Lightnews — Scholar-powered news

Reposted by Faraz Mardakheh

Rob Klose @robklose.bsky.social · 19h

Wonderful opportunity to work with Martin Howard and my group trying to understand how chromatin influences gene transcription and expression. Integration of theory, modelling, and experimentation. Come and join the team!
Please repost!

jobs.jic.ac.uk/Details.asp?...

John Innes Centre

jobs.jic.ac.uk

22 19

Reposted by Faraz Mardakheh

Diu Nguyen @diunguyenvnuk.bsky.social · 6d

Prestigious CRUK funded PhD studentship available in my lab for students with Black heritage backgrounds. See 👇Please apply and repost. UK home tuition fee status students only.

Cancer Research UK City of London Centre @cruk-cityoflondon.bsky.social · 6d

Are you interested in doing a #PhD in #cancerresearch?
🧪👩🏿‍🔬🧫🦠🔬
Do you want to develop new #biotherapeutics?
Are you of black heritage?
Applications for our fully funded 4-year BLiC PhD programme starting in Autumn 2026 are open now!
bit.ly/485QAga
#uclcancer #QMBCI #KCLcancer_pharm #KCL #TheCrick

Black Leaders PhD programme

For students of black ethnicity embarking on their research career Applications for 2026 PhD studentships are open! Application through Cancer Research UK/ Windsor Fellowship required in addition! W...

bit.ly

1 3

Reposted by Faraz Mardakheh

Mcclelland lab @mcclellandlab.bsky.social · 6d

We are looking for our next PhD student to join us 🤩 www.mcclellandlab.com to understand cancer radiation therapy's impact on DNA damage repair and chromosomal instability. Prestigious funding from CRUK RadNet. Please contact me informally - deadline 5th Nov! crukradnet.colcc.ac.uk/phd-students...

8 15

Reposted by Faraz Mardakheh

Dr Zeinab Rekad 🔬🧬🧪 @zeinabrekad.bsky.social · 10d

#RNAsky 😎

Evelina Tutucci @anilevetu.bsky.social · 10d

Collective homeostasis of condensation-prone proteins via their mRNAs | Nature share.google/zkKumKefL83G...

Collective homeostasis of condensation-prone proteins via their mRNAs - Nature

The authors discover a homeostatic process termed interstasis, in which an increased concentration of proteins within RNA–protein condensates induces the sequestration of their own mRNAs.

share.google

1 3

Reposted by Faraz Mardakheh

Lori Passmore @lapassmore.bsky.social · 11d

We have an open post-doc position in my group to study mRNA cleavage and polyadenylation using biochemical reconstitution and cryoEM.

Please get in touch if you are interested in joining this amazing team! 🔬🧬🤩
#RNA #cryoEM

51 55

Reposted by Faraz Mardakheh

Dave Shechner @shechnerlab.bsky.social · 19d

AWESOME CONFERENCE ALERT!!

I had an absolute blast at the Fusion “Genome Regulation Through RNA” meeting back in 2024, and psyched to see its upcoming return! Let’s geek out about all things Chromatin and RNA together, in Cancun!

Talk abstract deadline: 10/17

Details👇

4 5

Reposted by Faraz Mardakheh

Carolyn Bertozzi @carolynbertozzi.bskyverified.social · 26d

Check it out! The team at Acepodia reports efficacy of cetuximab-conjugated allogenic gamma/delta-T cells against EGFR+ tumors in mice, off-the-shelf, safer alternative to CAR-T. Currently in phase 1 clinical study (NCT06415487). Cell-surface chemistry for the win 👏

jitc.bmj.com/content/13/7...

Allogeneic cetuximab-armed gamma delta T cells using antibody-cell conjugation technology for the treatment of EGFR-expressing solid tumors

Background Targeting epidermal growth factor receptor (EGFR) has become a strategic approach in cancer therapy, using various modalities including chimeric antigen receptor (CAR)-αβT cell therapies. D...

jitc.bmj.com

1 9 77

Reposted by Faraz Mardakheh

BK. Titanji @boghuma.bsky.social · Sep 8

David Baltimore passed away this weekend. A pioneer of molecular virology who won the Nobel prize in medicine & physiology for his discovery of viral reverse transcriptase. This essay he wrote in 2018 reflecting of his 60yr career in science is a great read.
www.annualreviews.org/content/jour...

Sixty Years of Discovery | Annual Reviews

Each of us is a story. Mine is a story of doing science for 60 years, and I am honored to be asked to tell it. Even though this autobiography was written for the Annual Review of Immunology, I have ch...

www.annualreviews.org

6 82 260

Reposted by Faraz Mardakheh

Mehdi Jafarnejad @rnanomad.bsky.social · Sep 3

Looking forward to a few days of exciting discussions at the #EMBLProtein synthesis and translational control meeting www.embl.org/about/info/c...

Protein synthesis and translational control

www.embl.org

1 1 9

Reposted by Faraz Mardakheh

Albert Vilella, PhD. @albertvilella.bsky.social · Aug 31

Scientists no Longer Find Twitter Professionally Useful, and have Switched to Bluesky url: academic.oup.com/icb/article-...

Scientists no Longer Find Twitter Professionally Useful, and have Switched to Bluesky

Synopsis. Social media has become widely used by the scientific community for a variety of professional uses, including networking and public outreach. For

academic.oup.com

19 100 490

Reposted by Faraz Mardakheh

Jingchuan Luo @jingchuanluo.bsky.social · Aug 27

I'm thrilled to share our work from @weissmanlab.bsky.social (www.sciencedirect.com/science/arti...). We developed LOCL-TL, an optogenetic approach for monitoring localized translation in mammalian cells. LOCL-TL revealed two distinct strategies for mitochondrially localized translation.

1 6 17

Reposted by Faraz Mardakheh

Dr Zeinab Rekad 🔬🧬🧪 @zeinabrekad.bsky.social · Aug 8

Super happy to announce that our science magazine initiative is now on #BlueSky.
Follow @stemdoradoscimag.bsky.social for magazine life updates, release dates, kids contests, events we will attend to and more. All about making learning science and technology fun, inspiring and memorable for kids!

2 4

Reposted by Faraz Mardakheh

Vikram Paralkar @paralkarlab.bsky.social · Aug 2

📣 New preprint 📣

We present a detailed map of nascent and mature ribosomal RNAs in mouse hematopoiesis and AML (including absolute rRNA molecule numbers), and outline principles of rDNA regulation.

Work by Eleanor Sams (@eleanor44.bsky.social) & Victoria Feist (@victoriafeist.bsky.social). (1/x)

Dynamics of Ribosomal RNA Transcription and Abundance in Normal and Leukemic Hematopoiesis

Transcription of ribosomal RNAs (rRNAs) from rDNA repeats is the first step of ribosome biogenesis, accounting for a major portion of all cellular transcription. Often regarded as a housekeeping proce...

www.biorxiv.org

2 14 37

Reposted by Faraz Mardakheh

David Bartel's Lab @bartellab.bsky.social · Aug 2

Check out the latest study from our lab, led by Coffee Xiang (@coffeebond007.bsky.social) www.nature.com/articles/s41... (1/2)

PAL-AI reveals genetic determinants that control poly(A)-tail length during oocyte maturation, with relevance to human fertility - Nature Communications

Gene regulation in oocytes relies heavily on poly(A) tail-length changes. Here, the authors develop PAL-AI, a neural network model that predicts tail-length changes, identifies regulatory motifs, and ...

www.nature.com

1 14 32

Reposted by Faraz Mardakheh

Matthew Freeman @mjafreeman.bsky.social · Jul 30

This is a genuinely huge opportunity for the right person.

We @dunnschool.bsky.social are proud not only of our discovery science to transform human health, but also of the support we offer early career fellows.

Join us, and launch your independent career!

Please share.

The Dunn School, Oxford @dunnschool.bsky.social · Jul 30

📣 Applications now open 📣

We are seeking outstanding ECRs looking for a stimulating and supportive environment in which to establish their research group as externally-funded fellows, in any area or cell or molecular biology underlying disease!

Please share!

www.path.ox.ac.uk/work-with-us...

4 7

Faraz Mardakheh @mardakheh.bsky.social · Jul 23

Exciting times!!🎉🍾

Oxford Biochemistry @oxfordbiochemistry.bsky.social · Jul 23

Great news for the Advanced Proteomics Facility based here in Biochemistry @ox.ac.uk ! The Wolfson Foundation is supporting the acquisition of a state-of-the-art mass spectrometer – the first of its kind in the UK – opening up possibilities for breakthroughs in human health ⬇️ bit.ly/202507-apf

£840,000 award from the Wolfson Foundation to enhance Oxford’s proteomics research

State-of-the-art mass spectrometer to be installed at the University’s Advanced Proteomics Facility (APF)

bit.ly

1 11

Reposted by Faraz Mardakheh

Dave Shechner @shechnerlab.bsky.social · Jul 23

Woohoo! So psyched to see this awesome work from the Jovanovic lab out in the world! Congrats to all the authors on this tour-de-force!

www.cell.com/cell/fulltex...

SPIDR enables multiplexed mapping of RNA-protein interactions and uncovers a mechanism for selective translational suppression upon cell stress

SPIDR, a massively multiplexed method that simultaneously maps dozens of RNA-binding proteins to their RNA targets at single-nucleotide resolution, uncovers new RNA-protein interactions and provides c...

www.cell.com

1 4 12

Reposted by Faraz Mardakheh

Martin Turner @martint-babraham.bsky.social · Jul 19

An outstanding opportunity - a great Institute in a beautiful city

Manuel D. Diaz-Munoz @diazmunoz-lab.bsky.social · Jul 8

New opening in the lab!! We are looking for a research scientist with a strong passion and curiosity for Cancer and RNA immunobiology. If you love cutting-edge technologies, basic and translational science and strong support for career development in France and Europe, please check this out.

Research scientist in Cancer and RNA immunobiology

1 3

Reposted by Faraz Mardakheh

Evelina Tutucci @anilevetu.bsky.social · Jul 8

Optogenetic storage and release of protein and mRNA in live cells and animals | Nature Communications share.google/gz8nYXZ3hUVh...

#spatialbiology #imagingtools #fluorescencemicroscopy

Optogenetic storage and release of protein and mRNA in live cells and animals - Nature Communications

Spatiotemporal control of biomolecules is a key challenge in cell biology. Here, authors introduce RELISR, an optogenetic condensate system enabling reversible, light-dependent sequestration and relea...

share.google

15 44

Reposted by Faraz Mardakheh

Dr Zeinab Rekad 🔬🧬🧪 @zeinabrekad.bsky.social · Jul 8

#RNAsky

Genes & Development @genesdev.bsky.social · Jul 8

📽️ G&D Tapes 📽️

G&D author, Noah Helton tells us about their new study in #genesdev, revealing an intriguing link between stress granule formation and the integrated stress response. #OpenAccess @smslmoon.bsky.social

Read the full story here:
➡️ tinyurl.com/gd352899

2 6

Reposted by Faraz Mardakheh

Dan Bose @danbose.bsky.social · Jul 1

Thinking about who's hanging out with you RNA in cells? Here's a super overview of the (many!) things you can do to find out. Many thanks @mardakheh.bsky.social @shechnerlab.bsky.social #RNA #RNAinteractome

Dave Shechner @shechnerlab.bsky.social · Jun 30

Hello! Ever wonder what's "talking to" your favorite transcript, but were too scared to ask? In our review in @cp-cellreports.bsky.social, @mardakheh.bsky.social and I highlight new RNA-focused tools for discovering RNA interactions across organizational scales. Checkit!

tinyurl.com/ydn6e3ac

1 2 6

Faraz Mardakheh @mardakheh.bsky.social · Jul 1

It was a lot of fun writing this review with the amazing @shechnerlab.bsky.social! If you are looking for a review of the new RNA-centric methods to study RNA interactions, then look no more!

Dave Shechner @shechnerlab.bsky.social · Jun 30

Hello! Ever wonder what's "talking to" your favorite transcript, but were too scared to ask? In our review in @cp-cellreports.bsky.social, @mardakheh.bsky.social and I highlight new RNA-focused tools for discovering RNA interactions across organizational scales. Checkit!

tinyurl.com/ydn6e3ac

1 6 25

Reposted by Faraz Mardakheh

Chris Tape @christophertape.bsky.social · Jun 10

2 weeks left to apply for our new fully funded postdoc position studying plasticity regulators in metastatic CRC!

Chris Tape @christophertape.bsky.social · May 23

We are recruiting! We're searching for a postdoctoral research fellow to study patient-specific regulators of plasticity in primary and metastatic CRC. Please reach out if you have any questions! www.ucl.ac.uk/work-at-ucl/...

6 8

Reposted by Faraz Mardakheh

Susana Godinho @susanagodinho.bsky.social · Jun 3

👋 Are you looking for a postdoc position? Do you think microtubules are fascinating? Then we might have the job for you! 2-year funded postdoc to join our lab!
👉 deadline 20/06
👇 check it out

www.godinholab.com

43 38

Faraz Mardakheh @mardakheh.bsky.social · Jun 9

Check out this amazing work from @genophoria.bsky.social’s lab, revealing a novel post-transcriptional tumour suppressive programme in breast cancer 👇👇

Hani Goodarzi @genophoria.bsky.social · Jun 9

Been going back and forth on whether it makes sense to post science in the midst of all that is happening. But here it goes with a couple of days of delay:
www.biorxiv.org/content/10.1...

Integrative analysis of mRNA stability regulation uncovers a metastasis-suppressive program in breast cancer

Heterogeneity in cancer gene expression is typically linked to genetic and epigenetic alterations, yet post-transcriptional regulation likely influences these patterns as well. However, the quantitati...

www.biorxiv.org

2 4