England Society for Microscopy Spring Symposium! Thanks for the invitation, @andystoneimaging.bsky.social
Reposted by Shane McInally
How is mitochondrial volume maintained across successive generations of dividing cells? In our new preprint, we show how fission yeast cells use mitochondrial activity to control division timing and maintain mitochondrial homeostasis! (1/n)
📖 www.biorxiv.org/content/10.1...
📖 www.biorxiv.org/content/10.1...
April 9, 2025 at 2:53 AM
How is mitochondrial volume maintained across successive generations of dividing cells? In our new preprint, we show how fission yeast cells use mitochondrial activity to control division timing and maintain mitochondrial homeostasis! (1/n)
📖 www.biorxiv.org/content/10.1...
📖 www.biorxiv.org/content/10.1...
Reposted by Shane McInally
Striking new study from @archaeon-alex.bsky.social's lab just out in @science.org on multicellular development induced by compression in Archaea: www.science.org/doi/10.1126/...
Tissue-like multicellular development triggered by mechanical compression in archaea
The advent of clonal multicellularity is a critical evolutionary milestone, seen often in eukaryotes, rarely in bacteria, and only once in archaea. We show that uniaxial compression induces clonal mul...
www.science.org
April 3, 2025 at 6:24 PM
Striking new study from @archaeon-alex.bsky.social's lab just out in @science.org on multicellular development induced by compression in Archaea: www.science.org/doi/10.1126/...
Reposted by Shane McInally
📢Excited to share our new paper in Nature Physics
@naturephysics.bsky.social: Cooperative hydrodynamics accompany multicellular-like colonial organization in the unicellular Stentor!
How do single-celled organisms benefit from teamwork? Let’s dive in! #Multicellularity nature.com/articles/s41...?
@naturephysics.bsky.social: Cooperative hydrodynamics accompany multicellular-like colonial organization in the unicellular Stentor!
How do single-celled organisms benefit from teamwork? Let’s dive in! #Multicellularity nature.com/articles/s41...?
April 2, 2025 at 12:14 PM
📢Excited to share our new paper in Nature Physics
@naturephysics.bsky.social: Cooperative hydrodynamics accompany multicellular-like colonial organization in the unicellular Stentor!
How do single-celled organisms benefit from teamwork? Let’s dive in! #Multicellularity nature.com/articles/s41...?
@naturephysics.bsky.social: Cooperative hydrodynamics accompany multicellular-like colonial organization in the unicellular Stentor!
How do single-celled organisms benefit from teamwork? Let’s dive in! #Multicellularity nature.com/articles/s41...?
Reposted by Shane McInally
Alex Long, the last postdoc from my lab at Stanford, is starting her own lab, continuing her beautiful work on evolutionary cell biology using chytrid fungi as a model. Check it out! alonglab.org
Long Research Group
Long Research Group - Univ. Kentucky
alonglab.org
March 28, 2025 at 2:28 PM
Alex Long, the last postdoc from my lab at Stanford, is starting her own lab, continuing her beautiful work on evolutionary cell biology using chytrid fungi as a model. Check it out! alonglab.org
Reposted by Shane McInally
Many of these grants are fellowships and training grants supporting smart young people interested in bettering the world through their research. It is sad to see NIH funding used as an indiscriminate tool of retribution.
March 11, 2025 at 5:41 PM
Many of these grants are fellowships and training grants supporting smart young people interested in bettering the world through their research. It is sad to see NIH funding used as an indiscriminate tool of retribution.