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Reposted by Sarah Marzi

UK Dementia Research Institute @ukdri.ac.uk · 14d

❓ How can proteins lead to personalised Alzheimer’s treatment?

Discover how Prof @sj-marzi.bsky.social team have been observing changes in the brains microglia and their responses to Alzheimer’s.

Read more about Prof Marzi’s work 👉 lnkd.in/e4iaqqq9

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Reposted by Sarah Marzi

Dementia Researcher @dementiaresearcher.bsky.social · 21d

UK DRI @ukdri.ac.uk at King’s, London. Seeks Research Assistant in Dr Sarah Marzi’s @sj-marzi.bsky.social group to support stem cell culture, assays, and genomic work on neurodegenerative disease. Closing date: 6th October

www.dementiaresearcher.nihr.ac.uk/job/research...

Research Assistant: Stem Cell / iPSC work

UK DRI at King’s, London. Seeks Research Assistant in Dr Sarah Marzi’s group to support stem cell culture, assays, and genomic work on neurodegenerative disease

www.dementiaresearcher.nihr.ac.uk

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Reposted by Sarah Marzi

Dementia Researcher @dementiaresearcher.bsky.social · Aug 15

From fellowship heartbreak to rewriting success — stories of resilience in research funding on this week’s podcast. Available to Watch on YouTube now, or wait until Monday to find it in your podcast app.

youtu.be/ZbaRKM18hP0?...

Failing Forward: What My Grant Rejection Taught Me

YouTube video by Dementia Researcher

youtu.be

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Reposted by Sarah Marzi

Gonçalo Castelo-Branco @gocastelobranco.bsky.social · Aug 12

Join us at the FENS Single-Cell & Spatial Omics Winter School with:

@sarabiz86.bsky.social
@rongfan8.bsky.social
@gokcegroup.bsky.social
@gioelelamanno.bsky.social
@sj-marzi.bsky.social
@jplopez-atalaya.bsky.social
Ana Falcão
Florian Rosenberger
Gabriel Baró
Bosiljka Tasic
Barbara Treutlein

Federation of European Neuroscience Societies - FENS @fens.org · Aug 5

🌟 Registration is now OPEN! 🌟

Join the 2025-2026 #FENS-Hertie #WinterSchool and explore this year's topic – Single-cell and Spatial Omics to Understand Brain Heterogeneity! 🔬

📍 Alicante, Spain
🗓️ 11-17 Jan 2026

🔗 https://loom.ly/RM55lFQ

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Sarah Marzi @sj-marzi.bsky.social · Jul 24

It has been and continues to be an excellent collaboration and many thanks go to the brilliant team: Maria Tsalenchuk, Kyle Farmer, Sandra Castro, Abigail Scheirer, Yuqian Ye, Tim Greenamyre and Emily Rocha 🙏

@ukdri.ac.uk @kingsioppn.bsky.social @imperialbrains.bsky.social

Sarah Marzi @sj-marzi.bsky.social · Jul 24

Conversely, we see disruption of synaptic genes in the motor cortex. These results suggest reasons why neurons in the nigra may be particularly vulnerable in Parkinson's disease and why we see impairments in synaptic plasticity in the motor cortex.

Histone acetylation in the motor cortex of rats exposed to rotenone highlights disruption of synaptic pathways. This includes consistent upregulation of Homer1 and its binding partners.

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Sarah Marzi @sj-marzi.bsky.social · Jul 24

In this work, led by Maria Tsalenchuk, we show that chronic exposure to the pesticide rotenone leads to different histone acetylation patterns in the substantia nigra and motor cortex. In the nigra we see striking upregulation of immune pathways.

Staining images showing increased activation of microglia in the substantia nigra of rats exposed to rotenone.

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Sarah Marzi @sj-marzi.bsky.social · Jul 24

☣️🐀 Pesticide exposure in rats changes epigenetic signatures in different brain regions!

Latest paper from our fruitful collaboration with Emily Rocha and Tim Greenamyre, linking epigenetic signatures of exposure to toxicants to Parkinson's disease:

www.nature.com/articles/s41...

Unique nigral and cortical pathways implicated by epigenomic and transcriptional analyses in rotenone Parkinson’s model - npj Parkinson's Disease

npj Parkinson's Disease - Unique nigral and cortical pathways implicated by epigenomic and transcriptional analyses in rotenone Parkinson’s model

www.nature.com

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Reposted by Sarah Marzi

UK Dementia Research Institute @ukdri.ac.uk · Jul 24

Cells in key brain regions involved in Parkinson’s retain a ‘memory’ of pesticide exposure that disrupts gene expression🧬

Research by @sj-marzi.bsky.social & colleagues unlocks understanding of the mechanisms behind the role of pesticide exposure in Parkinson’s👉 buff.ly/1F16eUB

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Sarah Marzi @sj-marzi.bsky.social · Jul 10

Good times discussing all things #epigenetics and #microglia at our symposium with this awesome group: @jonasneher.bsky.social, @kooistrasm.bsky.social, @mancusorenzo.bsky.social. And enjoying the sun and science at #glia2025 in Marseille, while hoping that fires can be contained.

Jonas Neher, Sarah Marzi, Susanne Kooistra and Renzo Mancuso at the microglia epigenetics symposium for the Glia conference 2025 in Marseille.

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Sarah Marzi @sj-marzi.bsky.social · Jun 26

Really excited to speak at the Canadian Conference on Epigenetics. Join us in beautiful Banff in November 👇🏻

Canadian Epigenetics @ceehrc.bsky.social · Jun 26

Registration is now OPEN for the 11th Canadian Conference on Epigenetics!

The annual meeting will be held November 12-15, 2025 at the Banff Centre in Banff, Alberta.

You can register and find out more information at our website: event.fourwaves.com/ceehrc2025

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Sarah Marzi @sj-marzi.bsky.social · Jun 2

Thanks again for inviting me 🙏🏻

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Reposted by Sarah Marzi

Kitty Murphy @kittybmurphy.bsky.social · May 28

Excited to share that a chapter of my PhD has just been published in Nature Communications!

We profiled the transcriptomic and chromatin landscapes of microglia expressing the different APOE variants, which were xenografted into the brains of an Alzheimer's disease (AD) mouse model 🧠🧬

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Reposted by Sarah Marzi

UK Dementia Research Institute @ukdri.ac.uk · May 28

The APOE gene is a major genetic risk factor for Alzheimer's, but different versions of the protein confer strikingly different risk profiles.

New research led by ‪@sj-marzi.bsky.social‬ offers insight into how the different versions of APOE affect microglia👉https://buff.ly/pyFh7jy