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Reposted by Simonetta Gribaldo

Constantin Anoyatis @canopele.bsky.social · 15h

Proud of our new study out in @cp-cellreports.bsky.social!
Using E. coli lacking all 8 endopeptidases, we provide direct evidence that peptidoglycan expansion during elongation requires ED-mediated insertion of one glycan strand at a time. This can be performed by MepS, MepM, MepH and PBP7 #microsky

Role of endopeptidases in lateral cell wall expansion in Escherichia coli

Peptidoglycan, the major constituent of bacterial cell walls, is a giant macromolecule made of glycan strands cross-linked by short peptides, which pr…

www.sciencedirect.com

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Reposted by Simonetta Gribaldo

Nature @nature.com · 2d

BREAKING: The Nobel Prize in Physiology or Medicine has been awarded jointly to Mary E. Brunkow, Fred Ramsdell, and Shimon Sakaguchi "for their discoveries concerning peripheral immune tolerance"

Stay tuned for more.
#NobelPrize

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Basile Beaud Benyahia @babebe.bsky.social · 3d

Wonderful pair of papers by Augustinas Silale and Ben Berks on the diversity of BAM complexes.

Most diderm bacteria lack all BAM accessory previously identified in E. coli.

These two papers show a whole new set of accessory proteins in Bacteroidota.

How many more BAMs is there out there?
👁️👃🏼👁️

Augustinas Silale @augustsilale.bsky.social · 7d

Our paper on the Bacteroidota BAM complex is out in @natmicrobiol.nature.com! With @madejmar.bsky.social

We found that BAM in Bacteroides and Porphyromonas gingivalis has a distinct architecture from BAM in Proteobacteria.

doi.org/10.1038/s415...

Structure of a distinct β-barrel assembly machinery complex in the Bacteroidota - Nature Microbiology

Structural and functional characterization of the β-barrel assembly machinery complex in Bacteroidota reveals a distinct, seven-component complex with a large extracellular domain that may enable β-barrel–surface lipoprotein complex assembly.

doi.org

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Reposted by Simonetta Gribaldo

Augustinas Silale @augustsilale.bsky.social · 7d

Our paper on the Bacteroidota BAM complex is out in @natmicrobiol.nature.com! With @madejmar.bsky.social

We found that BAM in Bacteroides and Porphyromonas gingivalis has a distinct architecture from BAM in Proteobacteria.

doi.org/10.1038/s415...

Structure of a distinct β-barrel assembly machinery complex in the Bacteroidota - Nature Microbiology

Structural and functional characterization of the β-barrel assembly machinery complex in Bacteroidota reveals a distinct, seven-component complex with a large extracellular domain that may enable β-barrel–surface lipoprotein complex assembly.

doi.org

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Anthony Vecchiarelli @cellforganized.bsky.social · 15d

New PrePrint from the Vecchiarelli and Mosalaganti (@shyamalm.bsky.social) labs! 🧵

Collaboration with the Giessen and Pi labs

Congratulations to co-first authors Y Hoang (@hoanghamyy.bsky.social) and Pankaj Jadhav!

www.biorxiv.org/content/10.1...

Engineering Spatial Control of Bacterial Organelles

Bacteria were once thought to lack organelles, but it is now clear they confine cellular reactions using an array of membrane- and protein-based compartments. A central question, however, is how bacte...

www.biorxiv.org

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Camila Valenzuela, PhD @kamovalenz.bsky.social · 20d

New preprint from the lab! Great work led by @camimille.bsky.social #mycobacterium #TB #cryoET

bioRxiv Microbiology @biorxiv-microbiol.bsky.social · 21d

Nitrate-responsive Mycobacterial Intracytoplasmic Membranes dampen Inflammation during Mycobacterium tuberculosis Infection https://www.biorxiv.org/content/10.1101/2025.09.17.676823v1

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Sonja-Verena Albers @archaellum.bsky.social · 21d

Happy to share that our story on the bacterial archaellum was published today in @natmicrobiol.nature.com
www.nature.com/articles/s41...

Congrats to the authors: @sshamphavi.bsky.social @loumollat.bsky.social @mariejoest.bsky.social Najwa Taib and @sgribaldo.bsky.social

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Julie Le Bris @julielebris.bsky.social · 28d

How complex functions, with important physiological and evolutionary impacts get repeatedly and efficiently transferred across genomes?
That’s what we explored using one of the fastest-evolving loci in Bacteria: the capsule locus.
The paper: www.biorxiv.org/content/10.1...
Thread👇

Serotype swapping in Klebsiella spp. by plug-and-play

Understanding how complex, multi-gene systems evolve and function across genetic backgrounds is a central question in molecular evolution. While such systems often impose costs through epistatic inter...

www.biorxiv.org

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Julie Le Bris @julielebris.bsky.social · Sep 5

Delighted to share our recently published work!
Ever wondered how Klebsiella (and others) deals with capsule production’s costs ?
The paper: journals.asm.org/doi/10.1128/...
Thread👇

Phenotypic heterogeneity of capsule production across opportunistic pathogens | mBio

The polysaccharidic capsule is present in ~50% of species across the bacterial phylogeny, including all ESKAPE microorganisms, the six most significant multidrug-resistant (MDR) nosocomial pathogens. It is also an important virulence factor and a major ...

journals.asm.org

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Alexander Harms @aharms485.bsky.social · Aug 16

Elio Schaechter, eminent microbiologist and great human, leaves us his memoirs that tell the story of an extraordinary life: www.eliosmemoirs.org. What a fantastic and impactful journey!

Elio's Memoirs

www.eliosmemoirs.org

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Eileen Furlong @eileen-furlong.bsky.social · Jul 30

To all post-docs: The Genome Biology dept ‪@embl.org
has an Independent faculty position. Fantastic place to set up your lab –great package: core funding, fantastic Ph.D. students, cutting edge core facilities & great colleagues. Closing date Sept 19th
embl.wd103.myworkdayjobs.com/en-US/EMBL/j...

Group Leader - Genome Biology Unit

Are you ready to lead groundbreaking research in Genome Biology? Join us at EMBL! We are seeking a motivated scientist to lead an independent research group addressing exciting and original biological...

embl.wd103.myworkdayjobs.com

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Michael Deghelt @michaeldeghelt.bsky.social · Jul 29

#microsky
We challenge the long-standing view that peptidoglycan alone protects cells from bursting.

Our study shows that the periplasm — enclosed by OM–PG connections — acts as a pressure buffer essential for osmoprotection in Gram-negative bacteria.

📄 www.nature.com/articles/s41...

Peptidoglycan–outer membrane attachment generates periplasmic pressure to prevent lysis in Gram-negative bacteria - Nature Microbiology

Outer membrane attachment to peptidoglycan enables periplasmic pressure to build up and counter cytoplasmic turgor pressure, preventing lysis during osmotic challenges in Escherichia coli.

www.nature.com

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Simonetta Gribaldo @sgribaldo.bsky.social · Jul 7

thanks Sonja!

Simonetta Gribaldo @sgribaldo.bsky.social · Jul 7

Thank you Mart!

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Simonetta Gribaldo @sgribaldo.bsky.social · Jul 7

merci!

Simonetta Gribaldo @sgribaldo.bsky.social · Jul 7

merci!

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Simonetta Gribaldo @sgribaldo.bsky.social · Jul 7

thank you Christine! Between Austria and France, GIT methanogens on 🌋🌋🌋!!

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Simonetta Gribaldo @sgribaldo.bsky.social · Jul 7

thank you Tracy!

Simonetta Gribaldo @sgribaldo.bsky.social · Jul 7

Finally out of embargo!!
Happy to be among the recipients of a Chaire d'excellence from @agencerecherche.bsky.social
www.enseignementsup-recherche.gouv.fr/fr/media/37482
to further knowledge on #archaea #methanogens of the human #microbiome. We'll be very busy for the next 5 years @pasteur.fr !!

Projets lauréats Chaires d'excellence en biologie santé 2025 | enseignementsup-recherche.gouv.fr

www.enseignementsup-recherche.gouv.fr