Vojtech Dostal
@vojtechdostal.bsky.social
Cell biologist at @meduniibk.bsky.social. Wikipedia & Wikidata guy.
Reposted by Vojtech Dostal
In our cover, Waich et al. record progress for early-onset O2HE Syndrome–their analysis of the UNC45A c.710T>C 37 missense variant uncovered its pathogenic mechanisms & recessive 46 characteristics and may aid in the development of targeted therapies: buff.ly/sU0qlNx
March 24, 2025 at 4:04 PM
In our cover, Waich et al. record progress for early-onset O2HE Syndrome–their analysis of the UNC45A c.710T>C 37 missense variant uncovered its pathogenic mechanisms & recessive 46 characteristics and may aid in the development of targeted therapies: buff.ly/sU0qlNx
Reposted by Vojtech Dostal
Excellent set of guidelines for anyone developing software for life scientists, from @jwpylvanainen.bsky.social, @lankylaste.bsky.social and @guijacquemet.bsky.social
journals.biologists.com/jcs/article/...
journals.biologists.com/jcs/article/...
Practical recommendations for developing software for life science applications
ABSTRACT. Developing user-friendly image analysis software is essential for advancing biological and life science research. However, the interdisciplinary gap between software developers and life scie...
journals.biologists.com
March 19, 2025 at 3:56 PM
Excellent set of guidelines for anyone developing software for life scientists, from @jwpylvanainen.bsky.social, @lankylaste.bsky.social and @guijacquemet.bsky.social
journals.biologists.com/jcs/article/...
journals.biologists.com/jcs/article/...
An old timelapse I dug up... U937-derived macrophages bathed in green and red dextran... the green dextran is pH sensitive, leading to the appearance of mostly red lysosomes.
February 27, 2025 at 12:47 PM
An old timelapse I dug up... U937-derived macrophages bathed in green and red dextran... the green dextran is pH sensitive, leading to the appearance of mostly red lysosomes.
Reposted by Vojtech Dostal
NEW: Russia Has Failed to Break Ukraine: isw.pub/RussiaRetros...
Russia dedicated staggering amounts of manpower and equipment to several major offensive efforts in Ukraine in 2024, intending to degrade Ukrainian defenses and seize the remainder of Donetsk and Luhansk oblasts. (1/3)
Russia dedicated staggering amounts of manpower and equipment to several major offensive efforts in Ukraine in 2024, intending to degrade Ukrainian defenses and seize the remainder of Donetsk and Luhansk oblasts. (1/3)
February 24, 2025 at 3:40 PM
NEW: Russia Has Failed to Break Ukraine: isw.pub/RussiaRetros...
Russia dedicated staggering amounts of manpower and equipment to several major offensive efforts in Ukraine in 2024, intending to degrade Ukrainian defenses and seize the remainder of Donetsk and Luhansk oblasts. (1/3)
Russia dedicated staggering amounts of manpower and equipment to several major offensive efforts in Ukraine in 2024, intending to degrade Ukrainian defenses and seize the remainder of Donetsk and Luhansk oblasts. (1/3)
I actually tested these two and also SamCell (recently on Biorxiv). Here's the quick and dirty results - might still be finetuned, and I might have not always picked the best settings.
So much happening in the segmentation space for bioimage analysis. These two papers that were published online today really stood out to me as noteworthy (a thread).
February 16, 2025 at 9:29 PM
I actually tested these two and also SamCell (recently on Biorxiv). Here's the quick and dirty results - might still be finetuned, and I might have not always picked the best settings.
Reposted by Vojtech Dostal
Very nice! During our practical course we once used the ColorfulCell vector for a similar purpose www.addgene.org/62449/
February 7, 2025 at 8:49 AM
Very nice! During our practical course we once used the ColorfulCell vector for a similar purpose www.addgene.org/62449/
Reposted by Vojtech Dostal
Reposted by Vojtech Dostal
You an even go as far as to color-code each cell-level datapoint by the experimental run it came from, so the reader can see if there if the cell variability is clustered or dispersed.
November 18, 2024 at 7:02 PM
You an even go as far as to color-code each cell-level datapoint by the experimental run it came from, so the reader can see if there if the cell variability is clustered or dispersed.
ER-lysosome contact sites (green) in MEFs on the background of an ER stain (grey, GFP-VAPA)
December 4, 2024 at 6:29 PM
ER-lysosome contact sites (green) in MEFs on the background of an ER stain (grey, GFP-VAPA)