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Reposted by Shamphavi Sivabalasarma

The Daum Lab @daumlab.bsky.social · 2d

Out in Science Advances: Our #cryoEM structure of HFTV1, a virus infecting the halophile #archaea. *First full atomic structure (containing all structural proteins) of any tailed virus!* Congrats and thanks to all co-authors and our fantastic collaborators! www.science.org/doi/10.1126/...

Cryo-EM resolves the structure of the archaeal dsDNA virus HFTV1 from head to tail

This structure of an archaeal tailed virus (arTV) provides detailed insights into arTV assembly and infection mechanisms.

www.science.org

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Reposted by Shamphavi Sivabalasarma

Sonja-Verena Albers @archaellum.bsky.social · 6d

Look at this nice cover: beautiful archaella, image made by @sshamphavi.bsky.social !

Thanks also to Marta Rodeiguez for keeping the EM im shape in @ottlab.bsky.social lab!

At @biologyunifreiburg.bsky.social at @uni-freiburg.de @sfb1381.bsky.social @cibss.bsky.social

Nature Microbiology @natmicrobiol.nature.com · 7d

Some keen Observations in Our October issue!

🦠 Cancer microbiome
🌊 Marine microbes in warming oceans
🌐 broad-range phages
🧬 genetically minimised Salmonella
🔧 Viral infection mechanisms
🧪 Oxaloacetate antiviral defence

and more, here: www.nature.com/nmicrobiol/v...

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Reposted by Shamphavi Sivabalasarma

François Mayer @francoismayer.bsky.social · 7d

Our October issue is out now!

The images are negatively stained electron micrographs taken from archaella bundles isolated from the archaeon Sulfolobus acidocaldarius.

Check the issue out here:
www.nature.com/nmicrobiol/v...

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Shamphavi Sivabalasarma @sshamphavi.bsky.social · 7d

Beautiful archaellum filaments on the cover 😍🦠 Thanks to the Imaging Facility within MIAP at @biologyunifreiburg.bsky.social that made it possible! Curious how we got there? check our latest publication: www.nature.com/articles/s41...

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Reposted by Shamphavi Sivabalasarma

CIBSS – Centre for Integrative Biological Signalling Studies @cibss.bsky.social · 20d

Spinning into new evolutionary territory🌀🦠: The latest @natmicrobiol.nature.com paper from the lab of our Speaker Sonja Albers uncovers bacterial species with an ATP-driven archaellum for motility. Great work from @sshamphavi.bsky.social and our Cryo-EM facility

Sonja-Verena Albers @archaellum.bsky.social · 21d

Happy to share that our story on the bacterial archaellum was published today in @natmicrobiol.nature.com
www.nature.com/articles/s41...

Congrats to the authors: @sshamphavi.bsky.social @loumollat.bsky.social @mariejoest.bsky.social Najwa Taib and @sgribaldo.bsky.social

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Reposted by Shamphavi Sivabalasarma

Nature Microbiology @natmicrobiol.nature.com · 20d

#NewResearch

Structure of a functional archaellum in Bacteria of the Chloroflexota phylum

@archaellum.bsky.social @sgribaldo.bsky.social & co

#microsky 🧪🦠

www.nature.com/articles/s41...

Structure of a functional archaellum in Bacteria of the Chloroflexota phylum - Nature Microbiology

Bona fide gene clusters for archaella are widespread across a bacterial phylum and encode functional motility machinery.

www.nature.com

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Shamphavi Sivabalasarma @sshamphavi.bsky.social · 21d

Well that is a compliment! Great to hear that

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Shamphavi Sivabalasarma @sshamphavi.bsky.social · 21d

Bacteria with archaella, who would have thought that this existed. Happy to share that it does 🎉and we just published it today in @natmicrobiol.nature.com 🎉🥳. Congrats to everyone involved! 🦠

Sonja-Verena Albers @archaellum.bsky.social · 21d

Happy to share that our story on the bacterial archaellum was published today in @natmicrobiol.nature.com
www.nature.com/articles/s41...

Congrats to the authors: @sshamphavi.bsky.social @loumollat.bsky.social @mariejoest.bsky.social Najwa Taib and @sgribaldo.bsky.social

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Reposted by Shamphavi Sivabalasarma

Faculty of Biology - University of Freiburg @biologyunifreiburg.bsky.social · Sep 4

The state has funded a large amount of initiatives to make lab work more green and sustainable 🌱, including the "Nachhaltiger Bio-Campus Freiburg" proposal by our @corneliaklose.bsky.social & Henriette Rübsam. Congratulations!

Faculty of Biology - University of Freiburg @biologyunifreiburg.bsky.social · Sep 4

mwk.baden-wuerttemberg.de/de/service/p...

Land fördert 29 Projekte für klimafreundliche Labore an Hochschulen

In den Laboren unserer Hochschulen entstehen wegweisende Innovationen – doch der Energie- und Ressourcenverbrauch ist enorm. Der Ideenwettbewerb „BWGreenLabs“ des Wissenschaftsministeriums zeigt, wie ...

mwk.baden-wuerttemberg.de

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Kyle Harrington @kyleharrington.com · Aug 26

Better ML for cryo-ET starts with better benchmarks.

We built a phantom cryo-ET dataset (~500 tomograms) + hosted a Kaggle challenge.

The result: community models beat expert tools.

Read more in the @natmethods.nature.com article that just came out:
🔗 doi.org/10.1038/s415...

A realistic phantom dataset for benchmarking cryo-ET data annotation - Nature Methods

A standardized, realistic phantom dataset consisting of ground-truth annotations for six diverse molecular species is provided as a community resource for cryo-electron-tomography algorithm benchmarki...

doi.org

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Reposted by Shamphavi Sivabalasarma

Marie Joest @mariejoest.bsky.social · Aug 20

Started a PhD in the field of Archaea, ended up writing a paper about a bacterium! Enjoy new insights into the cell biology of Litorilinea aerophila, a member of the Chloroflexota 🦠

Sonja-Verena Albers @archaellum.bsky.social · Aug 20

🚨 Imagine a bacterium that refuses to follow the textbook:
It grows as tangled filaments, divides unevenly, reshapes its own membranes… and even builds grappling hooks.
Meet Litorilinea aerophila — and here’s why it blew our minds.

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Shamphavi Sivabalasarma @sshamphavi.bsky.social · Aug 20

Chloroflexi rules! Thrilled to share our latest preprint on this amazing bacterial (😱) organism of Chloroflexota. Long filaments, fascinating cell surface structures😍 Kudos to everyone involved and especially @mariejoest.bsky.social!

Sonja-Verena Albers @archaellum.bsky.social · Aug 20

🚨 Imagine a bacterium that refuses to follow the textbook:
It grows as tangled filaments, divides unevenly, reshapes its own membranes… and even builds grappling hooks.
Meet Litorilinea aerophila — and here’s why it blew our minds.

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Reposted by Shamphavi Sivabalasarma

César de la Fuente @delafuentelab.bsky.social · Aug 12

(1/5)For over a century, the hunt for new antibiotics has focused almost exclusively on bacteria and fungi. Today, that paradigm shifts. By coupling state-of-the-art AI with the vast, largely uncharted diversity of Archaea, we open a new frontier for molecular discovery.

Deep learning reveals antibiotics in the archaeal proteome - Nature Microbiology

Use of artificial intelligence to mine proteomes of archaea led to the discovery of archaeasins, antimicrobials that kill drug-resistant bacteria in laboratory and animal models, offering a promising ...

www.nature.com

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Pilhofer Lab 🦠❄️🔬 @pilhoferlab.bsky.social · Aug 12

Check out 🧐 our new preprint 📜:
www.biorxiv.org/content/10.1...
Congrats🎉 to @vasilgaisin.bsky.social and Corina Hadjicharalambous, who studied contractile injection systems directly in hot spring♨️ bacterial mats🦠
#microsky #teamtomo #Chloroflexota

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Robert Grosse @ grosselab @grosselab.bsky.social · Jul 31

Hi all, check out our new preprint where we uncover:"Regulation of YAP activity by nuclear G-actin binding", www.biorxiv.org/cgi/content/...
#actin #YAP/TAZ #transcription #nucleus with help from Sonja-Verena Albers
‪@archaellum.bsky.social‬

Regulation of YAP activity by nuclear G-actin binding

The Yes-associated protein YAP belongs to the TEAD (TEA/ATTS domain) transcriptional co-activators that shuttle between cytoplasm and nuclear compartment. YAP and its paralog TAZ (transcriptional co-a...

www.biorxiv.org

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Reposted by Shamphavi Sivabalasarma

Simonetta Gribaldo @sgribaldo.bsky.social · Jul 7

Finally out of embargo!!
Happy to be among the recipients of a Chaire d'excellence from @agencerecherche.bsky.social
www.enseignementsup-recherche.gouv.fr/fr/media/37482
to further knowledge on #archaea #methanogens of the human #microbiome. We'll be very busy for the next 5 years @pasteur.fr !!

Projets lauréats Chaires d'excellence en biologie santé 2025 | enseignementsup-recherche.gouv.fr

www.enseignementsup-recherche.gouv.fr

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Shamphavi Sivabalasarma @sshamphavi.bsky.social · Jul 8

Congrats Simonetta! 🎉

Reposted by Shamphavi Sivabalasarma

Florian Wollweber @florianwollweber.bsky.social · Jun 27

After 5 amazing years @pilhoferlab.bsky.social I'm starting my lab @embl.org Grenoble this November embl.org/wollweber
We'll image Asgard archaea and many other strange microbes ( #archaeasky, #protistsonsky..) to understand eukaryogenesis
First job ad: #teamtomo scientist!🔬❄️ tinyurl.com/2rdu2ze6

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DEEMteam_Orsay @deemteam.bsky.social · Jun 17

📣 We are proud of the publication of the second paper of @bbaker24.bsky.social PhD thesis. In collaboration with friends in Halifax we have studied the difficult question of the phylogeny of the DPANN archaea, composed of several phyla of highly reduced, fast-evolving epiparasites 🧵

rdcu.be/erkkU

Phylogenomic analyses indicate the archaeal superphylum DPANN originated from free-living euryarchaeal-like ancestors

Nature Microbiology - Phylogenetic reconstructions with conserved protein markers from the 11 known DPANN phyla reveal their monophyletic placement within the Euryarchaeota.

rdcu.be

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Reposted by Shamphavi Sivabalasarma

Arthur Charles-Orszag @acharlesorszag.bsky.social · May 29

Archaeal S-layer proteins can adopt different symmetries that can locally accommodate areas of high curvature. The S-layer is also involved in the control of turgor and osmotic pressure, ion transport, cell-cell interactions and mating.

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Reposted by Shamphavi Sivabalasarma

Arthur Charles-Orszag @acharlesorszag.bsky.social · May 29

The S-layer is the most widespread and fundamental component of archaeal cell envelopes and may represent one of the earliest and most fundamental cell wall polymers found in microorganisms

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Reposted by Shamphavi Sivabalasarma

Arthur Charles-Orszag @acharlesorszag.bsky.social · May 29

The archaeal S-layer is not only pretty, it also carries crucial cellular functions, and the list keeps growing! @sshamphavi.bsky.social @marleenvw.bsky.social @archaellum.bsky.social and I wrote a little sheath sheet (+10 pts if you got the pun)
📖 Curr Opin Cell Biol
🔗 doi.org/10.1016/j.ce...

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Svetlana Dodonova @dodonova-sveta.bsky.social · May 26

We’ve uncovered Asgard chromatin structures formed by a Hodarchaeal histone : closed hypernucleosome conserved in archaea and an open form resembling the H3-H4 eukaryotic octasome. Fantastic work by @harshranawat.bsky.social!
www.biorxiv.org/content/10.1...
#Chromatin #Asgard #Archaea #cryoEM

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Suckjoon Jun’s lab at UCSD @junlab.bsky.social · May 5

Our paper on the E. coli Min system in vivo with @physicsoflifelmu.bsky.social & Judy Kim (UCSD) has been published in Nature Physics today. Tight integration of experiment and theory, and physiology and biophysics. Incredible perseverance of our young students. rdcu.be/ekIpO

Robust and resource-optimal dynamic pattern formation of Min proteins in vivo

Nature Physics - Oscillatory Min protein patterns prevent abnormal bacterial cell division. Now it is shown that Min pattern formation is resource efficient and involves wavelength-invariant...

rdcu.be

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Arthur Charles-Orszag @acharlesorszag.bsky.social · Apr 16

Preprint alert! I’m publishing my last paper from my postdoc work on archaeal cell biology, with @mullinslab.bsky.social, @archaellum.bsky.social, @samjlord.bsky.social, @marleenvw.bsky.social, @arghya93.bsky.social, and more great folks (thread below with more details)

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