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Worboys Lab @worboyslab.bsky.social · 6d

It was fantastic to contribute to the latest research from @owenlabuob.bsky.social now out at @natcomms.nature.com. This is a great initiative and could be an important resource for the SMLM community.
www.nature.com/articles/s41...

Nano-org, a functional resource for single-molecule localisation microscopy data - Nature Communications

An open-access resource, nano-org, enables researchers to explore and compare the nanoscale 2 organisation of proteins imaged using single-molecule localisation microscopy, advancing insights 3 into cell biology, disease, and drug response.

www.nature.com

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Reposted by Worboys Lab

Doug Dyer @douglaspdyer.bsky.social · 26d

We have a new Postdoc position advertised as part of our recent long-term Wellcome funding to join an established Postdoc and technician. I’m so excited to explore the role of the glycocalyx in CNS-inflammation. So many tools and expertise to work with! www.jobs.manchester.ac.uk/Job/JobDetai...

Research Associate in in Neuro-Immunology and Extraceullar Matrix Biology (ImmunoMatrix):Oxford Road

Our Glyco-Immunology (Dyer) lab has produced published and preliminary data demonstrating that an under-appreciated structure, the glycocalyx, on endothelial- and immune- cells regulates immune cell recruitment by:

www.jobs.manchester.ac.uk

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Reposted by Worboys Lab

Olatz Niembro @olatznv.bsky.social · 19d

Our new paper is out! Khodor Hazime led the brilliant work at the @dandavis101.bsky.social lab that shows *how* engagers that bring NK cell receptors together at the immune synapse boost activation against tumour cells

www.pnas.org/doi/10.1073/...

PNAS

Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans...

www.pnas.org

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Reposted by Worboys Lab

Immunotherapy Advances @imtadvances.bsky.social · Jul 6

🧩 Antigen presentation is complex - but imaging is bringing clarity.

@doreenlau.bsky.social‬ & @timmunologist.bsky.social‬ review how advanced imaging illuminates T-cell–APC interactions, peptide-MHC dynamics, and more in cancer immunity.

📖 https://bit.ly/3TkIasN
##CancerImmunology

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Worboys Lab @worboyslab.bsky.social · Jul 14

Delighted to advertise a collaborative postdoc position available in the lab to develop new proximity labelling tools, funded by a BBSRC Transformative Research Technology grant:

www.jobs.manchester.ac.uk/Job/JobDetai...
#ChemicalBiology #SyntheticChemistry

Research Associate in Synthetic Chemistry and Chemical Biology:Oxford Road

www.jobs.manchester.ac.uk

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Worboys Lab @worboyslab.bsky.social · Jun 27

Brilliant overview of ‘Click Biology’

rdcu.be/etLqI

Click biology highlights the opportunities from reliable biological reactions

Nature Chemical Biology - This Perspective discusses click biology as an analogy to click chemistry and examines reactions carried out using building blocks present in every living cell, enabling...

rdcu.be

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Reposted by Worboys Lab

Madhvi Menon @madhvimenon.bsky.social · Jun 20

🚨 The Menon lab is hiring a postdoc!

Interested in mucosal immunology? Come join our team to study lung-infiltrating B cell dynamics in COPD & other chronic lung diseases
@ukri.org @lydiabeckeriii.bsky.social

Please help spread the word #ImmunoSky

www.jobs.manchester.ac.uk/Job/JobDetai...

Research Associate in Mucosal Immunology :Manchester

www.jobs.manchester.ac.uk

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Worboys Lab @worboyslab.bsky.social · Jun 9

Delighted to have visited the Dept. of Pathology at the University of Cambridge today to present our work. Some fantastic discussions!

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Worboys Lab @worboyslab.bsky.social · Jun 2

More evidence that TIGIT is an important player in autoimmunity and independent of its effect on CD226

www.nature.com/articles/s41...

#immunosky

TIGIT deficiency promotes autoreactive CD4+ T-cell responses through a metabolic‒epigenetic mechanism in autoimmune myositis - Nature Communications

Aberrant activation of autoreactive T cells is a hallmark of autoimmune diseases. Here, by analysing CD4 T cells from patients with polymyositis and mice with experimental autoimmune myositis, the aut...

www.nature.com

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Reposted by Worboys Lab

Waggoner Lab @labwaggoner.bsky.social · May 28

The subfornical organ is a nucleus for gut-derived T cells that regulate behavior @nature.com
www.nature.com/articles/s41...
www.nature.com/articles/d41...

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Worboys Lab @worboyslab.bsky.social · May 29

The deadline for this PhD is fast approaching. We are looking for a promising synthetic chemist to make new chemical biology tools to learn more about nucleic acid interactions. This is a collaborative project with the Trowbridge Lab in @uomscieng.bsky.social. If interested, get in touch soon!

Worboys Lab @worboyslab.bsky.social · May 16

We have a PhD available in the lab to design new chemical tools to do super resolution proximity labelling of nucleotides. Come join us!!

#ChemSky #ChemBio

www.findaphd.com/phds/project...

(EPSRC DTP) Super-resolution proximity nucleotide labelling at The University of Manchester on FindAPhD.com

PhD Project - (EPSRC DTP) Super-resolution proximity nucleotide labelling at The University of Manchester, listed on FindAPhD.com

www.findaphd.com

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Reposted by Worboys Lab

Worboys Lab @worboyslab.bsky.social · May 14

Our latest research is now available as a pre-print at BioRxiv. We show that the immune checkpoint receptor TIGIT cannot signal in T cells without simultaneous TCR stimulation.

#ImmunoSky

www.biorxiv.org/content/10.1...

Inhibitory TIGIT signalling is dependent on T cell receptor activation

TIGIT is an immune checkpoint receptor that can signal via cytoplasmic ITT-like and ITIM motifs to regulate T cell function. The signalling molecules that mediate inhibitory TIGIT signalling in T cell...

www.biorxiv.org

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Reposted by Worboys Lab

Journal of Cell Science @jcellsci.bsky.social · May 19

After the success of our 2023 Imaging Cell Dynamics conference, we’ll be hosting a second #JCSImaging meeting in 2026, organised by @franbottanelli.bsky.social, @guijacquemet.bsky.social‬, @drmichaelway.bsky.social‬ & Giulia Zanetti.
To register your interest: www.biologists.com/meetings/jcs...

Journal of Cell Science Meeting 2026
Imaging Cell Dynamics
Date: 11 – 14 May 2026
Venue: Montanyà Hotel, Catalonia, Spain
Register your interest

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Worboys Lab @worboyslab.bsky.social · May 16

We have a PhD available in the lab to design new chemical tools to do super resolution proximity labelling of nucleotides. Come join us!!

#ChemSky #ChemBio

www.findaphd.com/phds/project...

(EPSRC DTP) Super-resolution proximity nucleotide labelling at The University of Manchester on FindAPhD.com

PhD Project - (EPSRC DTP) Super-resolution proximity nucleotide labelling at The University of Manchester, listed on FindAPhD.com

www.findaphd.com

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Reposted by Worboys Lab

Matthew Sinton 🏳️‍🌈 @mcsinton.bsky.social · May 8

Hi everyone 👋 I’ve been nominated for the role of ECR representative position on the Member Representative Forum at @britsocimm.bsky.social. If you’d like to see me in this position and want to vote for me, you can follow this link: www.immunology.org/news/bsi-com... #immunosky

BSI committee elections 2025 | British Society for Immunology

www.immunology.org

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Worboys Lab @worboyslab.bsky.social · May 14

Our latest research is now available as a pre-print at BioRxiv. We show that the immune checkpoint receptor TIGIT cannot signal in T cells without simultaneous TCR stimulation.

#ImmunoSky

www.biorxiv.org/content/10.1...

Inhibitory TIGIT signalling is dependent on T cell receptor activation

TIGIT is an immune checkpoint receptor that can signal via cytoplasmic ITT-like and ITIM motifs to regulate T cell function. The signalling molecules that mediate inhibitory TIGIT signalling in T cell...

www.biorxiv.org

2 12 34

Reposted by Worboys Lab

Worboys Lab @worboyslab.bsky.social · Mar 26

Our lab has a postdoc position available to use super-resolution microscopy to understand how nanoscopic localisation of immune checkpoints dictates their function.

Please get in touch if interested in applying.

www.jobs.manchester.ac.uk/Job/JobDetai...

#ImmunoSky #Imaging #Microscopy

Research Associate in Imaging Human Immunology:Oxford Road

www.jobs.manchester.ac.uk

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Worboys Lab @worboyslab.bsky.social · Mar 28

Wow

Aakriti Jain @aakritijain.bsky.social · Mar 27

SO excited to share that a major part of the postdoctoral work in @robzonculab.bsky.social lab is now published: “Leucine aminopeptidase LyLAP enables lysosomal degradation of membrane proteins” www.science.org/doi/10.1126/...

Leucine aminopeptidase LyLAP enables lysosomal degradation of membrane proteins

Breakdown of every transmembrane protein trafficked to lysosomes requires proteolysis of their hydrophobic helical transmembrane domains. Combining lysosomal proteomics with functional genomic dataset...

www.science.org

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Reposted by Worboys Lab

Gillian Mackie @gillianmackie.bsky.social · Mar 26

New postdoc position in @frances-turrell.bsky.social lab. Great opportunity to join a new group, doing exciting work 🧪

Get in touch if you want to chat about life in the lab (it's fab)!

www.jobs.manchester.ac.uk/Job/JobDetai...

#ImmunoSky

Research Associate in Breast Cancer Metastasis:CRUK Oglesby Cancer Research Building, 555 Wilmslow Road, M20 4GJ

www.jobs.manchester.ac.uk

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Reposted by Worboys Lab

Wellcome Connecting Science Learning and Training @eventswcs.bsky.social · Mar 27

Explore #CRISPR screening in our two-part course! #CRISPRAnalysis25

Blends online learning with in-person training, to help you master the methods and applications of CRISPR screening and analysis.🧬

Focusing on:

▶️ #Oncology
▶️ #Neurodegeneration
▶️ #Immunology

Apply by 3 June
📎Info: bit.ly/4iBpEah

Wellcome Connecting Science
CRISPR Screening and Analysis
Course dates: 21-26 September 2025
Location: Wellcome Genome Campus, UK
Application and bursary deadline: 3 June
Apply now

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Worboys Lab @worboyslab.bsky.social · Mar 26

Our lab has a postdoc position available to use super-resolution microscopy to understand how nanoscopic localisation of immune checkpoints dictates their function.

Please get in touch if interested in applying.

www.jobs.manchester.ac.uk/Job/JobDetai...

#ImmunoSky #Imaging #Microscopy

Research Associate in Imaging Human Immunology:Oxford Road

www.jobs.manchester.ac.uk

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Worboys Lab @worboyslab.bsky.social · Feb 19

A recent study we were involved in is now online showing distinct populations of NK cells with different killing potential:

www.frontiersin.org/journals/imm...

Frontiers | CD8α and CD70 mark human natural killer cell populations which differ in cytotoxicity

www.frontiersin.org

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Reposted by Worboys Lab

Faraz Mardakheh @mardakheh.bsky.social · Feb 5

🚨Thanks to generous support from @cancerresearchuk.org, we have multiple postdoctoral positions available in our lab (www.mardakhehlab.info) @oxfordbiochemistry.bsky.social to study ribosomes synthesis in cancer. Get in touch if you’re interested + RT and spread the word! 📣 #cancer #RNA 🚨

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Reposted by Worboys Lab

Stefano Barbera @barbera-stefano.bsky.social · Feb 2

If you're a T cell enthusiast, check out our latest findings published recently in #Science Magazine | #Immunology.

Uncovering the mechanism of CAR trogocytosis between T cells has been extremely fun.

www.science.org/doi/10.1126/...

Trogocytosis of chimeric antigen receptors between T cells is regulated by their transmembrane domains

Chimeric antigen receptor trogocytosis transfers antitumor immunity between T cells and is dictated by their transmembrane domain.

www.science.org

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Reposted by Worboys Lab

Dr Róisín McManus @roisinmcmanus.bsky.social · Feb 3

I am thrilled to share our latest article that has been published in @cp-immunity.bsky.social. We describe a new role for NLRP3 outside of its #inflammasome complex, where it can regulate microglial #metabolism & key metabolites that affect the epigenetic landscape(1)
www.cell.com/immunity/ful...

NLRP3-mediated glutaminolysis controls microglial phagocytosis to promote Alzheimer’s disease progression

How NLRP3 impacts Alzheimer’s disease (AD) is unclear. McManus et al. find that NLRP3 is located at mitochondria where it regulates microglial metabolism. Depletion or chronic pharmacological inhibiti...

www.cell.com

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