Tara Fischer
@tarafisch.bsky.social
820 followers 1.1K following 49 posts
Molecular Cell Biologist. Organelles + immunity 🔬🧫🦠 Science + Labor 🤝 UAW Local 2750
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tarafisch.bsky.social
Apropos *first* post! We’ve discovered a central mechanism for how activation of STING induces NFkB related immune signaling - M1-linked/linear ubiquitin chains! I’m so excited to share it with you all, out now in t.co/zCIf2E4h2z a thread 1/X:
https://www.embopress.org/doi/full/10.1038/s44318-024-00291-2
t.co
Reposted by Tara Fischer
Reposted by Tara Fischer
greenrat.bsky.social
Neat trick if you polycolonal ab's suck. Incubate them with fixed cells with a KO of your protein of interest, then spin. Protocol here: www.med.upenn.edu/markslab/ass...
I was amazed how well it worked on first try (I'm sure that I can completely eliminate unspecific bands)
#WesternBlot #cellsky
On the left - western blot of B16F10 cells wt and KO for CDK8. Our in house produced antibodies give a lot of unspecific bands. On the right same probes with antibodies preincubated with fixed CDK8 KO cells - there is a specific band and faint unspecific bands, which can be probably eliminated with increase of amount of KO cells.
Reposted by Tara Fischer
jenna-m-norton.bsky.social
That’s a lot of science we left on the table.
jeremymberg.bsky.social
Here is NIDDK

61% as many new R01s in FY25 as in FY24.

17/n
Reposted by Tara Fischer
normative.bsky.social
This is sort of a classic prisoners' dilemma: If nobody defects, nobody has "priority". Which makes it essential that universities coordinate a united front.
brendannyhan.bsky.social
Trump's higher ed ransom note is here - everyone would have to acquiesce to their unprecedented demands or not be "given priority for grants," plus they can demand "reimbursement" for "violations" www.wsj.com/us-news/educ...

A mechanism to enforce fealty. An attack on academic freedom and democracy
Reposted by Tara Fischer
gregggonsalves.bsky.social
This is extortion. Faculty, students, staff, alumni across the country need to get to their Presidents & Trustees today. Just say no. This blackmail only works if most everyone folds. Capitulation now means the end of American higher education for a generation. www.nytimes.com/2025/10/02/u...
Trump Administration Asks Colleges to Sign ‘Compact’ to Get Funding Preference
www.nytimes.com
Reposted by Tara Fischer
katecavanaugh.bsky.social
See this? This = implanting mouse embryo. Usually this happens inside its mother and is invisible to us, but we can actually watch implantation ex vivo with the hope of understanding why implantation goes awry in embryos of older women. A 🧵...
Reposted by Tara Fischer
aaup.org
AAUP @aaup.org · 9d
BREAKING: WE WON!!!
💥 💥 💥

Federal Judge William G. Young ruled today in our lawsuit against the Trump administration that the policy of arresting, detaining, & deporting noncitizen students & faculty members for their pro-Palestinian advocacy violates the 1st Amendment.

Full ruling here:
Findings of Fact & Conclusions of Law – #261 in American Association of University Professors v. Rubio (D. Mass., 1:25-cv-10685) – CourtListener.com
Judge William G. Young: ORDER entered. FINDINGS OF FACT AND RULINGS OF LAW, PURSUANT TO FED. R. CIV. P. 52(A)(Sonnenberg, Elizabeth) (Additional attachment(s) added on 9/30/2025: # 1 Main Document) (J...
www.courtlistener.com
Reposted by Tara Fischer
altusaid.altgov.info
More than 5,000 federal workers (current and former) have now signed this letter urging "Congress to pass nothing less than a continuing resolution (CR) that reasserts Congress's constitutional powers, upholds our democracy and protects the American people."
Civil Servants Demand an End to Executive Overreach
Join federal workers from across the federal government as we urge Congress to pass nothing less than a continuing resolution (CR) that reasserts Congress's constitutional powers, upholds our democrac...
actionnetwork.org
Reposted by Tara Fischer
asherelbein.bsky.social
This is absolutely ridiculous, would devastate numerous academic fields, and would destroy the lives of people I love very much. Please, please join me in sending a comment in on this telling them so
ianlmorgan.bsky.social
DHS is proposing a rule that would end "duration of status" for J, F and other visa holders. This would decimate the international graduate student and postdoc population, which are a crucial part of the United States biomedical workforce. There's still time for you to comment on the proposed rule.
Establishing a Fixed Time Period of Admission and an Extension of Stay Procedure for Nonimmigrant Academic Students, Exchange Visitors, and Representatives of Foreign Information Media
Unlike most nonimmigrant classifications, which are admitted for a fixed time period, aliens in the F (academic student), J (exchange visitor), and most I (representatives of foreign information media...
www.federalregister.gov
Reposted by Tara Fischer
alt-dol.altgov.info
FUN (@fedworkersunited.bsky.social) is calling out the OMB memo threatening mass layoffs as a pressure tactic to get Congress to keep the federal government open.

Read the release: www.federalunionists.net/press/statem...
Not New Policy: The Feb. 11 and Feb. 26 “Department of Government Efficiency (DOGE)” orders already required RIF planning. The Sept. 24 memo just recycles those threats.

Fear Tactic: By framing layoffs as “shutdown planning,” OMB is trying to pressure Congress into a bad budget deal.

Lockout, Not Shutdown: Workers want to serve — but the administration is dismantling agencies and public services to advance an extremist, unpopular agenda.
Reposted by Tara Fischer
tyk314.net
The end of FY 2025 is coming, and #OMB appears perfectly content to use us as targets. We are not their chess pieces. We serve our PIs. We are here in our personal capacities. Follow the #NIH.
Reposted by Tara Fischer
rupress.org
In @jcb.org, @lysoluis.bsky.social, @markrcookson.bsky.social et al. show how two distinct pRAB effectors and RHD members, JIP4 and RILPL1, provide antagonistic motor force to regulate #lysosome tubulation. rupress.org/jcb/article/...
Reposted by Tara Fischer
drrabbithole.bsky.social
Wow. This administration really must be afraid of a shutdown to make these threats.

@schumer.senate.gov - You have the power to restore some semblance of balance to government. You mustn't squander it. #fightingcr

If you don't, Vought will fire everyone anyway. 🤷🏻‍♀️

www.politico.com/news/2025/09...
White House to agencies: Prepare mass firing plans for a potential shutdown
In memo, the Trump administration says the Reduction-in-Force plans would go beyond standard shutdown furloughs.
www.politico.com
Reposted by Tara Fischer
jenna-m-norton.bsky.social
It is extremely disingenuous to compare this to prior shutdown negotiations.

This isn’t mere policy debate.

This isn’t Dems “spoiling for a fight, damn the consequences.”

This is the fight of our lives to save our democracy and shutdown authoritarianism.

www.politico.com/news/2025/09...
Tables turn for Democrats as they use shutdown for leverage
The current standoff is a nearly precise inversion of the 2013 showdown over health care that closed government agencies for 17 days.
www.politico.com
Reposted by Tara Fischer
aaup.org
AAUP @aaup.org · 18d
The AAUP & @aft.org are fighting back to remind our elected leaders that higher education & public health research are transformative public goods.

We must keep life-saving NIH research fully funded & stop the Trump admin’s devastating funding cuts that are halting medical breakthroughs.
Reposted by Tara Fischer
fedsworkforyou.bsky.social
Check out our trip to Capitol Hill yesterday with @fedsagainstdoge.bsky.social and @safa-science.bsky.social -- and sign the petition at bit.ly/FIGHTINGCR. It's up to 2️⃣5️⃣0️⃣0️⃣ signers! #FightingCR
Reposted by Tara Fischer
Reposted by Tara Fischer
rosalafersousa.bsky.social
🇺🇸 Fed workers across the government are issuing a challenge to Congress: "We call on you to pass nothing less than a fighting CR: a funding bill that not only keeps the lights on, but that also includes statutory protections to rein in executive lawlessness."

✍️ Sign the letter. Spread the word 🔥
Civil Servants Demand an End to Executive Overreach
Join federal workers from across the federal government as we urge Congress to pass nothing less than a continuing resolution (CR) that reasserts Congress's constitutional powers, upholds our democrac...
actionnetwork.org