This structure of an archaeal tailed virus (arTV) provides detailed insights into arTV assembly and infection mechanisms.

HCV infection often promotes the formation of large LDs in HCV-infected cells. However, the molecular mechanism underlying large LD formation is poorly understood. LD turnover is regulated by SPG20, I...

Author summary Human astroviruses (HAstV) are understudied, globally prevalent pathogens capable of causing potentially fatal infections of the central nervous system in children, the elderly, and imm...

Encephalomyocarditis virus (EMCV) infects a range of species, causing economically important reproductive disorders in pigs and encephalitis and myocarditis in rodents. Due to its wide host range, it ...

Porcine deltacoronavirus (PDCoV) is an emerging pig pathogen that has recently been detected in humans. Here, the authors demonstrate that neutralizing antibodies against PDCoV target cryptic sites th...

Although porcine deltacoronavirus (PDCoV) poses a potential threat to public health, effective vaccines against PDCoV remain lacking. Here, we developed a novel nanoparticle-based C-terminal domain va...

In a groundbreaking advance that significantly deepens our understanding of viral replication machinery, researchers have unveiled high-resolution cryo-electron microscopy (cryo-EM) structures of the Nipah virus (NiV) polymerase complex. This detailed structural insight opens new avenues for the design of antiviral agents targeting a highly pathogenic zoonotic virus responsible for severe and often fatal human infections. Nipah virus, an emergent member of the Paramyxoviridae family, poses a persistent public health threat due to its zoonotic nature and the absence of approved therapeutics.

As the virus continues to evolve, experts assess its latest variants, seasonal prevalence and levels of vaccine uptake

npj Vaccines - DNA vaccine targeting betacoronavirus spike protein blocks neuroinvasion and neuroinflammation in swine via dual antiviral-immunomodulatory action

Cryo-EM structures of the full-length Junin virus and Machupo virus spike glycoprotein complexes stabilized in the prefusion conformation. Analyses reveal features that regulate glycoprotein pH-depend...

A wide range of viruses utilize sialic acid as receptors. Sialic acid binding may serve as a key determinant of viral host range. Different viruses exhibit distinct preferences for specific types of s...

Mouse models show that respiratory infections from viruses such as influenza and SARS-CoV-2 can trigger metastasis of dormant breast cancer cells in the lungs, a finding supported by epidemiological d...